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Social-ecological correlates of fundamental movement skills in young children

Journal of Sport and Health Science 2019年第2期8卷 122-129页

作者： Nan Zeng susan l.johnson Richard E.Boles laura l.Bellows Department of Food Science and Human Nutrition Colorado State University Department of Pediatrics University of Colorado Anschutz Medical Campus

Purpose: To identify the social-ecological correlates associated with fundamental movement skills at the child, family, and environment levels in young ***: Preschool children from 4 Colorado Head Start/preschool centers were recruited from 2010 to 2012. Two hundred twenty-eight children(128 girls; age = 56.08 § 4.09 months; body mass index(BMI) z-score = 0.53 § 1.12(mean § SD); 42.1% Hispanic/latino) and 159 families were included in the final analysis. Children's perceived competence and fundamental movement skills were assessed via the Pictorial Scale of Perceived Competence and Social Acceptance and the Bruininks-Oseretsky Test of Motor Proficiency, 2 nd edition. Data on the number of children in the family, parent age, BMI, education, employment status, family income, perception of child coordination, and home physical activity environment were collected via a questionnaire. linear regressions adjusted for child BMI, age, sex, and school site were performed at each ***: Child perceived cognitive competence was positively associated with locomotor skills(p = 0.04; adjusted R2= 0.035) and object-control skills(p = 0.003; adjusted R2= 0.083) at the child level. Parent education, BMI, and perception of child coordination were positively associated with locomotor skills and explained 8.8% of variance, but only parent education was significant(p = 0.04) at the family level. In addition, physical environment was positively associated with locomotor skills(p = 0.02) and explained 5.5% of variance at the environment ***: Social-ecological correlates associated with young children's fundamental movement skills are multidimensional and differ according to skill category at the child, family, and environment levels.

关键词： Activity environment Fundamental movement skills Parent education Perceived cognitive competence Preschool children

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The Decarbonization of Construction—How Can Alkali-Activated Materials Contribute?

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Engineering 2024年第6期37卷 18-21页

作者： John l.Provis susan A.Bernal Zuhua Zhang Department of Materials Science and Engineering University of SheffieldSheffield S13JDUK Paul Scherrer Institut Villigen PSI 5232Switzerland School of Civil Engineering University of LeedsLeeds LS29JTUK School of Materials Sciences and Engineering Tongji UniversityShanghai 201804China

*** and context Enormous emphasis is currently being paid to the decarbonization of the global built environment as a leading priority for the engineering community and related industrial sectors[1].One of the main contributors to the overall emissions footprint of the built environment-and thus a cornerstone of efforts to achieve decarbonization-is the emissions profile of construction materials during their production and *** cement and concrete sector is the largest-volume contributor to the emissions incurred in meeting the world’s construction material needs and is therefore targeted in the discussion of the deep,rapid decarbonization that must be achieved in order to minimize irreversible damage to the Earth and its ecosystems.

关键词： Alkali corners irreversible

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Therapeutic Potential of Thunbergia laurifolia *** in Gestational Diabetes Mellitus:Insights from a Rat Model

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Chinese Journal of Integrative Medicine 2024年第9期30卷 788-798页

作者： Sasitorn Kerdsuknirund Arreeya Kosinan Panida Khunkaewla Pakanit Kupittayanant Ratchadaporn Oonsivilai Pattama Tongdee Porntip Nimkuntod susan Wray Sajeera Kupittayanant School of Preclinical Sciences Institute of ScienceSuranaree University of TechnologyNakhon Ratchasima30000Thailand Biochemistry-Electrochemistry Research Unit School of BiochemistryInstitute of ScienceSuranaree University of TechnologyNakhon Ratchasima30000Thailand School of Animal Technology and Innovation Institute of Agricultural TechnologySuranaree University of TechnologyNakhon Ratchasima30000Thailand School of Food Technology Institute of Agricultural TechnologySuranaree University of TechnologyNakhon Ratchasima30000Thailand School of Obstetrics and Gynecology Institute of MedicineSuranaree University of TechnologyNakhon Ratchasima30000Thailand School of Internal Medicine Institute of MedicineSuranaree University of TechnologyNakhon Ratchasima30000Thailand Harris-Wellbeing Preterm Birth Research Centre Department of Women and Children’s Healththe Institute of Lifecourse and Medical SciencesUniversity of LiverpoolLiverpoolUK

Objective:To assess the effects of Thunbergia laurifolia ***(TlE)on gestational diabetes mellitus(GDM)in a rat ***:Thunbergia laurifolin *** were subjected to ethanolic *** vivo study,50 pregnant rats were randomly divided into 5 groups(10 for each):non-GDM group,GDM induced by streptozotocin(STZ,60 mg/kg i.p.),metformin(MET)100 mg/kg,TlE 50,and 500 mg/kg *** was performed on gestation day 7 until term(day 21).The effects of TlE on blood glucose,insulin levels,lipid profiles,liver enzymes,and maternal performances were *** in vitro study,the effect of TlE was examined using the organ bath for uterine force ***:In in vivo study,TlE significantly reduced blood glucose as compared to GDM(Plly increased insulin *** effect was consistent with islets of langerhans ***,the uterine muscular layer displayed a marked increase in fiber area in response to both doses as compared to GDM(Plly,TlE significantly reduced total cholesterol,triglyceride,and alanine transaminase levels(Ply,TlE also led to a notable augmentation in gravid uterus size,live fetuses count,and implantation numbers,while significantly reducing the post-implantation loss rate associated with fetal classification(Plose to those produced by *** in vitro study,TlE exerted a concentration-dependent inhibition of spontaneous uterine contractility(half-maximal inhibition concentration=1.2 mg/l).This inhibitory effect extended to potassium chloride depolarization and oxytocin-mediated *** combined with its major constituent,rosmarinic acid,TlE produced an enhanced inhibitory effect(Plusions:TlE ameliorated blood glucose levels,enhanced uterine muscular structure,and improved maternal and fetal performance in *** also displayed tocolytic *** findings underscore the need for further explor

关键词： myometrium gestational diabetes mellitus tocolytic oxytocin Thunbergia laurifolia l.

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Resolving place names in Amdo and Kham:A gazetteer for the Hengduan Mountains region of Southwest China

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植物分类学报 2006年第6期44卷 721-732页

作者： susan l. KEllEY Arnold Arboretum and Harvard University Herbaria 22 Divinity Avenue Cambridge MA 02138-2020 U.S.A.

Perhaps no region on earth presents such a confusing array of place names as does the area made up of the former provinces of Kham and Amdo in historic Tibet (Xizang). Within these areas, cities, towns, villages, mountains, lakes and other geographic features have at least two names applied to them, one Tibetan, the other Chinese. Overlying this indigenous nomenclature are the names applied by outsiders, mostly Europeans, each of whom used their native language to transliterate the names they heard or read from Tibetan or Chinese script, and names in the languages of other ethnic minorities who live within the area. Adding to the confusion are the conflicting “standards” for transliterating Tibetan and Chinese names. To resolve the inconsistencies and uncertainties of place names in this region, a multilingual gazetteer and thesaurus was prepared. The gazetteer-thesaurus was compiled to be used as a tool for correlating the often radically different names assigned to a single place or feature and to provide the geographic coordinates for each. The impetus for this project was the need to assign geographic coordinates to plant specimens collected in the area since the latter part of the 19th century up until the advent and widespread use of Global Positioning System (GPS) receivers in the 1990s. Georeferencing specimens is necessary for plotting the historical distribution of species and for more completely understanding the information contained on specimen labels. Knowing the distribution of plants is important for answering phylogenetic questions, determining local and widespread biogeographical patterns, identifying areas of unusually high diversity or endemism, and determining areas in need of special protection. The value of such a gazetteer, however, extends well beyond the field of botany. It is intended to be of use to anyone with a desire to know the nomenclatural history of places in the area and for pinpointing with a fair degree of accuracy the location

关键词： Tibet (Xizang) Amdo Kham Hengduan Mountains gazetteer biodiversity Geographic Information Systems (GIS) herbarium conservation georeferencing.

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Influence of Soil Properties on Zinc Solubility Dynamics Under Different Redox Conditions in Non-Calcareous Soils

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Pedosphere 2017年第1期27卷 96-105页

作者： Michelle Anne Belen BUNQUIN susan TANDY Sarah johnson BEEBOUT Rainer SCHUlIN Crop and Environmental Sciences Division International Rice Research InstituteCollegeLos Banos Soil Protection Institute of Terrestrial EcosystemsETH Zurich

Zinc(Zn) deficiency in paddy soils is often a problem for rice *** can decrease metal availability in some noncalcareous soils through different mechanisms associated with soil redox *** experiments were performed in order to better understand the processes that governed the dynamics of Zn in non-calcareous paddy soils at varying redox potentials(Eh).Airdried non-calcareous soil samples collected from four different paddy field sites in the Philippines were submerged and incubated in a reaction cell with continuous stirring and nitrogen purging for 4 weeks,and then purged with compressed air for another week to reoxidize the *** Eh of the four soils started at 120 to 300 mV,decreased to —220 to —300 mV after 100 to 250 h of reduction,and was maintained at this low plateau for about 2 weeks before increasing again upon *** solubility showed contrasting patterns in the four soils,with two of the soils showing a decrease in soluble Zn as the Eh became low,probably due to zinc sulfide(ZnS) *** contrast,the other two soils showed that Zn solubility was maintained during the reduced phase which could be due to the competition with iron(Fe) for precipitation with *** in the relative amounts of S,Fe,and manganese(Mn) oxides in the four soils apparently influenced the pattern of Zn solubility after flooding.

关键词： microcosm paddy soil precipitation rice soil sulfide speciation Zn availability

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Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang liu Junya Fujimoto lingzhi Hong Alexandre Reuben susan Varghese Carmen Behrens Tina McDowell luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning le Natalie I Vokes Chao Cheng John V.Heymach Don l.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSClC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

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Different faces of gastroparesis

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World Journal of Gastroenterology 2009年第48期15卷 6052-6060页

作者： Klaus Bielefeldt Naeem Raza susan l Zickmund Division of Gastroenterology University of Pittsburgh Medical Center Center of Health Equity Research and Practice at the Veteran Administration Health System Pittsburgh

AIM： To test the hypothesis that pain and affect rather than impaired emptying determine symptom severity in patients with gastroparesis. METHODS： Adult patients with documented gastroparesis were enrolled prospectively in a single center and asked to complete the Gastroparesis Cardinal Symptom Index （GCSt）, Hospital Anxiety and Depression Scale （HADS）, the Short Form 12 （SF-12） as quality of life index, rate pain severity and answer 10 open-ended questions. RESUlTS： A total of 55 patients （44 women） participated. Idiopathic （n = 29） or diabetic （n = 11） gastroparesis and connective tissue disease （n = 8） were the most common underlying causes. Antiemetics （n = 30） and prokinetics （n = 32） were most often prescribed. Seventeen patients used opioids on a daily basis. Nausea and/or vomiting （n = 28）, pain （n = 24） and bloating （n = 14） were most commonly listed as dominant symptoms. Patients subjectively attributed symptom improvement to nutritional and dietary therapy （n= 11）, prokinetics （n = 11）, antiemetics （n = 10） or analgesic agents （n = 3）. In univariate analyses, the physical subscore of the SF-12 and HADS, but not gastric emptying delay or symptom duration significantly correlated with disease severity as measured by the GCSI. In multivariate analyses, the combination of vomiting, bloating and depression best predicted the overall impact on quality of life. CONClUSION： The study confirms the importance of pain and affect in gastroparesis, which requires novel approaches to improve more effectively the quality of life in patients with this disorder.

关键词： Pain Depression Gastroparesis Quality oflife

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Hepatitis C Virus Experimental Model Systems and Antiviral drug Research

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Virologica Sinica 2010年第4期25卷 227-245页

作者： susan l.Uprichard Department of Medicine Section of Hepatology and Department of Microbiology and ImmunologyUniversity of Illinois at Chicago

An estimated 130 million people worldwide are chronically infected with hepatitis C virus (HCV) making it a leading cause of liver disease worldwide. Because the currently available therapy of pegylated interferon-alpha and ribavirin is only effective in a subset of patients, the development of new HCV antivirals is a healthcare imperative. This review discusses the experimental models available for HCV antiviral drug research, recent advances in HCV antiviral drug development, as well as active research being pursued to facilitate development of new HCV-specific therapeutics.

关键词： Hepatitis C virus Chronic liver disease Experimental model systems High throughput screening Drug targets

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Social distance integrated gravity model for evacuation destination choice

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International Journal of Digital Earth 2021年第8期14卷 1004-1018页

作者： Yuqin Jiang Zhenlong li susan l.Cutter Geoinformation and Big Data Research laboratory Department of GeographyUniversity of South CarolinaColumbiaSCUSA Hazards and Vulnerability Research Institute Department of GeographyUniversity of South CarolinaColumbiaSCUSA

Evacuation is an effective and commonly taken strategy to minimize death and injuries from an incoming *** decades,interdisciplinary research has contributed to a better understanding of evacuation *** destination choice modeling is an essential step for hurricane evacuation transportation *** factors are identified associated with evacuation destination choices,in which long-term social factors have been found essential,yet neglected,in most studies due to difficulty in data *** study utilized long-term human movement records retrieved from Twitter to(1)reinforce the importance of social factors in evacuation destination choices,(2)quantify individual-level familiarity measurement and its relationship with an individual’s destination choice,(3)develop a big data approach for aggregated county-level social distance measurement,and(4)demonstrate how gravity models can be improved by including both social distance and physical distance for evacuation destination choice modeling.

关键词： Big data disaster management evacuation social media social distance

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Epigenetic modification of the Wnt signaling pathway:a potential target for intestinal aging

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Gastroenterology & Hepatology Research 2024年第2期6卷 11-14页

作者： Ji-Da Wang Yue-Xuan Shi Ogbe susan Enechojo Huan-Tian Cui Ying Wang Abankwah Joseph Kofi Xiang-ling Wang Yu-Bong Bian Xiao-Qian Chu School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Physiology Federal UniversityWukari 670101Nigeria First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650500China

Intestinal aging is emerging as a major public health problem The world has entered an aging society,and it is expected that the global population aged 60 years or older will reach 1.5 billion by 2035[1].Aging is gradually becoming a major public health issue,posing a significant challenge to healthcare systems[2].It is a complex natural physiological process involving the irreversible degeneration of body cells,tissues,and organs,and it is a major risk factor for many chronic diseases.

关键词： aging irreversible potential

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