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journal of Environmental Sciences 2017年第8期29卷 1-1页

作者： Michael j.Plewa susan D.Richardson University of Illinois at Urbana-Champaign U.S.A. University of South Carolina U.S.A.

The disinfection of drinking water was an outstanding（and perhaps the most important）public health achievement of the 20^（th） *** to the United Nations World Health Organization,

关键词： DBPs Recycled Water and Wastewater Formation Disinfection By-Products in Drinking Water Preface in

Local tips, global impact: community-driven measures as avenues of promoting inclusion in the control of neglected tropical diseases: a case study in Kenya

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Infectious Diseases of Poverty 2022年第4期11卷 81-90页

作者： Elizabeth A.Ochola Diana M.S.Karanja susan j.Elliott Department of Geography and Environmental Management University ofWaterlooWaterlooONCanada

Background:Neglected tropical diseases(NTDs)affect poor populations with little or no’’political voice’to influence control *** most NTDs have interventions that work,the biggest challenge remains in delivering targeted interventions to affected populations residing in areas experiencing weak health *** the upward development trends in most countries of sub-Saharan Africa(SSA),the healthcare worker to population ratio remains exceptionally low,with some areas not served at all;thus,there is a need to involve other personnel for school and community-based healthcare ***,the current community-based programs suffer from inconsistent community participation due to a lack of coordinated response,and an expanded intervention agenda that lacks context-specific solutions applicable to rural,urban,and marginalized ***:This research investigated the capacity of local communities to address the burden of *** by the social theory of human capability,the research collected primary qualitative data by conducting key informant interviews and focus group discussions of people infected or affected by *** interview data were collected and transcribed verbatim for thematic analysis using Nvivo version ***:Our findings reveal,first,a need for intersectoral collaboration between governments and affected populations for inclusive and sustainable NTD ***,a’’bottom-up’approach that enhances capacity building,sensitization,and behaviour change for improved uptake of NTD ***,the enforcement of Public Health Legislative Acts that mandates the reporting and treatment of NTDs such as ***,the establishment of support groups and counseling services to assist persons suffering from debilitating and permanent effects of ***:Our research demonstrates the importance of human agency in encouraging new forms of participation leading to the co-production of inclusive and susta

关键词： Neglected tropical diseases Control Community-driven measure Local solution Global impact Inclusion Kenya

The effects of an experimental drought on the ecophysiology and fruiting phenology of a tropical rainforest palm

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journal of Plant Ecology 2020年第6期13卷 744-753页

作者： Nara O.Vogado Michael j.Liddell susan G.W.Laurance Mason j.Campbell Alexander W.Cheesman jayden E.Engert Ana C.Palma Françoise Y.Ishida Lucas A.Cernusak Centre for Tropical Environmental and Sustainability Science College of Science and EngineeringJames Cook UniversityCairnsAustralia College of Life and Environmental Sciences University of ExeterExeter EX44RJDevonUK

Aims Anthropogenic climate change is predicted to increase mean temperatures and rainfall *** tropical rainforest species will respond to this climate change remains ***,we analysed the effects of a 4-year experimental throughfall exclusion(TFE)on an Australian endemic palm(Normambya normanbyi)in the Daintree rainforest of North Queensland,*** aimed to understand the impact of a simulated reduction in rainfall on the species’physiological processes and fruiting *** We examined the fruiting phenology and ecophysiology of this locally abundant palm to determine the ecological responses of the species to *** water availability was reduced overall by~30%under a TFE experiment,established in May *** monitored monthly fruiting activity for 8 years in total(2009–2018),including 4 years prior to the onset of the *** the most recent year of the study,we measured physiological parameters including photosynthetic rate,stomatal conductance and carbon stable isotopes(δ13C,an integrated measure of water use efficiency)from young and mature leaves in both the dry and wet *** Findings We determined that the monthly fruiting activity of all palms was primarily driven by photoperiod,mean solar radiation and mean ***,individuals exposed to lower soil moisture in the TFE decreased significantly in fruiting activity,photosynthetic rate and stomatal *** found that these measures of physiological performance were affected by the TFE,season and the interaction of the *** of fruiting activity in the TFE palms was observed in 2018,when there was an increase in shallow soil moisture compared with previous years in the *** findings suggest that palms,such as the ***,will be sensitive to future climate change with long-term monitoring recommended to determine population-scale impacts.

关键词： climate change water use efficiency stable isotopes seasonality reproductive phenology

Cocaine-induced methemoglobinemia

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World journal of Emergency Medicine 2021年第1期12卷 81-82页

作者： Kamal Kant Sahu Ajay Kumar Mishra Amos Lal Ahmad Daniyal Siddiqui susan VGeorge MD Medicine Saint Vincent HospitalWorcester 10608USA MD Medicine Mayo ClinicRochester 55905USA

Dear editor,We congratulate Chowdhury et al[1] for their excellentreport and successful management of a young ladysuffering from cocaine-induced *** this letter, we aim to address some additionalconcerns, which would ... 详细信息

关键词： editor letter caine

Microsoft Access for Windows 95入门捷径

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A gap-free genome assembly of Chlamydomonas reinhardtii anddetection of translocations induced by CRISPR-mediated mutagenesis

丛书名：由美国Ziff-Davis Press授权出版

1996年

作者：（美）（j.N.库利克）julie nichols Kulik 马俊英等译

209 p. : 图 ; 26cm 附软盘一张

ISBN: (数字)7505338307

ISBN: (纸本)7505338307

209 p. : 图 ; 26cm 附软盘一张

关键词：基本知识数据库管理系统

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Plant Communications 2023年第2期4卷 249-271页

作者： Zachary L.Payne Gervette M.Penny Tychele N.Turner susan K.Dutcher Department of Genetics Washington University School of MedicineSaint LouisMO 63110USA

Genomic assemblies of the unicellular green alga Chlamydomonas reinhardtii have provided important resources for ***,assembly errors,large gaps,and unplaced scaffolds as well as strain-specific variants currently impede many types of *** combining PacBio HiFi and Oxford Nanopore long-read technologies,we generated a de novo genome assembly for strain CC-5816,derived from crosses of strains CC-125 and *** methods of evaluating genome completeness and base-pair error rate suggest that the final telomere-to-telomere assembly is highly *** CC-5816 assembly enabled previously difficult analyses that include characterization of the 17 centromeres,rDNA arrays on three chromosomes,and 56 insertions of organellar DNA into the nuclear *** Nanopore sequencing,we identified sites of cytosine(CpG)methylation,which are enriched at *** analyzed CRISPR-Cas9 insertional mutants in the PF23 *** of the three alleles produced progeny that displayed patterns of meiotic inviability that suggested the presence of a chromosomal *** Nanopore reads from pf23-2 and pf23-3 onto the CC-5816 genome showed that these two strains each carry a translocation that was initiated at the PF23 gene locus on chromosome 11 and joined with chromosomes 5 or 3,*** translocations were verified by demonstrating linkage between loci on the two translocated chromosomes in meiotic *** three pf23 alleles display the expected short-cilia phenotype,and immunoblotting showed that pf23-2 lacks the PF23 *** CC-5816 genome assembly will undoubtedly provide an important tool for the Chlamydomonas research community.

关键词： alga reference genome de novo PacBio Nanopore structural variation

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资源管理中的土地管理与地籍系统

测绘科学 1991年第1期22卷 19-23,28页

作者： j.D.MclaughIjn S.E.nichols 周德军

全世界,特别是发达国家和发展中国家,土地问题的危急,土地资源的开发利用和保护之间平衡的需求,都向资源管理提出了十分紧迫的任务。怎样才能制止诸如森林砍伐、沙漠化和温室效应这样一些重大问题呢? 本文并不打算回答这些在许多领域内... 详细信息

全世界,特别是发达国家和发展中国家,土地问题的危急,土地资源的开发利用和保护之间平衡的需求,都向资源管理提出了十分紧迫的任务。怎样才能制止诸如森林砍伐、沙漠化和温室效应这样一些重大问题呢? 本文并不打算回答这些在许多领域内使专家们头痛的问题,只是重点提出一个关于土地资源问题新设想的框架,这个框架基于这样一种观点:支配人与土地联系的机构设置是任何资源管理的基础。

关键词：土地管理资源管理土地资源土地问题地籍图土地评价土地信息土地权属土地利用土地开发

XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation

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Genes & Diseases 2024年第5期11卷 350-359页

作者： Yun Zhang susan Lin jing Yao Wantong Cai Huaqiu Chen Ailikemu Aierken Zhe Wang Weihong Song National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijing 100053China Townsend Family Laboratories Department of PsychiatryThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Institute of Aging Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceSchool of Mental Health and the Affiliated Kangning HospitalWenzhou Medical UniversityWenzhouZhejiang 325000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325001China

As a pathological hallmark of type 2 diabetes mellitus(T2DM),islet amyloid is formed by the aggregation of islet amyloid polypeptide(IAPP).Endoplasmic reticulum(ER)stress interacts with IAPP aggregates and has been implicated in the pathogenesis of *** examine the role of ER stress in T2DM,we cloned the hIAPP promoter and analyzed its promoter activity in human *** found that ER stress significantly enhanced hIAPP promoter activity and expression in human b-cells via triggering X-box binding protein 1(XBP1)*** identified a binding site of XBP1 in the hIAPP *** of this binding site by substitution or deletion mutagenesis significantly diminished the effects of ER stress on hIAPP promoter *** of XBP splicing by MKC3946 treatment inhibited ER stress-induced hIAPP up-regulation and improved human b-cell survival and *** study uncovers a link between ER stress and IAPP at the transcriptional level and may provide novel insights into the role of ER stress in IAPP cytotoxicity and the pathogenesis of T2DM.

关键词： b-cell function Endoplasmic reticulum stress Islet amyloid polypeptide Type 2 diabetes mellitus XBP1

Quantitative Analysis of Paleoatmospheric CO2 Level Based on Stomatal Characters of Fossil Ginkgo from jurassic to Cretaceous in China

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Acta Geologica Sinica(English Edition) 2007年第6期81卷 931-939页

作者： SUN Bainian XIAO Liang XIE Sanping DENG Shenghui WANG Yongdong jIA Hui susan Tumer Key Laboratory of Western China＇s Environmental Systems of the Ministry of Education Lanzhou University Lanzhou 730000 China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Nanjing 210008 China Research Institute of Petroleum Exploration and Development Beijing 100083 China Queensland Museum South Brisbane Queensland 4101 Australia

A better theoretical and practical understanding of the linkage between paleo-CO2 and climate during geological history is important to enhance the sustainable development of modern human society. Development in plant physiology since the 1980s has led to the realization that fossil plants can serve as a proxy for paleoatmosphere and paleobiosphere. As a relict gymnosperm with evolutionary stasis, Ginkgo is well suited for paleoenvironmental reconstruction. This paper analyzes fossil Ginkgo species from integrated strata in the north of China using anatomic data of plant physiology. Using stomatal parameters, a trend for the paleo-CO2 level during the Early-Middle jurassic and the Early Cretaceous was obtained, which is consistent with the estimates by GEOCARB. The trend is also similar to that of Mean Global Surface Temperature in geological time. Compared with three other atmospheric CO2 concentration parameters, the trend of paleo-CO2 level based on the stomatal parameter of the fossil Ginkgo specimens from three contiguous strata is more exact.

关键词： jurassic Cretaceous fossil Ginkgo stomatal parameter paleoatmospheric CO2

Weight Loss Impact on Change in Depression in Type 2 Diabetes Mellitus: Study to Help Improve Early Evaluation and Management of Risk Factors Leading to Diabetes (SHIELD)

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journal of Diabetes Mellitus 2014年第3期4卷 216-224页

作者： susan Grandy Andrew j. Green Kathleen M. Fox AstraZeneca LP Wilmington DE USA Midwestern Endocrinology Overland Park KS USA Strategic Healthcare Solutions LLC Baltimore MD USA

Objectives: This study evaluated the association between weight loss and change in depression among patients with type 2 diabetes mellitus (T2DM). Methods: Weight change from 2008 to 2009 among respondents (with and without T2DM) in the Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) was calculated. Change in depression was calculated as change from 2008 to 2009 in Patient Health Questionnaire-9 (PHQ-9) scores. Respondents with weight loss (>1%, >3%, >5%) were compared with respondents with weight gain (≥1%). Multivariate regression adjusted for baseline characteristics. Results: Among those with T2DM, more respondents with weight loss (n = 779) improved their depression scores, compared with respondents with weight gain (n = 731): 32.9%, 36.9%, 39.8% for >1%, >3%, and >5% weight loss, respectively, vs. 28.7% for weight gain (pjustment, T2DM respondents with weight loss had significantly greater improvement in depression scores (p 1%, 2.96 for >3%, and 3.31 for >5% weight loss, p < 0.01). Similar improvement in depression scores and severity of depression related to weight loss was observed among all SHIELD respondents (with and without T2DM). Conclusions: Our findings demonstrate an association between weight loss and improvement in depression over a 1-year period in adults with T2DM, and suggest the need for further investigation with respect to causality.

关键词： Depression Type 2 Diabetes Mellitus Weight Loss