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Liposome based drug delivery as a potential treatment option for Alzheimer’s disease

Neural Regeneration Research 2022年第6期17卷 1190-1198页

作者： Carely Hernandez surabhi shukla Department of Pharmaceutical Sciences College of PharmacyLarkin UniversityMiamiFLUSA

Alzheimer’s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million individuals in the United States age 65 and older of their cognitive ***’s disease is associated with dementia and a progressive decline in memory,thinking,and social skills,eventually leading to a point that the individual can no longer perform daily activities *** available drugs on the market temporarily alleviate the symptoms,however,they are not successful in slowing down the progression of Alzheimer’s *** and cures have been constricted due to the difficulty of drug delivery to the blood-brain *** studies have led to identification of vesicles to transport the necessary drugs through the blood-brain barrier that would typically not achieve the targeted area through systemic delivered ***,liposomes have emerged as a viable drug delivery agent to transport drugs that are not able to cross the blood-brain *** are being used as a component of nanoparticle drug delivery;due to their biocompatible nature;and possessing the capability to carry both lipophilic and hydrophilic therapeutic agents across the blood brain barrier into the brain *** indicate the importance of liposomal based drug delivery in treatment of neurodegenerative *** idea is to encapsulate the drugs inside the properly engineered liposome to generate a response of *** are engineered to target specific diseased moieties and also several surface modifications of liposomes are under research to create a clinical path to the management of Alzheimer’s *** review deals with Alzheimer’s disease and emphasize on challenges associated with drug delivery to the brain,and how liposomal drug delivery can play an important role as a drug delivery method for the treatment of Alzheimer’s *** review also sheds some light on variation of ***

关键词： Alzheimer’s disease beta-amyloid blood-brain barrier brain delivery drug delivery systems encapsulated drugs liposomes nanoparticles neurodegenerative diseases PEGylation targeted delivery tau

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Gastric leiomyoma presenting as an endophytic growth of cardia of the stomach: A case report

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 132-135页

作者： surabhi Sreekumar Jameel Akhter Sudarsan Srikanth Department of General Surgery Apollo HospitalsChennaiIndia

Gastric leiomyomas are rare submucosal neoplasms arising from smooth muscle *** accounts for approximately 2.5%of all gastric tumours,is slow growing and rarely causes symptoms such as upper abdominal discomfort and dyspepsia.1 On imaging,they appear similar to gastrointestinal stromal tumours(GISTs)and can be intraluminal or *** is mostly confirmed by histopathological examination of the *** resection of the tumour is the main treatment ***,we present a case of laparoscopic resection of an endophytic gastric tumour that turned out to be a leiomyoma.

关键词： Gastric stomach neoplasms

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Biological perspectives in geotechnics:Application and monitoring

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2854-2878页

作者： Partha Narayan Mishra surabhi Jain Thierry Bore Ilhan Chang Yeong-Man Kwon Yijie Wang Hirak Ranjan Dash Ashutosh Kumar Satyam Tiwari Ningjun Jiang Sarat Kumar Das Alexander Scheuermann Department of Civil Engineering Indian Institute of Technology KanpurKanpur208016India School of Civil Engineering University of QueenslandSt LuciaQLD4072Australia Department of Civil Engineering Indian Institute of Technology DhanbadDhanbad826004India Department of Civil System Engineering Ajou UniversitySuwon-si16499Republic of Korea School of Engineering and IT University of New South WalesCanberraACT2600Australia Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIL60208USA Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina National Forensic Sciences University New Delhi110085India Southeast University Nanjing211189China

This paper builds on exploring the applications of biomediated pathways to solve geotechnical ***,the state of the art of biological remediation strategies including microbial remediation and phytoremediation have been introduced and critically reviewed in the context of decontaminating the ***,biopolymerisation,biomineralisation and bioneutralisation processes have been depicted with a special emphasis on the applications including but not limited to soil stabilisation,soil erosion prevention,anti-desertification and pH *** of these methods have their own limitations and bottlenecks while scaling up,and these challenges have been summarised and some possible paths to overcome the challenges have also been *** state of the art of electromagnetic(EM)monitoring methods to capture the effects of biomediation on spatio-temporal soil properties are then highlighted as a non-invasive and rapid pathway to track the progress of biomediated soil ***,each of the technologies discussed have been evaluated for their maturity level using the principles of technology readiness level(TRL).A majority of the technologies amounting to around 77%are still in the TRL 4e7,*** the valley of *** is thus evident that development of these technologies needs to be supported with appropriate funding for improving their maturity to a level of industrial deployment.

关键词： Biogeotechnics Bioremediation Phytoremediation Biopolymers Biomineralisation Electromagnetic(EM)methods technology readiness level(TRL)

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竞争激烈的防护涂料市场

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中国涂料 2024年第6期39卷 75-76页

作者： Chirag Tripathi Atul Yadav surabhi Patankar Markets and Markets公司

在预测期内,防护涂料市场预计将从2023年的134亿欧元增长至2028年的159亿欧元,复合年增长率为3.5%。亚太地区包括了经济发展水平不同的各种经济体。按产值计算,2022年该地区防护涂料的份额占总收入的53%。该地区的增长主要归功于民用建... 详细信息

在预测期内,防护涂料市场预计将从2023年的134亿欧元增长至2028年的159亿欧元,复合年增长率为3.5%。亚太地区包括了经济发展水平不同的各种经济体。按产值计算,2022年该地区防护涂料的份额占总收入的53%。该地区的增长主要归功于民用建筑和基础设施、海洋和发电行业的发展,以及消费品和家电、建筑业和家具等各行各业的进步。将生产设施转移至亚太地区的主要好处在于生产成本低、可获得熟练且廉价的劳动力,并能够更好地服务于当地的新兴市场。

关键词：防护涂料复合年增长率基础设施新兴市场发电行业消费品经济发展水平竞争激烈

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Application of light emitting diodes (LEDs) for food preservation, post-harvest losses and production of bioactive compounds: a review

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Food Production, Processing and Nutrition 2022年第1期4卷 85-94页

作者： Amrita Poonia surabhi Pandey Vasundhara Department of Dairy Science and Food Technology Institute of Agricultural SciencesBanaras Hindu UniversityVaranasiUttar Pradesh221005India

Light-emitting diode (LED) technology is a new non-thermal food preservation method that works by converting light energy into heat. LED has potential to revolutionize crop production, protection and preservation. This technology is economical and environmentally friendly. LEDs have been shown to improve the nutritive quality and shelf life of foods, control the ripening of fruits, induce the synthesis of bioactive compounds and antioxidants and reduce the microbial contamination. This technology also has great scope in countries, where safety, hygiene, storage and distribution of foods are serious issues. While comparing this technology with other lighting technologies, LEDs can bring numerous advantages to food supply chain from farm to fork. In case of small growing amenities which exploit only LEDs, energy expenditure has been successfully reduced while producing nutritious food. LEDs can be used to give us better understanding and control over production and preservation of food with relation to spectral composition of light. LEDs also play significant role in food safety by inactivating the food borne pathogens. Therefore, LED lighting is a very effective and promising technology for extending shelf life of agricultural produce by increasing disease resistance and with increased nutritional values.

关键词： Light emitting diodes Food preservation Anti-microbial Bioactive compounds Non-thermal

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Impact of ovariectomy and estradiol-17β(E_(2))replacement on the brain steroid levels of the Indian stinging catfish Heteropneustes fossilis

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Aquaculture and Fisheries 2022年第5期7卷 474-483页

作者： surabhi Mishra Radha Chaube Zoology and Fisheries Department Dolphin(PG)College of Science and AgricultureChunni KalanFatehgarh SahibPunjab140406India Department of Zoology Institute of ScienceBanaras Hindu UniversityVaranasi221005India

In the present study,effects of ovariectomy(Ovx)and estradiol-17β(E2)replacement on the brain steroid levels were investigated in the resting and prespawning phases of the female catfish Heteropneustes *** study showed that Ovx resulted in significant decreases in plasma levels of estradiol-17β(E2)and its precursors,and the effect varied with the reproductive stage and *** study showed that E2 supplementation reversed the effect of Ovx in 3-week Ovx fish group,either restored or increased according to the *** contrast,E2 levels increased in the brain after Ovx in the resting stage and produced a biphasic effect of significant decreases on week 1 and 2,and significant increases on week 3,4 and 5 in the pre-spawning *** brain E2 levels significantly inhibited in E2 supplementation *** testosterone(T)levels showed biphasic effects,an initial decrease(up to 3 weeks Ovx)and an increase later(week 4,5)in the resting *** the pre-spawning stage,the T levels increased significantly after *** E2 supplementation significantly inhibited the T levels,more severely in the low dose group in the resting and pre-spawning *** 17-hydroxyprogesterone(17-OHP4)levels increased(week 1,2,3)but decreased on week 4 and 5 of Ovx in the resting stage and increased throughout Ovx in the pre-spawning stage except in the 5th week(though compared to other steroids,level was very low;almost negligible).The E2 replacement significantly decreased the steroid levels further down compared to the Ovx control *** progesterone(P4)and pregnenolone(P5)levels decreased initially(week 1 and 2 Ovx)and recovered *** E2 replacement significantly decreased P4 levels in the Ovx fish in the pre-spawning stage and in the lower dose group in the resting *** P5 levels remained inhibited after the E2 supplementation in the resting stage but unchanged or increased it in the pre-spawning *** cortisol(F)levels were inhibited initially(1 and 2

关键词： Catfish Neurosteroids Ovariectomy Estrogen replacement Seasonal variations

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Couple stress nanofluid flow through a bifurcated artery—Application of catheterization process

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Applied Mathematics(A Journal of Chinese Universities) 2021年第4期36卷 492-511页

作者： KM surabhi Arpitha Ravikanti D.Srikanth D.Srinivasacharya Department of Applied Mathematics Defence Institute of Advanced Technology(Deemed University)Girinagar Pune 411025India Department of Mathematics National Institute of TechnologyWarangal 506004India

In this article,we are exploring the hemodynamics of nanofluid,flowing through a bifurcated artery with atherosclerosis in the presence of a *** treating obstruction in the artery,one can use the catheter whose outer surface is carrying the drug coated with *** resultant solvent is considered as blood *** being a complex fluid,is modeled by couple stress *** the presence of nano-particles,the temperature and the concentration distribution are understood in a bifurcated stenotic *** concluded mathematical model is governed by coupled non-linear equations,and are solved by using the homotopy perturbation ***,we have explored is the effects of fluid and the embedded geometric parameters on the hemodynamics *** is also realized that high wall shear stress exists for couple stress nano-fluid when compared to Newtonian *** is computed at a location corresponding to maximum constriction(z=12.5)of the artery.

关键词： couple stress uid bifurcated stenotic artery homotopy perturbation method wall shear stress

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Semantic segmentation of landcover for cropland mapping and area estimation using Machine Learning techniques

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Data Intelligence 2023年第2期5卷 370-387页

作者： surabhi Lingwal Komal Kumar Bhatia Manjeet Singh Computer Science&Engineering G B Pant Institute of Engineering&TechnologyPauri Garhwal246194UttarakhandIndia Computer Engineering J C Bose Univerity of Science&TechnologyYMCAFaridabad121006HaryanaIndia

The paper has focussed on the global landcover for the identification of cropland *** growth and rapid industrialization are somehow disturbing the agricultural lands and eventually the food production needed for human *** agricultural land monitoring requires proper management of land *** paper has proposed a method for cropland mapping by semantic segmentation of landcover to identify the cropland boundaries and estimate the cropland areas using machine learning *** process has initially applied various filters to identify the features responsible for detecting the land boundaries through the edge detection *** images are masked or annotated to produce the ground truth for the label identification of croplands,rivers,buildings,and *** selected features are transferred to a machine learning model for the semantic segmentation *** methodology has applied Random Forest,which has compared to two other techniques,Support Vector Machine and Multilayer perceptron,for the semantic segmentation *** dataset is composed of satellite images collected from the QGIS *** paper has derived the conclusion that Random forest has given the best result for segmenting the image into different regions with 99%training accuracy and 90%test *** results are cross-validated by computing the Mean loU and kappa coefficient that shows 93%and 69%score value respectively for Random Forest,found maximum among *** paper has also calculated the area covered under the different segmented ***,Random Forest has produced promising results for semantic segmentation of landcover for cropland mapping.

关键词： Croplands Semantic Segmentation Machine Learning Random Forest Mask filters Edge detection Supportvectormachine

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Assessment of terrace gardens as modifiers of building microclimate

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能源与人工环境(英文) 2022年第1期3卷 105-112页

作者： Chitra Chidambaram surabhi S.Nath Pranjali Varshney Sakshi Kumar School of Architecture and Planning Sharda UniversityKnowledge Park IIIGreater NoidaUttar Pradesh 201310India Indraprastha Institute of Information Technology Delhi Okhla Industrial EstatePhase IIINew Delhi 110020India

Hard concrete roofs cause excessive heat gain impacting thermal comfort in *** gardens promoting greening at higher levels of built structures are seen as one of the key mitigating strategies for modifying building microclimate and improving urban *** have undertaken a research project to quantitatively assess the value of a terrace garden in a residential scale.A garden patch of about 15 m 2 in area,a typical size available in most urban terraces is *** temperatures are measured over a period of 15 months between July 2018 to January 2020 using four thermocouple sensors,placed within and outside the garden bed,on and below the *** compare the thermal performance of the terrace garden across years,seasons,time of the day,presence or absence of garden bed and type and height of *** surface temperature data was found to correlate well with the ambient air temperature *** results show that the terrace garden moderates and stabilises the ceiling temperatures and reduces it by about 2-3°C in winter months and 5-7°C in hot *** garden also provided nearly 400 g of fresh monthly vegetable harvest per m 2 of ***,the cooling impact of the terrace garden with natural,tall,wild vegetation is higher as compared to planted *** study demonstrates a sustainable approach to terrace garden design at residential scale through quantified dual benefits of temperature control within buildings and urban farming.

关键词： Green roof Residential terrace garden Building micro-climate Urban vegetation Terrace farming Quantitative assessment

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Visceral leishmaniasis: An immunological viewpoint on asymptomatic infections and post kala azar dermal leishmaniasis

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Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 98-108页

作者： Neeraj Tiwari Dhiraj Kishore surabhi Bajpai Rakesh K.Singh Department of Biochemistry Institute of ScienceBanaras Hindu University Department of Medicine Institute of Medical SciencesBanaras Hindu University Department of Bioscience and Biotechnology Banasthali University

Elimination of visceral leishmaniasis is a priority programme in Indian *** World Health Organization has set a new target to eliminate kala-azar by the year 2020 as previous target elimination year(2015) has *** elimination programme has successfully curbed the rate of infection in endemic regions; however, there are still few challenges in its *** current drug control regime is extremely limited and comprises only two(amphotericin B and miltefosine) drugs, which are also susceptible for parasites ***, these drugs do not produce sterile cure, and cured patients may develop post kala-azar dermal leishmaniasis even after a decade of cure leaving behind a potent source of parasitic reservoirs for further disease transmission.A significant proportion of endemic population remain seropositive but aymptomatic for many years without any clinical symptom that serve as latent parasitic *** lack of tools to identify live parasites in asymptomatic infections and there association in disease transmission, parameters of sterile cure along with post kala-azar dermal leishmaniasis progression remain a major threat in its *** this review, we discuss the potential of host immune inhibitory mechanisms to identify immune correlates of protective immunity to understand the mystery of asymptomatic infections, sterile cure and post kala azar dermal leishmaniasis.

关键词： Visceral leishmaniasis Immune response Asymptomatic infection Sterile cure Post kala-azar dermal leishmaniasis

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