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Role of color Doppler flow imaging in applicable anatomy of spleen vessels

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World Journal of Gastroenterology 2009年第5期15卷 607-611页

作者： Wei-li Xu suo-lin li Yan Wang Meng li Ai-Guo Niu Department of Pediatric Surgery the Second Hospital of Hebei Medical University Shijiazhuang 050000 Hebei Province China Department of Ultrasound the Second Hospital of Hebei Medical University Shijiazhuang 050000 Hebei Province China

AIM： To explore the role of color Doppler flow imaging （CDFI） in visualization of spleen vessels and to define its value for spleen micro-invasive operation. METHODS： A total of 36 patients requiring laparoscopic splenectomy （LS） for various hematopathies and autoimmune diseases were randomly selected from April 2005 to May 2008. Anatomic types of spleen pedicle, adjacent relations between spleen vessels and pancreas, diameters of spleen artery and vein were detected and recorded by preoperative CDFI. Different operative procedures were performed according to different anatomic frameworks. The parameters were recorded by telerecording during LS and compared with those by preoperative CDFI using Chi-square test. RESULTS： Two anatomic types of spleen pedicle and four different adjacent relations between spleen vessels and pancreas were detected by CDFI. The diameters of spleen artery and vein detected by CDFI were 0.46 ± 0.09 cm and 0.85 ± 0.35 cm, respectively. There was no statistical difference between the parameters recorded by CDFI and by telerecording （X^2 = 0.250, 0.677, P 〉 0.05）. LS was successfully performed following the anatomic information provided by preoperative ***： Different anatomic frameworks of spleen vessels can be provided by preoperative CDFI, which instructs micro-invasive operation of spleen and increase the safety of operation.

关键词： Ultrasound, Color Doppler imaging Spleen Anatomy Laparoscopic operation

Targeted inhibition of myeloid-derived suppressor cells in the tumor microenvironment by low-dose doxorubicin to improve immune efficacy in murine neuroblastoma

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Chinese Medical Journal 2021年第3期134卷 334-343页

作者： Wei-li Xu Bao-Jun Shi suo-lin li Feng-Xue Yu li-Na Guo Meng li Zhi-Gang Hu Gui-Xin li Hui Zhou Department of Pediatric Surgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of Central Laboratory The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of General Surgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China

Background:High agglomeration of myeloid-derived suppressor cells(MDSCs)in neuroblastoma(NB)impeded therapeutic *** study aimed to investigate the role and mechanism of targeted inhibition of MDSCs by low-dose doxorubicin(DOX)to enhance immune efficacy in ***:Bagg albino(BALB/c)mice were used as tumor-bearing mouse models by injecting Neuro-2a cells,and MDSCs were eliminated by DOX or dopamine(DA)***-bearing mice were randomly divided into 2.5 mg/kg DOX,5.0 mg/kg DOX,50.0 mg/kg DA,and control groups(n=20).The optimal drug and its concentration for MDSC inhibition were selected according to tumor *** antigen-specific cytotoxic T cells(CTLs)were ***-bearing mice were randomly divided into DOX,CTL,anti-ganglioside(GD2),DOX+CTL,DOX+anti-GD2,and control *** low-dose DOX administration,immunotherapy was *** levels of human leukocyte antigen(HLA)-I,CD8,interleukin(IL)-2 and interferon(IFN)-γin peripheral blood,CTLs,T-helper 1(Th1)/Th2 cytokines,perforin,granzyme and tumor growth were compared among the *** Wilcoxon two-sample test and repeated-measures analysis of variance were used to analyze ***:The slowest tumor growth(F=6.095,P=0.018)and strongest MDSC inhibition(F=14.632,P=0.001)were observed in 2.5 mg/kg DOX *** of T cells was increased(F=448.721,P<0.001)and then decreased(F=2.047,P=0.186).After low-dose DOX administration,HLA-I(F=222.489),CD8(F=271.686),Th1/Th2 cytokines,CD4^(+)and CD8^(+)lymphocytes,granzyme(F=2376.475)and perforin(F=488.531)in tumor,IL-2(F=62.951)and IFN-γ(F=240.709)in peripheral blood of each immunotherapy group were all higher compared with the control group(all ofP values<0.05).The most significant increases in the aforementioned indexes and the most notable tumor growth inhibition were observed in DOX+anti-GD2 and DOX+CTL ***:Low-dose DOX can be used as a potent immunomodulatory agent that selectively impairs MDSC-induce

关键词： Neuroblastoma Myeloid-derived suppressor cell Tumor microenvironment Doxorubicin Immunotherapy

Modified dynamic event-triggered scaled formation control for multi-agent systems via a sparrow search algorithm based co-design algorithm

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 197-213页

作者： Yanping YANG Siyu MA Dawei li Jinghui suo College of Information Science and Technology Donghua UniversityShanghai201620China Engineering Research Center of Digitized Textile&Apparel Technology Donghua UniversityShanghai201620China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Information Science and TechnologyDonghua UniversityShanghai201620China

This paper is concerned with the scaled formation control problem for multi-agent systems(MASs)over fixed and switching ***,a modified resilient dynamic event-triggered(DET)mechanism involving an auxiliary dynamic variable(ADV)based on sampled data is *** the proposed DET mechanism,a random variable obeying the Bernoulli distribution is introduced to express the idle and busy situations of communication ***,the operation of absolute value is introduced into the triggering condition to effectively reduce the formation ***,a scaled formation control protocol with the proposed resilient DET mechanism is designed over fixed and switching *** scaled formation error system is modeled as a time-varying delay ***,several sufficient stability criteria are derived by constructing appropriate Lyapunov-Krasovskii functionals(LKFs).A co-design algorithm based on the sparrow search algorithm(SSA)is presented to design the control gains and triggering parameters ***,numerical simulations of multiple unmanned aerial vehicles(UAVs)are presented to validate the designed control method.

关键词： Scaled consensus Formation control Dynamic event-triggered scheme Switching topology

Process intensification for the synthesis and purification of battery-grade li_(2)CO_(3)with microfluidics

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Particuology 2024年第7期90卷 106-117页

作者： Haodu li Jie Zhang lin Dai Le Du Jiqin Zhu The State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Battery-grade lithium carbonate(li_(2)CO_(3))with a purity of higher than 99.5 wt%is of great importance as a high value-added lithium ***,influences of different reaction systems and process control on product purity remain ***,a membrane dispersion microreactor was used to enhance the mass transfer of preparation and purification processes in homogeneous and heterogeneous *** systems of Na_(2)CO_(3)–liCl,NH_(4)HCO_(3)–liCl,and NH_(3)·H_(2)O−CO_(2)−liCl,CO_(2)purification based on carbonation and decomposition were *** li_(2)CO_(3)purity was increased by the improvement of mixing *** carbonation time was reduced by 62.5%and 58.3%for the NH_(3)·H_(2)O−CO_(2)and CO_(2)purification systems,*** the two ammonia-based systems,li_(2)CO_(3)particles with a purity of 99.7–99.8 wt%were one-step prepared with a size of 3–5μm,which also met the requirement of the battery-grade *** purity was further increased to 99.9 wt%by CO_(2)purification and liHCO_(3)*** investigation could provide a feasible alternative for the controllable preparation of battery-grade li_(2)CO_(3)in one or multiple steps.

关键词： Microfluidics Battery grade li_(2)CO_(3) Process intensification High purity

Accelerating lithium-sulfur battery reaction kinetics and inducing 3D deposition of li_(2)S using interactions between Fe_(3)Se_(4)and lithium polysulfides

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Journal of Energy Chemistry 2024年第8期95卷 540-553,I0012页

作者： Yihan lin liheng li Longjie Tan Yongliang li Xiangzhong Ren Peixin Zhang Chuanxin He lingna Sun College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060GuangdongChina

Although lithium-sulfur batteries(LSBs)exhibit high theoretical energy density,their practical application is hindered by poor conductivity of the sulfur cathode,the shuttle effect,and the irreversible deposition of li_(2)*** address these issues,a novel composite,using electrospinning technology,consisting of Fe_(3)Se_(4)and porous nitrogen-doped carbon nanofibers was designed for the interlayer of *** porous carbon nanofiber structure facilitates the transport of ions and electrons,while the Fe_(3)Se_(4)material adsorbs lithium polysulfides(liPSs)and accelerates its catalytic conversion ***,the Fe_(3)Se_(4)material interacts with soluble liPSs to generate a new polysulfide intermediate,li_(x)FeS_(y)complex,which changes the electrochemical reaction pathway and facilitates the three-dimensional deposition of li_(2)S,enhancing the reversibility of *** designed LSB demonstrates a high specific capacity of1529.6 mA h g^(-1)in the first cycle at 0.2 *** rate performance is also excellent,maintaining an ultra-high specific capacity of 779.7 mA h g^(-1)at a high rate of 8 *** investigation explores the mechanism of the interaction between the interlayer and liPSs,and provides a new strategy to regulate the reaction kinetics and li_(2)S deposition in LSBs.

关键词： lithium-sulfur batteries Polysulfide intermediates li_(2)S electrodeposition Interlayers Electrostatic spinning Adsorption Catalysis

Projecting Spring Consecutive Rainfall Events in the Three Gorges Reservoir Based on Triple-Nested Dynamical Downscaling

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Advances in Atmospheric Sciences 2024年第8期41卷 1539-1558页

作者： Yanxin ZHENG Shuanglin li Noel KEENLYSIDE Shengping HE lingling suo Department of Atmospheric Science CMA-CUG Joint Centre for Severe Weather and Climate and Hydro-geological HazardsChina University of GeosciencesWuhan 430074China Institute of Atmospheric Physics and Climate Change Research Center Chinese Academy of SciencesBeijing 100029China Three Gorges National Climatological Observatory Yichang 443099China Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5007Norway Nansen Environmental and Remote Sensing Center and Bjerknes Centre for Climate Research Bergen 5007Norway Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Spring consecutive rainfall events(CREs) are key triggers of geological hazards in the Three Gorges Reservoir area(TGR), China. However, previous projections of CREs based on the direct outputs of global climate models(GCMs) are subject to considerable uncertainties, largely caused by their coarse resolution. This study applies a triple-nested WRF(Weather Research and Forecasting) model dynamical downscaling, driven by a GCM, MIROC6(Model for Interdisciplinary Research on Climate, version 6), to improve the historical simulation and reduce the uncertainties in the future projection of CREs in the TGR. Results indicate that WRF has better performances in reproducing the observed rainfall in terms of the daily probability distribution, monthly evolution and duration of rainfall events, demonstrating the ability of WRF in simulating CREs. Thus, the triple-nested WRF is applied to project the future changes of CREs under the middle-of-the-road and fossil-fueled development scenarios. It is indicated that light and moderate rainfall and the duration of continuous rainfall spells will decrease in the TGR, leading to a decrease in the frequency of CREs. Meanwhile, the duration, rainfall amount, and intensity of CREs is projected to regional increase in the central-west TGR. These results are inconsistent with the raw projection of MIROC6. Observational diagnosis implies that CREs are mainly contributed by the vertical moisture advection. Such a synoptic contribution is captured well by WRF, which is not the case in MIROC6,indicating larger uncertainties in the CREs projected by MIROC6.

关键词： triple-nested downscaling Three Gorges Reservoir area consecutive rainfall events geological hazards projection

A li_(3)P nanoparticle dispersion strengthened ultrathin li metal electrode for high energy density rechargeable batteries

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Nano Research 2024年第5期17卷 4031-4038页

作者： lin Fu Xiancheng Wang Bao Zhang Zihe Chen Yuanjian li Yongming Sun Provincial Guizhou Key Laboratory of Green Chemical and Clean Energy Technology School of Chemistry and Chemical EngineeringGuizhou UniversityGuiyang 550025China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Institute of Materials Research and Engineering Agency for Science Technology and Research(A*STAR)Singapore 138634Singapore

Achievement of lithium(li)metal anode with thin thickness(e.g.,≤30µm)is highly desirable for rechargeable high energy density ***,the fabrication and application of such thin li metal foil electrode remain challenging due to the poor mechanical processibility and inferior electrochemical performance of metallic ***,mechanico-chemical synthesis of robust ultrathin li/li_(3)P(LLP)composite foils(~15µm)is demonstrated by employing repeated mechanical rolling/stacking operations using red P and metallic li as raw *** in-situ formed li+-conductive li_(3)P nanoparticles in metallic li matrix and their tight bonding strengthen the mechanical durability and enable the successful fabrication of free-standing ultrathin li metal composite ***,it also reduces the electrochemical li nucleation barrier and homogenizes li plating/stripping *** matching to high-voltage liCoO_(2),the full cell with a low negative/positive(N/P)capacity ratio of~1.5 offers a high energy density of~522 W·h·kg^(-1) at 0.5 C based on the mass of cathode and *** into account its facile manufacturing,potentially low cost,and good electrochemical performance,we believe that such an ultrathin composite li metal foil design with nanoparticle-dispersion-strengthened mechanism may boost the development of high energy density li metal batteries.

关键词： lithium metal anode high energy density battery mechanico-chemical synthesis ultrathin li/li_(3)P composite foil low negative/positive capacity ratio

Catalytic anode surface enabling in situ polymerization of gel polymer electrolyte for stable li metal batteries

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Nano Research 2024年第6期17卷 5216-5223页

作者： Guocheng li Kang liang Yuanjian li Xiangrui Duan lin Fu Zhao Cai Zhaofu Zhang Jiangnan Dai Yongming Sun Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China The Institute of Technological Sciences Wuhan UniversityWuhan 430074China Faculty of Materials Science and Chemistry China University of Geoscience(Wuhan)Wuhan 430074China

Employing quasi-solid-state gel polymer electrolyte(GPE)instead of the liquid counterpart has been regarded as a promising strategy for improving the electrochemical performance of li metal ***,the poor and uneven interfacial contact between li metal anode and GPE could cause large interfacial resistance and electrochemical li stripping/plating inhomogeneity,deteriorating the electrochemical ***,we proposed that the functional component of composite anode could work as the catalyst to promote the in situ polymerization reaction,and we experimentally realized the integration of polymerized-dioxolane electrolyte and li/li_(22)Sn_(5)/liF composite electrode with low interfacial resistance and good stability by in situ catalyzation ***,the reaction kinetics and stability of metallic li anode were significantly *** a demonstration,symmetric cell using such a GPE-li/li_(22)Sn_(5)/liF integration achieved stable cycling beyond 250 cycles with small potential hysteresis of 25 mV at 1 mA·cm^(−2)and 1 mAh·cm^(−2),far outperforming the counterpart regular GPE on pure *** with lini0.5Co0.3Mn0.2O2,the full cell with the GPE-li/li_(22)Sn_(5)/liF integration maintained 85.7%of the original capacity after 100 cycles at 0.5 C(1 C=200 mA·g^(−1)).Our research provides a promising strategy for reducing the resistance between GPE and li metal anode,and realizes li metal batteries with enhance electrochemical performance.

关键词： catalyzation polymerization interface resistance interfacial stability li metal batteries electrochemical performance

VOC emitted by biopharmaceutical industries:Source profiles,health risks,and secondary pollution

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Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei Ma lin li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for VOCs Pollution Control Material&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharmaceutical industry contributes substantially to volatile organic compounds(VOCs)emissions,causing growing concerns and social developmental *** study conducted an on-site investigation of the process-based emission of VOCs from three biopharmaceutical *** the workshops of the three enterprises,26 VOCs were detected,which could be sorted into 4 classes:hydrocarbons,aromatic hydrocarbons,oxygen-containing compounds,and nitrogen-containing *** were the main components of waste gases,accounting for 44.13%-77.85%of the overall ***-based source profiles were compiled for each process unit,with the fermentation and extraction units of tiamulin fumarate being the main source of VOC *** heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation *** level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of VOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km ***,the process-based formation potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone formation potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of *** results provide a basis for understanding the characteristics of VOC emission by biopharmaceutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharmaceutical Volatile organic compound Priority pollutant Exposure risk Secondary pollution