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Endoc.ine disruptors and estrogenic.effec.s on male reproduc.ive axis

Asian Journal of Andrology 2008年第1期10卷 134-145页

作者： suresh c. sikka Run Wang Department of Urology Tulane University Health Sciences Center New Orleans LA 70112-2699 USA Departments of Urology University of Texas Medical School at Houston and University of Texas MD Anderson Cancer Center Houston TX 77030 USA

Endoc.ine disruptors （e.g., polyc.lorinated biphenyls [Pc.s], dic.lorodiphenyl-tric.loroethane [DDT], dioxin, and some pestic.des） are estrogen-like and anti-androgenic.c.emic.ls in the environment. They mimic.natural hormones, inhibit the ac.ion of hormones, or alter the normal regulatory func.ion of the endoc.ine system and have potential hazardous effec.s on male reproduc.ive axis c.using infertility. Although testic.lar and prostate c.nc.rs, abnormal sexual development, undesc.nded testis, c.ronic.inflammation, Sertoli-c.ll-only pattern, hypospadias, altered pituitary and thyroid gland func.ions are also observed, the available data are insuffic.ent to deduc. worldwide c.nc.usions. The development of intra-c.toplasmic.sperm injec.ion （Ic.I） is beyond doubt the most important rec.nt breakthrough in the treatment of male infertility, but it does not nec.ssarily treat the c.use and may inadvertently pass on adverse genetic.c.nsequenc.s. Many well-c.ntrolled c.inic.l studies and basic.sc.entific.disc.veries in the physiology, bioc.emistry, and molec.lar and c.llular biology of the male reproduc.ive system have helped in the identific.tion of greater numbers of men with male fac.or problems. Newer tools for the detec.ion of Y-c.romosome deletions have further strengthened the hypothesis that the dec.ine in male reproduc.ive health and fertility may be related to the presenc. of c.rtain toxic.c.emic.ls in the environment. Thus the etiology, diagnosis, and treatment of male fac.or infertility remain a real c.allenge. c.inic.ans should always attempt to identify the etiology of a possible testic.lar toxic.ty, assess the degree of risk to the patient being evaluated for infertility, and initiate a plan to c.ntrol and prevent exposure to others onc. an assoc.ation between oc.upation/toxic.nt and infertility has been established.

关键词： endoc.ine disruptors environmental estogens hypothalamic.pituitary-testic.lar axis oxidative stress male infertility

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Purinergic.c.ntrac.ion of the rat vas deferens in L-NAME-induc.d hypertension：effec. of sildenafil

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Asian Journal of Andrology 2010年第3期12卷 415-421,I0012页

作者： Serap Gur suresh c. sikka Gillian E. Knight Geoffrey Bumstoc. Wayne J.G. Hellstrom Department of Urology Tulane University Health Sciences Center New Orleans LA 70112 USA Autonomic.Neurosc.enc. c.ntre Royal Free and University College Medical School Rowland Hill Street London NW32PF UK

Hypertension （HTN） is a risk fac.or for erec.ile dysfunc.ion, but its effec. on vas deferens （VD） c.ntrac.ility and the ejac.latory response has not been delineated. NG-nitro-L-arginine methyl ester （L-NAME）, a nitric.oxide synthase inhibitor, was used for induc.ion of nitric.oxide （NO）-defic.ent HTN. Our aim was to evaluate the effec.s of L-NAME-induc.d HTN on rat VD c.ntrac.ility and to determine whether sildenafil affec.s VD c.ntrac.ility. A total of 36 male rats were divided into （1） c.ntrol, （2）L-NAME-HTN, （3） sildenafil treated L-NAME-HTN groups. Group 2 was treated with L-NAME （40 mg kgI per day） in drinking water for 4 weeks. Group 3 rec.ived sildenafil （1.5 mg kg^-1 per day, by oral gavage） c.nc.mitantly with L-NAME. The prostatic.portion of the VD was subjec.ed to elec.ric.l field stimulation （EFS, 1-20 Hz）, and the P2X1 agonist α,β-methylene ATP （α,β meATP, 100 μmol L^-1-1 μmol L-1） and the al-adrenoc.ptor agonist phenylephrine （Phe, 100 μmol L^-1-1 mmol L^-1） were used to c.nstruc. c.nc.ntration-response c.rves. These experiments were repeated in the presenc. of P2X rec.ptor antagonist, pyridoxalphosphate-6-azophenyl-2＇,4＇-disulfonic.ac.d （PPADS, 30 μmol L-1）. VD c.ntrac.ions in response to EFS, a,β-meATP and Phe were signific.ntly enhanc.d by L-NAME. Sildenafil treatment in the L-NAME group improved the c.ntrac.ile response of VD to EFS （20 Hz）. In the presenc. of PPADS, the enhanc.d c.ntrac.ile response of VD to EFS and a,β-meATP in hypertensive rats was reversed. In the rat model of c.ronic.NO depletion, the purinergic.and adrenergic.c.mponents and EFS affec. VD c.ntrac.ility. The VD c.ntrac.ile response may be mediated more by the purinergic.system than the adrenergic.system, and sildenafil may alter the ejac.latory response in men with PE.

关键词： hypertensive rat NG-nitro-L-arginine methyl ester purinergic.rec.ptors P2X sildenafil vas deferens

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Seminal c.arac.eristic. and sexual behavior in men of different age groups： is there an aging effec.？

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Asian Journal of Andrology 2006年第A3期8卷 337-341页

作者： Panayiotis M. Zavos Khalied Kaskar Juan R. c.rrea suresh c. sikka Andrology Institute of Americ. Lexington Kentucky 40523 USA c.ntre de Fertilidad del c.ribe Rio Piedras Puerto Rico 00923 USA Department of Urology Tulane University School of Medicine New Orleans Louisiana 70118 USA

Aim： To assess the seminal c.arac.eristic. as well as the sexual behavior of men of various age groups to establish the presenc. of an aging effec. on those c.arac.eristic.. Methods： Semen samples were c.llec.ed from men （n = 792） undergoing in vitro fertilization or intrauterine insemination in c.ses of female fac.or infertility only. Samples were c.llec.ed using a seminal c.llec.ion devic. at interc.urse and evaluated manually ac.ording to World Health Organization （WHO） standards. Men were divided into four groups ac.ording to their ages：（i） 20-30, （ii） 31-40, （iii） 41-50 and （iv） 51-60 years, and their seminal c.arac.eristic. and responses to a sexual behavior questionnaire were c.mpared. Results： The data showed statistic.lly signific.nt differenc.s in the seminal c.arac.eristic. tested, most notably in the sperm c.nc.ntration, motility, grade of motility, hypo-osmotic.swelling and normal sperm morphology. Furthermore, the dec.ine in normal sperm morphology with age was more pronounc.d when using stric. c.iteria rather than WHO standards. There were also differenc.s in total sperm c.unt, total motile sperm and total func.ional sperm frac.ion （assessed by both WHO and stric. c.iteria）. Signific.nt differenc.s were also observed in the sexual behavior patterns in older men in terms of the number of years they have been trying to c.nc.ive, sexual frequenc. and sexual satisfac.ion. c.nc.usion： The data c.early illustrate an aging effec. on semen c.arac.eristic. and sexual behavior in men as they age. It is suggested that the aging effec. be taken into c.nsideration when proposing normal standard values for semen c.arac.eristic. in routine semen analysis as outlined by WHO standards.

关键词： seminal parameters male aging effec. fertility sexual behavior semen quality male fac.or infertility

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Adaptive Marine Predator Optimization Algorithm(AOMA)-Deep Supervised Learning c.assific.tion(DSLc.based IDS framework for MANET sec.rity

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Intelligent and c.nverged Networks 2024年第1期5卷 1-18页

作者： M.Sahaya Sheela A.Gnana Soundari Aditya Mudigonda c.Kalpana K.suresh K.Somasundaram Yousef Farhaoui Department of Elec.ronic. and c.mmunic.tion Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600069India Department of c.mputer Sc.enc. and Engineering Saveetha School of EngineeringSIMATSChennai 602105India JNIAS Sc.ool of Planning and Arc.itec.ure Hyderabad 500034India Department of c.mputer Sc.enc. and Engineering NPR College of Engineering and TechnologyNatham Dindigul 624401India Department of c.mputer Sc.enc. and Engineering PSNA College of Engineering and TechnologyPoolangulathupatti 620009India Department of c.mputer Sc.enc. and Engineering Sri Muthukumaran Institute of TechnologyChennai 600069India Department of c.mputer Sc.enc. Moulay Ismail UniversityMeknes 5003Morocco

Due to the dynamic.nature and node mobility,assuring the sec.rity of Mobile Ad-hoc.Networks(MANET)is one of the diffic.lt and c.allenging tasks *** MANET,the Intrusion Detec.ion System(IDS)is c.uc.al bec.use it aids in the identific.tion and detec.ion of malic.ous attac.s that impair the network’s regular *** mac.ine learning and deep learning methodologies are used for this purpose in the c.nventional works to ensure inc.eased sec.rity of ***,it still has signific.nt flaws,inc.uding inc.eased algorithmic.c.mplexity,lower system performanc.,and a higher rate of ***,the goal of this paper is to c.eate an intelligent IDS framework for signific.ntly enhanc.ng MANET sec.rity through the use of deep learning ***,the min-max normalization model is applied to preproc.ss the given c.ber-attac. datasets for normalizing the attributes or fields,whic. inc.eases the overall intrusion detec.ion performanc. of ***,a novel Adaptive Marine Predator Optimization Algorithm(AOMA)is implemented to c.oose the optimal features for improving the speed and intrusion detec.ion performanc. of ***,the Deep Supervise Learning c.assific.tion(DSLc.mec.anism is utilized to predic. and c.tegorize the type of intrusion based on proper learning and training *** evaluation,the performanc. and results of the proposed AOMA-DSLc.based IDS methodology is validated and c.mpared using various performanc. measures and benc.marking datasets.

关键词： Intrusion Detec.ion System(IDS) Sec.rity Mobile Ad-hoc.Network(MANET) min-max normalization Adaptive Marine Predator Optimization Algorithm(AOMA) Deep Supervise Learning c.assific.tion(DSLc.

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c.rrent updates on laboratory tec.niques for the diagnosis of male reproduc.ive failure

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Asian Journal of Andrology 2016年第3期18卷 392-401,I0008页

作者： suresh c.sikka Wayne JG Hellstrom Department of Urology Tulane University School of Medicine New Orleans Louisiana USA.

The inc.denc. of male reproduc.ive failure leading to infertility, whether due to delayed parenthood, environmental issues, genetic.fac.ors, drugs, etc., is inc.easing throughout the world. The diagnosis and prognosis of male subfertility have bec.me a c.allenge. While the basic.semen assessment has been performed for many years, a number of studies question the value of the traditional semen c.arac.eristic.. This is partly due to inadequate methods and standardization, limited knowledge of tec.nic.l requirements for quality assuranc., and an inc.mplete understanding of what c.inic.l information a semen assessment c.n provide. Laboratories c.rrently performing semen and endoc.ine assessment show great variability. The World Health Organization （WHO） manual for the evaluation of semen has been the c.re of andrology and fertility evaluation that has helped in further development of this field over many years. These inc.ude the physic.l appearanc. of the ejac.late, assessments of sperm c.unt, motility, vitality, morphology, and func.ional aspec.s of the sperm and semen sample. These tests also inc.ude male endoc.ine profile, bioc.emic.l evaluation of the semen, detec.ion of antisperm antibodies in serum, the use of c.mputer-aided sperm analysis （c.SA）, sperm DNA integrity, and its damage due to oxidative stress. Assisted reproduc.ive tec.niques （e.g., IVF, Ic.I） have shown great suc.ess but are too expensive. Further development in this field with newer tec.niques and extensive training/instruc.ions c.n improve ac.urac. and reduc. variability, thus maintaining the quality and standards of suc. an evaluation. There is an urgent need to have standardized training c.nters and inc.eased awareness in this area of men＇s health for reproduc.ive suc.ess.

关键词： male infertility quality c.ntrol management reproduc.ive failure semen evaluation World Health Organization manual

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Struc.ural,morphologic.l,optic.l and antibac.erial performanc.s of rare earth(Sm)-doped ZnO nanorods

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Journal of Rare Earths 2024年第11期42卷 2119-2127页

作者： A.Ravi J.Samuel S.Sahaya Jude Dhas S.Usharani Turibius Simon D.Senthil Kumar S.K.Jasmin Vijitha A.Sivakumar Raju suresh Kumar c.S.Biju Department of Physic. University College of Engineering Department of Physic. and Researc. c.ntre Malankara Catholic College Manonmaniam Sundaranar University Saveetha Sc.ool of Engineering Saveetha Institute of Medical and Technical SciencesSaveetha University Department of c.emistry S.I.V.E.T College Department of Biotec.nology Vivekanandha College of Arts and Science for Woman (Autonomous) Department of Physic. Vel Tech Rangarajan Dr.Sagunthala R & D Institute of Science and Technology Department of Physic. & Researc. c.ntre Muslim Arts College Key Laboratory of High-temperature and High-pressure Study of the Earth's Interior Institute of GeochemistryChinese Academy of Sciences Department of c.emistry College of ScienceKing Saud University Department of Physic. St. Alphonsa College of Arts and Science

The signific.nt rise of ultra-violet（UV） radiation and pathogenic.infec.ious bac.eria poses a serious threat to global *** researc.ers' interests are attrac.ed by novel materials with strong UVbloc.ing ability,antibac.erial ac.ivity and low toxic.ty to other *** this c.se,a simple wet c.emic.l method with different annealing temperatures（400,500,and 600℃） was employed to c.eate highly effec.ive rare earth（Sm）-doped ZnO ***（101） plane of wurtzite ZnO shifts towards a lower angle with inc.easing annealing temperature,ac.ording to the X-ray diffrac.ion（XRD） study findings,whic. additionally establishes the c.nsequenc. of lattic. *** of doublet peaks of Sm 3d(Sm 3d5/2and Sm 3d3/2) in the X-ray photoelec.ron spec.rosc.py（XPS） spec.rum c.early validates the substitution of Sm3+ions in the 500℃-annealed *** 500℃-annealed nanorods exhibit c.mbined performanc.s of the wide band gap,improved UV absorbanc.,and vivid green luminesc.nt emission（563 nm）.Additio nally,the nanorods have favorable UV-bloc.ing exec.tion of 96% for UVA at 360 nm,92% for UVB at 320 nm,and 57% for UVc.at 225 nm,whic. is greater than the majority of ZnO-related materials that have been reported up to this *** doping is also appropriate for improving bac.erial inhibition against the two studied strains（Esc.eric.ia c.li and Staphyloc.c.us aureus）,in addition to the intriguing features disc.ssed ***,with maximum inhibition zone diameters of 20±0.72 and 18±0.57 mm,respec.ively,these nanorods exhibit high inhibitory ac.ion against *** and *** bac.erial *** rare earth-doped material developed during the c.rrent experiment,whic. was annealed at 500℃,c.uld potentially serve as an effec.ive replac.ment for UV-bloc.ing and antibac.erial material,espec.ally for biomedic.l applic.tions.

关键词： Bac.erial inhibition Metal oxide Rare earth doping UV-Shielding Wet c.emic.l method

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Geoc.emic.l elements in suspended partic.late matter of Ensenada de La Paz Lagoon,Baja c.lifornia Peninsula,Mexic.:Sourc.s,distribution,mass balanc. and ec.toxic.logic.l risks

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Journal of Environmental Sc.enc.s 2024年第2期136卷 422-436页

作者： Sandra Soledad Morales-Garc.a Pilar de Ac.c.a Pérez-Esc.milla suresh Babu Sujitha Pic.aimani Godwyn-Paulson Andrés Felipe Zuniga-c.bezas Muthuswamy Ponniah Jonathan Instituto Politéc.ic. Nac.onal(IPN) Centro Mexicano para la Producción más Limpia(CMPL)Av.Acueducto s/nCol.Barrio la Laguna TicománDel Gustavo A.MaderoC.P.07340Ciudad de MéxicoMexico Instituto Politéc.ic. Nac.onal(IPN) Escuela Superior de Ingeniería y Arquitectura(ESIA)Unidad Ticomán***án 600Delg.Gustavo A.MaderoC.P.07340Ciudad de México(CDMX)Mexico Instituto Politéc.ic. Nac.onal(IPN) Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo(CIIEMAD)Calle 30 de Junio de 1520Barrio la Laguna TicománDel.Gustavo A.MaderoC.P.07340Ciudad de MéxicoMéxico

The present study aimed to evaluate multi-element c.nc.ntrations(Al,As,c.,c.,c.,c.,c.,Fe,Mg,Mn,Mo,Ni,Pb,Sr)in suspended partic.late material(SPM)c.llec.ed from Ensenada de La Paz(ELP)lagoon,Baja c.lifornia Sur,Mexic. in two different periods(September and May)to c.mprehend their origin,geoc.emic.l behavior,mass transfer and assoc.ated ec.toxic.logic.l *** 24 hr variation c.effic.ent of volumetric.SPM levels were found to be 51.7%in September and 40.5%in May,signifying the effec.s of oc.anic.*** c.lc.lated enric.ment fac.or(EF)values for all the studied elements were of higher magnitude bec.use of the high surfac. area and oxide nature of SPM,and in this study,Mo had the highest EF of 46.77 probably due to its origin from c.ntinental *** the ec.toxic.logic.l perspec.ive,the integrated toxic.risk index revealed low toxic.risk to the benthic.***,the mean-ERM-Quotient c.lc.lated using the partic.late c.nc.ntrations of As,c.,c.,c.,Ni,Pb indic.ted 9%probability of toxic.ty to *** c.mprehensive geoc.emic.l and ec.toxic.logic.l assessment of partic.late metal c.nc.ntrations in the ELP lagoon signify low to moderate c.ntamination.

关键词： Suspended partic.late material Heavy metals Risk assessment Mass transfer Ensenada de La Paz

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Palaeodepositional environment,implic.tions of Glossopteris flora,and organic.matter c.arac.eristic. from the Lower Permian,Karo Open c.st Mine,East Bokaro c.alfield,Damodar Basin,India

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Journal of Palaeogeography 2024年第3期13卷 528-546页

作者： Sankar suresh Kumar Pillai Rose Ann Sebastian Runc.e Paul Mathews Srikanta Murthy Anju Saxena Mrutyunjaya Sahoo Suraj Kumar Sahu Gulshan Kumar Dhingra Birbal Sahni Institute of Palaeosc.enc.s 53 University RoadLucknow-226007UPIndia Ac.demy of Sc.entific.and Innovative Researc.(Ac.IR) Ghaziabad-201002India Department of Geology School of Earth Science SystemsCentral University of KeralaKasaragod-671316KeralaIndia Department of Geology Ravenshaw UniversityCuttack-753003OdishaIndia Department of Botany Sri Dev Suman Uttarakhand UniversityUttarakhand-249145India

The present study deals with the Early Permian floral diversity,palaeoenvironment,palaeoc.imate and depositional setting using a multiproxy approac. that inc.udes morphotaxonomy,palynology,and organic.geoc.emistry of Karo Oc.(Open c.st Mine),East Bokaro c.alfield,Damodar Gondwana Basin,*** Permian sediments of Peninsular India are widely regarded as fluvial,along with some marine *** mac.oplant fossil assemblage exhibits the presenc. of Glossopteridales,c.mprising Glossopteris,Gangamopteris,and Vertebraria,as well as c.niferales,whic. inc.udes *** palynologic.l assemblage enc.mpasses the dominanc. of the striate bisac.ate pollen Faunipollenites *** the subdominanc. of the non-striate bisac.ate pollen Sc.euringipollenites *** glossopterid *** megafloral and palynofloral assemblage c.nfirms the biostratigraphic.l age to be Late Barakar palynoflora of Kungurian *** studied morphologic.l c.arac.eristic.,inc.uding small to large Glossopteris leaves exhibiting a lanc.olate shape,ac.te apic.s,and ac.te c.neate or tapering bases,as well as entire margins with narrower lamina and narrow meshes,suggest the existenc. of a dense forest with the prevalenc. of a warm and humid c.imate during their *** organic.geoc.emic.l c.arac.erization based on func.ional group and biomarker analyses reveals the diagenetic.effec.s on organic.*** symmetric.~2865-2855 c.^(-1))and asymmetric.stretc.ing(~2930-2910 c.^(-1))peaks are identifiable in c.al samples,whereas they are absent in c.rbonac.ous *** A-fac.or vs.c.fac.or plot suggests that the kerogen type is type Ⅲ,whic. c.n generate mainly gaseous *** vitrinite reflec.anc. studies(R_(r) av.1.1%)show inc.eased maturity of the samples,whic. is supported by the n-alkane distribution pattern and the absenc. of hopane *** Indian floral assemblages in c.ntemporary of southern Gondwana c.ntinents reveal a stronger inc.ination/affinity with th

关键词： Glossopteris Palynomorph FTIR Gc.S Gondwana Permian Palaeoc.imate

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Seismic.wave veloc.ties of rare gas solids through elastic.properties in Earth's lower mantle

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Sc.enc. c.ina Earth Sc.enc.s 2009年第10期52卷 1599-1611页

作者： Seema GUPTA suresh c. GOYAL Department of Physic. Agra College Fac.lty of Engineering and Tec.nology Raja Balwant Singh College

The expressions for sec.nd (SOE) and third order elastic.(TOE) c.nstants for rare gas solids are derived for c.mparative study of elastic.behavior within the framework of many body potentials inc.uding the effec. of p... 详细信息

关键词： elastic properties seismic wave veloc.ties RGS

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c.mparative evaluation of semen parameters in pre-and post-Hurric.ne Katrina human population

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Asian Journal of Andrology 2015年第4期17卷 676-680页

作者： c.ner Baran Wayne J Hellstrom suresh c.sikka Department of Urology Tulane University School of Medicine New Orleans LA 70112 USA.

A natural disaster leading to ac.umulation of environmental c.ntaminants may have substantial effec.s on the male reproduc.ive system. Our aim was to c.mpare and assess semen parameters in a normospermic.population residing in the Southern Louisiana, USA area pre- and post-Hurric.ne Katrina. We retrospec.ively evaluated semen analyses data （n = 3452） of 1855 patients who attended the Tulane University Andrology/Fertility c.inic.between 1999 and 2013. The study inc.usion c.iteria were men whose semen analyses showed -〉 1.5 ml volume; _〉15 million ml1 sperm c.nc.ntration; _〉39 million total sperm c.unt; _〉40% motility; 〉30% morphology, with an abstinenc. interval of 2-7 days. After the inc.usion c.iteria applied to the population, 367 normospermic.patients were inc.uded in the study. Desc.iptive statistic. and group-based analyses were performed to interpret the differenc.s between the pre-Katrina （Group 1, 1999-2005） and the post-Katrina （Group 2, 2006-2013） populations. There were signific.nt differenc.s in motility, morphology, number of white blood c.ll, immature germ c.ll c.unt, pH and presenc. of sperm agglutination, but surprisingly there were no signific.nt differenc.s in sperm c.unt between the two populations. This long-term c.mparative analysis further doc.ments that a major natural disaster with its ac.ompanied environmental issues c.n influenc. c.rtain semen oarameters （e.g.. motility and morphology） and, bv extension, fertility potential of the population of suc. areas.

关键词： environment Hurric.ne Katrina, New Orleans area normospermic.infertile population retrospec.ive semen analYSiS

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