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Oncologic outcomes with and without amniotic membranes in robotic-assisted radical prostatectomy:A propensity score matched analysis

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Asian Journal of Urology 2024年第1期11卷 19-25页

作者： Jonathan Noël Daniel Stirt Marcio Covas Moschovas sunil reddy Abdel Rahman Jaber Marco Sandri Seetharam Bhat Travis Rogers Subuhee Ahmed Anya Mascarenhas Ela Patel Vipul Patel Advent Health Global Robotics Institute CelebrationFLUSA University of Central Florida College of Medicine OrlandoFLUSA Big and Open Data Innovation Laboratory University of BresciaItaly SUNY Upstate Medical University SyracuseNYUSA Kansas City University College of Medicine Kansas CityMOUSA Harvard University CambridgeMAUSA

Objective:Placement of human placenta derived grafts during robotic-assisted radical prostatectomy(RARP)hastens the return of continence and potency.The long-term impact on the oncologic outcomes remains to be investigated.Our objective was to determine the oncologic outcomes of patients with dehydrated human amnion chorion membrane(dHACM)at RARP compared to a matched cohort.Methods:In a referral centre,from August 2013 to October 2019,599 patients used dHACM in bilateral nerve-sparing RARP.We excluded patients with less than 12 months follow-up,simple prostatectomy,and unilateral nerve-sparing.Patients with dHACM(amnio group)were 529,and were propensity score matched 1:1 to 2465 patients without dHACM(non-amnio group)and a minimum follow-up of 36 months.At the time of RARP,dHACM was placed around the neurovascular bundle in the amnio group.Continuous and categorical variables in matched groups was tested by two-sample Kolmogorov-Smirnov test and Fisher's exact test respectively.Outcomes measured were biochemical recurrence(BCR),adjuvant and salvage therapy rates.Results:Propensity score matching resulted in two groups of 444 patients.Cumulative incidence functions for BCR did not show a difference between the groups(p=0.3).Patients in the non-amnio group required salvage therapy more frequently than the amnio group,particularly after partial nerve-sparing RARP(6.3%vs.2.3%,p=0.001).Limitations are the absence of prospective randomization.Conclusion:The data suggest that using dHACM does not have a negative impact on BCR in patients.Outcomes of cancer specific and overall survival will require follow-up study to increase our understanding of these grafts’impact on prostate cancer biology.

关键词： Prostatectomy Prostatecancer Robotic Oncology Outcome Allograft Biomaterial Dehydrated human amnionchorion membrane

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Ipsilateral fractures of the acromion and coracoid processes of the scapula

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Chinese Journal of Traumatology 2024年第2期27卷 121-124页

作者： Yusuf Omar Qalib Srinivasa reddy Medagam sunil Dachepalli Department of Orthopaedics The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai519000GuangdongChina Department of Orthopaedics Yashoda HospitalsSomajigudaHyderabadTelangana500082India

A fracture of the acromion and coracoid processes of scapula is rarely seen in the outpatient clinic,due to the acromion's anatomical position and shape,as well as the strong ligaments and muscles that are attached to it.These fractures are caused by either direct or indirect high-energy trauma injuries to the shoulder joint,leading to severe pain and a grossly restricted range of motion.Several acromial classifications were reported,but this type of longitudinal plane fracture of the acromion process in our case is yet to be described in the current literature.We present a rare combination of the coracoid process and unstable acromion bony projection fractures that have not previously been noted for this type of fracture.The closest to this is Kuhn's type III classification.A 51-year-old male presented to our emergency department complaining of the right shoulder pain and difficulty raising his arm following a 2-wheeler accident.The patient was managed by open reduction and internal fixation with 3 cannulated cancellous screws fixation and progressed well with no postoperative complications.He was asymptomatic postoperatively and regained full range of motion after 4 months.

关键词： Acromion Scapular fracture Coracoid process

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Design,synthesis and screening of some novel benzoxazole based 1,3,4-oxadiazoles as potential antimicrobial agents

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Chinese Chemical Letters 2013年第7期24卷 625-628页

作者： sunil Vodela Raghu Vardhan reddy Mekala Ravinder reddy Danda Venkateshwarlu Kodhati Talla Padmavathi College of Engineering SomidiKazipet 506003Andhra PradeshIndia Department of Chemistry Kakatiya UniversityWarangal 506009Andhra PradeshIndia Department of Chemistry Mahathma Gandhi UniversityNalgonda 508254Andhra PradeshIndia Vaagdevi College of Pharmacy RamnagarHanamkonda 506001Andhra PradeshIndia

A series of novel 2-（5-substituted-[ 1,3,4]oxadiazol-2-yl）-benzoxazoles （Ta-h） were synthesized in good yields in two different directions by involving benzoxazole-2-carboxylic acid （1） as raw material and benzoxazole-2-carbonyl chloride （2）, benzoxazole-2-carboxylic acid methyl ester （3）, benzoxazole-2- carboxylic acid hydrazide （4）, benzoxazole-2-carboxylic acid N＇-acetyl hydrazide （Sa-d） and benzoxazole-2-carboxylic acid-ethylidene-hydrazides （6a-d） as reactive intermediates. The chemical structures of all the synthesized compounds were elucidated by their IR, 1H NMR and 13C NMR and mass spectral data. Further, the target compounds were screened for their antimicrobial activity against various Gram-positive and Gram-negative bacteria.

关键词： Benzoxazoles 1,3,4-Oxadiazoles Antimicrobial activity

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Magnesium based surface metal matrix composites by friction stir processing

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Journal of Magnesium and Alloys 2016年第1期4卷 52-61页

作者： B.Ratna sunil G.Pradeep Kumar reddy Hemendra Patle Ravikumar Dumpala Department of Mechanical Engineering Rajiv Gandhi University of Knowledge Technologies(AP-IIIT)Nuzvid 520202India Department of Mechanical Engineering Vignana Bharathi Institute of TechnologyHyderabad 501301India Department of Mechanical Engineering Visvesvaraya National Institute of TechnologyNagpur 440010India

Surface metal matrix composites(MMCs)are a group of modern engineered materials where the surface of the material is modified by dispersing secondary phase in the form of particles or fibers and the core of the material experience no change in chemical composition and structure.The potential applications of the surface MMCs can be found in automotive,aerospace,biomedical and power industries.Recently,friction stir processing(FSP)technique has been gaining wide popularity in producing surface composites in solid state itself.Magnesium and its alloys being difficult to process metals also have been successfully processed by FSP to fabricate surface MMCs.The aim of the present paper is to provide a comprehensive summary of state-of-the-art in fabricating magnesium based composites by FSP.Influence of the secondary phase particles and grain refinement resulted from FSP on the properties of these composites is also discussed.

关键词： Surface composites Friction stir processing Hardness Light weight Magnesium alloys Biomedical implants

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Influence of bimodal grain size distribution on the corrosion behavior of friction stir processed biodegradable AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2016年第1期4卷 68-76页

作者： N.Saikrishna G.Pradeep Kumar reddy Balakrishnan Munirathinam B.Ratna sunil Department of Mechanical Engineering Rajiv Gandhi University of Knowledge Technologies(AP-IIIT)Nuzvid 521202India Department of Mechanical Engineering Vignana Bharathi Institute of TechnologyHyderabad 501301India Department of Metallurgical and Materials Engineering Indian Institute of Technology MadrasChennai 600036India

In the present study,AZ31 magnesium alloy sheets were processed by friction stir processing(FSP)to investigate the effect of the grain refinement and grain size distribution on the corrosion behavior.Grain refinement from a starting size of 16.4±6.8µm to 3.2±1.2µm was attained after FSP.Remarkably,bimodal grain size distribution was observed in the nugget zone with a combination of coarse(11.62±8.4µm)and fine grains(3.2±1.2µm).Due to the grain refinement,a slight improvement in the hardness was found in the nugget zone of FSPed AZ31.The bimodal grain size distribution in the stir zone showed pronounced influence on the corrosion rate of FSPed AZ31 as observed from the immersion and electrochemical tests.From the X-ray diffraction analysis,more amount of Mg(OH)_(2) was observed on FSPed AZ31 compared with the unprocessed AZ31.Polarization measurements demonstrated the higher corrosion current density for FSPed AZ31(8.92×10^(−5)A/cm^(2))compared with the unprocessed condition(2.90×10^(−5)A/cm^(2))that can be attributed to the texture effect and large variations in the grain size which led to non-uniform galvanic intensities.

关键词： AZ31 Mg alloy Biodegradable implants Grain size distribution Corrosion Friction stir processing,texture

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Impact of medial open-wedge high tibial osteotomy for medial compartment osteoarthritis of the knee

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World Journal of Orthopedics 2020年第12期11卷 606-614页

作者： sunil Sheshrao Nikose Devashree Nikose Aditya L Kekatpure Shashank Jain Kiran Saoji Sridhar M reddy Department of Orthopedic and Trauma Surgery Jawaharlal Nehru Medical CollegeWardha 442001MaharashtraIndia General Doctor NKP Salve Institute of Medical SciencesNagpur 440019MaharashtraIndia

BACKGROUND Most populations worldwide,who are used to squatting and sitting cross-legged for their activities of daily living,largely comprise the lower socioeconomic strata,thus making them candidates for exclusion for total knee arthroplasty.Proximal/high tibial osteotomy(HTO)is a preferred strategy for clinically symptomatic osteoarthritis(OA)with genu varum due to painful medial compartment OA which is not amenable to conservative measures.AIM To evaluate the outcomes of medial open-wedge HTO along with autologous bone grafting and buttress plate for the treatment of genu varum due to OA of the knee in a rural population of central India.METHODS A total of 65 knees in 56 patients with a mean age of 58.22±5.63 years with genu varum due to intractable painful knee OA were treated with medial open-wedge HTO along with autologous bone grafting and buttress plate osteosynthesis from June 2015 to May 2018.The mean preoperative radiological angle of genu varum was 13.4°.Clinical outcomes were assessed by the range of movement,knee scores,pain scores,and functional scores.Radiographic studies were performed preoperatively and at regular intervals during the follow-up period.RESULTS All patients reported pain relief immediately after the osteotomy and during the long-term analysis covering between one to three years.The genu varum angle was overcorrected to approximately four degrees in all patients.There was a loss of reduction by approximately three degrees in all patients at around six weeks postoperatively.Preoperative knee movements were restored in all patients.No major perioperative complications were noted during surgery and postoperative follow-up and the clinical scores were significantly improved during the final analysis which revealed good pain relief.CONCLUSION Medial open-wedge HTO is a reliable,safe,practical,physiological,and feasible treatment for populations who are used to increased activity in their occupation and lifestyle and is associated with excellent short-term and long-term results for OA i

关键词： High tibial osteotomy Total knee arthroplasty Genu varum Osteoarthritis Osteosynthesis Knee Society Score

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An investigation on the hardness and corrosion behavior of MWCNT/Mg composites and grain refined Mg

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Journal of Magnesium and Alloys 2018年第1期6卷 83-89页

作者： N.Saikrishna G.Pradeep Kumar reddy Balakrishnan Munirathinam Ravikumar Dumpala M.Jagannatham B.Ratna sunil Department of Mechanical Engineering Rajiv Gandhi University of Knowledge Technologies(AP-IIIT)Nuzvid 520201India Department of Mechanical Engineering Vignana Bharathi Institute of TechnologyHyderabad 501301India Department of Metallurgical and Materials Engineering Indian Institute of Technology MadrasChennai 600036India Department of Mechanical Engineering Visvesvaraya National Institute of Technology(VNIT)Nagpur 440010India Reactor Engineering Division Bhabha Atomic Research CentreMumbai-400085India Department of Materials Science and Engineering Department Delft University of TechnologyDelftNetherlands

In the present work,multi walled carbon nanotubes(MWCNT)reinforced magnesium(Mg)matrix composite was fabricated by friction stir processing(FSP)with an aim to explore its mechanical and electrochemical behavior.Microstructural observations showed that the thickness of the produced composite layer was in the range of 2500μm.FSP resulted uniform distribution of CNT near the surface while agglomerated layers in the subsurface.Grain refinement of Mg achieved by FSP improved the hardness but significant enhancement in the hardness value was observed for FSPed MWCNT/Mg composites.Potentiodynamic polarization studies revealed that the increase in corrosion current density was observed for MWCNT/Mg composite compared with grain refined Mg and pure Mg,implying the significance of secondary phase(MWCNT)in decreasing the corrosion resistance of the composite.

关键词： Friction stir processing MWCNT/Mg composite Hardness Basal texture Corrosion resistance

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Effect of aluminum content on machining characteristics of AZ31 and AZ91 magnesium alloys during drilling

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Journal of Magnesium and Alloys 2016年第1期4卷 15-21页

作者： B.Ratna sunil K.V.Ganesh P.Pavan G.Vadapalli Ch Swarnalatha P.Swapna P.Bindukumar G.Pradeep Kumar reddy Department of Mechanical Engineering Rajiv Gandhi University of Knowledge Technologies(AP-IIIT)Nuzvid 521202India Department of Mechanical Engineering Vignana Bharathi Institute of TechnologyHyderabad 501301India

Magnesium(Mg)and its alloys are now becoming the promising choice for various structural applications due to their low density and high specific strength compared with other light metals such as aluminum and its alloys.Among all Mg alloys,AZ(aluminum and zinc)series is the most widely used alloy system for various structural applications.But,machining of magnesium and its alloys involves certain issues due to their brittle nature and risk of inflammability unlike other nonferrous metals.Particularly,alloys with considerable amount of secondary phase may exhibit different machining characteristics during metal cutting operations.In the present study,two AZ series alloys AZ31 and AZ91 were selected and drilling operation was performed to assess the effect of the secondary phase amount and distribution on machining characteristics.Drilling operation was carried out at different sets of process parameters and cutting forces were obtained and the chips which have been produced during drilling were analyzed.From the results,it can be clearly understood that the presence of secondary phase(Mg_(17)Al_(12))has a significant influence on cutting forces.Increase in cutting speed has reduced the required cutting force and load fluctuations in all the cases.

关键词： Light metals Magnesium Drilling AZ series Cutting force Compounds

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Joining of AZ91 Mg alloy and Al6063 alloy sheets by friction stir welding

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Journal of Magnesium and Alloys 2018年第1期6卷 71-76页

作者： B.Lakshmana Prasad G.Neelaiah M.Gopi Krishna S.V.V.Ramana K.Sai Prakash G.Sarika G.Pradeep Kumar reddy Ravikumar Dumpala B.Ratna sunil Department of Mechanical Engineering Rajiv Gandhi University of Knowledge Technologies(AP-IIIT)Nuzvid 520201India Department of Mechanical Engineering Vignana Bharathi Institute of TechnologyHyderabad 501301India Department of Mechanical Engineering Visvesvaraya National Institute of TechnologyNagpur 440010India

In the present work,the effect of process parameters on joining of AZ91 Mg alloy and Al6063 aluminum alloy sheets during friction stir welding(FSP)was studied.A successful joint was achieved at 1100 r.***.m.tool rotational speed and 25 mm/min tool travel speed.Combination of tool rotational speed and tool travel speed has observed a profound effect on the material flow mechanisms at the nugget zone.From the microstructural studies,the joint formation was observed as mainly due to mechanical mixing of the materials.The level of metallurgical continuity at the nugget zone was observed as poor and a sharp interface at the joint was noticed.The microhardness measurements across the weld joint also revealed the lack of establishment of a perfect metallurgical bonding.X-ray diffraction analysis of weld zone showed presence of both magnesium and aluminum.Hence from the preliminary observations,it can be understood that the joining of AZ91 Mg alloy and Al6063 alloy can be achieved by FSP;however,complex issues in material mixing still need further investigations.

关键词： Friction stir welding Dissimilar joints Magnesium Aluminum Nugget zone

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Joining of AZ31 and AZ91 Mg alloys by friction stir welding

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Journal of Magnesium and Alloys 2015年第4期3卷 330-334页

作者： B.Ratna sunil G.Pradeep Kumar reddy A.S.N.Mounika P.Navya Sree P.Rama Pinneswari I.Ambica R.Ajay Babu P.Amarnadh Department of Mechanical Engineering Rajiv Gandhi University of Knowledge Technologies(AP-IIIT)Nuzvid 521202India Department of Mechanical Engineering Vignana Bharathi Institute of TechnologyHyderabad 501301India

Two dissimilar magnesium(Mg)alloy sheets,one with low aluminium(AZ31)and another with high aluminium(AZ91)content,were successfully joined by friction stir welding(FSW).The effect of process parameters on the formation of hot cracks was investigated.A sound metallurgical joint was obtained at optimized process parameters(1400 rpm with 25 mm/min feed)which contained fine grains and distributed β(Mg_(17)Al_(12))phase within the nugget zone.An increasing trend in the hardness measurements has also confirmed more amount of dissolution of aluminium within the nugget zone.A sharp interface between nugget zone and thermo mechanical affected zone(TMAZ)was clearly noticed at the AZ31 Mg alloy side(advancing)but not on the AZ91 Mg alloy side(retreating).From the results it can be concluded that FSW can be effectively used to join dissimilar metals,particularly difficult to process metals such as Mg alloys,and hot cracking can be completely eliminated by choosing appropriate process parameters to achieve sound joint.

关键词： Dissimilar metal joining Magnesium alloys Friction stir welding AZ31 AZ91

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