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Histopathological analysis of infiltrating T cell subsets in acute T cell-mediated rejection in the kidney transplant

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World Journal of Transplantation 2017年第4期7卷 222-234页

作者： Francisco Salcido-Ochoa susan swee-shan hue Siyu Peng Zhaoxiang Fan Reiko Lixiang Li Jabed Iqbal John Carson Allen Jr Alwin Hwai Liang Loh Tregs and HLA Research Force and Renal Medicine Department Singapore General Hospital Tregs and HLA Research Force and Department of Pathology National University Hospital Tregs and HLA Research Force and Yong Loo Lin School of Medicine National University of Singapore Department of Pathology and Laboratory Medicine KK Women’s and Children’s Hospital Department of Pathology Singapore General Hospital Centre for Quantitative Medicine Duke-NUS Graduate Medical School

AIM To compare the differential immune T cell subset com-position in patients with acute T cell-mediated rejection in the kidney transplant with subset composition in the absence of rejection, and to explore the association of their respective immune profiles with kidney transplant *** A pilot cross-sectional histopathological analysis of the immune infiltrate was performed using immunohistochemistry in a cohort of 14 patients with acute T cellmediated rejection in the kidney transplant and 7 kidney transplant patients with no rejection subjected to biopsy to investigate acute kidney transplant dysfunction. All patients were recruited consecutively from 2012 to 2014 at the Singapore General Hospital. Association of the immune infiltrates with kidney transplant outcomes at up to 54 mo of follow up was also explored *** In a comparison to the absence of rejection, acute T cell-mediated rejection in the kidney transplant was characterised by numerical dominance of cytotoxic T lymphocytes over Foxp3^+ regulatory T cells, but did not reach statistical significance owing to the small sample size in our pilot study. There was no obvious difference in absolute numbers of infiltrating cytotoxic T lymphocytes, Foxp3^+ regulatory T cells and Th17 cells between the two patient groups when quantified separately. Our exploratory analysis on associations of T cell subset quantifications with kidney transplant outcomes revealed that the degree of Th17 cell infiltration was significantly associated with shorter time to doubling of creatinine and shorter time to transplant *** Although this was a small pilot study, results support our suspicion that in kidney transplant patients the immune balance in acute T cell-mediated rejection is tilted towards the pro-rejection forces and prompt larger and more sophisticated studies.

关键词： Acute T cell-mediated rejection in the kidney transplant Banff classification Cytotoxic T cell Regulatory T cell Th17 cell

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The Development of a Geographic Information System(GIS) Database for Jiuzhaigou National Nature Reserve and Its Application

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Journal of Mountain Science 2013年第3期10卷 398-409页

作者： DI Bao-feng ZHANG Kai-shan TANG Ya ZHANG Ming-hua susan L.USTIN Department of Environmental Science and Engineering Sichuan University Department of Land Airand Water ResourcesUniversity of California Davis

The objective of this paper is to develop a GIS(Geographic Information System) database for Jiuzhaigou National Nature Reserve(Jiuzhaigou,hereafter) in China and demonstrate its application as a research tool.A cost-effective procedure was developed to compile a variety of geographical and biological data of the study area in terms of popular GIS format such as shape *** files were further calibrated and validated using field surveys *** developed GIS database was used to quantify the distributions of the wildlife(amphibians,mammals,and birds) using the distances of the wildlife to the centerline of the bus-tour *** Pearson correlation coefficient was used to quantify the correlation in space between pairs of different wildlife using the number of habitats for given space *** ArcObject-based macro was developed to perform the *** results showed the majority of the habitats of wildlife are located in the proximity of the tour-bus routes with an average distance ranging from 564 to 894 m depending on types of *** indicates a possibility of the disturbance to the wildlife by human *** correlation coefficient of the wildlife ranged from 0.36 to 0.64 depending on pairs of wildlife,indicating some correlations in ***,due to the limited sample size,the statistical significances need to be further *** paper has successfully demonstrated the use of the GIS-based database as a research tool for environmental study.

关键词： Geographic Information System (GIS) Database Remote sensing Wildlife CorrelationCoefficient Jiuzhaigou

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Innovation and application of dyes with high fixation

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Chinese Journal of Chemical Engineering 2022年第11期51卷 146-152页

作者： Shufen Zhang Wei Ma Bingtao Tang Bin shan State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266033China

Reactive dyes are the main species for cotton dyeing due to their wide range of hue, satisfactory color fastness and facile application method. Aiming at increasing fixation on cotton fibers, benzimidazolone yellow reactive dyes, sulfonamide red reactive dyes and anthraquinone azo blue reactive dyes are designed. The preparation, characterization and application properties of these dyes with high fixation are introduced in detail. In order to achieve dye fixation to near 100%, macromolecular crosslinking reactive dyes are designed, their dyeing and fixing mechanism are discussed. These novel reactive dyes show promising application prospect in dyeing and printing of cotton fibers.

关键词： Reactive dyes Macromolecular crosslinking dyes Cotton fibers Fixation Dyeing properties

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Multi-spectral remote sensing image enhancement method based on PCA and IHS transformations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第6期12卷 453-460页

作者： shan-long LU Le-jun ZOU Xiao-hua SHEN Wen-yuan WU Wei ZHANG Department of Earth Sciences Zhejiang University Hangzhou 310027 China Institute of Remote Sensing Applications Chinese Academy of Sciences Beijing 100101 China China A ero Geophysical Survey & Remote Sensing Center for Land and Resources Beijing 100083 China

This paper introduces a new enhancement method for multi-spectral satellite remote sensing imagery,based on principal component analysis(PCA) and intensity-hue-saturation(IHS) *** PCA and the IHS transformations are used to separate the spatial information of the multi-spectral image into the first principal component and the intensity component,*** enhanced image is obtained by replacing the intensity component of the IHS transformation with the first principal component of the PCA transformation,and undertaking the inverse IHS *** objective of the proposed method is to make greater use of the spatial and spectral information contained in the original multi-spectral *** the basis of the visual and statistical analysis results of the experimental study,we can conclude that the proposed method is an ideal new way for multi-spectral image quality enhancement with little color *** has potential advantages in image mapping optimization,object recognition,and weak information sharpening.

关键词： Remote sensing Principal component analysis(PCA) Intensity-hue-saturation(IHS) transformation Image enhancement Spatial information Spectral information

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Chinese Scientists Have Obtained Great Achievements in Comprehensive Research on the Qinghai-Tibet Plateau

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Acta Geologica Sinica(English Edition) 2013年第2期87卷 629-630页

作者： HAO Ziguo FEI Hongcai LIU Lian susan TURNER Chinese Academy of Geological Sciences Editorial Office of Acta Geological Sinica Geological Society of China

The China Geological Survey carried out 1：250000 regional geological surveys of the Qinghai-Tibet Plateau from 1999 to 2005. With a total investment of 300 million yuan, more than 1000 geologists were involved annually to conduct mapping at a grid of one line to every four km along the Kunlun Mts-Altyn shan-Tanggula Shah, Kokoxili-Qiangtang, Gangdese, Yalun Zangbu River, and finally to the Himalayan ranges. The extensive mapping culminated in a total of 112 maps covering an area of 152 square kilometers. Based on this success, the China Geological Survey launched another program, the ＂Integration and Comprehensive Study of Basic Geological Survey Result（s） in the Qinghai-Tibet Plateau＂. The program lasted from 2006 to 2010 and has yielded copious research results, making big strides in upgrading our understanding of the Qinghai-Tibet Plateau. The achievements are manifold. Around 100 maps have been drafted, including the 1：1500000 geological map, tectonic, tectono-magmatic, metamorphic rocks, Precambrian geology, lithofacies palaeogeography, Cenozoic geology, geophysical-geochemical maps and others.

关键词： Chinese Scientists Have Obtained Great Achievements in Comprehensive Research on the Qinghai-Tibet Plateau

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Impact of a nationwide training program for neonatal resuscitation in China

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Chinese Medical Journal 2012年第8期125卷 1448-1456页

作者： XU Tao WANG Hui-shan YE Hong-mao YU Ren-jie HUANG Xing-hua WANG Dan-hua Wang Li-xin FENG Qi GONG Li-min MA Yi William Keenan susan Niermeyer National Center for Women and Children＇s Health Chinese Center for Disease Control and Prevention Beijing 100089 China Department of Pediatrics Peking University Third Hospital Beijing 100191 China Department of Pediatrics Tsinghua University First Hospital Beijing 100016 China Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University Beijing 100026 China Department of Pediatrics Peking Union Medical College Hospital Beijing 100730 China Department of Pediatrics Peking University First Hospital Beijing 100034 China Cardinal Glennon Children＇s Hospital and St. Louis University School of Medicine St. Louis Missouri USA Section of Neonatology Children＇s Hospital and University of Colorado Denver School of Medicine Colorado School of Public Health13121 E. 17th Avenue Mail Stop 8402 Aurora Colorado 80045 USA

Background Seventeen million births occur in China each year. Neonatal mortality is the leading cause of under 5-year-old child deaths, and intrapartum-related injury accounts for much of mental retardation in young children. The Chinese Ministry of Health sought to improve infant and child survival through a nationwide initiative to have at least one person trained in neonatal resuscitation at every birth. The aim of the current study was to evaluate the impact of China Neonatal Resuscitation Program （NRP） on policy and infrastructure changes and its effectiveness in decreasing the incidence of mortality among newborn infants. Methods The Chinese NRP incorporated policy change, professional education, and creation of a sustainable health system infrastructure for resuscitation. Multidisciplinary teams from all 31 provinces and municipal states disseminated NRP in a train-the-trainer cascade. The intervention targeted 20 provinces with high neonatal mortality and programs to reduce maternal mortality. Program evaluation data came from 322 representative hospitals in those provinces. Results Changes in policy permitted midwives to initiate resuscitation and required resuscitation training for licensure. From 2004 through 2009 more than 110 659 professionals received NRP training in the 20 target provinces, with 94% of delivery facilities and 99% of counties reached. Intrapartum-related deaths in the delivery room decreased from 7.5 to 3.4 per 10 000 from 2003 to 2008, and the incidence of Apgar 〈7 at 1 minute decreased from 6.3% to 2.9%. Conclusions The Chinese NRP achieved policy changes promoting resuscitation, trained large numbers of professionals, and contributed to reduction in delivery room mortality. Improved adherence to the resuscitation algorithm, extension of training to the township level, and coverage of births now occurring outside health facilities can further increase the number of lives saved.

关键词： resuscitation infant, newborn asphyxia neonatorum neonatal mortality in-service training, China

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西夏佛教雕版扉畫重探（英文）

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浙江大学艺术与考古研究 2014年第1期 129-182,8-9页

作者：黄士珊萊斯大學

本研究以20世紀以來寧夏、甘肅等地所發現的爲數可觀的西夏佛教雕版扉畫爲主要材料,重新探索西夏視覺文化與周邊中國文化(包括宋朝及其他構成中國史上的所謂征服王朝如遼、金、元等)的關係。本文以視覺分析爲主要研究方法,透過對西夏及... 详细信息

本研究以20世紀以來寧夏、甘肅等地所發現的爲數可觀的西夏佛教雕版扉畫爲主要材料,重新探索西夏視覺文化與周邊中國文化(包括宋朝及其他構成中國史上的所謂征服王朝如遼、金、元等)的關係。本文以視覺分析爲主要研究方法,透過對西夏及其他地區佛教版畫中被重複使用的格套、子模之識别及比較,探討佛教雕版扉畫在中古中國各文化圈的製作、傳播與交流。西夏的佛教視覺文化遺產,亦反映在元初由活躍在宫廷及江南地區的西夏僧人所主持、印行於杭州的佛經及扉畫作品上。從佛教雕版扉畫研究所見之西夏多元視覺文化爲中古中國研究提供了新的視野。西夏在中國視覺文化研究上原本趨於邊緣的地位亦應被重新評估。

关键词：西夏版畫佛經扉畫印刷文化

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版畫與繪畫的互動——從宋元佛教版畫所見之宋畫元素談起

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浙江大学艺术与考古研究 2017年第1期 1-75,3-4页

作者：黄士珊萊斯大學

木刻版畫自10世紀以來盛行於宋、遼、金、西夏、元等朝及日、韓等地,現存作品尤以考古發現及散落各地收藏之佛教版畫數量最爲驚人,也最值得藝術史學界進一步關注。從宋畫研究的角度來看,這批佛教版畫與存世之宋代主流繪畫相比,雖然在質... 详细信息

木刻版畫自10世紀以來盛行於宋、遼、金、西夏、元等朝及日、韓等地,現存作品尤以考古發現及散落各地收藏之佛教版畫數量最爲驚人,也最值得藝術史學界進一步關注。從宋畫研究的角度來看,這批佛教版畫與存世之宋代主流繪畫相比,雖然在質材及主題方面不盡相同,但其中許多標準化、格套化的母題、構圖乃至風格,顯示了其與宋畫的密切關係,並揭示了繪畫乃爲新興版畫最主要的圖像資料庫,有助吾人管窺已失落的宋畫面向。本文更積極的目的,在以版畫與繪畫之互動的角度,重新評估10至14世紀的佛教版畫,如何在挪用繪畫元素後,塑造自身的版畫語彙,以其高度的流通性、複製性之優勢,透過宗教、多民族、區域的互動,成爲與繪畫並駕齊驅的主要圖像庫,甚或反過來成爲繪畫的跨國圖源。

关键词：佛教版畫扉畫宋畫宫廷畫樣軸式版畫《御製秘藏詮》修行山水杭州高麗繪畫伊斯蘭繪畫西亞

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帕金森病患者色觉功能与焦虑和抑郁的相关性

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中国康复理论与实践 2020年第3期26卷 359-362页

作者：王珊珊李晓红锦州医科大学辽宁锦州市121001 锦州医科大学附属大连市友谊医院辽宁大连市116001

目的探讨帕金森病患者色觉辨识功能改变与焦虑和抑郁症状之间的关系。方法选取2018年11月至2019年11月大连市友谊医院神经内科帕金森病资料库中确诊的63例帕金森病患者,采用孟塞尔色棋(FMT)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(... 详细信息

目的探讨帕金森病患者色觉辨识功能改变与焦虑和抑郁症状之间的关系。方法选取2018年11月至2019年11月大连市友谊医院神经内科帕金森病资料库中确诊的63例帕金森病患者,采用孟塞尔色棋(FMT)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、医院焦虑抑郁量表(HADS)进行评定。收集患者的年龄、性别、病程、受教育程度、Hoehn-Yahr(H-Y)分期、帕金森统一评分量表第3部分(UPDRSⅢ)评分、左旋多巴剂量、简易精神状态检查(MMSE)评分和蒙特利尔认知评估量表(MoCA)评分作为相关因素,进行相关性分析和多元回归分析。结果HAMA、SAS、HAMD、SDS、HADS的焦虑和抑郁评分均与FMT评分相关(r>0.561,P<0.001)。患者年龄、H-Y分期、病程、UPDRSⅢ评分、左旋多巴剂量、MMSE评分、MoCA评分是FMT评分的独立影响因素。结论帕金森病患者的色觉与焦虑和抑郁相关,患者的年龄、病情严重程度和认知功能损害均影响其色觉功能。

关键词：帕金森病色觉焦虑抑郁

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“被产权”:农地确权的实践逻辑及启示——基于某土地产权改革试点村的实证考察

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南京农业大学学报（社会科学版） 2013年第1期13卷 80-87,102页

作者：李祖佩管珊华中科技大学中国乡村治理研究中心湖北武汉430074 华中农业大学文法学院湖北武汉430070

在农地确权的具体实践过程中,自上而下的确权政策表达遭遇到多方面的抵制,导致确权实践的"被产权"逻辑。即一方面政策实践脱离农村社会实际和农民需要,表现出浓厚的行政命令色彩;另一方面,作为政策实施对象的农村和农民被动接受政策,不... 详细信息

在农地确权的具体实践过程中,自上而下的确权政策表达遭遇到多方面的抵制,导致确权实践的"被产权"逻辑。即一方面政策实践脱离农村社会实际和农民需要,表现出浓厚的行政命令色彩;另一方面,作为政策实施对象的农村和农民被动接受政策,不得不用某些策略性方式纠正政策内容与实际需要的背离。具体而言,基层治理原有秩序机制、村庄社会运作逻辑和农民的土地认知结构等成为形塑"被产权"实践的主要因素,诸种反制因素在政策执行过程中起消极作用,但是契合当前农村社会现实和农民实际需求,具有实质合理性。在与制度环境不相适应的情况下,依靠产权制度孤军深入,往往陷入"头疼医脚"的实践困境,损害而并非保障农民利益。

关键词：农地确权基层治理机制村庄社会农民土地认知结构

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