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Ethnopharmacological,phytochemical and clinical studies on Fenugreek(Trigonella foenum-graecum L.)

Food Bioscience 2022年第2期46卷 24-54页

作者： Neetu singh surender singh yadav Sanjiv Kumar Balasubramaniam Narashiman Department of Botany Maharshi Dayanand UniversityRohtakHaryana124001India Department of Pharmaceutical Sciences Ch.Bansi Lal UniversityBhiwaniHaryanaIndia Department of Pharmaceutical Sciences M.D.UniversityRohtakHaryana124001India

Trigonella foenum-graecum(fenugreek)belonging to the family Fabaceae,is widely used for both culinary as well as clinical purposes since antiquity.Folkloric medicines across globe particularly use this plant for boosting immunity and combating digestive and reproductive impairments.The plant is rich reservoir of different phytoconstituents attributed to their diverse pharmacological effects.Therefore,the present article is planned on its ethnomedicinal uses,botanical description,phytochemistry,pharmacology,toxicology,clinical efficacy,mechanism of action and nanoparticle synthesis.In all pharmacological studies,the dose,major bioactive,type of extract and possible outcomes is also discussed,to establish its specific role against a particular ailment.It was hypothesized that the nanoparticle synthesis will lead to the enhanced pharmacology.Results showed that ethnomedicinal data well supports the different pharmacological aspects of Trigonella formulations in different countries.Trigonelline(phytoestrogen)renders most of therapeutic potential of Trigonella.The reported therapeutics can also be accounted as the synergistic pharmacology of different bioactives.Nanoparticle synthesis significantly improves its pharmacological efficacy.Clinical studies well validated its antidiabetic and reproductive health improving efficacies.Though no serious toxic effects were observed with the use of this plant but further well-designed placebo trials are still needed to demonstrate its full therapeutic potential.

关键词： Trigonella Fenugreek Traditional uses Pharmacology Clinical study Toxicology

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Impact Analysis of Genetically Modified (Bt) Cotton Genotypes on Economically Important Natural Enemies under Field Conditions

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Advances in Entomology 2016年第2期4卷 61-74页

作者： Dalip Kumar surender singh yadav Vivek Kumar Saini Krishan Kumar Dahiya Department of Entomology College of Agriculture CCS HAU Hisar India Government College Hisar India Cotton Section Department of Plant Breeding and Genetics CCS HAU Hisar India

Field studies were conducted at Hisar during Kharif, 2009-2010 and 2010-2011 under natural and unsprayed condition. RCH 134 Bt, HS 6 (non Bt), H 1117 and Ganganagar Ageti (non Bt) were selected for the studies. The experiment was laid down in Randomized Block Design replicated thrice having plant spacing 67.5 × 60 cm. Among the bollworms, Erias spp. exhibited positive correlation with rainfall, minimum temperature and relative humidity morning hours significantly at 5 percent level whereas Helicoverpa and Pectinophora displayed positive relations only with evening hours relative humidity significantly while Spodoptera were significantly positive correlated with relative humidity of morning and evening hours. Bollworm complex was negatively correlated with all the weather parameters employed to study although being non-significant in case of rainfall, maximum and minimum of temperature, morning and evening hours of relative humidity. Among the sucking pests, leafhoppers, whitefly, thrips and aphids population showed significantly negative correlation with weather parameters. The comparison of natural bio-agents in cotton hybrids under study revealed that overall mean population of natural enemies were higher in Bt cotton hybrid as compared to non-Bt. These results confirm that use of genetically modified (Bt) cotton in lieu of conventional genotypes could positively impact non-target and beneficial insect species by preserving their host populations.

关键词： Bt Cotton Natural Enemies Sucking Pests Bollworm Complex Population Dynamics Correlation Co-Efficient Abiotic Factors

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Human Factors While Using Head-Up-Display in Low Visibility Flying Conditions

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Intelligent Automation & Soft Computing 2023年第5期36卷 2411-2423页

作者： Jhulan Kumar surender singh Saini Divya Agrawal Vinod Karar Aman Kataria Academy of Scientific and Innovative Research(AcSIR) Ghaziabad201002India CSIR-Central Scientific Instruments Organisation 160030India

Flying an aircraft in low visibility is still a challenging task for the pilot.It requires precise and accurate situational awareness(SA)in real-time.A Head-up Display(HUD)is used to project collimated internal and externalﬂight information on a transparent screen in the pilot’s forwardﬁeld of view,which eliminates the change of eye position between Head-Down-Display(HDD)instru-ments and outer view through the windshield.Implementation of HUD increases the SA and reduces the workload for the pilot.But to provide a betterﬂying capability for the pilot,projecting extensive information on HUD causes human factor issues that reduce pilot performance and lead to accidents in low visibility conditions.The literature shows that human error is the leading cause of more than 70%of aviation accidents.In this study,the ability of the pilot able to read background and symbology information of HUD at a different level of back-ground seen complexity,such as symbology brightness,transition time,amount of Symbology,size etc.,in low visibility conditions is discussed.The result shows that increased complexity on the HUD causes more detection errors.

关键词： HUD avionics human factor situational awareness background complexity

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Investigation of Flexible and Lightweight RTP-CVD-grown Graphene for Thermal Management of Consumer Electronics

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新型炭材料（中英文） 2023年

作者： Satendra Kumar Manoj Goswami Netrapal singh Uday Deshpande surender Kumar N.Sathish CSIR-Advanced Materials and Processes Research Institute (AMPRI) Academy of Scientific and Innovative Research (AcSIR) UGC-DAE Consortium for Scientific Research University Campus

Next-generation and faster technologies are being developed and require better thermal management. The thermal conductivity of pristine graphene is 13-fold more than copper. Here, single-, bi-and few-layers graphene (SLG, BLG, FLG) with large sp2 domains are grown by rapid thermal processing chemical vapour deposition (RTP-CVD). High thermal conducting graphene recipes are being prepared by diluting H2 concentration. A transition from FLG to high-quality BLG is observed at low H2 concentrations. Pristine SLG is prepared at growth temperature and time of 1 000°C and 25 minutes, respectively. The quality of graphene is investigated by Raman spectroscopy and transmission electron microscopy (TEM). To demonstrate the heat dissipation capability of RTP-CVD-grown graphene, a 2TB SSD is used and the temperature was measured by FLIR IR-thermal camera. RTP-CVD-grown graphene is demonstrated for thermal management in consumer electronics. SLG shows 5°C less temperature (max.) than commercial copper heat dissipator. The heat spreading capability of SLG is found approximately 200 times faster than commercial copper heat dissipators. Flexible and lightweight RTP-CVD-grown graphene can be a better choice for thermal management in next-generation 5G devices and consumer electronics.

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Gastric antisecretory and cytoprotective effects of hydroalcoholic extracts of Plumeria alba Linn. leaves in rats

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Journal of Integrative Medicine 2014年第1期12卷 42-51页

作者： Manjusha Choudhary Vipin Kumar surender singh Institute of Pharmaceutical Sciences Kurukshetra University All India Institute of Medical Sciences

OBJECTIVE： This study was conducted to evaluate the antiulcerogenic property of hydroalcoholic extract obtained from the leaves of Plumeria alba Linn. METHODS： Antiulcer assays were performed using the protocols of ulcer induced by non- steroidal anti-inflammatory drugs, ethanol and pylorus ligation. The hydroalcoholic extract （HAPA）, and various fractions of HAPA like, n-hexane extract （HPA）, ethyl acetate extract （EAPA） and n-butanol extract （BPA） were administered at doses of 200 and 400 mg/kg for HAPA and 100 and 200 mg/kg for fractions of extracts. Parameters of gastric secretion （volume, pH, total protein, and free and total acidity） were determined by the pylorus ligation model. Parameters like aspartate aminotransferase and alanine aminotransferase were also determined in ethanol- induced ulcer model. To determine the mechanism of action, role of nitric oxide was also evaluated. RESULTS： EAPA and BPA （100 and 200 mg/kg, p.o.） showed gastric ulcer-healing effect in indomethacin-induced ulcer model, while HAPA （200 mg/kg） and HPA showed no significant antiulcer effect. Both EAPA and BPA showed gastric cytoprotective effect in ethanol-induced gastric ulcer and inhibited gastric secretion in pylorus-ligated rats. CONCLUSION： The results of the present study show that some hydroalcoholic extract of Plumeria alba L. displays antiulcer activity, as demonstrated by the significant inhibition of ulcer formation induced by different models, which is consistent with the literature report in folk medicine.

关键词： Plumeria anti-ulcer agents plant extracts rats

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sp^(2)碳用于3D打印技术综述:材料、性能和应用

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新型炭材料（中英文） 2022年第6期37卷 1046-1065页

作者： Satendra Kumar Manoj Goswami Netrapal singh Sathish Natarajan surender Kumar Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India CSIR-Advanced Materials and Processes Research Institute(AMPRI) Bhopal 462026India

3D打印可以改变现有的生产方法,是第四次工程革命中的一项现代技术。它从成型原理上提出了分层制造、逐层叠加成型的新颖生产方法,从根本上简化了制造工艺,实现了大规模定制生产。然而,这一新技术仍存在许多问题。除了纯石墨烯外,sp^(2... 详细信息

3D打印可以改变现有的生产方法,是第四次工程革命中的一项现代技术。它从成型原理上提出了分层制造、逐层叠加成型的新颖生产方法,从根本上简化了制造工艺,实现了大规模定制生产。然而,这一新技术仍存在许多问题。除了纯石墨烯外,sp^(2)碳具有好的亲水性,3D打印难度较小。sp^(2)碳还可在3D打印中的各种阶段应用。纯石墨烯的疏水性使其难以在水系介质中打印和加工。毛细管油墨的发展使得纯石墨烯的3D打印成为可能。本文综述了sp^(2)碳的3D打印技术的最新进展。首先简要概述了3D打印技术,随后概述了sp^(2)碳的3D打印及其在各种方面的应用。最后,讨论了这一新领域的发展前景和机遇。

关键词： 3D打印技术 sp^(2)碳碳基复合材料应用

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快速热处理化学气相沉积法制备用于电子产品热管理的轻质柔性石墨烯

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新型炭材料（中英文） 2023年第3期38卷 534-542页

作者： Satendra Kumar Manoj Goswami Netrapal singh Uday Deshpande surender Kumar N.Sathish Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India CSIR-Advanced Materials and Processes Research Institute(AMPRI) Bhopal 462026India UGC-DAE Consortium for Scientific Research University CampusIndore 452001India

下一代电子产品的飞速发展对热管理提出了更高的要求。初始石墨烯的导热性是铜的13倍。本文通过快速热处理化学气相沉积(RTP-CVD)法制备了具有大sp^(2)结构域的单层、双层和多层石墨烯(SLG、BLG、FLG),进一步通过低浓度H_(2)还原制备了... 详细信息

下一代电子产品的飞速发展对热管理提出了更高的要求。初始石墨烯的导热性是铜的13倍。本文通过快速热处理化学气相沉积(RTP-CVD)法制备了具有大sp^(2)结构域的单层、双层和多层石墨烯(SLG、BLG、FLG),进一步通过低浓度H_(2)还原制备了高导热石墨烯。在1000℃下生长25 min制备出SLG,利用拉曼光谱和透射电子显微镜(TEM)研究了石墨烯的品质。为了验证RTP-CVD法生成的石墨烯的散热能力,将其作为2TB固态硬盘的散热器,通过红外热成像仪进行了研究。结果证明,RTP-CVD生长的石墨烯用于消费电子产品的热管理测试时性能表现优异。SLG显示温度(最高)比商用铜散热器低5℃,SLG的散热能力比商用铜散热器快200倍左右。综上,利用RTP-CVD法制备的轻质的柔性石墨烯可以成为下一代5G设备和消费电子产品热管理的更好选择。

关键词：石墨烯热管理消费类电子产品化学气相沉积

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Structural characterization of Nd-doped in silica host matrix prepared by wet chemical process

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Journal of Rare Earths 2009年第1期27卷 83-86页

作者： surender Duhan Sunita Devi M.singh Materials Science Lab Department of Applied Physics Guru Jambheshwar University of Science & Technology Materials Science Lab Department of Physics Department of Chemistry Lajpat Rai College Department of Physics Amity School of Engineering and TechnologyAmity University Sec-125

Silica host matrix containing neodymium which is potentially important for the formation of nanocrystalline metal oxides was prepared by solgel method, using tetra-ethoxysilane and Nd（NO3）3 as precursor materials.The prepared samples were changed from amorphous to nanocrystallites phase at sintered temperature 550 °C（4 h）, 750 °C（8 h） and 950 °C（12 h）.The thermally treated sample microstructures were investigated using X-ray diffraction（XRD）, Fourier transformation infrared spectroscopy（FTIR）, and scanning electron mi-croscopy（SEM）.While a further increase of the temperature at 750 °C and annealing time（8 h） resulted in the formation of cubic and hexagonal Nd2O3 nanocrystallites.At constant sintering temperature 950 °C for 12 h, the samples showed sharper and intense peaks.The sizes of Nd2O3 nanocrystallites were characterized by XRD with average size ～46 nm.

关键词： rare earth oxide silica annealing/calcination nanocrystallites

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Rare double fracture-dislocation of the thumb： a case report and review of the literature

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Chinese Journal of Traumatology 2013年第4期16卷 240-242页

作者： Davinder singh Loveneesh G Krishna Sunil Dhaka surender Kumar Sumit Arora Central Institute of Orthopaedics Vardhman MahavirMedical College & Safdarjung Hospital New Delhi 110029India

metacarpophalangeal (MCP ) 的关节和脱臼连接的姆指 carpometacarpal (CMC ) 的同时的破裂 / 脱臼被看作一个稀罕损害模式。我们报导与底的 extraarticular 骨折联系的姆指联合的 MCP 的背面的脱臼的一个不平常的案例第一在一个 28 ... 详细信息

metacarpophalangeal (MCP ) 的关节和脱臼连接的姆指 carpometacarpal (CMC ) 的同时的破裂 / 脱臼被看作一个稀罕损害模式。我们报导与底的 extraarticular 骨折联系的姆指联合的 MCP 的背面的脱臼的一个不平常的案例第一在一个 28 岁的人掌部。MCP 关节的脱臼在一个外部中心在起始的表示期间被错过了。病人与 1.25 使一个平静恢复追随者成为了开的减小和固定；与尺骨的并行的系带的修理一起的 MCP 关节的公里 Kirschner 电线。这个损害模式以前没在英语语言的基于的医药文学就我们的知识而言被报导。

关键词：医学文献骨折拇指复习 MCP 关节 CMC 伤害

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Thiamine deficiency perturbed energy metabolism enzymes in brain mitochondrial fraction of Swiss mice

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Frontiers in Biology 2017年第4期12卷 290-297页

作者： Anupama Sharma Renu Bist surender singh Department of Bioscience and Biotechnology Banasthali University BanasthaIL Rajasthan lndia Animal Biotechnology Centre National Dairy Research Institute Karnal India

BACKGROUND： Thiamine is an essential cofactor associated with several enzymes in energy metabolism and its deficiency may lead to neurological deficits. Current research evaluated the biochemical and molecular changes in TCA cycle enzymes using the mitochondrial fraction of the brain following thiamine deficiency （TD） in mice. METHODS： The investigation was carried out on Swiss mice （6-8 week old） allocated into three groups. First group was control; second and third group were made thiamine deficient for 8 and 10 days. RESULTS： Current study showed that alpha-ketoglutarate dehydrogenase （KGDHC）（thiamine-dependent enzyme） level found to be significantly reduced in experimental groups as compared to control group. In comparison to control group, a significant decrease in the succinate dehydrogenase （SDH） activity was calculated in group II and group III （p 〈 0.0001） mice. Diminished enzymatic activity of fumarase and MDH enzyme in thiamine deficient groups exposed for 8 and 10 days was calculated as compared to control group. The expression analysis of different genes governing TCA cycle enzymes in different experimental groups showed that there was a negotiable change in the expression of fumarase and DLD （dihydrolipoyl dehydrogenase- E3 subunit of KGDHC） whereas a declined in the expression of SDH and two subunits of KGDHC i.e. OGDH （2-oxoglutarate dehydrogenase- E1 subunit of KGDHC） and DLST （dihydrolipoyllysine-residue succinyltransferase- E2 subunit of KGDHC） was observed as compared to control group. CONCLUSIONS： Hence, current findings strongly entail that TD promotes alteration in energy metabolism in brain mitochondria which will decline the neuronal progression which may lead to neurodegenerative diseases such as Alzheimer＇s diseases.

关键词： thiamine brain TCA cycle enzymes mitochondrial dysfunction

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