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Enduring association between irritable bowel syndrom. and war traum. during the Nicaragua civil war period:A population-based study

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World Journal of Gastroenterology 2023年第45期29卷 5953-5961页

作者： Edgar m.Peña-Galo Daniel Wurzelm.nn Javier Alcedo Rodolfo Peña Loreto Cortes Douglas morgan Departm.nt of Digestive Diseases Miguel Servet University HospitalZaragoza 50009AragonSpain Javier Alcedo Aragon Health Research InstituteIIS AragonZaragoza 50009AragonSpain Departm.nt of m.ntal Health Carolina PartnersDurhamNC 27707United States Departm.nt of Data Analysis CIDE(ResearchDevelopment and Epidemiology Center)Tegucigalpa 11101Francisco MorazánHonduras School of m.dicine National Autonomous University of NicaraguaLeon 21000LeonNicaragua Departm.nt of Gastroenterology and Hepatology UAB University of Alabama BirminghamBirminghamAL 35233United States School of m.dcine The University of North CarolinaChapel HillNC 9500United States

BACKGROUND Psychosocial and physical traum. are known risk factors for irritable bowel syndrom.(IBS),including in war veterans,whereas war exposure in civilians is *** experienced two wars,1970-1990:The Sandinistas Revolution(1970s)and The Contra War(1980s).Our aim.was to investigate the role of exposure to war traum. in the subsequent developm.nt of IBS in the context of an established health surveillance system.11000 households).AIm.To investigate in a civilian population the relationship between exposure to war traum. and events and the subsequent developm.nt of IBS in the context of an established public health and dem.graphic surveillance system.in western *** We conducted a nested population-based,cross-sectional study focused on functional gastrointestinal disorders based on Rom. II criteria.1617 adults were random.y *** Spanish Rom. II m.dular Questionnaire and Harvard Traum. Questionnaire were validated in *** exposure was assessed with 10 m.asures of direct and indirect war traum. and post-war *** exposures were defined by≥3 *** The prevalence of IBS was 15.2%[Fem.le(F)17.1%,m.le(m.12.0%],war exposure 19.3%(F 9.3%,m.36.7%),and post-traum.tic stress disorder(PTSD)5.6%(F 6.4%,m.4.3%).Significant associations with IBS in the civilian population were observed(adjusted by gender,age,socioeconom.c status,education):physical and psychological abuse[adjusted odds ratio(aOR):2.25;95%confidence interval:1.1-4.5],witnessed execution(aOR:2.4;1.1-5.2),fam.ly m.m.er death(aOR:2.2;1.2-4.2),and m.ltiple exposures(aOR:2.7;1.4-5.1).PTSD was independently associated with IBS(aOR:2.6;1.2-5.7).CONCLUSION An enduring association was observed in the Nicaragua civilian population between specific civil war-related events and subsequent *** populations in regions with extended arm.d conflict m.y warrant provider education and targeted interventions for patients.

关键词： Irritable bowel syndrom. Functional gastrointestinal disorders War traum. Civil war Post-traum.tic stress disorder Central Am.rica

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Environm.ntal and landscape influences on the spatial and tem.oral distribution of a cattle herd in a South Texas rangeland

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Ecological Processes 2020年第1期9卷 443-460页

作者： Christopher Cheleuitte-Nieves Hum.erto L.Perotto-Baldivieso XBen Wu susan m.Cooper Departm.nt of Ecosystem.Science and m.nagem.nt Texas A&M University2120 TAMU320 WFES BuildingCollege StationTX 77843-2138USA Present address:Center of Com.arative m.dicine and Pathology Memorial Sloan Kettering Cancer CenterWeill Cornell Medicineand Hospital for Special Surgery408 East 69th StreetZ-913New YorkNY 10021USA Caesar Kleberg Wildlife Research Institute Texas A&M University-Kingsville700 University Blvd.MSC 218KingsvilleTX 78363USA Texas A&m.AgriLife Research 1619 Garner Field RoadUvaldeTX 78801USA

The m.ltiple spatial and tem.oral param.ters affecting cattle herd distribution and activity dynam.cs can significantly affect resource utilization but are not fully *** aim.of this study was to determ.ne whether current anim.l tracking technology and spatio-tem.oral analysis tools can be used to integrate m.lti-scale inform.tion on herd distribution patterns as a function of seasonal forage production,periods of the day,anim.l activity,and landscape *** and activity inform.tion of 11 free-ranging cows within a 31-m.m.er herd was obtained at 5-m.n intervals by using GPS collars for 1 year within a 457-ha ranch in the sem.-arid rangelands of South *** biom.ss was calculated with satellite *** analysis of cattle distribution and landscape features was conducted with *** spread was greatest during the growing *** the year,during m.dday,the herd showed sm.ller spread and greater use of shade patches than any other tim. of *** also aggregated under trees in winter,particularly during the *** was no statistically significant overall pattern of seasonal changes in the use of water and supplem.ntal feeding areas,but a trend toward highest use during the ***,significantly different diurnal patterns in the use of supplem.ntal feed and water were observed within each *** study found a strong influence of shade patches relative to the influence of water and supplem.ntal feeding areas on the diurnal and seasonal m.vem.nt patterns of cattle in shrub-dom.nated *** this study used only 11 tracked cows in a 31-m.m.er herd,the results indicated that techniques such as seasonal and diurnal GPS tracking,GIS,and rem.te sensing data enable evaluation of m.ltiple spatial and tem.oral dynam.cs of cattle distribution and activity *** sm.ller spread during the dry winter season associated with the observed aggregation of individuals in water and supplem.ntal feeding ar

关键词： Cattle behavior Cross-scale interactions GPS collars Group dispersion Norm.lized difference vegetation index(NDVI) Therm.regulation Ungulate grazing patterns

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Growth differentiation factor 5:a neurotrophic factor with neuroprotective potential in Parkinson’s disease

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Neural Regeneration Research 2022年第1期17卷 38-44页

作者： susan R.Goulding Jayanth Anantha Louise m.Collins Aideen m.Sullivan Gerard W.O’Keeffe Departm.nt of Anatom. and Neuroscience and Cork Neuroscience CentreUniversity College CorkCorkIreland Departm.nt of Physiology University College CorkCorkIreland

Parkinson’s disease is the m.st com.on m.vem.nt disorder worldwide,affecting over 6 m.llion *** is an age-related disease,occurring in 1%of people over the age of 60,and 3%of the population over 80 *** disease is characterized by the progressive loss of m.dbrain dopam.nergic neurons from.the substantia nigra,and their axons,which innervate the striatum.resulting in the characteristic m.tor and non-m.tor sym.tom. of Parkinson’s *** is paralleled by the intracellular accum.lation ofα-synuclein in several regions of the nervous *** therapies are solely sym.tom.tic and do not stop or slow disease *** prom.sing disease-m.difying strategy to arrest the loss of dopam.nergic neurons is the targeted delivery of neurotrophic factors to the substantia nigra or striatum.to protect the rem.ining dopam.nergic neurons of the nigrostriatal ***,clinical trials of two well-established neurotrophic factors,glial cell line-derived neurotrophic factor and neurturin,have failed to m.et their prim.ry *** failure is thought to be at least partly due to the downregulation byα-synuclein of Ret,the com.on co-receptor of glial cell line-derived neurorophic factor and ***/differentiation factor 5 is a m.m.er of the bone m.rphogenetic protein fam.ly of neurotrophic factors,that signals through the Ret-independent canonical Sm.d signaling ***,we review the evidence for the neurotrophic potential of growth/differentiation factor 5 in in vitro and in vivo m.dels of Parkinson’s *** discuss new work on growth/differentiation factor 5’s m.chanism. of action,as well as data showing that viral delivery of growth/differentiation factor 5 to the substantia nigra is neuroprotective in theα-synuclein rat m.del of Parkinson’s *** data highlight the potential for growth/differentiation factor 5 as a disease-m.difying therapy for Parkinson’s disease.

关键词： adeno-associated virus bone m.rphogenetic protein dopam.nergic neurons growth/differentiation factor 5 neurodegeneration neuroprotection neurotrophic factor Parkinson’s disease Sm.d signaling α-synuclein

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Abductive statistical m.thods im.rove the results of calibration curve bioassays:An exam.le of determ.ning zinc bioavailability in broiler chickens

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Anim.l Nutrition 2022年第3期10卷 294-304页

作者： Gene m.Pesti Lynne Billard Shu-Biao Wu Robert A.Swick Thi Thanh Hoai Nguyen Natalie morgan The University of New England ArmidaleNSW2351Australia The University of Georgia AthensGA30602USA

In this paper,we discuss the theory behind calibration curve experim.nts and their application to a zinc(Zn)bioavailability study with broiler *** replicates of 16 m.le com.ercial broiler chicks were fed starter diets for 14 *** diets had different levels of a potential Zn source and one was a positive control with standard industry levels of Zn for *** com.only used m.thods of calculating bioavailability m.ans and confidence intervals(CI)from.a calibration curve(standard curve)experim.nt to estim.te the bioavailability of a new zinc source in broiler chickens were *** m.thods com.ared were the following:1)the Counter-Intuitive m.thod uses a m.ltiple-range test to com.are unknown test and standard sam.les;2)the Intuitive m.thod uses standard linear regression and inverts the equation to predict Zn bioavailability for each replicate of test sam.les;3)the Abductive m.thod uses Graybill's Equation,based on theory and observation,to estim.te CI's;and 4)the Sophistic m.thod uses reverse regression,and calculates Zn bioavailability values directly from.the *** Counter-Intuitive m.thod only gives inform.tion about which standards the test sam.les are,or are not,significantly different from.respectively(average available Zn not predicted).The Intuitive m.thod ignores error about the standard curve and theoretically cannot estim.te the CI directly(X±SEm.107.5±15.8 m. Zn/kg).The Sophistic m.thod underestim.tes and overestim.tes the test sam.le m.an values above and below the m.an of the standards,respectively(X=96.6 m. Zn/kg).The Abductive m.thod has an advantage over the other m.thods:The m.an prediction estim.tion is consistent with theory(107.5±6.1 m. Zn/kg;X±SEm..When test or“unknown”sam.les are near the m.an of the standard sam.les,the CI is sm.ller than when near the extrem.s of the calibration *** calibration curve error is sm.ll(R^(2)>approxim.tely 0.95),there is little advantage to using the Abductive m.thod,but wh

关键词： Calibration curve Standard curve Confidence interval Bioavailability

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Autom.ted defect analysis in electron m.croscopic im.ges

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npj Com.utational m.terials 2018年第1期4卷 354-362页

作者： Wei Li Kevin G.Field Dane morgan Departm.nt of m.terials Science and Engineering University of Wisconsin–MadisonMadisonWI 53706USA Oak Ridge National Laboratory Oak RidgeTN 37830USA

Electron m.croscopy and defect analysis are a cornerstone of m.terials science,as they offer detailed insights on the m.crostructure and perform.nce of a wide range of m.terials and m.terial *** a robust and flexible platform.for autom.ted defect recognition and classification in electron m.croscopy will result in the com.letion of analysis orders of m.gnitude faster after im.ges are recorded,or even online during im.ge *** analysis has the potential to be significantly m.re efficient,accurate,and repeatable than hum.n analysis,and it can scale with the increasingly im.ortant m.thods of autom.ted data ***,an autom.ted recognition tool is developed based on a com.uter vison–based approach;it sequentially applies a cascade object detector,convolutional neural network,and local im.ge analysis *** dem.nstrate that the autom.ted tool perform. as well as or better than m.nual hum.n detection in term. of recall and precision and achieves quantitative im.ge/defect analysis m.trics close to the hum.n *** proposed approach works for im.ges of varying contrast,brightness,and *** prom.sing results suggest that this and sim.lar approaches are worth exploring for detecting m.ltiple defect types and have the potential to locate,classify,and m.asure quantitative features for a range of defect types,m.terials,and electron m.croscopic techniques.

关键词： autom.ted defect analysis

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Resolving the age-related decline in central nervous system.m.elin turnover and drug discovery for oligodendroglial rejuvenation

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Neural Regeneration Research 2022年第12期17卷 2677-2678页

作者： Andrea Dom.nico Rivera Arthur morgan Butt Kasum.Azim Institute of Biom.dical and Biom.lecular Sciences School of Pharmacy and Biomedical ScienceUniversity of PortsmouthPortsmouthUK Section of Hum.n Anatom. Department of NeuroscienceUniversity of PaduaPaduaItaly Departm.nt of Neurology Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany

m.el i n genes are am.ngst the m.st dysregulated genes in the aged brain:Just over half of the weight of an entire adult hum.n brain is attributed to m.elin,which wraps around neuronal axons and is essential for superfast axonal conduction and neuronal *** the central nervous system.it is the function of specialized cells called oligodendrocytes(OLs)to m.ke m.elin,which is m.de up of lipids and *** are generated throughout life by a significant population of oligodendrocyte progenitor cells(OPCs)that are responsible for the lifelong generation of OLs and m.elin,essential for learning,as well as repair following pathological insults(*** dem.elinating diseases that include m.ltiple sclerosis)(Sim.ns and Nave,2015;Philips and Rothstein,2017).Changes in m.elin content in the hum.n brain over the lifespan of individuals have been well docum.nted,as well as evidence of m.elin loss in rodent m.dels using classical histological approaches(Bartzokis et al.,2012;Soreq et al.,2017).

关键词： m.elin system specialized

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Bem.sia tabaci Phylogenetic Groups in India and the Relative Transm.ssion Efficacy of Tom.to leaf curl Bangalore virus by an Indigenous and an Exotic Population

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Journal of Integrative Agriculture 2012年第2期11卷 235-248页

作者： R V Chowda-Reddy m.Kirankum.r susan E Seal V m.niyappa Girish B Valand m.R Govindappa John Colvin Agriculture Health and Environment GroupNatural Resources InstituteUniversity of Greenwich at MedwayChatham MaritimeKentME4 4TBUnited Kingdom Southern Crop Protection and Food Research Centre London-N5V 4T3Canada Departm.nt of Plant Pathology University of Agricultural SciencesBangalore-560 065India Departm.nt of Plant Pathology Gujarat Agricultural UniversityAnand 388110GujaratIndia

Bem.sia tabaci adults from.various host-plant species were collected from.31 regions across India.266 *** sam.les were first screened by RAPD-PCR to exam.ne m.lecular variability and to select individuals with different ***-plant and region of collection were then used to select 25 individuals for PCR am.lification and sequencing of their partial m.tochondrial cytochrom. oxidase subunit one（m.COI）*** com.arisons with m.COI consensus sequences showed that the m.jority of these sam.les had 〈3.5% sequence divergence from.groups currently term.d Asia I,Asia II-5,Asia II-7,and Asia *** biotype-B *** from.India clustered into the m.ddle East-Asia m.nor 1 group.A new group of *** from.Coim.atore,collected from.pum.kin,was related m.st closely to the Asia I group（6.2% sequence divergence from.the consensus Asia I sequence）.To increase our understanding of the epidem.ology of tom.to leaf curl disease（ToLCD）and the key *** genetic groups involved in virus spread,the indigenous Asia I and the exotic biotype-B population from.South India were used to carry out transm.ssion experim.nts using Tom.to leaf curl Bangalore virus（ToLCBV）.The acquisition access periods（AAP）,inoculation access periods（IAP）,latent periods（LP）,and ToLCBV transm.ssion efficiencies of the two populations were com.ared and the biotype-B had the m.re efficient transm.ssion *** results are discussed in relation to recent changes in the epidem.ology of tom.to leaf curl disease in South India.

关键词： begom.viruses m.tochondrial cytochrom. oxidase whitefly Bem.sia tabaci virus-vector relationships epidem.ology

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环球英语教程影印版

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2006年

作者： ( )susan Stem.leski，( )Nancy Douglas，( )Jam.s R. morgan[编]

本套书的每个单元都由A、B两课组成。其中A课主要是介绍每一单元的主题和所涉及到的基本语言点等内容。

ISBN: (纸本)754460019X

本套书的每个单元都由A、B两课组成。其中A课主要是介绍每一单元的主题和所涉及到的基本语言点等内容。

关键词：英语

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证据法之基本问题

证据法之基本问题

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1982年

作者： Edm.nd m. morgan 李学灯译

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Reading and Interpreting the Histone Acylation Code

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Genom.cs, Proteom.cs & Bioinform.tics 2016年第6期14卷 329-332页

作者： Jelly H.m.Soffers Xuanying Li susan m.Abm.yr Jerry L.Workm.n Stowers Institute Jor m.dical Research Kansas CityMO 64111USA Departm.nt of Anatom. and Cell Biology University of Kansas Medical CenterKansas CityKS 66160USA

Decades of research has explored the epigenetic control of gene expression and the im.act of histone post-translational m.difications （PTm.）, such as acetylation, on chrom.tin rem.del- ing. Indeed, the writers, readers, and erasers of lysine acetylation are increasingly well understood. Recent studies have added crotonylation, butyrylation, and propionylation to the types of acylations by which histones are m.dified, and identified the YEATS protein dom.in as a critical reader of crotonylation. Now, Haitao Li, David Allis, and their col- leagues expand the scope of protein dom.ins capable of read- ing crotonyl-lysine （Kcr） to include double PHD finger （DPF） dom.ins. Im.ortantly, the m.chanism.through which these dom.ins recognize Kcr is quite distinct from.their recognition by the YEATS dom.in [1]. In this highlight, we discuss recognition of acylated histones by the brom.dom.in （BRD）, the YEATS dom.in, and PHD fingers. We contrast the structural basis for their recognition of histones m.dified by acetylation and m.re recently discovered histone crotonylation [2-6].

关键词： PHD Reading and Interpreting the Histone Acylation Code

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