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Land use change in highland area and its impact on river water quality:a review of case studies in Malaysia

Ecological Processes 2018年第1期7卷 189-205页

作者： Azlini Razali Sharifah Norkhadijah Syed Ismail suriyani awang Sarva Mangala Praveena Emilia Zainal Abidin Department of Environmental and Occupational Health Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia River Basin Research Centre National Hydraulic Research Institute of Malaysia(NAHRIM)Lot 5377Jalan Putra Permai43300 Seri KembanganSelangorMalaysia

The policy of encouraging agriculture and development for mass tourism has led to environmental problems in Cameron Highlands,*** development and land clearing have significantly altered the land cover of Cameron Highlands for the past 30 *** highlands areas are prone to landslides and soil erosion which then contributed to the main water pollution issues in the network of river system,sedimentation and *** continuous trend of river water quality deterioration in Cameron Highlands has raised the issues for discussion in this review *** purpose of this review is to briefly summarize the land use change,agriculture practices,agro-tourism,and agriculture policy and management toward water quality of the river system network in Cameron Highlands specifically in the downtown where most of the development and agriculture activities are concentrated.A rigorous review has been done on the existing literature to determine the relationship between land use change and agriculture practices toward river water quality in Cameron Highlands from 2001 to *** total number of reviewed papers was *** outcomes established from previous researchers have highlighted factors such as soil erosion,landslides,agriculture activities,urbanization,and unplanned development associated with land use change have significantly influenced the river water quality in the highland *** land use changes without proper development plan and law enforcement may critically threaten the sustainability of river network in the highlands area.

关键词： Agriculture River water quality Highlands Land use Soil erosion Cameron Highlands

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Male reproductive hormones and semen quality

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Asian pacific Journal of Reproduction 2019年第5期8卷 189-194页

作者： Sulagna Dutta Pallav Sengupta suriyani Muhamad Department of Oral Biology and Biomedical Sciences Faculty of DentistryMAHSA UniversityMalaysia Department of Physiology Faculty of Medicine and Biomedical SciencesMAHSA UniversityMalaysia School of Social and Economic Development Universiti Malaysia TerengganuMalaysia

Male reproductive functions are mediated by different hormones whose orchestrations remain a major research interest. The 'master' regulator hormonal axis is the hypothalamo-pituitary-gonadal/testicular axis which is led by the pulsatile release of hypothalamic gonadotropin-releasing hormone. This, in turn, stimulates the anterior pituitary trophic hormones, the luteinizing hormone and follicle-stimulating hormone. Luteinizing hormone and follicle-stimulating hormone act upon the testicular cells, the Leydig cells for steroidogenesis and Sertoli cells to aid spermatogenesis, respectively. This primary axis is influenced by an array of other testicular hormones, metabolic hormones, and different regulatory factors. These hormonal crosstalks influence the intricate testicular functions, sexual behavior and semen quality in men. Given the growing concern in the last few decades over the increasing prevalence of male subfertility and/or infertility mostly in terms of deteriorating semen quality, it is required to find its underlying mechanisms. In this regard, the endocrine regulation of testicular functions is of prime importance in the determination of semen quality and sperm functions. This review article aims to present a concise updated overview on the mechanism by which the key hormones integrate the male reproductive functions and maintain the semen quality.

关键词： Gonadotrophin Leydig cells Sertoli cells Semen quality

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Methanolic extract of Abrus precatorius promotes breast cancer MDA-MB-231 cell death by inducing cell cycle arrest at G0/G1 and upregulating Bax

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Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 249-256页

作者： Wan suriyani Wan-Ibrahim Norzila Ismail Siti Farhanah Mohd-Salleh Aidy Irman Yajid Michael Pak-KaiWong Mohd Nizam Md Hashim Department of Pharmacology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia Department of Surgery School of Medical SciencesUniversiti Sains Malaysia16150Kubang KerianKelantanMalaysia

Objective:To determine the anti-proliferative activity of Abrus precatorius(***)leaf extracts and their effect on cell ***:*** leaves were extracted successively with hexane,ethyl acetate and methanol by Soxhlet *** extract was prepared by decoction at 50 ℃.Extracts of *** leaves were used to treat selected cancer and normal cell lines for72 ***,3-(4,5-dimethyl thiazol-2-yl)2,5-diphenyl tetrazolium bromide assay was performed to determine cell *** of cell cycle arrest,apoptosis assay and apoptosis protein expressions were determined by flow ***:Methanolic extract of *** leaves showed the lowest IC50 on MDA-MB-231 cells at(26.40±5.40)μg/*** cytometry analysis revealed that cell arrest occurred at G0/G1 phase and the apoptosis assay showed the occurrence of early apoptosis at 48 h in MDAMB-231 cells treated with methanolic extract of *** *** extract of *** leaves induced apoptosis by upregulation of Bax,p53 and caspase-3 and downregulation of ***:Methanolic extract of A precatorius leaves promotes MDA-MB-231 cell death by inducing cell cycle arrest and apoptosis possibly via the mitochondrial-related pathway.

关键词： Abrus precatorius MDA-MB-231 Apoptosis Cell cycle Breast cancer

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Phytocompounds of Anonna muricata leaves extract and cytotoxic effects on breast cancer cells

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Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 659-665页

作者： Husna Syakirah Ab Rahman Wan suriyani Wan-Ibrahim Norzila Ismail Tuan Nadrah Naim Tuan Ismail Siti Farhanah Mohd-Salleh Michael Pak-Kai Wong Mohd Ridzuan Abdul Samad Mohd Nizam Md Hashim Department of Surgery School of Medical Sciences Universiti Sains Malaysia Department of Pharmacology School of Medical Sciences Universiti Sains Malaysia School of Dental Sciences Universiti Sains Malaysia

Objective: To identify the phytochemical compounds from Annona muricata(A. muricata) and to determine their in vitro anti-proliferative activities against breast cancer cells, MCF7 and MDA-MB-231. Methods: A. muricata leaves were successively extracted by soxhlet method using n-hexane, ethyl acetate and methanol, and decocted with water. Each extract was analysed by gas chromatography mass spectrometry(GCMS) and characterized with Wiley and NIST library searches. Anti-proliferative activity of each extract was evaluated on MCF7 and MDA-MB-231 breast cancer cells using MTT assay. Results: The GCMS analysis of different solvent extracts of A. muricata leaves showed presence of different chemical groups of compounds such as steroids, terpenoids, phenolic compounds, sugars, sugars alcohol and others including vitamin E. Ethyl acetate leaves extract exhibited the lowest IC_(50) value on the MDA-MB-231 breast cancer cell and n-hexane leaves extract showed the the lowest IC_(50) value on the MCF-7 breast cancer cell. Conclusion: Steroids and phenolic compounds were the main phytocompound groups identified from all A. muricata leaves extracts. The antiproliferative activity of n-hexane and ethyl acetate extract towards breast cancer MCF7 and MDA-MB-231 respectively might be due to the presence of biologically active compounds in the extracts, hence, providing some scientific evidences of the effectiveness of its traditional usages.

关键词： Annona muricata GCMS Anti-proliferative Breast cancer Graviola

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