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Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers

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World Journal of Gastroenterology 2008年第39期14卷 6052-6059页

作者： Worrawit Wanitsuwan Samornmas Kanngurn Teeranut Boonpipattanapong Rassamee Sangthong surasak Sangkhathat Tumor Biology Research Group and Department of Surgery Faculty of MedicinePrince of Songkla UniversityThailand Tumor Biology Research Group and Department of Pathology Faculty of MedicinePrince of Songkla UniversityThailand Tumor Biology Research Group and Epidemiology Unit Faculty of MedicinePrince of Songkla UniversityThailand

AIM： To examine the expression of beta-catenin in colorectal cancer and look for association with other dinico-pathological parameters. METHODS;： Tumor samples from 163 cases of colorectal cancer （CRC） who had undergone primary colectomy between May, 1998 and November, 2002 with complete follow-up data for either 5 years or until death were recruited for a beta-catenin immunohistochemical study. The percentage of immunoreacted tumor cells was defined as overall staining density （OSD） and percentage of cells having nuclear localization was counted as nuclear staining density （NSD）. Univariate exploration used log-rank test and multivariate survival analysis used Cox＇s hazard regression model. RESULTS： Beta-catenin immunoreactivity was detected in 161 samples （98.8%）, of which 131 cases had nuclear staining. High OSD （≥ 75%）, detected in 123 cases （75.5%）, was significantly associated with earlier clinical staging （P 〈 0.01）, lower nodal status （P = 0.02）, non-metastatic status （P 〈 0.01） and better differentiation （P = 0.02）. Multivariate analysis found that high OSD was independently associated with better survival [Cox＇s hazard ratio 0.51, 95% confidence interval （CI） 0.31-0.83]. Although high NSD （≥ 75%） was correlated with high pre-operative serum CEA （P = 0.03）, well differentiation （P 〈 0.01）, and increased staining intensity（P 〈 0.01）, the parameter was not significantly associated with survival. CONCLI3SIOM： Unlike previous reports, the study did not find a predictive value of nuclear beta-catenin in CRC. Instead, the overall expression of beta-catenin in CRC showed an association with better differentiation and earlier staging. Moreover, the parameter also independently predicted superior survival.

关键词： Colorectal carcinoma beta-catenin CTNNB1 Wnt-signaling pathway Prognosis

Recovery shape of physical activity after COVID-19 pandemic

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运动与健康科学(英文) 2023年第4期12卷 501-512页

作者： Piyawat Katewongsa Dyah Anantalia Widyastari Narumol Haemathulin Aunyarat Khanawapee surasak Penmai Institute for Population and Social Research Mahidol UniversitySalayaPhutthamonthonNakhon Pathom 73170Thailand Thailand Physical Activity Knowledge Development Centre(TPAK) SalayaPhutthamonthonNakhon Pathom 73170Thailand

Background:Since shutdowns associated with the coronavirus disease 2019 pandemic,there has been limited discourse on physical activity(PA)recovery(i.e.,the ability of individuals to resume PA at pre-pandemic levels),including recovery rate,speed of recovery,which individuals are able to return quickly,who is left behind,and what are the causes of those *** study aimed to estimate the level and shape of PA recovery rate in ***:This study employed 2 rounds(2020 and 2021)of Thailand's Surveillance on Physical Activity dataset for the *** round included over 6600 samples from individuals aged 18 years or *** was assessed *** rate was calculated from the relative difference in the cumulative minutes of moderate-to-vigorous PA(MVPA)from 2 different ***:The Thai population experienced a medium level of recession of PA(-26.1%)and a moderate level of recovery of PA(37.44%).PA recovery in the Thai population resembled an imperfect V shape,reflecting a sharp decline followed by an immediate upturn;still,recovered PA remained lower than pre-pandemic *** quickest recovery was found among older adults,whereas students,young adults,residents of Bangkok,the unemployed,and those who had a negative attitude toward PA experienced the highest recession of PA and were among the slowest to ***:The level of recovery of PA among Thai adults is largely determined by the preventive behaviors demonstrated by groups within the population who have a higher awareness of their *** effect of the mandatory coronavirus disease 2019 containment measures on PA was ***,the slower recovery rate of PA among some individuals was caused by a combination of restrictive measures and socioeconomic inequality,which required more time and effort to overcome.

关键词： Health promotion Preventive behavior Resilience Surveillance

Influence of Pre-Deformation on Springback Effect of Advanced High Strength Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 855-861页

作者： Chongthairungruang Bunyong Uthaisangsuk Vitoon Suranuntchai surasak Jirathearanat Suwat Department of Tool and Materials Engineering Faculty of EngineeringKing Mongkut's University of Technology Thonburi91 Pracha-u-tit Rd.Bangmod Tungkru Bangkok 10140 Thailand Department of Mechanical Engineering Faculty of EngineeringKing Mongkut's University of Technology Thonburi91 Pracha-u-tit Rd.Bangmod Tungkru Bangkok 10140 Thailand National Metal and Materials Technology Center 114 Paholyotin RoadKlong 1Klong LuangPathumtani Province 12120 Thailand

In sheet metal forming process of automotive components,the springback effect is significant,in particular for Advanced High Strength Steels (AHSS),for example the Dual Phase (DP) *** of construction parts of modern vehicles have very complex shapes and therefore multi-step procedures are necessary to form such a *** sheets,which firstly undergo pre-deformation,can show considerable change in mechanical behavior during the forming ***,at present there are limited sufficient data concerning pre-deformation effect on the springback *** this work,a study of influences of different pre-strain levels on the springback of steel sheet made of AHSS materials has been carried *** sheet specimens were firstly pre-stretched on a tensile testing machine and the pre-strain values were calculated based on the engineering ***,the steel sheets prepared parallel,transverse,and 45° to the rolling direction have been investigated.A modified U-shape forming was used to evaluate the degree of springback of the steel sheets under various *** parallel,FE simulation of the U-shape forming was *** isotropic model using stress-strain responses from tensile test of specimens with different directions and anisotropic Hill’s 48 model have been *** experimental results are compared with the sheet metal forming FE *** primarily aim is to basically understand the springback mechanism by means of the simple *** finally,conclusions with regard to the springback modeling will be presented.

关键词： springback high strength steels pre-deformation

Population-based prevalence study of common congenital malformations of the alimentary tract and abdominal wall in Thailand:a study using data from the National Health Security Office

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World Journal of Pediatric Surgery 2023年第3期6卷 129-135页

作者： Kulpreeya Sirichamratsakul Wison Laochareonsuk Komwit Surachat surasak Sangkhathat Department of Surgery Faculty of MedicinePrince of Songkla UniversityHat YaiThailand Translational Medicine Research CenterFaculty of MedicinePrince of Songkla UniversityHat YaiThailand Department of Biomedical Sciences and Biomedical EngineeringPrince of Songkla UniversityHat YaiThailand

Background The study aimed to estimate the prevalence of major congenital anomalies of the alimentary system and the abdominal wall in Thailand using a nationwide hospital discharge database from the National Health Security Office(2017–2020).Methods The study extracted data from records with International Classification of Diseases-10(ICD-10)codes related to esophageal malformation(ESO),congenital duodenal obstruction(CDO),jejunoileal atresia(INTES),Hirschsprung’s disease(HSCR),anorectal malformation(ARM),abdominal wall defects(omphalocele(OMP)and gastroschisis(GAS)),and diaphragmatic hernia from the database with patient age selection set to less than *** A total of 2539 matched ICD-10 records were found in 2376 individuals over the 4-year study *** foregut anomalies,the prevalence of ESO was 0.88/10000 births,while that of CDO was 0.54/10000 *** prevalence figures of INTES,HSCR,and ARM were 0.44,4.69,and 2.57 cases per 10000 births,*** abdominal wall defects,the prevalences of OMP and GAS were 0.25 and 0.61 cases/10000 births,*** mortality in our cases was 7.1%,and survival analysis found that associated cardiac defects had a statistically significant influence on survival in most anomalies *** HSCR,both Down syndrome(DS)(hazard ratio(HR)=7.57,95%confidence interval(CI)=4.12 to 13.91,p<0.001)and cardiac defects(HR=5.82,95%CI=2.85 to 11.92,p<0.001)were significantly associated with poorer survival ***,only DS(adjusted HR=5.55,95%CI=2.63 to 11.75,p<0.001)independently predicted worse outcomes by multivariable *** Our analysis of the hospital discharge database found that the prevalence of gastrointestinal anomalies in Thailand was lower than that reported in other countries,except for HSCR and anorectal *** Down syndrome and cardiac defects influence the survival outcomes of these anomalies.

关键词： database Office tar

Infliximab stopped severe gastrointestinal bleeding in Crohn's disease

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World Journal of Gastroenterology 2012年第21期18卷 2730-2734页

作者： Satimai Aniwan surasak Eakpongpaisit Boonlert Imraporn Surachai Amornsawadwatana Rungsun Rerknimitr Division of Gastroenterology Department of MedicineKing Chulalongkorn Memorial HosptialBangkok 10330Thailand Institute of Liver and Gastrointestinal Diseases Samitivej HospitalBangkok 10330Thailand

To report the result of rapid ulcer healing by infliximab in Crohn's patients with severe enterocolic bleeding. During 2005 and 2010, inflammatory bowel disease database of King Chulalongkorn Memorial and Samitivej hospitals were reviewed. There were seven Crohn's disease (CD) patients (4 women and 3 men; mean age 52 ± 10.4 years; range: 11-86 years). Two of the seven patients developed severe gastrointestinal bleeding (GIB) as a flare up of CD whereas the other five patients presented with GIB as their first symptom for CD. Their mean hemoglobin level dropped from 12 ± 1.3 g/ dL to 8.7 ± 1.3 g/dL in a 3-d period. Median packed red blood cells units needed for resuscitation was 4 units. Because of uncontrolled bleeding, surgical resection was considered. However, due to the poor surgical candidacy of these patients (n = 3) and /or possible development of short bowel syndrome (n = 6), surgery was not pursued. Likewise angiographic embolization was not considered in any due to the risk of large infarction. All severe GIBs successfully stopped by one or two doses of intravenous infliximab. Our data suggests that infliximab is an alternative therapy for CD with severe GIB when surgery has limitation or patient is a high risk.

关键词： Crohn’s disease Gastrointestinal bleeding Complications Infliximab Biologic agents

Validation and modification of the‘Chiang Mai University Intussusception scoring system’used to predict failure of non-surgical treatment in infantile intussusception

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World Journal of Pediatric Surgery 2019年第3期2卷 13-19页

作者： Kaimook Boonsanit Supika Kritsaneepaiboon Piyawan Chiengkriwate surasak Sangkhathat Department of Surgery Prince of Songkla UniversityFaculty of MedicineHat YaiThailand Department of Radiology Prince of Songkla UniversityFaculty of MedicineHat YaiThailand

background This study aimed to validate and modify the recently released Chiang Mai University Intussusception(CMUI)scoring system in predicting failure of non-surgical management of infantile *** A retrospective review was conducted in 151 cases of infantile intussusception who were primarily treated with pneumatic reduction in our institute during *** analysis focused on the validation of the CMUI scoring *** this analysis,the scoring system was modified to be more suitable for our clinical practice,in which we perform pneumatic reduction in all *** Pneumatic reduction was successfully performed in 120/151 cases(79.5%).A high CMUI score was significantly associated with increased likelihood of failure at the positive likelihood ratio of 1.49(sensitivity 25.8 and specificity 82.7).The area under the receiver operating characteristic curve(AUC)was *** modified the CMUI System in two ways,first by removing the item‘method of reduction’and replacing it with‘hyponatremia’,and by changing the definition of low body weight to less than 9 *** modified CMUI had an AUC of 0.76.A high score(>9 points)on the modified version gave a positive likelihood ratio of 4.77(sensitivity 53.0 and specificity 80.9).Conclusion In infantile intussusception primarily treated with pneumatic reduction,the modified CMUI scoring system gave a better prediction reliability than the original.

关键词： system likelihood primarily

Clinical outcomes of gastrointestinal stromal tumor in southern Thailand

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World Journal of Gastrointestinal Oncology 2012年第11期4卷 216-222页

作者： Kittima Pornsuksiri Siripong Chewatanakornkul Samornmas Kanngurn Wanwisa Maneechay Walawee Chaiyapan surasak Sangkhathat Department of Surgery and Tumor Biology Research Unit Faculty of Medicine Prince of Songkla University Hat Yai Songkhla 90110 Thailand Anatomical Pathology Unit Department of Pathology Faculty of Medicine Prince of Songkla Uni- versity Hat Yai Songkhla 90110 Thailand Central Molecular Research Laboratory Faculty of Medicine Prince of Songkla University Hat Yai Songkhla 90110 Thailand

AIM: To review a single institutional experience in clinical management of gastrointestinal stromal tumors (GIST) and analyze for factors determining treatment outcome. METHODS: Clinicopathological data of patients with a diagnosis of GIST who were treated at our institute during November 2004 to September 2009 were retrospectively reviewed. RESULTS: Ninety-nine cases were included in the analysis. Primary tumor sites were at the stomach in and small bowel in 44% and 33%, respectively. Thirty-one cases already had metastasis at presentation and the most common metastatic site was the liver. Sixty-four cases (65%) were in the high-risk category. Surgical treatment was performed in 77 cases (78%), 3 of whom received upfront targeted therapy. Complete resection was achieved in 56 cases (73% of operative cases) and of whom 27 developed local recurrence or distant metastasis at a median duration of 2 years. Imatinib was given as a primary therapy in unresectable cases (25 cases) and as an adjuvant in cases with residual tumor (21 cases). Targeted therapy gave partial response in 7 cases (15%), stable disease in 27 cases (57%) and progressive disease in 13 cases (28%). Four-year overall survival was 74% (95% CI: 61%-83%). Univariate survival analysis found that low-risk tumor, gastric site, complete resection and response to imatinib were associated with better survival. CONCLUSION: The overall outcomes of GIST can be predicted by risk-categorization. Surgery alone may not be a curative treatment for GIST. Response to targeted therapy is a crucial survival determinant in these patients.

关键词： Gastrointestinal stromal tumor Targeted therapy Overall survival Progress free survival Progressive disease

Efficacy and safety of different dual antiplatelet strategies in patients undergoing percutaneous coronary intervention:A systematic review and network meta-analysis

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Chronic Diseases and Translational Medicine 2023年第4期9卷 299-308页

作者： Yuttana Wongsalap Kirati Kengkla Preyanate Wilairat Khemanat Ratworawong surasak Saokaew Chaisiri Wanlapakorn Division of Clinical Pharmacy Department of Pharmaceutical CareUniversity of PhayaoPhayaoThailand Center of Health Outcomes Research and Therapeutic Safety(Cohorts) School of Pharmaceutical SciencesUniversity of PhayaoPhayaoThailand Unit of Excellence on Clinical Outcomes Research and Integration(UNICORN) School of Pharmaceutical SciencesUniversity of PhayaoPhayaoThailand Division of Social and Administrative Pharmacy Department of Pharmaceutical CareSchool of Pharmaceutical SciencesUniversity of PhayaoPhayaoThailand Cardiac Centre King Chulalongkorn Memorial HospitalKrung Thep Maha NakornThailand

Background:Dual antiplatelet therapy(DAPT)is key for preventing ischaemic events post-percutaneous coronary intervention(PCI).Various DAPT modifications like the shortened duration or P2Y12 inhibitor(P2Y12i)de-escalation are implemented to reduce bleeding ***,these strategies lack direct comparative *** study aimed to assess the efficacy and safety of such DAPT strategies,including de-escalated and short DAPT,in patients undergoing ***:We searched PubMed,Embase,Cochrane Central Register of Controlled Trials,and *** databases for relevant randomized controlled trials(RCTs).We performed a network meta-analysis(NMA)to estimate risk ratios(RRs)and 95%confidence intervals(CIs).The primary efficacy endpoint was major adverse cardiac events(MACEs),and the primary safety endpoint was major *** endpoints included individual components of MACEs and net adverse clinical events(NACEs).Results:A total of 17 RCTs comprising 53,156 patients(median age,62.0 years,24.8%female)were *** suggested that de-escalation DAPT was associated with a significantly lower risk of MACEs(risk ratio[RR]=0.79,95%confidence interval[CI]=0.64-0.98),bleeding(RR=0.63,95%CI=0.49-0.82),and NACEs(RR=0.69,95%CI=0.60-0.79)compared with standard *** DAPT followed by P2Y12i monotherapy exhibited a significantly decreased risk of major bleeding(RR=0.63,95%CI=0.46-0.86)compared with standard ***:De-escalation DAPT was the most effective strategy for preventing the risk of MACEs without increasing bleeding events,while short DAPT followed by P2Y12i monotherapy was the most effective strategy for reducing the risk of bleeding among patients undergoing PCI.

关键词： de-escalation percutaneous coronary intervention short dual antiplatelet therapy

Current management of pediatric soft tissue sarcomas

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World Journal of Clinical Pediatrics 2015年第4期4卷 94-105页

作者： surasak Sangkhathat Department of Surgery and Tumor Biology Research Unit Faculty of MedicinePrince of Songkla University

Pediatric soft tissue sarcomas are a group of malignant neoplasms arising within embryonic mesenchymal tissues during the process of differentiation into muscle, fascia and fat. The tumors have a biphasic peak for age of incidence. Rhabdomyosarcoma(RMS) is diagnosed more frequently in younger children, whereas adult-type non-RMS soft tissue sarcoma is predominately observed in adolescents. The latter group comprises a variety of rare tumors for which diagnosis can be difficult and typically requires special studies, including immunohistochemistry and molecular genetic analysis. Current management for the majority of pediatric sarcomas is based on the data from large multi-institutional trials, which has led to great improvements in outcomes over recent decades. Although surgery remains the mainstay of treatment, the curative aim cannot be achieved without adjuvant treatment. Pre-treatment staging and risk classification are of prime importance in selecting an effective treatment protocol. Tumor resectability, the response to induction chemotherapy, and radiation generally determine the risk-group, and these factors are functions of tumor site, size and biology. Surgery provides the best choice of local control of small resectable tumors in a favorable site. Radiation therapy is added when surgery leaves residual disease or there is evidence of regional spread. Chemotherapy aims to reduce the risk of relapse and improve overall survival. In addition, upfront chemotherapy reduces the aggressiveness of the required surgery and helps preserve organ function in a number of cases. Long-term survival in low-risk sarcomas is feasible, and the intensity of treatment can be reduced. In high-risk sarcoma, current research is allowing more effective disease control.

关键词： Pediatric tumor Rhabdomyosarcoma Soft tissue sarcoma Non-rhabdomyosarcoma pediatric soft tissue tumor