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Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion

World Journal of Gastroenterology 2007年第10期13卷 1561-1568页

作者： Kawin Leelawat Surang Leelawat Siriluck Narong suradej hongeng Department of Surgery Rajavithi Hospital Faculty of Pharmacy Rangsit University Department of Pedriatric Ramathibodi HospitalMahidol University

AIM： To evaluate the expression of C-X-C motif chemokine receptor 4 （CXCR4） and its signaling cascades, which were previously identified as a key factor for cancer cell progression and metastasis, in cholangiocarcinoma cell lines. METHODS： The expression of CXCR4 and its signaling cascades were determined in the cholangiocarcinoma cell lines （RMCCA1 and KKU100） by Western blotting. The invasion assays and the detection of actin polymerization were tested in these cholangiocarcinoma cells treated with CXC chemokine ligand -12 （CXCL12）. RESULTS： Expression of CXCR4 was detected in both cholangiocarcinoma cell lines and activation of CXCR4 with CXCL12 triggered the signaling via the extracellular signal-regulated kinase-1/2 （ERK1/2） and phosphoinositide 3-kinase （PI3K） and induction of cholangiocarcinoma cell invasion, and displayed high levels of actin polymerization. Addition of CXCR4 inhibitor （AMD3100） abrogated CXCL12-induced phosphorylation of MEKI/2 and Akt in these cells. Moreover, treatment with MEK1/2 inhibitor （U0126） or PI3K inhibitor （LY294002） also attenuated the effect of CXCL12- induced cholangiocarcinoma cell invasion. CONCLUSION： These results indicated that the activation of CXCR4 and its signaling pathways （MEK1/2 and Akt） are essential for CXCL12-induced cholangiocarcinoma cell invasion. This rises Implications on a potential role for the inhibition of CXCR4 or its signal cascades in the treatment of cholangiocarcinoma.

关键词： Cholangiocarcinoma CXCR4 CXCL12 MEK1/2 PI3K

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High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

High resolution HLA-matched unrelated donor hematopoietic st...

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中华医学会第十七次全国儿科学术大会

作者： Yasuhiro Okamoto Godfrey Chi-fung CHAN suradej hongeng TAN Poh Lin TAN Ah Moy Kleebsabai Sanpakit Anselm LEE Shanghai Jiao Tong University School of Medicine Shanghai Children Prince of Wales Hospital Hong Kong Kagoshima University Medical and Dental Hospital Japan Queen Mary Hospital the University of Hong Kong Faculty of Medicine Ramathibodi Hospital Mahidol University Thailand National University Health System Singapore KK Women’s and Children’s Hospital Singapore Faculty of Medicine Siriraj hospital Mahidol UniversityThailand Nanfang Hospital Southern Medical University China Mount Elizabeth Hospital Singapore

From August 2000 to November 2011,127 children under the age of 18 years with acquired severe aplastic anemia(SAA) received hematopoietic stem cell transplantation(HSCT) in one of the 10 Asia Pacific institutions of the VABMT Consortium,including 53 with matched sibling donor(MSD) and 74 with alternative donor(AD).Among these 74 AD,22 were matched unrelated donor(MUD), 32 were mismatched unrelated donor(MMUD) and 20 were mismatched related donor(MMRD).

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High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

High resolution HLA-matched unrelated donor hematopoietic st...

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2012年江浙沪儿科学术年会暨浙江省医学会儿科学分会学术年会、儿内科疾病诊治新进展国家级学习班

作者： Jing Chen Cheng Juan Luo Chi Kong LI Yasuhiro Okamoto Godfrey Chi-fung CHAN suradej hongeng TAN Poh Lin TAN Ah Moy Kleebsabai Sanpakit Chun Fu LI Shanghai Jiao Tong University School of Medicine Shanghai Children’s Medical Centre Prince of Wales Hospital Kagoshima University Medical and Dental Hospital Japan Queen Mary Hospital the University of Hong Kong Faculty of Medicine Ramathibodi Hospital Mahidol University Thailand National University Health System KK Women’s and Children’s Hospital Faculty of Medicine Siriraj hospital Mahidol University Nanfang Hospital Southern Medical University Mount Elizabeth Hospital Singapore Anselm LEE and for Viva-Asia Blood and Marrow Transplantation (VABMT) Group

From August 2000 to November 2011, 127 children under the age of 18 years with acquired severe aplastic anemia (SAA) received hematopoietic stem cell transplantation (HSCT) in one of the 10 Asia Pacific institutions of the VABMT Consortium, including 53 with matched sibling donor (MSD) and 74 with alternative donor (AD). Among these 74 AD, 22 were matched unrelated donor (MUD), 32 were mismatched unrelated donor (MMUD) and 20 were mismatched related donor (MMRD). Although the MSD group developed less grade

关键词： HLA High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

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CINRAD/SA雷达诊断工具的释用

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气象科学 2005年第6期25卷 645-650页

作者：周红根王明亮焦圣明段素连曹德煜连云港市气象局连云港222006 海南省气象台海口570000 河北省气象台石家庄050021

敏视达公司生产的CINRAD/SA多普勒天气雷达系统中,包含一个独立运行的雷达诊断工具软件RDASOT(雷达数据采集系统运行测试Radar DataAcquisition System Operability Test),RDASOT是专用于确定雷达数据采集单元RDA(Radar Data Acquisiti... 详细信息

敏视达公司生产的CINRAD/SA多普勒天气雷达系统中,包含一个独立运行的雷达诊断工具软件RDASOT(雷达数据采集系统运行测试Radar DataAcquisition System Operability Test),RDASOT是专用于确定雷达数据采集单元RDA(Radar Data Acquisition)硬件状态及增强维护能力的软件,是帮助雷达保障人员进行故障诊断测试的辅助工具。RDASOT主要运用于诊断测试、标定测试和辅助维护。

关键词： CINRAD雷达诊断子测试

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急性淋巴细胞性白血病患儿在应用皮质类固醇和其他细胞毒性药物诱导治疗后的肾上腺功能抑制

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 39-39页

作者： Mahachoklertwattana P. Vilaiyuk S. hongeng S. Okascharoen C. 郭战宏 Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Rama 6 Road Bangkok 10400 Thailand

目的:为了评价急性淋巴细胞性白血病(ALL)患儿在应用皮质类固醇和其他细胞毒性药物诱导治疗后的肾上腺功能。研究设计:ALL患儿(n=24)在诱导期应用强的松龙28d,40mg/(m2·d),然后每4周口服地塞米松1周。在强的松龙停止2周时进行小剂量(1... 详细信息

目的:为了评价急性淋巴细胞性白血病(ALL)患儿在应用皮质类固醇和其他细胞毒性药物诱导治疗后的肾上腺功能。研究设计:ALL患儿(n=24)在诱导期应用强的松龙28d,40mg/(m2·d),然后每4周口服地塞米松1周。在强的松龙停止2周时进行小剂量(1μg)促肾上腺皮质激素(ACTH)试验,在2周后再重复此试验并对有肾上腺抑制的患儿每4周重复进行。

关键词：诱导治疗皮质类固醇肾上腺功能细胞毒性药物白血病患儿淋巴细胞性强的松龙诱导期 adrenal 研究设计

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