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Does offering only the spherical contact lens trial to the low astigmats mislead the practitioners?

International Journal of Ophthalmology(English edition) 2021年第8期14卷 1281-1284页

作者： Monica Chaudhry surendra prasad sah Indra prasad Sharma Soujanya Mondal Department of Optometry and Vision Science Amity UniversityHaryana 122003India School of Health Sciences Ansal UniversityGurugramHaryana 122003India Himalaya Eye Hospital GharinpatanPokhara 00977Nepal Gyalyum Kesang Choeden Wangchuck National Eye Center JDW National Referral HospitalThimphu 11001Bhutan Optsight Eye Care HCB RoadAmulapattiNear MFCSivasagarAssam 785640India

AIM:To compare the visual acuity(VA),comfort,and patient preference in a soft toric contact lens(TCL)versus soft spherical contact lens(SCL)in low astigmatic subjects during the contact lens(CL)***:This subject-masked,block randomized,2×2 crossover study recruited 40 neophyte subjects(80 eyes)aged 18 to 33 y with astigmatism in the range of 0.75-1.25 D with or without spherical power from-6.00 D to+6.00 *** participants were scheduled for two days CL trial and were fitted with the best-fit SCL and *** 4 h of wear,they were assessed objectively for high contrast VA and subjective vision,comfort,and ***:The responses of 36 subjects(response rate 90%)with a mean age of 23.02±2.97 y(range 18 to 33 y)were ***-line improvement of monocular VA in the logMAR chart was reported to TCL as compared to SCL(-0.044±0.06 vs 0.04±0.03 logMAR,P=0.01)but the binocular vision remained similar(-0.12±0.07 vs-0.14±0.04 logMAR,P=0.38).Subjects felt a noticeable difference in clarity when shifted to TCL as compared to the *** satisfaction with vision(vision quality)was significantly better with TCL(P=0.03).The fatigue with TCL was graded less at 2.5±0.6,compared to SCL at 4.6±1.3(P=0.04).Thirty-three participants(91.6%)preferred to use contact lens of which 26 participants(79%)preferred ***:The findings suggest that VA and comfort are better with TCL as compared to SCL which is only observed if the patient was offered both offering SCL with spherical equivalent power alone as the first option can mislead the practitioner;TCL trial should be the first choice of the lens in low-to-moderate astigmatism.

关键词： astigmatism comfort spherical contact lens toric contact lens visual acuity

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Effect of Doxorubicin on Histomorphology of Liver of Wistar Albino Rats

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Journal of Pharmacy and Pharmacology 2016年第4期4卷 174-178页

作者： Deepak Chaudhary Saroj Khatiwada surendra Kumar sah Man Kumar Tamang Soumya Bhattacharya Chandra Bhushan Jha M.Sc. Human Anatomy Department of Anatomy Nobel Medical College Biratnagar Nepal MSc. Medical Biochemistry Department of Biochemistry Modern Technical College Lalitpur Nepal M Sc. Medical Biochemistry Department of Nutrition and Dietetics Central Campus of Technology Dharan Nepal MD Anatomy Department of Human Anatomy B P Koirala Institute of Health Sciences Dharan Nepal

Doxorubicin is associated with adverse effects on organs like liver. This study was done to find the effects of doxorubicin on liver of wistar albino rats. Sixty healthy wistar albino rats were taken for the study. The rats were randomly divided in to 4 groups （2 experimental groups; group AI and A2, and 2 control groups;group Bland B2 each containing 16 rats）. The experimental groups were given a single dose of doxorubicin i.e. 10 mg/kg body weight intraperitoneally and sacrificed after 7 days and 14 days for each group. Rats under control groups were given a single intraperitoneal dose of 2.5 ml/kg body weight normal saline and sacrificed with their respective experimental groups. A significant difference （p 〈 0.001） and （p = 0.005） in final body weight was observed among group A1 experimental and BI control rats, and among group A2 experimental and B2 control rats. As compared to group B2 control, group A2 experimental rats had significantly （p = 0.043） lower liver weight. Diameter ofhepatocyte （p 〈 0.001 for both groups） and nucleus （p=0.004 for group A1 and control BI, and p 〈 0.001 for group A2 and control B2） was significantly higher in experimental rats as compared to their respective controls. Cross-sections of the liver of both control groups had normal architecture. However, there was progressive destruction of liver architecture across the experimental groups. Doxorubicin causes the disruption of normal architecture of liver in rats. Thus care needs to be taken during doxorubicin chemotherapy to minimize effects on river.

关键词： Doxorubicin Histomorphometry Liver Wistar albino rot.

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