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Journal of Acute Disease 2024年第2期13卷 85-86页

作者： sunny chi lik au Department Ophthalmology Tung Wah Eastern HospitalHong KongChina

Acute infectious conjunctivitis(AIC)is one of the most common communicable diseases encountered in acute hospital *** exists long before *** showed COVID-19 infections were associated with AIC,as the most common ocular manifestations[1].Thus,an increase in AIC during COVID-19 is expected[2].However,personal hygiene practices and public health measures throughout COVID-19 negatively impacted the incidence of influenza and other upper respiratory tract infections,as for AIC[3].Our retrospective study extracted the data between July 2016 to June 2023,from the hospital communicable ocular diseases *** aim to reveal the incidence of AIC across the pre-and post-COVID era in a local regional acute hospital.A total of 1512 patients with AIC were identified in the last 7 years across the pre-and post-COVID *** incidences of AIC over the past 7 years were plotted as a line chart(Figure 1A).

关键词： acute diseases Acute

Pearls of meta-analyses and systematic review in scientific evidence

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World Journal of Clinical Cases 2024年第16期12卷 2701-2703页

作者： sunny chi lik au Department of Ophthalmology Tung Wah Eastern HospitalHong KongChina

Scientific evidence develops bit by bit from case reports,case series;to larger casecontrol,case-cohort;and further escalate to randomized controlled *** echoed the importance of continue publishing World journal of Clinical Cases,where novel and advancing discoveries start from a single *** contrast,at the other end of the realm of evidence synthesis,systematic review and meta-analysis represent distinct yet interconnected *** in epidural labor analgesia has long been studied since 1989,and with 70 publications from MEDLINE ***,there was no meta-analysis,nor any systematic review published so *** latest in-press article published by Tang et *** the protocol for the systematic review and meta-analysis on the safety and effectiveness of butorphanol in epidural labor analgesia is *** believe the findings of this study will be valuable for clinical practice as well as for future research.

关键词： Meta-analysis Systematic review Methodology Research Journal Academic

Stroke care in the ChatGPT era:Potential use in early symptom recognition

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Journal of Acute Disease 2023年第3期12卷 129-130,I0001,I0002页

作者： Wai Yan Lam sunny chi lik au Department Ophthalmology Grantham HospitalHong KongChina Department Ophthalmology Tung Wah Eastern HospitalHong KongChina

Dear editor,Generative Pre-trained Transformer-based Chatbot(ChatGPT)[1]or similar natural language processing[2]and large language models[3]are artificial intelligence systems designed to understand and respond to human languages,allowing them to provide information,answer questions,and provide guidance on a wide range of *** of their key benefits is immediate access to information in a conversational format,as if a hotline call,which is essential in acute medical ***,medical utilization of ChatGPT is a hot research *** its intrinsic difference from search engines,ChatGPT has the potential to revolutionize our mode of information access.

关键词： conversational editor Chat

Prevalence of SARS-CoV-2 among central retinal artery occlusion patients:A case series-HORA study report No.3

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Journal of Acute Disease 2021年第4期10卷 147-149页

作者： sunny,chi lik au Callie,Ka Li Ko Department of Ophthalmology Pamela Youde Nethersole Eastern HospitalHong KongChina Department of Ophthalmology Tung Wah Eastern HospitalHong KongChina

Introduction:COVID-19 patients are susceptible to hypercoagulability,thromboembolic,and vasculitis state;central retinal artery occlusion(CRAO)could be caused by hyperviscosity syndrome,thromboembolic accidents,and *** case reports are correlating CRAO with COVID-19 *** case series aims to reveal the prevalence of SARS-CoV-2 among CRAO patients under the COVID-19 ***:Medical records of all CRAO patients who attended our tertiary referral hospital,during COVID-19 local outbreak(March to November 2020),were *** tract samples were tested for SARS-CoV-2 by the validated Xpert Xpress SARS-CoV-2 *** patients were able to cooperate,oropharyngeal saliva samples were ***,nasopharyngeal and deep throat swabs were taken by registered ***:A total of 15 CRAO patients(7 males,8 females)were identified during the 9-month study *** mean age was 72.1-years(range 45-88 year).None of the patients were infected by SARS-CoV-2 before their CRAO disease *** patients had a history of CRAO over the contralateral *** patient was diagnosed with COVID-19 up to their last follow-up(mean 255.4 days,range 152-341 days).Without any COVID-19 positive case,correlation statistical tests on SARS-CoV-2 infection and CRAO were not ***:Some of the presumed COVID-19 related CRAO cases may be just coincident with at-risk patients,as COVID-19 is prevalent across the *** in-depth research,with adjustment to known confounding risk factors,is needed to establish a genuine correlation.

关键词： COVID-19 Coronavirus SARS-CoV-2 Retinal artery occlusion Central retinal artery occlusion Hyperbaric oxygen therapy

Importance of well-designed meta-analyses in assessing medical and surgical treatments

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World Journal of Meta-Analysis 2023年第7期11卷 313-316页

作者： sunny chi lik au Department of Ophthalmology Tung Wah Eastern HospitalHong KongChina

When evaluating the efficacy of medical or surgical treatments,the most robust study design is often considered to be the high-quality randomized clinical trial(RCT).However,the true answer lies in the meta-analysis of high-quality *** RCTs have their merits,meta-analyses possess two crucial qualities that make them superior:Generalizability and the ability to verify replicability across different trials.A well-designed meta-analysis,defined here as a systematic review that pools data,holds significant advantages over individual *** and observational surgical research is prone to biases that are not mutually offsetting;instead,they *** bias,transfer bias,and assessment bias all taint retrospective studies more than randomized trials,making the novel treatment appear more effective than it truly *** studies suffering from these limitations in a meta-analysis amplifies these biases,causing an overestimation of treatment *** becomes particularly concerning when the treatment itself carries substantial risks,as is often the case in surgical *** consequences can result in harm or even death for *** a well-designed meta-analysis is the best tool for assessing medical and surgical treatments,a weak meta-analysis amplifies biases and promotes flawed *** readers must become proficient in honing their methodological toolkits,delving deeper into topics like heterogeneity and publication *** is essential to avoid wasting time on meta-analyses drawing data from retrospective or observational research regarding surgical treatments.

关键词： Meta-analysis Systematic review Methodology Research Journal Academic

COVID-19 vaccine-related retinal vascular occlusion

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Journal of Acute Disease 2023年第6期12卷 254-254页

作者： Wai Yan Lam sunny chi lik au Department Ophthalmology Grantham HospitalHong KongChina Department Ophthalmology Tung Wah Eastern HospitalHong KongChina

Retinal artery or vein occlusion(RAVO)is the ocular analog of cerebral stroke,and the iatrogenic causes,such as vaccines,were reported[1].The popularity of COVID-19 vaccines caused concerns about their potential association with RAVO[2,3].To investigate this potential association,we searched PubMed,MEDLINE,and EMBASE on March 28,2023,with the following keywords:[“retinal artery occlusion”OR“retinal vein occlusion”]AND“COVID-19 vaccines”.

关键词： occlusion vaccines artery

Nanofluids:Critical issues,economics and sustainability perspectives

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Particuology 2024年第4期87卷 147-172页

作者： Sayantan Mukherjee Sylwia Wcislik Purna Chandra Mishra Paritosh Chaudhuri Instiute for Plasma Research Gandhinagar GujaratIndia Department of Building Physics and Renewable Energy Faculy of Environmental EngineeringGeodesy and Renewable EnergyKielce University of TechnologyAleja Tysiaclecia Panstwa Polskiego 7.25-314 KielcePoland Thermal Research Laboratory(TRL) School of Mechanical Engineering.KIT Deemed to be UniversityBhubaneswarOdishaIndia Homi Bhabha National Instirute(HBNI) AnushaktinagarMumbai 400094India

According to the Scopus database,every year several hundreds of new research papers are published in the field of *** area is attracting growing attention because of the significant improvement in the heat transfer and energy efficiency of the systems working with ***,as results from numerous scientific studies conducted by independent laboratories,there are several fundamental problems related to the unambiguous determination of their physical properties,their production,and economic *** most studies often focus on one issue or cover one kind of research or math-ematical correlation,this review paper provides insights into many problems during nanofluids research by proposing solving possibilities,which is the strength of our *** paper discusses the case of nanofluids quality,and morphology,thermal conductivity enhancement and the discrepancies in mathematical modelling,errors in dimensional and similarity analysis,nanofluid erosion,safety guide-lines,and toxicology ***,the sustainability and economics of nanofluids usage are also being discussed.

关键词： Nanofluids Thermal conductivity Stability Erosion Economics Sustainability

Bilateral Valsalva retinopathy after general anesthesia: A case report

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Journal of Acute Disease 2020年第3期9卷 131-133页

作者： sunny chi lik au Department of Ophthalmology Tung Wah Eastern Hospital Hong Kong China

Rationale: Symptoms of floaters and signs of retinal hemorrhages are common acute visual complaints and diagnoses. Diabetic or hypertensive retinopathy is prevalent, yet their differential of Valsalva retinopathy is *** concerns: A 32-year-old lady presented with floaters was found to have bilateral multi-layered retinal hemorrhages one day after laparoscopic surgery under general anesthesia. Diagnosis: Bilateral Valsalva retinopathy after general anesthesia. Interventions: The patient was offered observational conservative treatment. Outcomes: Multi-layered retinal hemorrhages resolved, but with residual left eye metamorphopsia from epiretinal membrane formation. Lessons: Valsalva retinopathy can be differentiated from common diabetic or hypertensive retinopathy by its characteristics of multi-layered hemorrhage. Valsalva retinopathy after general anesthesia is a rare disease. General anesthesia can cause Valsalva retinopathy in a few ways: intubation, positioning, iatrogenic Valsalva maneuver intra-operatively, post-operative coughing or vomiting, etc. In addition, permanent visual impairment could sometimes occur.

关键词： Valsalva maneuver Retinopathy Vitreous hemorrhage Retinal hemorrhage General anesthesia

Cardiac implantable therapeutic medical devices:A narrative review

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Journal of Acute Disease 2021年第3期10卷 93-97页

作者： Christine Pui Sum Ho sunny chi lik au Li Ka Shing Faculty of Medicine the University of Hong KongHong KongChina Special Out-Patient Clinic Pamela Youde Nethersole Eastern HospitalHong KongChina

Heart diseases are common life-threatening acute *** are leading causes of mortality worldwide,especially significant in developed *** than medications for therapies and prophylaxis,special treatment considerations with implantable cardiac devices are important to reduce mortality and medical *** paper aims to review indications,contraindications,efficacy,complications,and generic considerations of several commonly implanted cardiac devices including pacemakers,cardiac resynchronization devices,implantable cardiac defibrillators,left atrial appendage occlusion watchman devices,and ventricular assist *** various implantable therapeutic cardiac devices are sometimes carried in the bodies of patients with cardiac disease,practitioners of various specialties should be familiar with different cardiac devices on the management of different cardiac conditions while providing holistic care.

关键词： Cardiology Cardiac devices Heart disease Therapeutics Implants

Corneal perforation and rare primary adenocarcinoma of the lacrimal gland: A case report

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Journal of Acute Disease 2020年第5期9卷 227-230页

作者： sunny chi lik au Edwin Chan Simon Tak Chuen Ko Department of Ophthalmology Tung Wah Eastern HospitalHong KongChina

Rationale:Primary adenocarcinoma of the lacrimal gland is rare,and its presentation as corneal perforation is even *** perforation is an ocular emergency that warrants urgent ophthalmic surgery,yet complete staging of lacrimal gland tumor pre-operatively is essential for optimal oncological ***'s concerns:A 57-year-old man presented with left eye pain was found to have left eye proptosis and fleshy tissue mass around the *** tissue was prolapsing over the perforated keratitis cornea,and the eye was full of ***:Bedside ultrasound B-scan confirmed vitreous haze,and emergency contrast computed tomography(CT)revealed soft tissue density mass(>40 mm)molding around the left globe and optic nerve without any rim enhancing *** exogenous endophthalmitis from exposure keratopathy secondary to proptosis caused by the bulky lacrimal tumor located in the confined orbital cone was ***:Emergency enucleation surgery of the left eyeball was done for this painful blind eye to control the infection from *** walls were biopsied intra-operatively,and tumor staging was completed by positron emission tomography-CT scan and magnetic resonance *** evidence of metastasis,left orbital exenteration was followed by adjuvant orbital chemoradiotherapy for the sake of close proximity of resection ***:Left exenterated orbit was fully epithelialized at around 2 months,and there was no recurrence of the disease up to present at the 1 year ***:Thorough workup on the staging of the disease to minimize the number of operations for oncological patients is always a top priority,yet it may not always be possible as in our case presenting with corneal perforation.

关键词： Lacrimal apparatus Adenocarcinoma Orbital neoplasms Corneal perforation Keratitis Eye enucleation