检索结果-南通市图书馆

World Journal of Cardiovascular Diseases 2018年第6期8卷 298-306页

作者： Uma Balasubramaniam Usha Kiran suruchi hasija V. Devagourou Department of Cardiothoracic and Vascular Anaesthesia AIIMS New Delhi India Department of Cardiothoracic and Vascular Surgery AIIMS New Delhi India

Objectives: Hypoglycemia is a recognized danger in pediatric patients. Extended period of preoperative fasting in this subset of patients is not well tolerated with metabolic derangements. The oral carbohydrate loading preoperatively can ameliorate many adverse effects. The aim of this study was to compare the glycemic profile in pediatric cardiac surgical patients kept fasting preoperatively with those fed oral clear solutions of carbohydrate half hour prior to induction of anaesthesia. Also we tried to establish a correlation with other factors contributing to preoperative hypoglycemia. Methodology: We planned a randomized controlled study. Group A included patients who were kept fasting according to the ASA guidelines preoperatively and Group B included patients who received 2 ml per kg of body weight of 10% Dextrose water as oral feeds half hour before the expected time of start of anaesthesia. Results: The mean (SD) preoperative BG concentrations were higher in group B (102.5 ±16.97) as compared to group A (64.08 ± 25.37) (p value -0.86 and -0.67) (pvalue Conclusion: Preoperative oral carbohydrate preloading can develop as the easiest and cheapest path to better perioperative blood glucose concentration management in congenital cardiac disease children.

关键词： Congenital Cardiac Disease Hypoglycemia Hypocalcemia Oral Carbohydrate Solution Preoperative Cyanotics Hematocrit

Comparison of Parasternal Intercostal Block Using Ropivacaine or bupivacaine for Postoperative Analgesia in Patients Undergoing Cardiac Surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Surgery 2015年第6期5卷 49-57页

作者： Kulbhushan Saini Sandeep Chauhan Usha Kiran Akshay Kumar Bisoi Minati Choudhury suruchi hasija Department of Cardiothoracic and Vascular Anaesthesia CN Centre All India Institute of Medical Science New Delhi India M.CH Cardiothoracic and Vascular Surgery All India Institute of Medical Science New Delhi India

Objective: The objective of this study was to compare the efficacy of 0.5% ropivacaine and 0.25% bupivacaine for parasternal intercostal block for postoperative analgesia in children undergoing cardiac surgery. Design: A randomized, controlled, prospective, double blind study. Setting: A tertiary care teaching hospital. Participants: One Hundred children scheduled for cardiac surgery through a median sternotomy were divided into 3 groups of at least 33 children each, receiving either ropivacaine, bupivacaine or saline (control). Interventions: A bilateral parasternal block performed either with 0.5% ropivacaine or 0.25% bupiacaine or 0.9% saline with 5 doses of 0.5 mL on each side in the 2nd to 6th parasternal intercostal spaces 1 to 1.5 cm lateral to the sternal edge, before sternal wound closure. Measurements and Main Results: The time to extubation was significantly less in children administered the parasternal blocks with ropivacaine or bupivacaine compared to the saline (control) group. The pain scores were lower and comparable in the ropivacaine and bupivacaine groups compared to the saline group. The cumulative fentanyl dose requirement over a 24-hour period was higher in the saline group than the ropivacaine (p < 0.001) and bupivacaine group. No side effects were observed in any of the children. Conclusions: Parasternal blocks either with ropivacaine or bupivacaine appear to be a simple, safe, and useful technique for supplementation of postoperative analgesia in children undergoing cardiac surgery with a median sternotomy.

关键词： Pediatric Cardiac Patients Parasternal Intercostalblock Sternotomy Ropivacaine Bupivacaine Postoperative Pain

Comparison of the Hemodynamic Effects of the Induction Agents Ketamine, Etomidate and Sevoflurane Using the Model of Electrical Velocimetry Based Cardiac Output Monitoring in Pediatric Cardiac Surgical Patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Surgery 2014年第10期4卷 167-175页

作者： suruchi hasija Sandeep Chauhan Neeti Makhija Sarvesh Pal Singh Sanjay Kumar Arin Choudhury Sachin Talwar Usha Kiran Department of Cardiac Anaesthesiolgy All India Institute of Medical Sciences New Delhi India Department of Cardiothoracic and Vascular Surgery All India Institute of Medical Sciences New Delhi India

Objective: To compare the haemodynamic effects of the induction agents ketamine, etomidate and sevoflurane using the model of electrical velocimetry based cardiac output monitoring in paediatric cardiac surgical patients. Design: Prospective randomized study. Setting: Tertiary care hospital. Participants: 60 children < 2 years age undergoing cardiac surgery. Interventions: The patients were randomized into 3 equal groups to receive 1.5-2.5 mg/kg iv ketamine (group K), 0.2-0.3 mg/kg iv etomidate (group E) or upto 8% sevoflurane (group S) as the induction agent. Hemodynamic parameters were noted before and after induction of anaesthesia utilizing a noninvasive cardiac monitor based on the model of electrical velocimetry. Measurements and Main Results: The demographic characteristics of the patients were similar in the three groups. The HR decreased in all groups, least in group E (P ≤ 0.01) but the MAP decreased only in group S (P ≤ 0.001). In group S, the stroke volume improved from 9 ± 3.2 ml to 10 ± 3.2 ml (P ≤ 0.05) and the stroke volume variation decreased from 25% ± 6.4% to 13% ± 6.2% (P ≤ 0.001). The stroke index and systemic arterial saturation improved in all groups (P ≤ 0.01). The cardiac index and index of contractility were unchanged. The transthoracic fluid content reduced in groups E and S, but did not change in group K (P ≤ 0.05). Conclusions: Etomidate appeared to provide the most stable conditions for induction of anesthesia in children undergoing cardiac surgery, followed by ketamine and sevoflurane.

关键词： Anesthesia Induction Agents Electrical Velocimetry Noninvasive Hemodynamic Monitoring Pediatric Cardiac Surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

正在崛起的全球供应链新兴力量

董事会 2024年第7期 18-19页

作者： Sameer hasija 王梦菲

着眼新兴技术和能力建设，所谓“印太地区”国家可能在全球价值链中发挥越来越大的作用。利用好现有优势，并加强合作，有助于提高增长质量在过去5年中，保护主义、区域化和疫情等重塑了价值链。特别是，疫情和地缘政治的动态揭示了经...

着眼新兴技术和能力建设，所谓“印太地区”国家可能在全球价值链中发挥越来越大的作用。利用好现有优势，并加强合作，有助于提高增长质量在过去5年中，保护主义、区域化和疫情等重塑了价值链。特别是，疫情和地缘政治的动态揭示了经济体之间更深层次的相互联系。这些全球动态并没有导致各国的主体地位变化，只是导致了全球供应链的重组。尽管阻力很大，但中国的主导地位基本没有动摇。

关键词：

Comparative analysis of metabolic network of pathogens

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Frontiers in Biology 2017年第2期12卷 139-150页

作者： Kumar Gaurav Yasha hasija Department of Biotechnology Delhi Technological University Delhi - 110042 India

BACKGROUND： Metabolic networks are complex and system of highly connected chemical reactions and hence it needs a system level computational approach to identify the genotype- phenotype relationship. The study of essential genes and reactions and synthetic lethality of genes and reactions plays a crucial role in explaining functional links between genes and gene function predictions. METHODS： Flux balance analysis （FBA） has been developed as a powerful method for the in silico analyses of metabolic networks. In this study, we present the comparative analysis of the genomic scale metabolic networks of the four microorganisms i.e. Salmonella typhimurium, Mycobacterium tuberculosis, Staphylococcus aureus, and Helicobacter pylori. The fluxes of all reaction were obtained and the growth rate of the organism was calculated by setting the biomass reaction as the objective function. RESULTS ＆ CONCLUSIONS： The average lethality fraction of all the four organisms studied ranged from 0.2 to 0.6. It was also observed that there are very few metabolites which are highly connected. Those metabolites that are highly connected are supposed to be the ‘global players＇ similar to the hub protein in the protein - protein interaction network.

关键词： essential genes synthetic lethal genes metabolite connectivity robustness analysis

miRACA： A database for miRNAs associated with cancers and age related disorders （ARD）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers in Biology 2018年第1期13卷 36-50页

作者： Razia Rahman Lokesh Kumar Gahlot Yasha hasija Department of Biotechnology Delhi Technological University Shahbad Daulatpur Main Bawana Road Delh# l l O042 India

BACKGROUND： With the given diversity and abundance of several targets of miRNAs, they functionally appear to interact with several elements of the multiple cellular networks to maintain physiologic homeostasis. They can function as tumor suppressors or oncogenes, whose under or overexpression has both diagnostic and prognostic significance in various cancers while being implicated as prospective regulators of age-related disorders （ARD） as well. Establishing a concatenate between ARD and cancers by looking into the insights of the shared miRNAs may have a practical relevance. METHODS： In the present work, we performed network analysis of miRNA-disease association and miRNA-target gene interaction to prioritize miRNAs that play significant roles in the manifestation of cancer as well as ARD. Also, we developed a repository that stores miRNAs common to both ARD and cancers along with their target genes. RESULTS： We have comprehensively curated all miRNAs that we found to be shared in both the diseases in the human genome and established a database, miRACA （Database for microRNAs Associated with Cancers and ARD） that currently houses information of 1648 miRNAs that are significantly associated with 38 variants supported with pertinent data. It has been made available online at http：//***/miraca/for easy retrieval and utilization of data by the scientific community. CONCLUSION： To the best of our knowledge, our database is the first attempt at compilation of such data. We believe this work may serve as a significant resource and facilitate the analysis of miRNA regulatory mechanisms shared between cancers and ARD to apprehend disease etiology.

关键词： miRNA cancer age related disorders (ARD) target genes database

Crystal and Molecular Structure Analysis in Knoevenagel Condensation Product of Substituted Napthofuran-2-Carbaldehydes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crystal Structure Theory and Applications 2020年第3期9卷 49-62页

作者： Avantika hasija V. Prakash M. Shet Prakash Vasu G. Krishnasamy Deepak Chopra Crystallography and Crystal Chemistry Laboratory Department of Chemistry Indian Institute of Science Education and Research Bhopal Bhopal Madhya Pradesh India Sri Sairam College of Engineering Karnataka India Department of Studies and Research in Chemistry University College of Science Tumkur University Tumakuru Karnataka India Vivekananda Degree College Malleshwaram Karnataka India Department of Studies and Research in Organic Chemistry Tumkur University Tumakuru Karnataka India

In the current study, two novel Knoevenagel condensation products of substituted napthofuran-2-carbaldehydes were designed, synthesized and characterized. In order to study the intermolecular interactions of title compounds, single crystals were grown by slow evaporation solution growth technique at room temperature and crystal structure has been determined by single crystal X-ray diffraction technique. Both the molecules crystallize in the monoclinic centrosymmetric space group P21/c with one molecule in the asymmetric unit. In compound [4] the molecules are connected via bifurcated C-H···O=C and C-H···N=C H-bonds and van der Waals interactions forming a layered structure, whereas in compound [5a] the molecular conformation is stabilized via intramolecular C-H···O H-bond and molecule interacts with other molecule generated via 21-screw via bifurcated C-H···O=C alo

关键词： Napthofuran-2-Carbaldehyde 8-Nitro Napthafura-2-Carbaldehyde Knoevenagel Condensation Single Crystal and Hirshfeld Surface Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

硅谷正在吞噬自己?

董事会 2021年第7期 54-55页

作者： Aly Madhavji Sameer hasija Mike Grandinetti 不详

硅谷的卓越地位不会消失,但它特有的光泽已经褪色。这对未来的社会和创新都是一件好事几十年来,硅谷一直是全球创新中心。圣塔克拉拉谷(Santa Clara Valley)聚集了许多世界级科技巨头,是一个由初创企业、创新创业人才以及风险资本组成... 详细信息

硅谷的卓越地位不会消失,但它特有的光泽已经褪色。这对未来的社会和创新都是一件好事几十年来,硅谷一直是全球创新中心。圣塔克拉拉谷(Santa Clara Valley)聚集了许多世界级科技巨头,是一个由初创企业、创新创业人才以及风险资本组成的庞大生态系统。然而,任何看到该地区企业和人才外流数据的人可能会说,这里的发展已经达到了顶峰,开始在走下坡路。

关键词：初创企业克拉拉硅谷风险资本创新创业人才生态系统人才外流全球创新

Longitudinal evaluation of time related femoral neck narrowing after metal-on-metal hip resurfacing

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2013年第2期4卷 75-79页

作者： Wenbao Wang Jeffrey A Geller Rohit hasija Jung Keun Choi David A Patrick Jr. William Macaulay Center for Hip and Knee Replacement Department of Orthopaedic SurgeryNew York-Presbyterian Hospital at Columbia University Medical Center New York NY 10032 United States

AIM: To track the short-term neck narrowing changes in Birmingham metal-on-metal hip resurfacing(MOMHR) patients. METHODS: Since 2001, the Center for Hip and Knee Replacement started a registry to prospectively collect data on hip and knee replacement patients. From June 2006 to October 2008, 139 MOMHR were performed at our center by two participate surgeons using Birmingham MOMHR prosthesis(Smith Nephew, United States). It is standard of care for patients to obtain low, anteriorposterior(LAP) pelvis radiographs immediately after MOMHR procedure and then at 3 mo, 1 year and 2 year follow up office visits. Inclusion criteria for the present study included patients who came back for follow up office visit at above mentioned time points and got LAP radiographs. Exclusion criteria include patients who missed more than two follow up time points and those with poor-quality X-rays. Two orthopaedic residency trained research fellows reviewed the X-rays independently at 4 time points, i.e., immediate after surgery, 3 mo, 1 year and 2 year. Neck-to-prosthesis ratio(NPR) was used as main outcome measure. Twenty cases were used as subjects to identify the reliability between two observers. An intraclass correlation coefficient at 0.8 was considered as satisfied. A paired t-test was used to evaluate the significant difference between different time points with P < 0.05 considered to be statistically ***: The mean NPRs were 0.852 ± 0.056, 0.839 ± 0.052, 0.835 ± 0.051, 0.83 ± 0.04 immediately, 3 mo, 1 year and 2 years post-operatively respectively. At 3 mo, NPR was significantly different from immediate postoperative X-ray(P < 0.001). There was no difference between 3 mo and 1 year(P = 0.14) and 2 years(P = 0.53). Femoral neck narrowing(FNN) exceeding 10% of the diameter of the neck was observed in only 4 patients(5.6%) at two years follow up. None of these patients developed a femoral neck fracture(FNF). CONCLUSION: Femoral neck narrowing after MOMHR occurred as e

关键词： Hip joint Arthroplasty Complications Hip resurfacing Femoral neck narrowing