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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： chun Qin Gan-Rong huang Ai-Xing Guan Wen-Ting Zhou Hao chen Pei-Pei Luo Xian-Ke Luo Yan-Qiang huang Zan-Song huang Guangxi Technology Innovation cooperation Base of Prevention and control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BAcKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(cagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PcR and Western *** was used to analyze cagA,cagM,cagE,cag1,cag3,and cagT.c57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** cagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as cagA,cagM,cagE,cag1,cag3,and *** these factors,cagM and cagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,cagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.c57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

Quantitative lithium substitution of carboxyl hydrogens in polyacrylic acid binder enables robust SiO electrodes with durable lithium storage stability

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Journal of Energy chemistry 2024年第10期97卷 352-360页

作者： Weihua Wang Wenyi Li Siyi Jing Huiping Yang Huiqun Wang Ling huang Yuxiang Mao Xikun Pang Yudai huang Li Zhang State Key Laboratory of Physical chemistry of Solid Surfaces Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringCollaborative Innovation Centre of Chemistry for Energy Materials (iChEM) Xiamen University State Key Laboratory of chemistry and Utilization of carbon-Based Energy Resources College of Chemistry Xinjiang University

The design of advanced binders plays a critical role in stabilizing the cycling performance of large-volume-effect silicon monoxide（SiO） *** the classic polyacrylic acid（PAA） binder,the self-association of-cOOH groups in PAA leads to the formation of intramolecular and intermolecular hydrogen bonds,greatly weakening the bonding force of the binder to SiO ***,strengthening the binder-material interaction from the perspective of binder molecular regulation poses a significant ***,a modified PAA-Lix（0.25 ≤x≤1） binder with prominent mechanical properties and adhesion strength is specifically synthesized for SiO anodes by quantitatively substituting the carboxylic hydrogen with *** appropriate lithium substitution（x=0.25） not only effectively increases the number of hydrogen bonds between the PAA binder and SiO surface owing to charge repulsion effect between ions,but also guarantees moderate entanglement between PAA-Lixmolecular chains through the ion-dipole *** such,the PAA-Li0.25/SiO electrode exhibits exceptional mechanical properties and the lowest volume change,as well as the optimum cycling(1237.3 mA h g-1after 100cycles at 0.1 c) and rate performance(1000.6 mA h g-1at 1 c),significantly outperforming the electrode using pristine PAA *** work paves the way for quantitative regulation of binders at the molecular level.

关键词： Adhesion strength charge repulsion effect Polyacrylic acid binder Quantitative lithium substitution SiO anode

Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-Sheng LAN Shuo cHEN You-Yi huang Lan-Jin WU Zhi-Qing QIN Ying huang Wan-Zhong huang Ting ZENG Xin HAO Hua-Bin SU Qiang SU Department of cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BAcKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(Pch 8 plasma metabolites[propionylglycine levels(OR=0.922,95%cI:0.881–0.965,Pcine levels(OR=0.903,95%cI:0.861–0.948,Pcanedioate(c16-Dc)levels(OR=0.941,95%cI:0.911–0.973,Pcid levels(OR=0.923,95%cI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%cI:0.902–0.971,Pcine levels(OR=0.936,95%cI:0.909–0.964,Pcine to serine ratio(OR=0.930,95%cI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%cI:0.869–0.958,Pcorrelated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%cI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%cI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%cI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

Indium-based electrocatalysts for cO_(2) reduction to c1 products

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chinese chemical Letters 2024年第6期35卷 134-145页

作者： Qin cheng Ming huang Qingqing Ye Bangwei Deng Fan Dong Research center for carbon-Neutral Environmental&Energy Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou)&Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaHuzhou 313000China Suzhou Industrial Technology Research Institute of Zhejiang University Suzhou 215163China

Electrocatalytic cO_(2) reduction at mild conditions is a promising strategy to transform greenhouse gases into fuels or value-added chemicals to solve the increasingly serious environmental and energy *** most crucial factor in determining the cO_(2) reduction performance is to develop efficient electrocatalysts with high selectivity and *** the various electrocatalysts,indium-based catalysts have attracted extensive attention due to their non-toxicity,low cost,and high formic acid/formate *** this work,we comprehensively review the recent development and research progress of indium-based electrocatalysts for cO_(2)*** reaction mechanism,reaction pathways,structure-activity relationship,and strategies to enhance the activity of cO_(2)RR on indium-based catalysts have also been briefly presented and ***,the existing challenges and future developments for indium-based highperformance catalysts for cO_(2)RR are proposed.

关键词： Electrocatalytic cO_(2) reduction In-based catalysts Formate Reaction mechanism Structure-activity relationship

Identification and characterization of camptothecin tailoring enzymes in Nothapodytes tomentosa

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Journal of Integrative Plant Biology 2024年第6期66卷 1158-1169页

作者： Yin chen Jian-Ping huang Yong-Jiang Wang Meng-Ling Tu Junheng Li Bingyan Xu Guoqing Peng Jing Yang Sheng-Xiong huang State Key Laboratory of Phytochemistry and Plant Resources in West china and Yunnan Key Laboratory of Natural Medicinal chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of chinese Academy of Sciences Beijing 100049China Key Laboratory for Economic Plants and Biotechnology Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

camptothecin is a complex monoterpenoid indole alkaloid with remarkable antitumor *** that two c-10 modified camptothecin derivatives,topotecan and irinotecan,have been approved as potent anticancer agents,there is a critical need for methods to access other aromatic ringfunctionalized congeners(e.g.,c-9,c-10,etc.).However,contemporary methods for chemical oxidation are generally harsh and low-yielding when applied to the camptothecin scaffold,thereby limiting the development of modified *** herein,we have identified four tailoring enzymes responsible for c-9 modifications of camptothecin from Nothapodytes tomentosa,via metabolomic and transcriptomic *** consist of a cytochrome P450(Nt cPT9H)which catalyzes the regioselective oxidation of camptothecin to 9-hydroxycamptothecin,as well as two methyltransferases(Nt OMT1/2,converting 9-hydroxycamptothecin to 9-methoxycamptothecin),and a uridine diphosphate-glycosyltransferase(Nt UGT5,decorating 9-hydroxycamptothecin to9-β-D-glucosyloxycamptothecin).Importantly,the critical residues that contribute to the specific catalytic activity of Nt cPT9H have been elucidated through molecular docking and mutagenesis *** work provides a genetic basis for producing camptothecin derivatives through metabolic *** will hasten the discovery of novel c-9 modified camptothecin derivatives,with profound implications for pharmaceutical manufacture.

关键词： camptothecin biosynthesis enzymatic assay Nothapodytes tomentosa tailoring enzyme transcriptomic analysis

The early life immune dynamics and cellular drivers at single-cell resolution in lamb forestomachs and abomasum

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Journal of Animal Science and Biotechnology 2024年第1期15卷 218-235页

作者： Kailang huang Bin Yang Zebang Xu Hongwei chen Jiakun Wang Institute of Dairy Science College of Animal SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Molecular Animal Nutrition Ministry of EducationZhejiang UniversityHangzhou 310058China

Background Four-chambered stomach including the forestomachs(rumen,reticulum,and omasum)and abomasum allows ruminants convert plant fiber into high-quality animal *** early development of this four-chambered stomach is crucial for the health and well-being of young ruminants,especially the immune ***,the dynamics of immune development are poorly *** We investigated the early gene expression patterns across the four-chambered stomach in Hu sheep,at 5,10,15,and 25 days of *** found that forestomachs share similar gene expression patterns,all four stomachs underwent widespread activation of both innate and adaptive immune responses from d 5 to 25,whereas the metabolic function were significantly downregulated with *** constructed a cell landscape of the four-chambered stomach using single-cell *** transcriptomic and single-cell transcriptomic analyses revealed that the immune-associated module hub genes were highly expressed in T cells,monocytes and macrophages,as well as the defense-associated module hub genes were highly expressed in endothelial cells in the four-stomach ***,the non-immune cells such as epithelial cells play key roles in immune *** communication analysis predicted that in addition to immune cells,non-immune cells recruit immune cells through macrophage migration inhibitory factor signaling in the *** Our results demonstrate that the immune and defense responses of four stomachs are quickly developing with age in lamb's early *** also identified the gene expression patterns and functional cells associated with immune ***,we identified some key receptors and signaling involved in immune *** results help to understand the early life immune development at single-cell resolution,which has implications to develop nutritional manipulation and health management strategies based on specific targets including key

关键词： Early life Forestomachs Four-chambered stomach Immune cells Immune system maturation MIF signaling Rumen Ruminant development Single-cell transcriptomic sequencing

High-performance and robust high-temperature polymer electrolyte membranes with moderate microphase separation by implementation of terphenyl-based polymers

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Journal of Energy chemistry 2024年第5期92卷 572-578页

作者： Jinyuan Li congrong Yang Haojiang Lin Jicai huang Suli Wang Gongquan Sun Division of Fuel cells and Battery Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Key Laboratory of Fuel cells&Hybrid Power Sources Chinese Academy of SciencesDalian 116023LiaoningChina University of chinese Academy of Sciences Beijing 100039China

Acid loss and plasticization of phosphoric acid(PA)-doped high-temperature polymer electrolyte membranes(HT-PEMs)are critical limitations to their practical application in fuel *** overcome these barriers,poly(terphenyl piperidinium)s constructed from the m-and p-isomers of terphenyl were synthesized to regulate the microstructure of the *** rigid p-terphenyl units prompt the formation of moderate PA aggregates,where the ion-pair interaction between piperidinium and biphosphate is reinforced,leading to a reduction in the plasticizing *** a result,there are trade-offs between the proton conductivity,mechanical strength,and PA retention of the membranes with varied m/p-isomer *** designed PA-doped PTP-20m membrane exhibits superior ionic conductivity,good mechanical strength,and excellent PA retention over a wide range of temperature(80–160°c)as well as satisfactory resistance to harsh accelerated aging *** a result,the membrane presents a desirable combination of performance(1.462 W cm^(-2) under the H_(2)/O_(2)condition,which is 1.5 times higher than that of PBI-based membrane)and durability(300 h at 160°c and 0.2 A cm^(-2))in the fuel *** results of this study provide new insights that will guide molecular design from the perspective of microstructure to improve the performance and robustness of HT-PEMs.

关键词： Fuel cell High-temperature polymer electrolyte membranes Microphase separation Poly(terphenyl piperidinium)s Phosphoric acid

Precise regulation of the phase transformation for pyrolusite during the reduction roasting process

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 81-90页

作者： Ruofeng Wang Peng Gao Shuai Yuan Yanjun Li Yingzhi Liu cheng huang School of Resources and civil Engineering Northeastern UniversityShenyang 110819China National-Local Joint Engineering Research center of High-efficient Exploitation Technology for Refractory Iron Ore Resources Shenyang 110819China

The mechanism involved in the phase transformation process of pyrolusite (MnO_(2)) during roasting in a reducing atmosphere was systematically elucidated in this study,with the aim of effectively using low-grade complex manganese ore *** to single-factor experiment results,the roasted product with a divalent manganese (Mn^(2+)) distribution rate of 95.30% was obtained at a roasting time of 25 min,a roasting temperature of 700℃,a cO concentration of 20at%,and a total gas volume of 500 mL·min^(-1),in which the manganese was mainly in the form of manganosite (MnO).Scanning electron microscopy and Brunauer–Emmett–Teller theory demonstrated the microstructural evolution of the roasted product and the gradual reduction in the pyrolusite ore from the surface to the core Thermodynamic calculations,X-ray photoelectron spectroscopy,and X-ray diffractometry analyses determined that the phase transformation of pyrolusite followed the order of MnO_(2)→Mn_(2)O_(3)→Mn_(3)O_(4)→MnO phase by phase,and the reduction of manganese oxides in each valence state proceeded simultaneously.

关键词： pyrolusite phase transformation reduction roasting microstructural evolution reaction mechanism

Regulating the non-effective carriers transport for high-performance lithium metal batteries

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Journal of Energy chemistry 2024年第5期92卷 132-141页

作者： Simeng Wang Youchun Yu Shaotong Fu Hongtao Li Jiajia huang Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China School of chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Haike Group Research Institute of Innovation&Technology Dongying 257000ShangdongChina

The absence of control over carriers transport during electrochemical cycling,accompanied by the deterioration of the solid electrolyte interphase(SEI)and the growth of lithium dendrites,has hindered the development of lithium metal ***,a separator complexion consisting of polyacrylonitrile(PAN)nanofiber and MIL-101(cr)particles prepared by electrospinning is proposed to bind the anions from the electrolyte utilizing abundant effective open metal sites in the MIL-101(cr)particles to modulate the transport of non-effective *** binding effect of the PANM separator promotes uniform lithium metal deposition and enhances the stability of the SEI layer and long cycling stability of ultra-high nickel layered oxide *** PANM as the Li||NcM96 separator enables high-voltage cycling stability,maintaining 72%capacity retention after 800 cycles at a charging and discharging rate of 0.2 c at a cut-off voltage of 4.5 V and 0°***,the excellent high-rate performance delivers a specific capacity of 156.3 mA h g^(-1) at 10 *** addition,outstanding cycling performance is realized from−20 to 60°*** separator engineering facilitates the electrochemical performance of lithium metal batteries and enlightens a facile and promising strategy to develop fast charge/discharge over a wide range of temperatures.

关键词： Functional separators Metal-organic frameworks 3D continuous ion transport networks Electrospinning Lithium metal batteries