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Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 98-108页

作者： Neeraj Tiwari Dhiraj Kishore surabhi bajpai Rakesh K.Singh Department of Biochemistry Institute of ScienceBanaras Hindu University Department of Medicine Institute of Medical SciencesBanaras Hindu University Department of Bioscience and Biotechnology Banasthali University

Elimination of visceral leishmaniasis is a priority programme in Indian *** World Health Organization has set a new target to eliminate kala-azar by the year 2020 as previous target elimination year(2015) has *** elimination programme has successfully curbed the rate of infection in endemic regions; however, there are still few challenges in its *** current drug control regime is extremely limited and comprises only two(amphotericin B and miltefosine) drugs, which are also susceptible for parasites ***, these drugs do not produce sterile cure, and cured patients may develop post kala-azar dermal leishmaniasis even after a decade of cure leaving behind a potent source of parasitic reservoirs for further disease transmission.A significant proportion of endemic population remain seropositive but aymptomatic for many years without any clinical symptom that serve as latent parasitic *** lack of tools to identify live parasites in asymptomatic infections and there association in disease transmission, parameters of sterile cure along with post kala-azar dermal leishmaniasis progression remain a major threat in its *** this review, we discuss the potential of host immune inhibitory mechanisms to identify immune correlates of protective immunity to understand the mystery of asymptomatic infections, sterile cure and post kala azar dermal leishmaniasis.

关键词： Visceral leishmaniasis Immune response Asymptomatic infection Sterile cure Post kala-azar dermal leishmaniasis

Detection of urinary antigens and their seroreactivity with serum of patients in Leishmania donovani infection

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 367-370页

作者： Vinod Kumar Jalaj Kumar Gour surabhi bajpai Manish Mishra Rakesh Kumar Singh Molecular Immunology Laboratory Department of BiochemistryFaculty of ScienceBanaras Hindu UniversityVaranasi-221005India

Objective:To detect leishmanial antigens in pre and post treated urine of visceral leishmaniasis (VL) ***:Urine and serum sample from three VL patients were collected. Ammonium sulphate precipitation and purification of urine sample was done for proteins *** PAGE of proteins was done followed by western blotting,with the patient’s pre and post treatment ***:Eight proteins of molecular weights 17 kDa,25 kDa,28 kDa,42 kDa, 47 kDa,54 kDa,60 kDa and 85 kDa were detected in the urine of VL patients before treatment. After treatment with miltefosine,none of the above proteins was detected in urine *** western blot analysis with pre treatment serum confirmed the antigenicity of four urinary proteins of molecular weights 25 kDa,28 kDa,54 kDa and 60 *** seropositivity with 25 kDa and 28 kDa antigens was negative with serum obtained after the completion of ***:In the context to unavailability of a prognostic tool,urinary leishmanial antigens may offer a better choice and may also be useful as immunoprophylactic candidates.

关键词： Visceral leishmaniasis Urinary antigens Seroreactivity

Liposome based drug delivery as a potential treatment option for Alzheimer’s disease

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Neural Regeneration Research 2022年第6期17卷 1190-1198页

作者： Carely Hernandez surabhi Shukla Department of Pharmaceutical Sciences College of PharmacyLarkin UniversityMiamiFLUSA

Alzheimer’s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million individuals in the United States age 65 and older of their cognitive ***’s disease is associated with dementia and a progressive decline in memory,thinking,and social skills,eventually leading to a point that the individual can no longer perform daily activities *** available drugs on the market temporarily alleviate the symptoms,however,they are not successful in slowing down the progression of Alzheimer’s *** and cures have been constricted due to the difficulty of drug delivery to the blood-brain *** studies have led to identification of vesicles to transport the necessary drugs through the blood-brain barrier that would typically not achieve the targeted area through systemic delivered ***,liposomes have emerged as a viable drug delivery agent to transport drugs that are not able to cross the blood-brain *** are being used as a component of nanoparticle drug delivery;due to their biocompatible nature;and possessing the capability to carry both lipophilic and hydrophilic therapeutic agents across the blood brain barrier into the brain *** indicate the importance of liposomal based drug delivery in treatment of neurodegenerative *** idea is to encapsulate the drugs inside the properly engineered liposome to generate a response of *** are engineered to target specific diseased moieties and also several surface modifications of liposomes are under research to create a clinical path to the management of Alzheimer’s *** review deals with Alzheimer’s disease and emphasize on challenges associated with drug delivery to the brain,and how liposomal drug delivery can play an important role as a drug delivery method for the treatment of Alzheimer’s *** review also sheds some light on variation of ***

关键词： Alzheimer’s disease beta-amyloid blood-brain barrier brain delivery drug delivery systems encapsulated drugs liposomes nanoparticles neurodegenerative diseases PEGylation targeted delivery tau

Application of light emitting diodes (LEDs) for food preservation, post-harvest losses and production of bioactive compounds: a review

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Food Production, Processing and Nutrition 2022年第1期4卷 85-94页

作者： Amrita Poonia surabhi Pandey Vasundhara Department of Dairy Science and Food Technology Institute of Agricultural SciencesBanaras Hindu UniversityVaranasiUttar Pradesh221005India

Light-emitting diode (LED) technology is a new non-thermal food preservation method that works by converting light energy into heat. LED has potential to revolutionize crop production, protection and preservation. This technology is economical and environmentally friendly. LEDs have been shown to improve the nutritive quality and shelf life of foods, control the ripening of fruits, induce the synthesis of bioactive compounds and antioxidants and reduce the microbial contamination. This technology also has great scope in countries, where safety, hygiene, storage and distribution of foods are serious issues. While comparing this technology with other lighting technologies, LEDs can bring numerous advantages to food supply chain from farm to fork. In case of small growing amenities which exploit only LEDs, energy expenditure has been successfully reduced while producing nutritious food. LEDs can be used to give us better understanding and control over production and preservation of food with relation to spectral composition of light. LEDs also play significant role in food safety by inactivating the food borne pathogens. Therefore, LED lighting is a very effective and promising technology for extending shelf life of agricultural produce by increasing disease resistance and with increased nutritional values.

关键词： Light emitting diodes Food preservation Anti-microbial Bioactive compounds Non-thermal

Impact of ovariectomy and estradiol-17β(E_(2))replacement on the brain steroid levels of the Indian stinging catfish Heteropneustes fossilis

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Aquaculture and Fisheries 2022年第5期7卷 474-483页

作者： surabhi Mishra Radha Chaube Zoology and Fisheries Department Dolphin(PG)College of Science and AgricultureChunni KalanFatehgarh SahibPunjab140406India Department of Zoology Institute of ScienceBanaras Hindu UniversityVaranasi221005India

In the present study,effects of ovariectomy(Ovx)and estradiol-17β(E2)replacement on the brain steroid levels were investigated in the resting and prespawning phases of the female catfish Heteropneustes *** study showed that Ovx resulted in significant decreases in plasma levels of estradiol-17β(E2)and its precursors,and the effect varied with the reproductive stage and *** study showed that E2 supplementation reversed the effect of Ovx in 3-week Ovx fish group,either restored or increased according to the *** contrast,E2 levels increased in the brain after Ovx in the resting stage and produced a biphasic effect of significant decreases on week 1 and 2,and significant increases on week 3,4 and 5 in the pre-spawning *** brain E2 levels significantly inhibited in E2 supplementation *** testosterone(T)levels showed biphasic effects,an initial decrease(up to 3 weeks Ovx)and an increase later(week 4,5)in the resting *** the pre-spawning stage,the T levels increased significantly after *** E2 supplementation significantly inhibited the T levels,more severely in the low dose group in the resting and pre-spawning *** 17-hydroxyprogesterone(17-OHP4)levels increased(week 1,2,3)but decreased on week 4 and 5 of Ovx in the resting stage and increased throughout Ovx in the pre-spawning stage except in the 5th week(though compared to other steroids,level was very low;almost negligible).The E2 replacement significantly decreased the steroid levels further down compared to the Ovx control *** progesterone(P4)and pregnenolone(P5)levels decreased initially(week 1 and 2 Ovx)and recovered *** E2 replacement significantly decreased P4 levels in the Ovx fish in the pre-spawning stage and in the lower dose group in the resting *** P5 levels remained inhibited after the E2 supplementation in the resting stage but unchanged or increased it in the pre-spawning *** cortisol(F)levels were inhibited initially(1 and 2

关键词： Catfish Neurosteroids Ovariectomy Estrogen replacement Seasonal variations

Semantic segmentation of landcover for cropland mapping and area estimation using Machine Learning techniques

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Data Intelligence 2023年第2期5卷 370-387页

作者： surabhi Lingwal Komal Kumar Bhatia Manjeet Singh Computer Science&Engineering G B Pant Institute of Engineering&TechnologyPauri Garhwal246194UttarakhandIndia Computer Engineering J C Bose Univerity of Science&TechnologyYMCAFaridabad121006HaryanaIndia

The paper has focussed on the global landcover for the identification of cropland *** growth and rapid industrialization are somehow disturbing the agricultural lands and eventually the food production needed for human *** agricultural land monitoring requires proper management of land *** paper has proposed a method for cropland mapping by semantic segmentation of landcover to identify the cropland boundaries and estimate the cropland areas using machine learning *** process has initially applied various filters to identify the features responsible for detecting the land boundaries through the edge detection *** images are masked or annotated to produce the ground truth for the label identification of croplands,rivers,buildings,and *** selected features are transferred to a machine learning model for the semantic segmentation *** methodology has applied Random Forest,which has compared to two other techniques,Support Vector Machine and Multilayer perceptron,for the semantic segmentation *** dataset is composed of satellite images collected from the QGIS *** paper has derived the conclusion that Random forest has given the best result for segmenting the image into different regions with 99%training accuracy and 90%test *** results are cross-validated by computing the Mean loU and kappa coefficient that shows 93%and 69%score value respectively for Random Forest,found maximum among *** paper has also calculated the area covered under the different segmented ***,Random Forest has produced promising results for semantic segmentation of landcover for cropland mapping.

关键词： Croplands Semantic Segmentation Machine Learning Random Forest Mask filters Edge detection Supportvectormachine

Couple stress nanofluid flow through a bifurcated artery—Application of catheterization process

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Applied Mathematics(A Journal of Chinese Universities) 2021年第4期36卷 492-511页

作者： KM surabhi Arpitha Ravikanti D.Srikanth D.Srinivasacharya Department of Applied Mathematics Defence Institute of Advanced Technology(Deemed University)Girinagar Pune 411025India Department of Mathematics National Institute of TechnologyWarangal 506004India

In this article,we are exploring the hemodynamics of nanofluid,flowing through a bifurcated artery with atherosclerosis in the presence of a *** treating obstruction in the artery,one can use the catheter whose outer surface is carrying the drug coated with *** resultant solvent is considered as blood *** being a complex fluid,is modeled by couple stress *** the presence of nano-particles,the temperature and the concentration distribution are understood in a bifurcated stenotic *** concluded mathematical model is governed by coupled non-linear equations,and are solved by using the homotopy perturbation ***,we have explored is the effects of fluid and the embedded geometric parameters on the hemodynamics *** is also realized that high wall shear stress exists for couple stress nano-fluid when compared to Newtonian *** is computed at a location corresponding to maximum constriction(z=12.5)of the artery.

关键词： couple stress uid bifurcated stenotic artery homotopy perturbation method wall shear stress

Influence of size and concentration of carbonate biomineral on biocementation and bioclogging for mitigating soil degradation

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Biogeotechnics

Biogeotechnics 2023年第2期1卷 34-41页

作者： surabhi Jain Sarat Kumar Das Department of Civil Engineering IT(ISM)DhanbadJharkhandIndia

Microbially induced carbonate precipitation(MICP)is a promising technique to enhance the geotechnical properties of geomaterial either by strengthening via biocementation or reducing the hydraulic conductivity via *** rate of modification mainly depends on the amount,and nature of biomineral pre-cipitated and it is influenced by various environmental,chemical,and microbial *** this,the present study aims to investigate the effect of biochemical conditions such as concentration of biomass and chemical reagents on the amount and nature of biomineral and its impact on the strength and permeability of biomodified *** this,the two microbes i.e.,Sporosarcina pasteuri and isolated Proteus species at three different initial concentrations and chemical reagents by varying 0.1-1 molar of urea and calcium were *** amount and microstructural behavior of biomineral in different biochemical conditions concluded that the governing mechanism differs for both biocementation and bioclogging under identical MICP *** strength enhancement or biocementation is dependent on the size of the biomineral precipitated whereas the reduction in permeability or bioclogging is mainly dominated by the amount of *** optimum value of biochemical conditions i.e.,1o°cells/ml of biomass and 0.25 M con-centration of cementation reagents was chosen to further evaluate the effect of equal MICP treatment on the biocementation and bioclogging of sands having different grain *** study infers that not the absolute size of the biomineral but the relative size of soil grain and biomineral influence the linkage between the soil particles and hence affect the strength of biomodified soil.

关键词： MICP Biocementation Bioclogging Biochemical conditions Carbonatebiomineral

Natural compounds as potential inhibitors of SARS-CoV-2 main protease: An insilico study

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 155-163页

作者： Amaresh Mishra Yamini Pathak Anuj Kumar surabhi Kirti Mishra Vishwas Tripathi School of Biotechnology Gautam Buddha UniversityGreater Noida-201310India Bioinformatics Laboratory Uttarakhand Council for BiotechnologyBiotech BhawanPantnagarU.S.NagarUttarakhand-263145India Advanced Centre for Computational and Applied Biotechnology Uttarakhand Council for BiotechnologyDehradun-248007India School of Biotechnology Jawaharlal Nehru UniversityNew DelhiIndia

Objective:To explore natural compounds as potential inhibitors against main protease(Mpro)of ***:In the current study,systematic molecular docking analysis was conducted using AutoDock 4.2 to determine the binding affinities and interactions between natural compounds and *** natural compounds were further validated using a combination of molecular dynamic(MD)simulations and molecular mechanic Poisson-Boltzmann surface area(MM/PBSA)free energy c alculation ***:Out of twenty natural compounds,four natural metabolites namely,amentoflavone,guggulsterone,puerarin,and piperine were found to have strong interaction with Mpro of SARS-CoV-2 based on docking *** MD simulations,all four natural compounds bound to Mpro at 50 ns and MM/G/P/BSA free energy calculations showed that all four shortlisted ligands had stable and favorable energies with strong binding to Mpro ***:Guggulsterone is a potential inhibitor of COVID-19 main protease *** in vitro and pre-clinical studies are needed.

关键词： SARS-CoV-2 COVID-19 Amentoflavone Guggulsterone Puerarin Piperine

Assessment of terrace gardens as modifiers of building microclimate

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Energy and Built Environment 2022年第1期3卷 105-112页

作者： Chitra Chidambaram surabhi S.Nath Pranjali Varshney Sakshi Kumar School of Architecture and Planning Sharda UniversityKnowledge Park IIIGreater NoidaUttar Pradesh 201310India Indraprastha Institute of Information Technology Delhi Okhla Industrial EstatePhase IIINew Delhi 110020India

Hard concrete roofs cause excessive heat gain impacting thermal comfort in *** gardens promoting greening at higher levels of built structures are seen as one of the key mitigating strategies for modifying building microclimate and improving urban *** have undertaken a research project to quantitatively assess the value of a terrace garden in a residential scale.A garden patch of about 15 m 2 in area,a typical size available in most urban terraces is *** temperatures are measured over a period of 15 months between July 2018 to January 2020 using four thermocouple sensors,placed within and outside the garden bed,on and below the *** compare the thermal performance of the terrace garden across years,seasons,time of the day,presence or absence of garden bed and type and height of *** surface temperature data was found to correlate well with the ambient air temperature *** results show that the terrace garden moderates and stabilises the ceiling temperatures and reduces it by about 2-3°C in winter months and 5-7°C in hot *** garden also provided nearly 400 g of fresh monthly vegetable harvest per m 2 of ***,the cooling impact of the terrace garden with natural,tall,wild vegetation is higher as compared to planted *** study demonstrates a sustainable approach to terrace garden design at residential scale through quantified dual benefits of temperature control within buildings and urban farming.

关键词： Green roof Residential terrace garden Building micro-climate Urban vegetation Terrace farming Quantitative assessment