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中国组织化学与细胞化学杂志 2019年第2期28卷 99-107页

作者：暴素青曹艳丽天津市第一中心医院内分泌科天津300192 中国医科大学附属第一医院内分泌科沈阳110001

目的探讨表没食子儿茶素没食子酸酯(epigallocatechin gallate, EGCG)对高脂饮食大鼠胰腺组织炎症状态的作用及其与胰岛素抵抗的关系。方法将30只SPF级雄性SD大鼠随机分为正常饮食组(the normal diet group as the control,NC组,n=10)... 详细信息

目的探讨表没食子儿茶素没食子酸酯(epigallocatechin gallate, EGCG)对高脂饮食大鼠胰腺组织炎症状态的作用及其与胰岛素抵抗的关系。方法将30只SPF级雄性SD大鼠随机分为正常饮食组(the normal diet group as the control,NC组,n=10)和高脂饮食组(high-fat diet group,HFD组,n=20)。喂养16周,当两组大鼠体重出现显著差异后,将HFD组按随机区组原则分为单纯高脂组(high-fat diet group,HFD组,n=10)和EGCG干预组(HFD+0.32% EGCG,EGCG组,n=10);干预16周。留取血清及胰腺组织,检测每组大鼠空腹血糖(fasting blood glucose,FBG)、胰岛素(fasting insulin,FINS)及游离脂肪酸(free fatty acids,FFAs),并计算胰岛素抵抗指数(homeostasis model assessment-insulin resistance index,HOMA-IR);应用免疫组织化学方法检测胰岛中CD68^+巨噬细胞数目及TNF-α表达;应用Real-time RT-PCR及Western blot方法检测胰腺组织中CD68及Toll样受体4(Toll-like receptor 4,TLR4)、肿瘤坏死因子受体相关因子6(TNF receptor-associated factor 6,TRAF6)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)及白介素6(interleukin- 6,IL-6)等炎症相关因子表达水平。结果 HFD组大鼠体重、FFAs和FINS水平与HOMA-IR指数均明显升高,胰岛中巨噬细胞浸润明显增多,胰腺CD68水平及TLR4、TRAF6、TNF-α和IL-6等炎性因子表达明显上升;EGCG干预的HFD大鼠体重、FFAs和FINS水平、HOMA-IR指数、胰岛巨噬细胞浸润、胰腺CD68水平、胰腺TNF-α和IL-6表达的升高不如HFD大鼠明显,与NC大鼠接近;三组大鼠FBG水平无明显统计学差异;EGCG干预的HFD大鼠TLR4表达水平较HFD组未见明显下降。结论 EGCG可减少高脂饮食大鼠胰岛中巨噬细胞浸润,抑制炎症因子TNF-a及IL-6表达的上调,改善胰岛素敏感性;该作用并非通过TLR4信号通路实现。

关键词： EGCG 肿瘤坏死因子-α 胰腺巨噬细胞胰岛素敏感性

Dll4蛋白在高脂饮食喂养大鼠脂肪组织炎症中的作用

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中国组织化学与细胞化学杂志 2013年第6期22卷 462-465页

作者：曹艳丽暴素青冯金单忠艳中国医科大学附属第一医院内分泌科内分泌研究所辽宁省内分泌疾病重点实验室沈阳110001 辽宁电力中心医院内分泌科沈阳110003

目的探讨Delta-like ligand 4(Dll4)蛋白在高脂饮食喂养大鼠脂肪组织中的表达及其与脂肪组织炎症的关系。方法将20只SPF级雄性Sprague-Dawley大鼠随机分为正常饮食组(SD,n=10)和高脂饮食组(HFD,n=10)喂养16w后,应用免疫组化及Western b... 详细信息

目的探讨Delta-like ligand 4(Dll4)蛋白在高脂饮食喂养大鼠脂肪组织中的表达及其与脂肪组织炎症的关系。方法将20只SPF级雄性Sprague-Dawley大鼠随机分为正常饮食组(SD,n=10)和高脂饮食组(HFD,n=10)喂养16w后,应用免疫组化及Western blot方法检测脂肪组织中Dll4及炎症通路NF-κB磷酸化、IL-6的表达。结果免疫组化结果显示,HFD组Dll4表达量显著升高(P<0.001);Western blot结果与免疫组化结果相一致,Dll4蛋白表达量是SD组的1.34倍(P<0.01);磷酸化核转录因子NF-κB表达水平升高,HFD组为SD组的2.03倍(P<0.01);HFD组炎症细胞因子IL-6水平明显升高,为SD组的3.02倍(P<0.01)。结论高脂饮食可增加脂肪组织中Dll4蛋白表达,促进了脂肪组织中炎症的发生。

关键词：高脂饮食 Dll4 NF-κB IL-6 脂肪组织

gestational week increase subsequent miscarriage in low-risk women:a prospective cohort study

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gestational week increase subsequent miscarriage in low-risk...

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

中华医学会第十二次全国内分泌学学术会议

作者： Haixia Liu Zhongyan Shan Chenyan Li Jinyuan Mao Xiaochen Xie Weiwei Wang Chenling Fan Hong Wang Hongmei Zhang Cheng Han Xinyi Wang Xin Liu Yuxin Fan suqing bao Weiping Teng Department of Endocrinology and Metabolism Institute of EndocrinologyLiaoning Provincial Key Laboratory of Endocrine DiseasesThe First Hospital of China Medical University Department of Endocrinology and Metabolism The Second Hospital of Dalian Medical University

Aim Are there associations between subclinical hypothy-roidism, thyroid autoimmunity in early pregnancy and miscar-riage? Methods We screened 3315 low-risk women at 4-8 weeks’ ***,and free T4 and autoantibodies were ...

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang Wei Pi Sheng Hu Haifeng bao Na Yao Wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

大鼠妊娠期母体亚临床甲状腺功能减退下调后代海马胰岛素样生长因子Ⅰ通路相关蛋白水平

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中华内分泌代谢杂志 2014年第12期30卷 1068-1073页

作者：范雨鑫张媛媛暴素青范晨玲滕卫平单忠艳中国医科大学附属第一医院内分泌科内分泌研究所辽宁省内分泌疾病重点实验室沈阳110001

目的探究妊娠期母体亚临床甲状腺功能减退（甲减）是否可以导致后代仔鼠海马胰岛素样生长因子Ⅰ （IGF-Ⅰ）、胰岛素样生长因子Ⅰ受体（IGF-Ⅰ R）和磷酸化蛋白激酶B（p-Akt）的表达降低,进而影响后代空间学习和记忆能力.方法 60只SPF... 详细信息

目的探究妊娠期母体亚临床甲状腺功能减退（甲减）是否可以导致后代仔鼠海马胰岛素样生长因子Ⅰ （IGF-Ⅰ）、胰岛素样生长因子Ⅰ受体（IGF-Ⅰ R）和磷酸化蛋白激酶B（p-Akt）的表达降低,进而影响后代空间学习和记忆能力.方法 60只SPF级雌性Wistar大鼠随机分成3组,正常对照组（CON）20只,亚临床甲减组（SCH）20只,甲减组（CH）20只.仔鼠出生后的第3天和第7天冰上断头,分别取海马组织,以实时定量PCR方法检测IGF-Ⅰ mRNA表达,以ELISA方法检测IGF-Ⅰ、IGF-Ⅰ R蛋白表达,以Western印迹方法检测蛋白激酶B（Akt）及p-Akt蛋白表达.仔鼠出生后第40天行Morris水迷宫行为学检测及海马兴奋性突触后电位长时程增强检测.结果与正常对照组仔鼠相比,亚临床甲减组仔鼠海马IGF-Ⅰ mRNA水平的表达在第3天和第7天时降低幅度分别为27％（P＜0.01）和21％（P＜0.01）,IGF-Ⅰ蛋白含量的表达降低幅度分别为29％（P＜0.01）和25％（P＜0.01）,IGF-Ⅰ R蛋白的表达在第3天和第7天时降低幅度约为23％（P＜0.01）和19％（P＜0.05）,p-Akt蛋白的表达在第3天和第7天时降低幅度约为19％（P＜0.01）和11％（P＜0.05）.与甲减组相比,仔鼠IGF-Ⅰ mRNA水平的表达和IGF-Ⅰ蛋白含量的表达在第3天和第7天时均增高（P＜0.05）,而IGF-Ⅰ R和总Akt蛋白含量的表达在第3天时高于甲减组（P＜0.05）,而在第7天时与甲减组表达无统计学差异（P＞0.05）.第40天时,对仔鼠进行Morris水迷宫定位航向检测,各组仔鼠的逃避潜伏期均随训练天数的增加而缩短.甲减组的逃避潜伏期始终长于正常对照组.亚临床甲减组的逃避潜伏期在第1、2天与正常对照组无明显差异（P＞0.05）,第3、4天逃避潜伏期长于正常对照组,有统计学差异（P=0.034;P=0.047）.在第40天时对仔鼠进行兴奋性突触后电位长时程增强检测,海马经强直刺激后各组仔鼠兴奋性突触后电位的斜率均增加,亚临床甲减组仔鼠电位斜率增加百分比低于正常对照组（P＜0.05）,高于甲减组（P＜0.05）.结论妊娠期母体亚临床甲减可能和仔鼠海马与长时程增强相关蛋白IGF-Ⅰ、p-Akt蛋白含量的表达降低有关,减弱了长时程增强的产生,进而损害仔鼠空间学习和记忆能力.

关键词：妊娠亚临床甲状腺功能减退症胰岛素样生长因子Ⅰ 胰岛素样生长因子Ⅰ受体磷酸化蛋白激酶B Morris水迷宫长时程增强

Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang Wei Wang Xuheng Chen Junfang bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li Jian-Hong Shi Tan Li Wan-Su bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-Lin Jiang bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

盆腔炎对女性性激素的影响及其与不孕症的关系

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中国性科学 2015年第4期24卷 5-7页

作者：鲍苏青蒋郡瑛楼青娟义乌市妇幼保健院妇产科浙江金华322000

目的:探讨盆腔炎对女性性激素水平的影响,研究盆腔炎与不孕不育的关系。方法:76例女性不孕症合并盆腔炎患者设为观察组1,50例单纯女性不孕症设为观察组2,并以同期有生育史健康女性62例为对照组,比较三组性激素水平及炎性因子差异。结果... 详细信息

目的:探讨盆腔炎对女性性激素水平的影响,研究盆腔炎与不孕不育的关系。方法:76例女性不孕症合并盆腔炎患者设为观察组1,50例单纯女性不孕症设为观察组2,并以同期有生育史健康女性62例为对照组,比较三组性激素水平及炎性因子差异。结果:三组性激素水平FSH、T差异无统计学意义(P>0.05),观察组1与观察组2及对照组比较,观察组1 LH、PRL、E2、P出现升高差异有统计学意义(P0.05);三组炎性因子比较,观察组1TNF、IL-2均出现升高,与观察组2及对照组差异有统计学意义(P0.05);合并盆腔炎不孕症患者炎性因子TNF、IL-2与LH、PRL、E2、P均呈正相关,均有统计学意义(P<0.05)。结论:盆腔炎与不孕症关系密切。

关键词：盆腔炎不孕症性激素炎性因子