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Role of over the scope clips in the management of iatrogenic gastrointestinal perforations

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World Journal of Gastroenterology 2014年第32期20卷 11460-11462页

作者： Kinesh Changela Muhhamad A Virk Niravkumar Patel Sushil Duddempudi Mahesh Krishnaiah sury anand Division of Gastroenterology The Brooklyn Hospital Center New York Presbyterian Healthcare System Brooklyn NY 11201 United States

Advances in endoscopic and surgical techniques have increased the frequency and complexity of these procedures and associated complications such as gastrointestinal perforation. With the advancements in the field of gastroenterology, the promising use of an over the scope clips(OTSC) has fulfilled the unmet need for a reliable endoscopic devise in approximation of gastrointestinal perforation. This novel approach has raised the level of confidence in endoscopist in dealing with this serious complication during endoscopy. Here we have shared our experience with OTSC to evaluate its efficacy and safety in managing iatrogenic gastrointestinal perforations during endoscopy.

关键词： Gastrointestinal perforation Over-the-scope clip Over the scope clip system Endoscopic adverse events

Importance of reporting segmental bowel preparation scores during colonoscopy in clinical practice

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World Journal of Gastroenterology 2015年第13期21卷 3994-3999页

作者： Deepanshu Jain Mojdeh Momeni Mahesh Krishnaiah sury anand Shashideep Singhal Internal Medicine Department Albert Einstein Medical CentrePh 19141United States Division of Gastroenterology Department of Internal MedicineThe Brooklyn hospital CentreBrooklynNY 11205United States Division of Gastroenterology hepatology and NutritionUniversity of Texas health Science Centre at houstonhoustonTX 77030United States

AIM: To evaluate the impact of reporting bowel preparation using Boston Bowel Preparation Scale(BBPS) in clinical ***: The study was a prospective observational cohort study which enrolled subjects reporting for screening colonoscopy. All subjects received a gallon of polyethylene glycol as bowel preparation regimen. After colonoscopy the endoscopists determined quality of bowel preparation using BBPS. Segmental scores were combined to calculate composite BBPS. Site and size of the polyps detected was recorded. Pathology reports were reviewed to determine advanced adenoma detection rates(AADR). Segmental AADR's were calculated and categorized based on the segmental BBPS to determine the differential impact of bowel prep on AADR. RESULTS: Three hundred and sixty subjects were enrolled in the study with a mean age of 59.2 years, 36.3% males and 63.8% females. Four subjects with incomplete colonoscopy due BBPS of 0 in any segment were excluded. Based on composite BBPS subjects were divided into 3 groups; Group-0(poor bowel prep, BBPS 0-3) n = 26(7.3%), Group-1(Suboptimal bowel prep, BBPS 4-6) n = 121(34%) and Group-2(Adequate bowel prep, BBPS 7-9) n = 209(58.7%). AADR showed a linear trend through Group-1 to 3; with an AADR of 3.8%, 14.8% and 16.7% respectively. Also seen was a linear increasing trend in segmental AADR with improvement in segmental BBPS. There was statistical significant difference between AADR among Group 0 and 2(3.8% vs 16.7%, P < 0.05), Group 1 and 2(14.8% vs 16.7%, P < 0.05) and Group 0 and 1(3.8% vs 14.8%, P < 0.05). χ2 method was used to compute P value for determining statistical ***: Segmental AADRs correlate with segmental BBPS. It is thus valuable to report segmental BBPS in colonoscopy reports in clinical practice.

关键词： Colorectal cancer screening Adenomas Polyps Boston

Nonlinear system dynamics of calcium and nitric oxide due to cell memory and superdiffusion in neurons

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Communications in Theoretical Physics 2024年第5期76卷 16-32页

作者： anand Pawar Kamal Raj Pardasani Department of Mathematics Bioinformatics and Computer ApplicationsMaulana Azad National Institute of TechnologyBhopal-462003Madhya PradeshIndia

The integer-order interdependent calcium([Ca^(2+)])and nitric oxide(NO)systems are unable to shed light on the influences of the superdiffusion and memory in triggering Brownian motion(BM)in ***,a mathematical model is constructed for the fractional-order nonlinear spatiotemporal systems of[Ca^(2+)]and NO incorporating reaction-diffusion equations in *** two-way feedback process between[Ca^(2+)]and NO systems through calcium feedback on NO production and NO feedback on calcium through cyclic guanosine monophosphate(cGMP)with plasmalemmal[Ca^(2+)]-ATPase(PMCA)was incorporated in the *** Crank–Nicholson scheme(CNS)with Grunwald approximation along spatial derivatives and L1 scheme along temporal derivatives with Gauss–Seidel(GS)iterations were *** numerical outcomes were analyzed to get insights into superdiffusion,buffer,and memory exhibiting BM of[Ca^(2+)]and NO *** conditions,events and mechanisms leading to dysfunctions in calcium and NO systems and causing different diseases like Parkinson’s were explored in neurons.

关键词： [Ca^(2+)]and nitric oxide signaling reaction-diffusion equations fractional-order systems Grunwald approximation Gauss-Seidel iterations

PML nuclear bodies:new players in familial amyotrophic lateral sclerosis-frontotemporal dementia?

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Neural Regeneration Research 2024年第9期19卷 1875-1876页

作者： anand Goswami Serena Carra Institute of Neuropathology RWTH Aachen University HospitalAachenGermany Department of Neurology Eleanor and Lou Gehrig ALS CenterColumbia UniversityNew YorkNYUSA Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly

Amyotrophi c lateral s c lerosis(ALS)and frontotemporal dementia(FTD)are two closely related disorders with overlapping clinical,genetic,and neuropathological features,forming a continuous disease spectrum(Ling et al.,2013).The major pathological hallmark of ALS and FTD are the depletion from the nucleus of the RNA-binding proteins TAR DNA‐binding protein 43(TDP-43)and FUsed in Sarcoma(FUS)and their abnormal accumulation in ubiquitin-positive cytoplasmic inclusions(Ling et al.,2013).

关键词： clinical familial

Numerical Analysis of Phase Change and Container Materials for Thermal Energy Storage in the Storage Tank of Solar Water Heating System

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Journal of Thermal Science 2024年第2期33卷 408-421页

作者： SINGH Shailendra anand Abhishek SHUKLA Amritanshu SHARMA Atul Non-Conventional Energy Laboratory Rajiv Gandhi Institute of Petroleum TechnologyJais Amethi229304India

This study evaluates the effectiveness of phase change materials(PCMs) inside a storage tank of warm water for solar water heating(SWH) system through the theoretical simulation based on the experimental model of *** et *** model is explained by five fundamental equations for the calculation of various parameters like the effectiveness of PCMs,the mass of hot water,total heat content,and duration of *** study simulated eleven PCMs to analyze their effectiveness like Sodium hydrogen phosphate dodecahydrate(SHPD),OM 37,N-Eicosane(NE),Lauric acid(LA),Paraffin wax(PW),OM 48,Paraffin wax C_(20-33)(PW-C20-33),Sodium acetate trihydrate(SAT),Palmitic acid(PA),Myristic acid(MA),and Stearic acid(SA).Among all PCMs,the SHPD has found the highest value of effectiveness factor of ***,it is the most recommended PCM for the storage tank of the SWH *** study also includes the melt fraction analysis of all enumerated PCMs corresponding to container materials of stainless steel,glass,aluminum mixed,tin,aluminum,and *** melt fraction analysis is performed by making a coding program in the FORTRAN programming *** the analysis,copper container material is found to have high melting rate for all PCMs so it is superior to other container materials.

关键词： theoretical model solar water heating system phase change material effectiveness factor melt fraction

Ag-integrated mixed metallic Co-Fe-Ni-Mn hydroxide composite as advanced electrode for high-performance hybrid supercapacitors

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Journal of Energy Chemistry 2024年第1期88卷 579-591,I0013页

作者： Anki Reddy Mule Bhimanaboina Ramulu Shaik Junied Arbaz anand Kurakula Jae Su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea

Direct growth of redox-active noble metals and rational design of multifunctional electrochemical active materials play crucial roles in developing novel electrode materials for energy storage *** this regard,silver(Ag)has attracted great attention in the design of efficient *** by the house/building process,which means electing the right land,it lays a strong foundation and building essential columns for a complex ***,we report the construction of multifaceted heterostructure cobalt-iron hydroxide(CFOH)nanowires(NWs)@nickel cobalt manganese hydroxides and/or hydrate(NCMOH)nanosheets(NSs)on the Ag-deposited nickel foam and carbon cloth(i.e.,Ag/NF and Ag/CC)***,the formation and charge storage mechanism of Ag are described,and these contribute to good conductive and redox chemistry *** switching architectural integrity of metal and redox materials on metallic frames may significantly boost charge storage and rate performance with noticeable drop in *** as-fabricated Ag@CFOH@NCMOH/NF electrode delivered superior areal capacity value of 2081.9μA h cm^(-2)at 5 mA cm^(-2).Moreover,as-assembled hybrid cell based on NF(HC/NF)device exhibited remarkable areal capacity value of 1.82 mA h cm^(-2)at 5 mA cm^(-2)with excellent rate capability of 74.77%even at 70 mA cm^(-2)Furthermore,HC/NF device achieved maximum energy and power densities of 1.39 mW h cm^(-2)and 42.35 mW cm^(-2),*** verify practical applicability,both devices were also tested to serve as a self-charging station for various portable electronic devices.

关键词： Current collectors Redox-active silver Transition metal-hydroxides Electrochemical performance Hybrid supercapacitor

Review of efficacy and safety of laxatives use in geriatrics

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 334-342页

作者： Manhal Izzy Anju Malieckal Erin Little sury anand Division of Gastroenterology and Liver Diseases Montefiore Medical Center Albert Einstein College of Medicine Division of Gastroenterology the Brooklyn Hospital Center Division of Gastroenterology NYU-Lutheran Medical Center

AIM:To study the efficacy and safety of pharmacolo-gical treatment of constipation in ***:Pub Med,MEDLINE,google scholar,and Ovid were searched to identify human studies performed on the use of laxatives in elderly with constipation,which were conducted between January1990 and January 2013 using the specified *** studies that enrolled geriatric patients with a diagnosis of constipation and addressed the efficacy and/or the safety of pharmacological treatments were *** were excluded from this review if they were non-controlled trials,case series,or case ***:Out of twenty three studies we initially retrieved in our search,only nine studies met the eligibility criteria of being controlled trials within *** laxatives examined in the nine studies were senna,lactulose,sorbital,polyethylene glycol(PEG),lubiprostone,linaclotide,and *** those studies,senna combinations had a higher efficacy than sorbitol or lactulose as well as,a very good adverse effect *** was also shown to be safe and effective in geriatric ***,it has been shown that PEG is as safe in geriatrics as in general *** agents like lubiprostone and prucalopride show promising results but the data about these agents in geriatrics are still limited which warrant further ***:Senna combinations and PEG appear to have a more favorable profile over the other traditionally used laxatives in elderly patients with constipation.

关键词： Chronic constipation Laxatives Elderly Lubiprostone Linaclotide Prucalopride

Systematic review of the efficacy of data-driven urban building energy models during extreme heat in cities:Current trends and future outlook

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Building Simulation 2024年第5期17卷 695-722页

作者： Nilabhra Mondal Prashant anand Ansar Khan Chirag Deb David Cheong Chandra Sekhar Dev Niyogi Mattheos Santamouris Department of Architecture and Regional Planning Indian Institute of Technology KharagpurKharagpurIndia Department of Geography Lalbaba CollegeUniversity of CalcuttaKolkataIndia School of Architecture Design and PlanningThe University of SydneyAustralia Department of the Built Environment National University of SingaporeSingapore Department of Geological Sciences Jackson School of GeosciencesThe University of Texas at AustinAustinUSA DepartmentofCivil Architecturaland Environmental EngineeringThe Universityof Texas at AustinAustinUSA Faculty of Built Environment University of New South WalesAustralia

Energy demand fluctuations due to low probability high impact(LPHI)micro-climatic events such as urban heat island effect(UHI)and heatwaves,pose significant challenges for urban infrastructure,particularly within urban *** short term load forecasting(STLF)of buildings in urban micro-climatic setting(UMS)is obscured by the complex interplay of surrounding morphology,micro-climate and inter-building energy *** urban building energy modelling(UBEM)approaches to provide quantitative insights about building energy consumption often neglect the synergistic impacts of micro-climate and urban morphology in short temporal *** order modelling,unavailability of rich urban datasets such as building key performance indicators for building archetypes-characterization,limit the inter-building energy dynamics consideration into *** addition,mismatch of resolutions of spatio-temporal datasets(meso to micro scale transition),LPHI events extent prediction around UMS as well as its accurate quantitative inclusion in UBEM input organization step pose another degree of *** review aims to direct attention towards an integrated-UBEM(i-UBEM)framework to capture the building load fluctuation over multi-scale spatio–temporal *** highlights usage of emerging data-driven hybrid approaches,after systematically analysing developments and limitations of recent physical,data-driven artificial intelligence and machine learning(AI-ML)based modelling *** also discusses the potential integration of google earth engine(GEE)-cloud computing platform in UBEM input organization step to(i)map the land surface temperature(LST)data(quantitative attribute implying LPHI event occurrence),(ii)manage and pre-process high-resolution spatio-temporal UBEM *** the potential of digital twin,central structed data models to integrate along UBEM workflow to reduce uncertainties related to building archetype characterizat

关键词： urban heat island(UHI) urbanmicro-climate urban morphology urban building energy modelling(UBEM) digitaltwin shorttermload forecasting(STLF) googleearthengine(GEE)

Peroral endoscopic reduction of dilated gastrojejunal anastomosis after bariatric surgery: Techniques and efficacy

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World Journal of Gastrointestinal Endoscopy 2016年第4期8卷 239-243页

作者： Kinesh Changela Emmanuel Ofori Sushil Duddempudi sury anand Shashideep Singhal Division of Gastroenterology the Brooklyn Hospital Center-Clinical Affiliate of Mount Sinai Hospital Division of Gastroenterology Hepatology and Nutrition University of Texas Health Science Center at Houston

AIM: To investigate the techniques and efficacy of peroral endoscopic reduction of dilated gastrojejunal anastomosis after bariatric ***: An extensive English language literature search was conducted using Pub Med, MEDLINE, Medscape and Google to identify peer-reviewed original and review articles using the keywords "bariatric endoscopic suturing", "overstitch bariatric surgery", "endoscopic anastomotic reduction", "bariatric surgery", "gastric bypass", "obesity", "weight loss". We identified articles describing technical feasibility, safety, efficacy, and adverse outcomes of overstitch endoscopic suturing system for transoral outlet reduction in patients with weight regain following Roux-en-Y gastric bypass(RYGB). All studies that contained material applicable to the topic were considered. Retrieved peer-reviewed original and review articles were reviewed by the authors and the data extracted using a standardized collection tool. Data were analyzed using statistical analysis as percentages of the event. RESULTS: Four original published articles which met our search criteria were pooled. The total number cases were fifty-nine with a mean age of 46.75 years(34-63 years). Eight of the patients included in those studies were males(13.6%) and fifty-one were females(86.4%). The mean time elapsed since the primary bypass surgery was 5.75 years. The average pre-endoscopic procedure body mass index(BMI) was 38.68(27.5-48.5). Mean body weight regained post-RYGB surgery was 13.4 kg from their post-RYGB nadir. The average pouch length at the initial upper endoscopy was 5.75 cm(2-14 cm). The pre-intervention anastomotic diameter was averaged at 24.85 mm(8-40 mm). Average procedure time was 74 min(50-164 min). Mean post endoscopic intervention anastomotic diameter was 8 mm(3-15 mm). Weight reduction at 3 to 4 mo post revision noted to be anaverage of 10.1 kg. Average overall post revision BMI was recorded at 37.7. The combined technical and clinical success rate was

关键词： Endoscopic anastomosis reduction Bariatricsurgery Endoscopic suturing EndoCinch Overstitchbariatric surgery