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Increased Activity of Nk.Cells and Plasmacytoid Dendritic Cells in HIV-Exposed Seronegative (ESN) Individuals

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World Journal of AIDS 2012年第1期2卷 6-16页

作者： Anuj Singla Roland Jacobs Reinhold E. Schmidt Ajay Wanchu sunil k. arora Clinic for Immunology and Rheumatology Hannover Medical School Hannover Germany Departments of Immunopathology Post Graduate Institute of Medical Education and Research Chandigarh India Internal Medicine Post Graduate Institute of Medical Education and Research Chandigarh India

The mechanisms involved in resistance to HIV-1 infection, especially the role of innate immune response, have not been thoroughly explored in individuals who are repeatedly exposed to HIV-1, but do not get the infection, termed as Exposed sero-negative or ESN. Frequency and activation state of natural k.ller (Nk. cells and plasmacytoid dendritic cells (pDC) in ESNs from North India were compared with those in recently infected HIV positives (RHIV), chronically infected HIV positives (HIV+) and healthy controls (HC). The activation state of Nk.cells in terms of cytok.ne response (IFNγ & TNFα) was significantly higher in ESNs compared to the healthy controls, recently infected HIV+ and chronically infected HIV+. Although the number of circulating pDC in different study groups was not significantly different, yet these cells seem to have significantly higher activation state in terms of IFNα production (ex-vivo in response to CpG ODN) in ESNs when compared with other groups. Increased activation status of Nk.cells and pDC in Exposed but Seronegative individuals indicates their continuous stimulation with HIV antigens due to regular exposure with infected partners and which might be imparting resistance to viral infection in these individuals.

关键词： HIV Exposed Seronegative Innate Immune Responses Nk Cells Plasmacytoid Dendritic Cells

Agreement in experimental and theoretically obtained electrocaloric effect in optimized Bi^(3+)doped PbZr_(0.52)Ti_(0.48)O_(3)material

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Journal of Advanced Dielectrics 2022年第3期12卷 17-27页

作者： Shubhpreet k.ur Mehak.arora sunil k.mar Parambir Singh Malhi Mandeep Singh Anupinder Singh Department of Physics Guru Nanak Dev UniversityAmritsar143001 PunjabIndia Department of Chemistry Guru Nanak Dev UniversityAmritsar143001 PunjabIndia

This work.harmonizes the experimental and theoretical study of electrocaloric effect(ECE)in(Pb_(0.8)Bi_(0.2))(Zr_(0.52)Ti_(0.48))O_(3)solid solution by optimizing sintering ***^(3+)-doped PbZr_(0.52)Ti_(0.48)O_(3)solid solutions were synthesized by the conventional solid-state reaction *** samples were prepared by varying the sintering temperature.X-ray diffraction study con-firms the crystalline nature of all the *** immense value of polarization has been acquired in the optimized *** maximum adiabatic temperature change of order 2.53 k.with electrocaloric strength of 1.26 k.mm k.^(−1)has been achieved *** a comparatively close value of ECE has been acquired from the theoretical calculations using a phenomeno-logical ***,a large value(218 mJ cm^(−3))of thermal energy conversion has been obtained using the Olsen cycle.

关键词： Ferroelectrics solid-state reaction method electrocaloric effect energy harvesting

Ipsilateral open anterior hip dislocation and open pos- terior elbow dislocation in an adult

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Chinese Journal of Traumatology 2014年第1期17卷 60-62页

作者： sunil k.mar Ak.ilesh Rathi sunil Sehrawat Vik.s Gupta Jatin Talwar Sumit arora Central Institute of Orthopaedics Vardhman Mahavir Medical College & Associated Safdarjung Hospital New Delhi 110029 India

臀部的开的前面的脱臼在成年人特别是很稀罕的损害。它是 hyperabduction 外部旋转和延期损害。它有肘的开的以后的脱臼的联合没在英语基于语言的医药文学被描述。主要复活清创术脱臼和足够的抗菌素支持的迫切减小在我们的病人导致了好... 详细信息

臀部的开的前面的脱臼在成年人特别是很稀罕的损害。它是 hyperabduction 外部旋转和延期损害。它有肘的开的以后的脱臼的联合没在英语基于语言的医药文学被描述。主要复活清创术脱臼和足够的抗菌素支持的迫切减小在我们的病人导致了好临床的结果。在 18 ；月后续大腿骨的头或感染的 avascular 坏死的迹象都没被观察。

关键词：髋关节脱位肘关节成人医学文献语言基础心肺复苏股骨头抗生素

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Missed posterior shoulder dislocation with malunited proximal humerus fracture

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Chinese Journal of Traumatology 2013年第6期16卷 375-378页

作者： sunil k.mar Rajesh k.mar Chopra Abhishek.k.shyap Sumit arora Central Institute of Orthopaedics Vardhman MahavirMedical College & Safdarjung Hospital New Delhi 110029India

肩膀的以后的脱臼可以特别在开发国家在起始的表示被错过或忽视。我们在场与肱骨的解剖的颈的 malunited 骨折一起有右肩膀的 3 月的错过的以后的脱臼的 40 岁的印度人的一个案例。有修改 McLaughlin 过程的开的减小和稳定被执行。近似... 详细信息

肩膀的以后的脱臼可以特别在开发国家在起始的表示被错过或忽视。我们在场与肱骨的解剖的颈的 malunited 骨折一起有右肩膀的 3 月的错过的以后的脱臼的 40 岁的印度人的一个案例。有修改 McLaughlin 过程的开的减小和稳定被执行。近似肱骨的旋转截骨术不得不作为增补过程被表现在运动的功能的范围期间在浅窝的洞使肱骨的头稳定。在 3 年后续的肩膀的耐心的有的优秀结果。

关键词：肩关节肱骨骨折发展中国家不作为程序稳定解剖

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Rare double fracture-dislocation of the thumb： a case report and review of the literature

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Chinese Journal of Traumatology 2013年第4期16卷 240-242页

作者： Davinder Singh Loveneesh G k.ishna sunil Dhak. Surender k.mar Sumit arora Central Institute of Orthopaedics Vardhman MahavirMedical College & Safdarjung Hospital New Delhi 110029India

metacarpophalangeal (MCP ) 的关节和脱臼连接的姆指 carpometacarpal (CMC ) 的同时的破裂 / 脱臼被看作一个稀罕损害模式。我们报导与底的 extraarticular 骨折联系的姆指联合的 MCP 的背面的脱臼的一个不平常的案例第一在一个 28 ... 详细信息

metacarpophalangeal (MCP ) 的关节和脱臼连接的姆指 carpometacarpal (CMC ) 的同时的破裂 / 脱臼被看作一个稀罕损害模式。我们报导与底的 extraarticular 骨折联系的姆指联合的 MCP 的背面的脱臼的一个不平常的案例第一在一个 28 岁的人掌部。MCP 关节的脱臼在一个外部中心在起始的表示期间被错过了。病人与 1.25 使一个平静恢复追随者成为了开的减小和固定；与尺骨的并行的系带的修理一起的 MCP 关节的公里 k.rschner 电线。这个损害模式以前没在英语语言的基于的医药文学就我们的知识而言被报导。

关键词：医学文献骨折拇指复习 MCP 关节 CMC 伤害

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Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-Ⅱexpression on dendritic cells in chronic hepatitis C infection

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World Journal of Gastroenterology 2016年第22期22卷 5173-5182页

作者： Shallu Tomer Yogesh k.Chawla Ajay Duseja sunil k.arora Department of Immunopathology Postgraduate Institute of Medical Education and Research Department of Hepatology Postgraduate Institute of Medical Education and Research

AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 ***: This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral therapy. Myeloid DCs were isolated from the peripheral blood of each subject using CD1c(BDCA1)+ DC isolation k.t. Monocytes from healthy donor were cultured with DC growth factors such as IL-4 and GM-CSF either in the presence or absence of hepatitis C virus(HCV) viral proteins followed by LPS stimulation. Phenotyping was done by flowcytometry and gene expression profiling was evaluated by real-time ***: Non-responders [sustained virological response(SVR)-ve] to conventional antiviral therapy had significantly higher expression of genes associated with interferon responsive element such as IDO1 and PD-L1(6-fold) and negative regulators of JAk.STAT pathway such as SOCS(6-fold) as compared to responders(SVR+ve) to antiviral therapy. The downregulated genes in non-responders included factors involved in antigen processing and presentation mainly belonging to major histocompatibility complex(MHC) Class-Ⅱ family as HLA-DP, HLA-DQ(2-fold) and superoxide dismutase(2-fold). Cells grown in the presence of HCV viral proteins had genes downregulated for factors involved in innate response, interferon signaling, DC maturation and co-stimulatory signaling to T-cells, while the genes for cytok.ne signaling and Toll-lik. receptors(4-fold) were upregulated as compared to cells grown in absence of viral ***: Underexpressed MHC class-Ⅱ genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs.

关键词： Dendritic cells Hepatitis C Non-responders Negative regulators Major histocompatibility complex Clas

Evaluation of dielectric,energy storage and multiferroic properties of PrFeO_(3)-PbTiO_(3)solid solutions

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Journal of Advanced Dielectrics 2022年第5期12卷 19-31页

作者： Mehak.arora Shubhpreet k.ur sunil k.mar Parambir Singh Malhi Mandeep Singh Anupinder Singh Department of Physics Guru Nanak Dev UniversityAmritsar 143001 PunjabIndia Department of Chemistry Guru Nanak Dev UniversityAmritsar 143001 PunjabIndia

This work.promotes the room temperature energy storage properties of the *** this approach,impacts of PrFeO_(3)doping on PT-based solid solutions(Pb1−xPrxTi1−xFexO_(3),x=0.21,0.22,0.23,0.24,0.25 and 0.26)have been explored.X-ray diffraction(XRD)patterns were used to estimate the crystallographic parameters,confirming the single phase tetragonal *** ferroelectric Curie temperature(Tc FE)is observed to drop from 410 k.to below room temperature as the Pr concentration *** ferroelectric P-E loops were used to determine the energy storage values at room *** sample x=0.24 achieved the maximum value of energy storage density of 362.25 mJ/cm^(3)with the efficiency of 40.5%.The ferroelectric P-E loops were used to determine the energy storage values at room *** validity of magnetoelectric coupling in all samples was confirmed by magneto-dielectric studies and found that the sample x=0.24 shows the maximum response with the coupling coefficient(γ)=15.54 g^(2)/emu^(2).

关键词： Ferroelectrics energy storage multiferroics magneto-dielectric coupling coefficient.

Dendritic cells: The warriors upfront-turned defunct in chronic hepatitis C infection

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World Journal of Hepatology 2015年第19期7卷 2202-2208页

作者： Meenak.hi Sachdeva Yogesh k.Chawla sunil k.arora Department of Immuno-pathology Post Graduate Institute of Medical Education and Research Department of Hepatology Post Graduate Institute of Medical Education and Research

Hepatitis C virus(HCV) infection causes tremendousmorbidity and mortality with over 170 million people infected worldwide. HCV gives rise to a sustained, chronic disease in the majority of infected individuals owing to a failure of the host immune system to clear the virus. In general, an adequate immune response is elicited by an efficient antigen presentation by dendritic cells(DCs), the cells that connect innate and adaptive immune system to generate a specific immune response against a pathogen. However, HCV seems to dysregulate the activity of DCs, mak.ng them less proficient antigen presenting cells for the optimal stimulation of virusspecific T cells, hence interfering with an optimal antiviral immune response. There are discordant reports on the functional status of DCs in chronic HCV infection(CHC), from no phenotypic or functional defects to abnormal functions of DCs. Furthermore, the molecular mechanisms behind the impairment of DC function are even so not completely elucidated during CHC. Understanding the mechanisms of immune dysfunction would help in devising strategies for better management of the disease at the immunological level and help to predict the prognosis of the disease in the patients receiving antiviral therapy. In this review, we have discussed the outcomes of the interaction of DCs with HCV and the mechanisms of DC impairment during HCV infection with its adverse effects on the immune response in the infected host.

关键词： Dendritic cells Hepatitis C Mechanism of functiona

Immunology of hepatocellular carcinoma

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World Journal of Hepatology 2015年第17期7卷 2080-2090页

作者： Meenak.hi Sachdeva Yogesh k.Chawla sunil k.arora Department of Immuno- pathology Postgraduate Institute of Medical Education and Research Department of Hepatology Postgraduate Institute of Medical Education and Research

Hepatocellular carcinoma(HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. A diverse array of infiltrating immunocytes regulates the development and progression of HCC, as is the case in many other cancers. An understanding of the various immune components during HCC becomes necessary so that novel therapeutic strategies can be designed to combat the disease. A dysregulated immune system(including changes in the number and/or function of immune cells, cytok.ne levels, and the expression of inhibitory receptors or their ligands) plays a k.y role in the development of HCC. Alterations in either the innate or adaptive arm of the immune system and cross-talk.between them mak. the immune system tolerant to tumors, leading to disease progression. In this review, we have discussed the status and roles of various immune effector cells(e.g., dendritic cells, natural k.ller cells, macrophages, and T cells), their cytok.ne profile, and the chemok.ne-receptor axis in promoting or impeding HCC.

关键词： Hepatocellular carcinoma Immune cells Immune-dysregulation Adaptive immunity Innateimmunity