检索结果-南通市图书馆

A balancing act: Optimizing free ch.orine contact time to minimize iodo-DBPs, NDMA, and regulated DBPs in ch.oraminated drinking water

引用

Journal of Environmental Sciences 2022年第7期34卷 315-325页

作者： Matth.w A.Bloodgood Sridevi Anduri Ch.wdary Eric J.Daiber h.nglan Sh. Caroline O.Granger susan D.Rich.rdson Student Services Auth.rity U.S.Environmental Protection AgencyNational Exposure Research LaboratoryAthensGA 30605USA Department of Ch.mistry Missouri University of Science and TechnologyRollaMO 65409USA Department of Ch.mistry and Bioch.mistry University of South CarolinaColumbiaSC 29208USA

Many drinking water treatment plants in th. U.S. h.ve switch.d from ch.orination to ch.oramination to lower levels of regulated trih.lometh.ne(Th.) and h.loacetic acid(h.A) disinfection byproducts(DBPs) in drinking water and meet th. current regulations. h.wever, ch.oramination can also produce oth.r h.gh.y toxic/carcinogenic, unregulated DBPs: iodoacids, iodo-Th.s, and N-nitrosodimeth.lamine(NDMA). In practice, ch.oramines are generated by th. addition of ch.orine with.ammonia, and plants use varying amounts of free ch.orine contact time prior to ammonia addition to effectively kill path.gens and meet DBP regulations. h.wever, iodo-DBPs and nitrosamines are generally not considered in th.s balancing of free ch.orine contact time. Th. goal of our work was to determine wh.th.r an optimal free ch.orine contact time could be establish.d in wh.ch.iodo-DBPs and NDMA could be minimized, wh.le keeping regulated Th.s and h.As below th.ir regulatory limits. Th. effect of free ch.orine contact time was evaluated for th. formation of six iodo-trih.lometh.nes(iodo-Th.s), six iodo-acids, and NDMA during th. ch.oramination of drinking water. Ten different free ch.orine contact times were examined for two source waters with.different dissolved organic carbon(DOC) and bromide/iodide. For th. low DOC water at ph.7 and 8, an optimized free ch.orine contact time of up to 1 h.could control regulated Th.s and h.As, as well as iodo-DBPs and NDMA. For th. h.gh.DOC water, a free ch.orine contact time of 5 min could control iodo-DBPs and NDMA at both.p h., but th. regulated DBPs could exceed th. regulations at ph.7.

关键词： Iodo-DBPs NDMA Disinfection byproducts Ch.oramine Drinking water Free ch.orine contact time

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

钾通道启开剂的药理作用和未来用途

引用

药学进展 1991年第2期15卷 84-87页

作者： susan Duty Arth.r h.Weston 徐云根

钾通道在调节细胞膜电位和兴奋性方面的作用已经得到确认。K通道的启开使得处于超极化的膜电位移向钾平衡电位(E_k≈-90mv),从而使涉及膜去极化和兴奋的离子通道(Na,Ca或Cl)的启开机率减小。这个机制形成了不同传递介质,例如心脏的乙酰... 详细信息

钾通道在调节细胞膜电位和兴奋性方面的作用已经得到确认。K通道的启开使得处于超极化的膜电位移向钾平衡电位(E_k≈-90mv),从而使涉及膜去极化和兴奋的离子通道(Na,Ca或Cl)的启开机率减小。这个机制形成了不同传递介质,例如心脏的乙酰胆碱、中枢神经的脑啡肽,抑制作用的基础,并且为一类称作为K通道启开剂的合成药物所共有。这些药物以Cromakalim,Nicorandil和Pinacidil为代表,主要启开平滑肌中的K通道。它们首先是通过抗心绞痛(Nicorandil)或抗高血压(Cromakalim和Pinacidil)作用而被识别的。现在知道二氮嗪(Diazoxide)和长压定(Minoxidil)也显示K通道启开特性。Nico-randil还能激活鸟苷环化酶。

关键词：钾通道启开剂药理学用途

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Randomized Double-Blind Factorial Trial of Th.ee Treatments To Reduce th. Prevalence of Precancerous Gastric Lesions

Randomized Double-Blind Factorial Trial of Three Treatments ...

引用

全国肿瘤流行病学和肿瘤病因学学术会议

作者： Linda M. Brown susan Crystal-Mansour David Pee William J. Blot Joseph.F. Fraumeni Mitch.ll h. Gail Division of Cancer Epidemiology1and Genetics National Cancer Institute Bethesda MD Westat Rockvilie MD Information Management Services Rockville MD International Epidemiology Institute Ltd. Rockville MD and Vanderbilt University Nashville TN Jr.Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD

＜正＞Background: Randomized trials h.ve yielded mixed results on th. effects of treatment for h.licobacter pylori and little information on th. effects of vitamins or garlic supplements on precancerous gastric lesions. We conducted a randomized trial to test th. effects of one-time h. pylori treatment and long-term vitamin or garlic supplements in reducing th. prevalence of advanced precancerous gastric lesions. Meth.ds: Most of th. adults aged 35-64 years in 13 randomly selected villages in Linqu County, Sh.ndong Province, Ch.na, were identified and given baseline endoscopies in 1994. In 1995, 3365 eligible subjects were randomly assigned in a factorial

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

环球英语教程

引用

2006年

作者： susan Stempleski

本书是从美国引进的英语立体化教材，以增强英语表达流利和准确程度为中心目的，适合成人英语培训和有一定基础的英语自学者使用。本书为其中的视听教程。

ISBN: (数字)7544600106

ISBN: (纸本)7544600106

关键词：英语

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

犬猫解剖学彩色图谱

引用

2007年

作者： STANLEY h.DONE PETER C.GOODY susan A.EVANS等

本书收录了一系列细致的犬、猫解剖彩色图片，为读者展示了局部解剖中的一些重要结构特征。

ISBN: (纸本)9787538148268

本书收录了一系列细致的犬、猫解剖彩色图片，为读者展示了局部解剖中的一些重要结构特征。

关键词：犬动物解剖学图谱猫

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Nursing culture assessment tool (NCAT): Empirical validation for use in long-term care

引用

International Journal of Nursing Sciences 2014年第3期1卷 241-249页

作者： Tracey L.Yap susan M.Kennerly Elizabeth.P.Flint Duke University Sch.ol of Nursing 307 Trent Dr.DurhamNC 27710United States Duke University Center for th. Study of Aging and h.man Development Box 3003 DUMCDurhamNC 27710United States University of North.Carolina at Ch.rlotte Sch.ol of Nursing United States

Background:Capturing general aspects of th. occupational subculture of nursing is needed in long-term care(LTC)given its latent influence on th. quality of care th.t residents receive and on th. ability of nursing staff(licensed nurses and certified nursing assistants)to implement evidence-based practice *** psych.metrically validated Nursing Culture Assessment Tool(NCAT)provides a compreh.nsive assessment using six dimensions(teamwork,communication,satisfaction,professional commitment,beh.viors,and expectations),and evaluation of th.se dimensions could h.lp positively resh.pe th. culture before any ch.nge ***:Aims were to:(1)assess th. validity and reliability of th. NCAT across nursing staff in a single type of clinical setting e LTC facilities,and(2)present a refined th.oretical model of th. interaction of culture and practice ***:A cross-sectional,exploratory investigation of th. NCAT in LTC settings was *** construct validity of th. 19-item NCAT's six subscales was investigated by confirmatory factor analysis using a sample of licensed nurses and certified nursing assistants(n?318).Results:Th. model fit was judged using th. comparative fit index(0.94)and standardized root mean-square residual(0.05).Cronbach.s alph. correlation coefficients of items in each.subscale and in th. overall scale ranged from 0.76 to ***:A summary of th. NCAT development and report on its psych.metric properties wh.n administered in LTC settings is provided,extending previous findings of th. NCAT's enh.nced stability wh.n used in assessing nursing staff perceptions in LTC and by demonstrating th.t th. NCAT is a reliable and valid psych.metric screening tool for nursing culture.

关键词： Nursing culture Staff assessment Long-term care Occupational subculture framework

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is tumor cell specificity distinct from tumor selectivity in vivo?A quantitative NIR molecular imaging analysis of nanoliposome targeting

引用

Nano Research 2021年第5期14卷 1344-1354页

作者： Girgis Obaid Kimberley Samkoe Kenneth.Tich.uer Sh.zia Bano Yeonjae Park Zach.ry Silber Sassan h.dge susan Callagh.n Mina Guirguis Srivalleesh. Mallidi Brian Pogue Tayyaba h.san Wellman Center for Ph.tomedicine Massachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Bioengineering University of Texas at DallasRichardsonTX75080USA Th.yer Sch.ol of Engineering Dartmouth CollegeHanoverNH037551USA Armour College of Engineering Illinois Institute of TechnologyChicagoIL60616USA Division of h.alth.Sciences and Tech.ology Harvard University and Massachusetts Institute of TechnologyCambridgeMA02139USA

Th. significance and ability for receptor targeted nanoliposomes(tNLs)to bind to th.ir molecular targets in solid tumors in vivo h.s been questioned,particularly as th. efficiency of th.ir tumor accumulation and selectivity is not always predictive of th.ir efficacy or molecular *** study presents,for th. first time,in situ near-infrared(NIR)molecular imaging-based quantitation of th. in vivo specificity of tNLs for th.ir target receptors,as opposed to tumor selectivity,wh.ch.includes influences of enh.nced tumor permeability and *** sh.w th.t neith.r tumor delivery nor selectivity(tumor-to-normal ratio)of cetuximab and IRDye conjugated tNLs correlate with.epidermal growth.factor receptor(EGFR)expression in U251,U87,and 9L tumors,and in fact underrepresent th.ir imaging-derived molecular specificity by up to 94.2%.Conversely,th.ir in vivo specificity,wh.ch.we quantify as th. concentration of tNL-reported tumor EGFR provided by NIR molecular imaging,correlates positively with.EGFR expression levels in vitro and ex vivo(Pearson’s r=0.92 and 0.96,respectively).Th.s study provides a unique opportunity to address th. problematic disconnect between tNL synth.sis and in vivo *** findings encourage th.ir continued adoption as platforms for precision medicine,and facilitates intelligent synth.sis and patient customization in order to improve safety profiles and th.rapeutic outcomes.

关键词： molecular recognition receptors nanoparticles specificity cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新世纪大学英语视听说教程(1)学生用书

引用

2007年

作者： (美)susan Stempleski

《视听说教程:学生用书1》科学性、系统性和时代性的完美体现：以国内外先进外语教学理论为指导，融多种教学模式和手段为一体，满足一般要求、较高要求和更高要求的分层次教学需要。选材贴近时代、贴近生活；强化听说，注重听、说、读... 详细信息

ISBN: (数字)9787544603003

ISBN: (纸本)9787544603003

《视听说教程:学生用书1》科学性、系统性和时代性的完美体现：以国内外先进外语教学理论为指导，融多种教学模式和手段为一体，满足一般要求、较高要求和更高要求的分层次教学需要。选材贴近时代、贴近生活；强化听说，注重听、说、读、写、译等技能协调发展；练习编写充分体现实用性、新颖性和可操作性。语言能力和文化素质的同步提升:注重培养学习者的英语思维习惯，开拓跨文化交际视野，实现语言综合应用能力和人文素养的全面提高。分类指导和因材施教的教学原则：综合、视听说、阅读、写作、快速阅读等主干教程和经贸、文化类选修课教程，涵盖语言知识、应用技能、学习策略和跨文化交际，充分满足个性化教学的需要，有助于学生提高语言综合应用能力，从容应对各级语言能力测试。基于计算机和课堂的教学模式：提供完整、多元、立体化的英语教学平台，个性化的学习光盘、方便实用的电子教案、丰富多样的网络资源，使课堂内外教与学充分体现交互性、自主式和合作型的新型教学模式，实现培养学生终身学习能力的教学目标。新世纪大学英语视听教材是按照《大学英语课程教学要求》，由外教社组织国内十余所著名高校英语教学专家，邀请国际知名视听教学专家，为我国大学生度身打造而成。

关键词：英语

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

在线全文

学校读者我要写书评

暂无评论

Functional analysis of h.man Na^+/K^+-ATPase familial or sporadic h.miplegic migraine mutations expressed in Xenopus oocytes

引用

World Journal of Biological Ch.mistry 2014年第2期5卷 240-253页

作者： susan Spiller Th.mas Friedrich Institute of Ch.mistry Technical University of Berlin D-10623 Berlin Germany

AIM: Functional ch.racterization of ATP1A2 mutations th.t are related to familial or sporadic h.miplegic migraine(Fh.2, Sh.). METh.DS: cRNA of h.man Na+/K+-ATPase α2- and β1-subunits were injected in Xenopus laevis oocytes. Fh.2 or Sh. mutations of residues located in putative α/β interaction sites or in th. α2-subunit's C-terminal region were investigated. Mutants were analyzed by th. twoelectrode voltage-clamp(TEVC) tech.ique on Xenopus oocytes. Stationary K+-induced Na+/K+ pump currents were measured, and th. voltage dependence of apparent K+ affinity was investigated. Transient currents were recorded as ouabain-sensitive currents in Na+ buffers to analyze kinetics and voltage-dependent presteady state ch.rge translocations. Th. expression of constructs was verified by preparation of plasma membrane and total membrane fractions of cRNA-injected oocytes. RESULTS: Compared to th. wild-type enzyme, th. mutants G900R and E902K sh.wed no significant dif-ferences in th. voltage dependence of K+-induced currents, and analysis of th. transient currents indicated th.t th. extracellular Na+ affinity was not affected. Mutant G855R sh.wed no pump activity detectable by TEVC. Also for L994del and Y1009X, pump currents could not be recorded. Analysis of th. plasma and total membrane fractions sh.wed th.t th. expressed proteins were not or only minimally targeted to th. plasma membrane. Wh.reas th. mutation K1003E h.d no impact on K+ interaction, D999h.affected th. voltage dependence of K+-induced currents. Furth.rmore, kinetics of th. transient currents was altered compared to th. wild-type enzyme, and th. apparent affinity for extracellular Na+ was reduced. CONCLUSION: Th. investigated Fh.2/Sh. mutations influence protein function differently depending on th. structural impact of th. mutated residue.

关键词： Na+/K+-ATPase Electroph.siology Voltage dependence Familial h.miplegic migraine C-terminus β -subunit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neutroph.l-lymph.cyte ratio:A prognostic tool in patients with.inh.spital cardiac arrest

引用

World Journal of Critical Care Medicine 2019年第2期8卷 9-17页

作者： Vish.l h.Patel Ph.lip Vendittelli Rajat Garg susan Szpunar Th.mas LaLonde Joh. Lee h.ward Rosman Rajendra h.Meh.a h.ssein Oth.an Department of Cardiovascular Medicine Ascension-St John Hospital and Medical Center Department of Internal Medicine Cleveland Clinic Department of Biomedical Investigations and Research Ascension-St John Hospital and Medical Center Department of Critical Care Medicine Ascension-St John Hospital and Medical Center Duke Clinical Research.Institute Duke University Medical Center

BACKGROUND In-h.spital cardiac arrest(Ih.A) portends a poor prognosis and survival to disch.rge rate. Prognostic markers such.as interleukin-6, S-100 protein and h.gh.sensitivity C reactive protein h.ve been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); h.wever; th.se variables are not routine laboratory tests and incur additional cost making th.m difficult to incorporate and less attractive in assessing patient's prognosis. Th. neutroph.l-lymph.cyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We h.poth.size th.t an elevated NLR is associated with.poor outcomes including mortality at disch.rge in patients with.*** To determine th. prognostic significance of NLR in patients suffering Ih.A wh. ach.eve *** A retrospective study was performed on all patients wh. h.d Ih.A with.th. advanced cardiac life support protocol administered in a large urban community United States h.spital over a one-year period. Patients were divided into two groups based on th.ir NLR value(NLR h.s cutpoint was derived from receiving operator ch.racteristic curve analysis(area under th. curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-h.spital death.after Ih.A. Th. primary outcome was death.or disch.rge at 30 d, wh.ch.ver came *** We reviewed 153 patients with.a mean age of 66.1 ± 16.3 years; 48% were ***-h.spital mortality occurred in 65%. Th. median NLR in survivors was 4.9(range 0.6-46.5) compared with.8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated th.t an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of *** An NLR ≥ 4.5 may

关键词： Neutroph.l-lymph.cyte ratio In-h.spital cardiac arrest Prognosis Lactate Asystole Ventricular fibrillation Pulseless electrical alternans Pulseless ventricular tach.cardia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：