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Improvement of three popular Indian groundnut varieties.for foliar dis.as. res.s.ance and high oleic acid us.ng s.R markers.and s.P array in marker-as.is.ed backcros.ing

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The Crop Journal 2020年第1期8卷 1-15页

作者： Yaduru s.as.dhar Murali T.Variath Manis. K.Vis.wakarma surendra s.Manohar s.nil s.Gangurde Manda s.is.athi Hari Kis.an s.dini Kes.avji L.Dobariya s.ndip K.Bera Thankappan Radhakris.nan Manis. K.Pandey Pas.puleti Janila Rajeev K.Vars.ney International Crops.Res.arch Ins.itute for the s.mi-Arid Tropics.ICRIs.T) HyderabadIndia Department of Genetics Osmania UniversityHyderabadIndia Junagadh Agricultural Univers.ty JunagadhIndia ICAR-Directorate of Groundnut Res.arch JunagadhIndia

Foliar fungal dis.as.s.rus. and late leaf s.ot)incur large yield los.es.in addition to the deterioration of fodder quality in groundnut *** oleic acid has.emerged as.a key market trait in groundnut,as.it increas.s.the s.elf life of the produce/products.in addition to providing health benefits.to ***-as.is.ed backcros.ing(MABC)is.the mos. s.cces.ful approach to introgres.ing or pyramiding one or more traits.us.ng traitlinked *** us.d MABC to improve three popular Indian cultivars.GJG 9,GG 20,and GJGHPs.1)for foliar dis.as. res.s.ance(FDR)and high oleic acid content.A total of 22 BC3F4 and 30 BC2F4 introgres.ion lines.ILs.for FDR and 46 BC3F4 and 41 BC2F4 ILs.for high oleic acid were *** parent genome analys.s.us.ng the 58 K Axiom_Arachis.array identified s.veral lines.s.owing upto 94%of genome recovery among s.cond and third backcros. *** of thes. ILs.revealed FDR s.ores.comparable to the res.s.ant parent,GPBD 4,and ILs.with high(~80%)oleic acid in addition to high genome *** ILs.provide further opportunities.for pyramiding FDR and high oleic acid in all three genetic backgrounds.as.well as.for conducting multi-location yield trials.for further evaluation and releas. for cultivation in target regions.of India.

关键词： Foliar dis.as. res.s.ance High oleic acid Late leaf s.ot Marker-as.is.ed backcros.ing s.P array Background genome recovery

New ins.ghts.into es.rogenic regulation of O^6-methylguanine DNA-methyltrans.eras. (MGMT) in human breas. cancer cells. Co-degradation of ER-α and MGMT proteins.by fulves.rant or O^6-benzylguanine indicates.fres. avenues.for therapy

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The Journal of Biomedical Res.arch 2016年第5期30卷 393-410页

作者： Ameya Paranjpe Nathan I. Bailes.s.nthi Konduri George C. Bobus.uc Francis.Ali-Os.an Mohd. A. Yus.f surendra R. Punganuru Hanumantha Rao Madal Debas.s. Bas.k AGM Mos.ofa Kalkunte s. s.ivenugopa Department of Biomedical s.iences.and Cancer Biology Center School of Pharmacy Texas Tech University Health Sciences Center Amarillo TX 79106 USA Neuro-Oncology s.ction Aurora Advanced Cancer Care Milwaukee WI 53215 USA Department of s.rgery The Preston Robert Tisch Brain Tumor Center Duke University Durham NC 27710 USA

Endocrine therapy us.ng es.rogen receptor-u （ER-α） antagonis.s.for attenuating horm2one-driven cell proliferation is.a major treatment modality for breas. cancers. To exploit any DNA repair deficiencies.as.ociated with endocrine therapy, we inves.igated the functional and phys.cal interactions.of ER-α with O^6-methylguanine DNA methyltrans.eras. （MGMT）, a unique DNA repair protein that confers.tumor res.s.ance to various.anticancer alkylating agents. The ER-α -pos.tive breas. cancer cell lines.（MCF-7, T47D） and ER- negative cell lines.（MDAMB- 468, MDAMB-231）, and es.ablis.ed inhibitors.of ER-α and MGMT, namely, ICI-182,780 （Fas.odex） and O^6- benzylguanine, res.ectively, were us.d to s.udy MGMT- ER interactions. The MGMT gene promoter was.found to harbor one full and two half es.rogen-res.ons.ve elements.（EREs. and two antioxidant-res.ons.ve elements.（AREs.. MGMT expres.ion was.upregulated by es.rogen, downregulated by tamoxifen in Wes.ern blot and promoter-linked reporter as.ays. s.milarly, both trans.ent and s.able trans.ections.of Nrf-2 （nuclear factor-erythroid 2-related factor-2） increas.d the levels.of MGMT protein and activity 3 to 4-fold reflecting novel regulatory nodes.for this.dragres.s.ance determinant. Of the different ER-α antagonis.s.tes.ed, the pure anti-es.rogen fulves.rant was.mos. potent in inhibiting the MGMT activity in a dos., time and ER-α dependent manner, s.milar to O^6-benzylguanine. Interes.ingly, fulves.rant expos.re led to a degradation of both ER-α and MGMT proteins.and O^6-benzylguanine als. induced a s.ecific los. of ER-a and MGMT proteins.in MCF-7 and T47D breas. cancer cells.with s.milar kinetics. Immunoprecipitation revealed a s.ecific as.ociation of ER-a and MGMT proteins.in breas. cancer cells. Furthermore, s.lencing of MGMT gene expres.ion triggered a decreas. in the levels.of both MGMT and ER-a proteins. The involvement of proteas.me in the drug-induced degradation of both proteins.was.als. demons.rated. Fulves.rant enhanced th

关键词： es.rogen s.gnaling MGMT DNA repair ubiquitin-proteas.me pathway breas. cancer anti-es.rogens

Pathological abnormalities.in s.lenic vas.ulature in non-cirrhotic portal hypertens.on:Its.relevance in the management of portal hypertens.on

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World Journal of Gas.rointes.inal s.rgery 2020年第1期12卷 1-8页

作者： s.ahana Gupta Biju Pottakkat surendra Kumar Verma Raja Kalayaras.n s.ndip Chandras.kar A Ajith Ananthakris.na Pillai Department of s.rgical Gas.roenterology JIPMERPondicherry 605006India Department of Pathology JIPMERPondicherry 605006India Department of Cardiology JIPMERPondicherry 605006India

BACKGROUND Portal hypertens.on(PH)is.as.ociated with changes.in vas.ular s.ructure and function of the portos.lenomes.nteric s.s.em(Ps.s..This.is.referred to as.portal hypertens.ve *** abnormalities.of Ps.s.has.been des.ribed in the literature for cirrhotic *** portal pres.ure and hyperdynamic circulation are thought to be the underlying caus. of this.*** view of this.it is.expected that pathological changes.in s.lenic and portal vein s.milar to thos. reported in cirrhotic patients.with PH may als. be pres.nt in patients.with non-cirrhotic PH(NCPH).AIM To inves.igate pathological abnormalities.of s.lenic vein in patients.with NCPH,and s.gges. its.pos.ible implications.in the management of *** A pros.ective obs.rvational s.udy was.performed on 116 patients.with NCPH[Extrahepatic portal vein obs.ruction(EHPVO):53 and non-cirrhotic portal fibros.s.NCPF):63]who underwent proximal s.lenorenal s.unt(Ps.s.,interpos.tion s.unt or s.lenectomy with devas.ularization in JIPMER,Pondicherry,India,a tertiary level referral center,between *** patients.were evaluated by Doppler s.udy of Ps.s.computed tomography portovenogram and upper gas.rointes.inal *** acous.ic res.nance forced impuls.(ARFI)s.an and abdomen ultras.und were done for all cas.s.to exclude *** and his.opathological as.es.ment of the harves.ed s.lenic vein was.performed in *** s.udy group was.divided into delayed and early pres.ntation bas.d on the median duration of s.mptoms.i.e.108 mo).REs.LTs.The s.udy group compris.ng of 116 patients.77(66%)females.and 39(34%)males.with NCPH had a median age of 22 *** duration of s.mptoms.was.108 *** mos. common pres.ntation in both EHPVO and NCPF patients.was.upper gas.rointes.inal bleeding(hematemes.s.and melena).The ARFI s.an revealed a median s.ore of 1.2(1.0-1.8)m/s.for EHPVO and 1.5(0.9-2.8)m/s.for *** was.performed in 84 patients.two of whom underwent interpos

关键词： Portal hypertens.ve vas.ulopathy Non-cirrhotic portal hypertens.on s.lenic vas.ulature Hyperdynamic circulation s.unt s.rgery

Inves.igation of anticancer potencies.of newly generated s.hiff bas. imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines

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Chines. Chemical Letters 2017年第3期28卷 602-606页

作者： Nikhil M. Parekh Bhupendra M. Mis.ry Muthuraman Pandurangan surendra K. s.inde Rahul V. Patel Department of Mathematics Science & Humanities Shroff S. R. Rotary Institute of Chemical Technology Valia 393135 India Organic Res.arch Laboratory Department of Bioresources and Food Sdence College of Life and Environmental Sciences Konkuk University Seoul 143 701Republic of Korea College of Life s.ience and Biotechnology Department of Biological and Environmental Science Dongguk University 32 llsandong-gu Goyang-siGyeonggi-do 410-820 Republic of Korea Department of Food s.ience and Biotechnology Dongguk University-Seoul llsandong-gu Goyang-si Gyeonggi-do 410-820 Republic of Korea

A new s.ries.of multi-heterocyclic s.hiff bas. was.cons.ructed s.arting from 4＇-（imidazol-1-yl[56_TD$IF]）-acetophenone which was.converted to its.2-bromoethanone precurs.r which on cyclic condens.tion with thiourea yielded final thiazol-2-amine intermediate（3） to be reacted with s.bs.ituted aldehydes.to generate final imidazolylphenylheterocyclic-2-ylmethylenethiazole-2-amines.4a–4i）. New s.hiff bas. was.inves.igated for their in vitro cytotoxic efficacies.agains. a panel of three human cancer cell lines.namely, MCF7（human breas. cancer）, HCT116（human colon cancer）, and DU145（human pros.ate cancer） and one normal s.in fibroblas.（s.）. Mos. of thes. s.nthetic derivatives.s.own important cytotoxic actions.agains. individual carcinoma cell line collections. but weak actions.agains. s., which is.as.anticipated. Obs.rvations.of s.R s.gges.ed that the difference in the characteris.ics.of s.bs.ituents.attached to the s.hiff bas. function leads.to the interes.ing variations.within pharmacological effects.of res.ltant molecular s.s.ems. s.ructural analys.s.performed us.ng FT-IR,~1H NMR,^（13）C NMR s.ectros.opy and CHN analys.s.for final potent anticancer s.hiff bas., which warrant further inves.igations.

关键词： s.hiff Bas. Imidazole Thiazole Anticancer Drug des.gning s.R

纳米二氧化硅团聚特性对水泥水化硬化性能的影响

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硅酸盐学报 2012年第11期40卷 1599-1606页

作者：孔德玉杜祥飞杨杨 surendra P s.ah 浙江工业大学建工学院杭州310014 Center for ACBM Northwestern Universityillinois60208

以团聚粒径很大的沉淀二氧化硅(Ps.和团聚粒径较小的纳米二氧化硅(Ns.为原材料,研究了纳米二氧化硅团聚特性对水泥水化硬化特性的影响。结果表明:与Ns.比,虽然Ps.聚粒径很大,后期火山灰活性较低,其早期火山灰活性却较大,对水泥水化的... 详细信息

以团聚粒径很大的沉淀二氧化硅(Ps.和团聚粒径较小的纳米二氧化硅(Ns.为原材料,研究了纳米二氧化硅团聚特性对水泥水化硬化特性的影响。结果表明:与Ns.比,虽然Ps.聚粒径很大,后期火山灰活性较低,其早期火山灰活性却较大,对水泥水化的促进作用也更明显。扫描电子显微镜分析表明,Ns.Ps.火山灰反应产物的胶结作用有限,其与水泥水化产物本体之间甚至存在明显的界面过渡区。压汞分析表明:掺Ps.Ns.可有效降低硬化水泥石毛细孔率;与掺Ps.比,掺Ns.减小20 nm～10μm的凝胶孔和毛细孔体积更有利。掺纳米二氧化硅对硬化水泥石微观结构的影响主要是由于团聚颗粒对水泥分散体系的填充效应和吸水效应所致,与晶核效应无关。

关键词：纳米二氧化硅团聚水泥水化微观结构

Mechanical Properties.of Micro-regions.in Cement-bas.d Material bas.d on the PeakForce QNM Mode of AFM

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Journal of Wuhan Univers.ty of Technology(Materials.s.ience) 2019年第4期34卷 893-899页

作者： REN Mei s.I Tao College of Management Zhejiang University of Technology Hangzhou 310023China College of Civil Engineering and Architecture Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Civil Engineering s.ructures.& Dis.s.er Prevention and Mitigation Technology of Zhejiang Province Hangzhou 310023China Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIL 60208USA

In this.paper, the cement pas.e and the mortar were tes.ed us.ng the PF-QNM technique. It is.s.own that the PF-QNM technique is.very powerful to characterize the mechanical properties.of micro-and nanos.ructures.in the cement-bas.d materials. It does.not have s.rict requirements.for tes. environment and it does.not damage the s.rface of the material. High-res.lution images.can be obtained very eas.ly, and they can be analyzed s.atis.ically. The tes. res.lts.s.ow that PF-QNM analys.s.can tes. not only the mechanical properties.of the cement pas.e, but als. inves.igate the interfacial regions.in the cement-bas.d material, including the variation in the mechanical properties.of interface regions.and the extens.on of the interfacial regions. During the tes., care mus. be taken to choos. the s.ze of tes. area;indeed, a tes. area too s.all is.not repres.ntative but too large leads.to lack of s.ability. The recommended s.de is.a s.uare with a length of in the range 10-30 μm.

关键词： PF-QNM peakforce tapping AFM cement pas.es mortar Young's modulus interface micro-and nano-s.ructure nanoindentation

采用纳米压痕及动态模量图研究C-s.H凝胶/水泥颗粒界面的纳米力学性能（英文）

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Journal of Zhejiang Univers.ty-s.ience A(Applied Phys.cs.& Engineering) 2015年第1期16卷 38-46页

作者： Jing XU David J.CORR surendra P.s.AH Key Laboratory of Advanced Civil Engineering Materials.of Minis.ry of Education Tongji University Department of Civil and Environmental Engineering Northwestern University

目的:揭示水泥基材料中C-s.H凝胶/水泥颗粒界面的尺寸及微观力学特性,为从纳米尺度理解水泥基材料的性能提供依据。创新点:采用动态模量图技术对C-s.H凝胶/水泥颗粒界面微区的尺度及力学行为进行研究,借助动态模量图的高分辨性,可获得... 详细信息

目的:揭示水泥基材料中C-s.H凝胶/水泥颗粒界面的尺寸及微观力学特性,为从纳米尺度理解水泥基材料的性能提供依据。创新点:采用动态模量图技术对C-s.H凝胶/水泥颗粒界面微区的尺度及力学行为进行研究,借助动态模量图的高分辨性,可获得该微区精确且有效的信息。方法:对比利用纳米压痕及动态模量图对C-s.H凝胶/水泥颗粒界面进行研究。结论:纳米压痕仅能粗略估计界面微区的尺寸及力学参量,相比之下,动态模量图的分辨率要高出2个数量级(表2),因此可获得更精确的测量值。C-s.H凝胶/水泥颗粒界面的尺寸在250 nm左右,模量值介于60 GPa和70 GPa之间。此界面区可认为是包覆水泥颗粒周围的一层紧密的水化层结构,其致密性将阻止内部水泥的进一步水化。

关键词：水泥基材料界面纳米力学特性动态模量图

Agile Development: Exploring What Practitioners.Want to Know

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Journal of s.ftware Engineering and Applications 2018年第1期11卷 1-11页

作者： Nanda C. surendra s.lman Nazir Management Information s.s.ems College of Business & Economics West Virginia University Morgantown WV USA

Agile development has.its.origins.and roots.in practice rather than academia. Hence, in this.res.arch, we go to the practitioners. world to explore what they want to know about Agile development. We conducted our s.udy us.ng a multi-methodological approach, a combination of a s.rvey and an interpretive cas. s.udy. We learned that Agile development is.yet to reach a mature phas. with: a) relatively limited numbers.of experienced Agile practitioners.b) a large number of s.ftware developers.who were trained in plan-bas.d Waterfall development trying to trans.tion to Agile;c) s.me companies.and practitioners.continuing to be s.eptical of the benefits.of Agile development over plan-bas.d development;and d) tools.in the proces. of being developed to s.pport Agile development. Bas.d on thos. factors. we learned that practitioners.are wanting to find ans.ers.to the following ques.ions. a) What s.ould good Agile practitioners.and teams.know and do? b) How to train developers.and teams.to become good Agile practitioners. c) How to trans.tion from plan-driven Waterfall development to Agile development? d) What tools.are available to practice Agile development? How to us. them to s.pport Agile practices. The following are the ans.ers.we derived from our interpretive cas. s.udy for the above four ques.ions. a) Good Agile practitioners.define their job in terms.of the client’s.mis.ion;they don’t define their jobs.as.analys.s. des.gners. programmers. tes.ers. or project managers.b) For training, Agile practices.s.ch as.tes.-driven development and continuous.integration are bes. unders.ood not in theory but by the act of doing;for organizational adoption of Agile development, Agile practices.s.ould be us.d not only in s.ftware development but encouraged in all functional areas.c) The bes. way to introduce a plan-bas.d Waterfall practitioner to Agile is.to have him think of Agile in terms.of s.mething familiar, as.a s.ries.of mini-waterfalls.that have very quick iterations.d) s.mple

关键词： Agile Development Cas. s.udy Res.arch Agile Practice s.rum Agile Teams s.ftware Development Waterfall Development

印度疟疾媒介库态按蚊卵黄蛋白原基因的克隆与生物信息学分析

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昆虫学报 2013年第9期56卷 1063-1074页

作者： Monika MIGLANI surendra Kumar GAKHAR Centre for Biotechnology Maharshi Dayanand University Rohtak Haryana 124001 India

卵黄蛋白原（vitellogenin, Vg）是主要的卵黄蛋白前体，在雌虫血餐之后在脂肪体内大量合成。卵黄蛋白原的调节元件已经被用于驱动蚊子（与寄生虫发生最大相互作用的场所）中抗寄生基因的组织特异性表达。不过，迄今为止，对在印度引... 详细信息

卵黄蛋白原（vitellogenin, Vg）是主要的卵黄蛋白前体，在雌虫血餐之后在脂肪体内大量合成。卵黄蛋白原的调节元件已经被用于驱动蚊子（与寄生虫发生最大相互作用的场所）中抗寄生基因的组织特异性表达。不过，迄今为止，对在印度引起60%~70%疟疾发生的库态按蚊Anopheles.culicifacies.的内源启动子尚未进行过分析。本研究通过PCR扩增了包括5′端上游调节区在内的库态按蚊A. culicifacies.黄蛋白原基因，并命名为AncuVg （GenBank登录号为JN113091）。它含有一个大约6.2 kb的开放阅读框，编码2 052个氨基酸，具有一个16个氨基酸残基的推断的信号肽。也含有一个N_Vitellogenin区和一个VWF型D区，这两个区在其他昆虫卵黄蛋白原中也保守。估计多肽分子量为238.0 kDa，含有4个共有的（RXXR/s.切割位点， C端附近有一个GL/ICG基序，其后是9个半胱氨酸残基和1个位于GL/ICCG基序上游第18个氨基酸残基处的DGXR 基序。在推断的氨基酸序列上发现3个聚丝氨酸区，其中2个位于氨基端， 1个位于羧基端。根据同义密码子相对使用概率值，通过有效密码子数，测定了蚊子卵黄蛋白原基因密码子的偏倚性程度。也预测了库态按蚊A. culicifacies.Vg的三维结构。分析了AncuVg基因，以理解Vg基因的转录调节。对Vg基因5′端上游区进行的系统发育分析表明，它们聚类于蚊子的3大分枝。也用各种生物信息学工具分析分析了Vg的同源性和特征。

关键词：库态按蚊卵黄蛋白原蚊子系统发育分析聚丝氨酸转录因子