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Survival outcomes and predictors of mortality,re-bleeding and complications for acute severe variceal bleeding requiring balloon tamponade

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World Journal of Hepatology 2022年第8期14卷 1584-1597页

作者： Charlotte Y Keung Aparna Morgan suong t le Marcus Robertson Paul Urquhart Michael P Swan Department of Gastroenterology Monash HealthMelbourne 3168VictoriaAustralia Department of Gastroenterology Eastern HealthMelbourne 3128VictoriaAustralia Department of Medicine Monash UniversityMelbourne 3168VictoriaAustralia Monash Digital therapeutics and Innovation Laboratory Monash UniversityMelbourne 3168VictoriaAustralia

BACKGROUND Acute severe variceal bleeding(AVB)refractory to medical and endoscopic therapy is infrequent but associated with high *** cohort studies from 1970-1980s no longer represent the current population as balloon tamponade is no longer first-line therapy for variceal bleeding;treatments including vasoactive therapies,intravenous antibiotics,endoscopic variceal band ligation are routinely used,and there is improved access to definitive treatments including transjugular intrahepatic portosystemic ***,only a few studies from the current era exist to describe the practice of balloon tamponade,its outcomes,and predictors with a requirement for further updated *** to describe current management of AVB requiring balloon tamponade and identify the outcomes and predictors of mortality,re-bleeding and *** A retrospective multi-centre cohort study of 80 adult patients across two large tertiary health networks from 2008 to 2019 in Australia who underwent balloon tamponade using a Sengstaken-Blakemore tube(SBt)were included for *** were identified using coding for balloon *** primary outcome of this study was all-cause mortality at 6 wk after the index *** outcomes included re-bleeding during hospitalisation and complications of balloon *** of these outcomes were determined using univariate and multivariate binomial *** the all-cause mortality rates during admission and at 6-,26-and 52 wk were 48.8%,51.2%and 53.8%,*** haemostasis was achieved in 91.3%and re-bleeding during hospitalisation occurred in 34.2%.Independent predictors of 6 wk mortality on multivariate analysis included the Model for Endstage Liver disease(MELD)score(OR 1.21,95%CI 1.06-1.41,P=0.006),advanced hepatocellular carcinoma(OR 11.51,95%CI 1.61-82.20,P=0.015)and re-bleeding(OR 13.06,95%CI 3.06-55.71,Pthere were no relevant predictors of re-bleeding but a larg

关键词： Balloon tamponade Acute variceal bleeding Sengstaken-Blakemore tube Mortality Complications Haemostasis

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-tALOOKOLAEI H.GHANDVAR E.JUMAEV S.KHAtIR t.CUONG-le School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and technology Solutions Ho Chi Minh City Open University

this paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. the strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. the curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. the accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词： double curved beam finite element method functionally graded porous (FGP) material intermediate straight beam O313 vibration analysis

Control of Differential tectonic Evolution on tectonic Fractures in Different tectonic Segments of tight Gas Sandstone Reservoirs: Upper triassic Xujiahe Formation， Western Sichuan Foreland Basin

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Journal of Earth Science 2025年

作者： Yunzhao Zhang Lianbo Zeng Rongjun Zhang le Qu Hao Wu Quanqi Dai School of Earth Sciences and Engineering， Xi'an Shiyou University Shaanxi Key Laboratory of Petroleum Accumulation Geology， School of Earth Sciences and Engineering， Xi'an Shiyou University State Key Laboratory of Petroleum Resources and Prospecting， China University of Petroleum (Beijing) College of Geosciences， China University of Petroleum (Beijing) College of Petroleum Engineering， Xi'an Shiyou University Xi'an Key Laboratory of tight oil (Shale oil) Development， Xi'an Shiyou University China Key Laboratory of Mineral Resources in Western China， School of Earth Sciences， Lanzhou University State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development， SINOPEC Key Laboratory of Carbon Capture， Utilization and Storage， Petroleum Exploration and Production Research Institute of SINOPEC

In the context of complex tectonic evolution， due to the control of tectonic compression stress and faults on tectonic fractures， the formation and development of tectonic fractures in the t3x2tight reservoirs present significant variations across different tectonic segments in the Western Sichuan Foreland Basin. We clarified the control of differential tectonic evolution on the formation and development of tectonic fractures in different tectonic segments through field-based observations， core samples， image logging， as well as fluid inclusion petrography and temperature determinations of fracture-filling materials， combined with 2D balanced cross-section restoration. the study area primarily manifests two types of tectonic fractures in the tight reservoirs: orogen-related fractures （regional fractures） and fault-related fractures. the orientations of these fractures are predominantly E-W， nearly N-S， NE， and NW. Specifically， the northern segment area only shows the development of regional fractures， while the southern and middle segments exhibit the development of both regional and tectonic fractures. there are three phases of tectonic fractures in different tectonic segments， and their formation times are relatively consistent. the Mesozoic tectonic events had a significant impact on the northern and central segments， with the amount of tectonic shortening and the rate of stratigraphic shortening gradually decreasing from the northeast to the southwest. the compressional stress resulting from tectonic compression also decreases from the northeast to the southwest. As a result， the development of first-phase and second-phase tectonic shear fractures is more pronounced in the northern and middle segments compared to the southern segment. Under the significant control of faults， the development of N-S- and NE-oriented fault-related fractures is more pronounced in the southern segment， while the development of NE-oriented fault-related fractures is relatively higher

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Research landmarks on the 60th anniversary of Epstein-Barr virus

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Science China(Life Sciences) 2025年第2期68卷 354-380页

作者： Lan-Yi Zhong Chu Xie le-le Zhang Yan-Lin Yang Yuan-tao Liu Ge-Xin Zhao Guo-Long Bu Xian-Shu tian Zi-Ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong Sun Mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Viral Immunobiology Institute of Experimental ImmunologyUniversity of ZürichZürich 8092Switzerland Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalBoston MA 02115USA Department of Microbiology Harvard Medical SchoolBoston MA 02115USA Harvard Program in Virology Boston MA 02115USA Broad Institute of Harvard and MIt Cambridge MA 02142USA

Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human *** we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex *** this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.

关键词： Epstein-Barr virus oncovirus immune response epidemiology vaccines antibodies

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Exotic hybrid pseudopotentials at finite temperature and chemical potential

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Chinese Physics C 2025年第1期49卷 186-194页

作者： le Zhang Fei-Yang Cai Xun Chen College of Physics and Electronic Science Hubei Normal UniversityHuangshi 435002China

Using gauge/gravity duality,we studied the exotic hybrid pseudopotentials at finite temperature and chemical *** Σ hybrid meson can be described by a model including an object called"defect"on a string linking the quark and *** Σ_(u)^(-) hybrid potential at zero temperature and chemical potential was first proposed by Andreev and is perfectly *** this study,we extended the aforementioned model to finite chemical potential and compared the separate distance and pseudopotentials of Σ_(g)^(+) and Σ_(u)^(-).Unlike the Σ_(g)^(+) ground state,the Σ_(u)^(-),hybrid pseudopotentials no longer exhibit Coulomb-like behavior at short *** addition,temperature and chemical potential have a significant impact on the Σ_(u)^(-) hybrid *** screen distances and hybrid pseudopotentials of Σ_(u)^(-) significantly decrease when increasing temperature and chemical *** represented the melting diagram of Σ_(g)^(+) and Σ_(u)^(-) in the t-μ plane and confirmed that the quark-antiquark pair in Σ_(u)^(-) excited state is easier to melt than that in Σ_(g)^(+) ground state.

关键词： holographic QCD hybrid potential heavy quark

Intestinal glucagon-like peptide-1:A new regulator of impaired counterregulatory responses to hypoglycemia in type 1 diabetes mellitus

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World Journal of Diabetes 2025年第1期16卷 217-221页

作者： le-Rong Liu Yuan-Yuan Luo Pei-Zhu Su Cong Zhang Zhao-tao Li Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Endocrinology Chongqing University Three Gorges HospitalChongqing 404100China Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic Diseases Chongqing University Three Gorges HospitalChongqing 404100China Department of Endocrinology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400013China Department of Gastroenterology The First People's Hospital of FoshanFoshan 528000Guangdong ProvinceChina

In this article,we review the study by Jin et al,which examined the role of intestinal glucagon-like peptide-1(GLP-1)in counterregulatory responses to hypoglycemia in patients with type 1 diabetes mellitus(t1DM).With the global rise of t1DM,there is an increased burden on society and healthcare *** to insulin therapy and islet dysfunction,t1DM patients are highly vulnerable to severe hypoglycemia,a leading cause of *** healthy individuals,counterregulatory mechanisms restore blood glucose during hypoglycemia,but repeated episodes impair these *** et al demonstrated that overexpression of GLP-1 attenuates the sympathetic-adrenal reflex and disrupts the secretion of counterregulatory hormones such as glucagon during hypoglycemia,leading to counterregulatory *** findings highlight the critical role of GLP-1 in the impaired counterregulatory response to hypoglycemia in t1DM patients and provide new insights into the potential application of GLP-1-related therapies in t1DM patients.

关键词： Glucagon-like peptide-1 Impaired counterregulation type 1 diabetes mellitus Sympathetic-adrenal reflex Glucagon

Stochastic framework for modeling the linear apparent behavior of complex materials:Application to random porous materials with interphases

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Acta Mechanica Sinica 2013年第6期29卷 773-782页

作者： J.Guilleminot t.t.le C.Soize Universit Paris-Est Laboratoire Modlisation et Simulation Multi EchelleMSME UMR8208 CNRS5 Bd Descartes77454 Marne la ValleFrance

this paper is concerned with the modeling of randomness in multiscale analysis of heterogeneous materials. More specifically, a framework dedicated to the stochastic modeling of random properties is first introduced. A probabilistic model for matrix-valued second-order random fields with symmetry propertries, recently proposed in the literature, is further reviewed. Algorithms adapted to the Monte Carlo simulation of the proposed representation are also provided. the derivations and calibration procedure are finally exemplified through the modeling of the apparent properties associated with an elastic porous microstructure containing stochastic interphases.

关键词： Apparent properties MaxEnt Probabilistic model

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On the derivation of the entropy of ideal quantum gases confined in a three-dimensional harmonic potential

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Communications in theoretical Physics 2020年第4期72卷 106-111页

作者： le tri Dat Vinh N t Pham Laboratory of Applied Physics Advanced Institute of Materials ScienceTon Duc Thang UniversityHo Chi Minh City 756636Vietnam Faculty of Applied Sciences Ton Duc Thang UniversityHo Chi Minh City 756636Vietnam Ho Chi Minh City University of Education Ho Chi Minh City 748342Vietnam

In this work,the entropy functions of ideal quantum gases in a three-dimensional harmonic trap are analytically calculated using temperature as an explicit ***,the applicability of the analytical formulas is validated by comparison with the numerical *** results illustrate that the obtained functions could be applied for the whole temperature regime with a maximum relative deviation of less than 7.5%in the vicinity of the critical temperature tcin the case of Bose ***,for Fermi gases,although the analytical formula fits well at very low-and high-temperature regimes,it cannot be applied at temperature in the range[0.3-0.5]t_F,where t_F is the Fermi *** addition,the consistency between our formulas and classical ones at significantly high temperatures is also discussed.

关键词： thermodynamic properties entropy 3D harmonic trap ideal quantum gases

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Emotional Vietnamese Speech Synthesis Using Style-transfer learning

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Computer Systems Science & Engineering 2023年第2期44卷 1263-1278页

作者： thanh X.le An t.le Quang H.Nguyen School of Information and Communication technology Hanoi University of Science and TechnologyHanoi10000Vietnam

In recent years,speech synthesis systems have allowed for the produc-tion of very high-quality ***,research in this domain is now turning to the problem of integrating emotions into ***,the method of con-structing a speech synthesizer for each emotion has some ***,this method often requires an emotional-speech data set with many *** data sets are very time-intensive and labor-intensive to ***,training each of these models requires computers with large computational capabilities and a lot of effort and time for model *** addition,each model for each emotion failed to take advantage of data sets of other *** this paper,we propose a new method to synthesize emotional speech in which the latent expressions of emotions are learned from a small data set of professional actors through a Flow-tron *** addition,we provide a new method to build a speech corpus that is scalable and whose quality is easy to ***,to produce a high-quality speech synthesis model,we used this data set to train the tacotron 2 *** used it as a pre-trained model to train the Flowtron *** applied this method to synthesize Vietnamese speech with sadness and *** opi-nion score(MOS)assessment results show that MOS is 3.61 for sadness and 3.95 for *** conclusion,the proposed method proves to be more effec-tive for a high degree of automation and fast emotional sentence generation,using a small emotional-speech data set.

关键词： Emotional speech synthesis ﬂowtron speech synthesis style transfer vietnamese speech