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Identifying timing and risk factors for early recurrence of resectable rectal cancer: A single center retrospective study

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2842-2852页

作者： Tsung-Jung Tsai Kai-Jyun Syu Xuan-Yuan Huang Yu Shih Liu chang-Wei Chen Yen-Hang Wu Ching-Min Lin Yu-Yao chang Division of Colon and Rectal Surgery Department of SurgeryChanghua Christian HospitalChanghua 50006TaiwanChina Department of Surgery Changhua Christian HospitalChanghua 50006TaiwanChina Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUnD Colorectal cancer is a common malignancy and various methods have been introduced to decrease the possibility of *** recurrence(ER)is related to worse *** date,few observational studies have reported on the analysis of rectal ***,we reported on the timing and risk factors for the ER of resectable rectal cancer at our *** To analyze a cohort of patients with local and/or distant recurrence following the radical resection of the primary *** Data were retrospectively collected from the institutional database from March 2011 to January *** data at diagnosis,perioperative and postoperative data,and first recurrence were collected and *** was defined via receiver operating characteristic *** factors were evaluated using the Kaplan–Meier method and Cox proportional hazards *** We included 131 *** optimal cut off value of recurrence-free survival(RFS)to differentiate between ER(n=55,41.9%)and late recurrence(LR)(n=76,58.1%)was 8 *** median post-recurrence survival(PRS)of ER and LR was 1.4 mo and 2.9 mo,respectively(P=0.008)but PRS was not strongly associated with RFS(R^(2)=0.04).Risk factors included age≥70 years[hazard ratio(HR)=1.752,P=0.047],preoperative concurrent chemoradiotherapy(HR=3.683,Pn(HR=2.221,P=0.036),and length of stay>9 d(HR=0.441,P=0.006).COnCLUSIOn RFS of 8 mo was the optimal cut-off *** ER was not associated with PRS,it was still related to prognosis;thus,intense surveillance is recommended.

关键词： Rectal cancer Early recurrence Prognosis Post-recurrence survival

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In-beam gamma rays of CSnS Back-n characterized by black resonance filter

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nUCLEAR SCIEnCE AnD TECHnIQUES 2024年第10期35卷 1-12页

作者： Wang, Jin-Cheng Ren, Jie Jiang, Wei Ruan, Xi-Chao Liu, Ying-Yi Yang, Hao-Lan Xu, Kuo-Zhi Pan, Xin-Yi Sun, Qi Bao, Jie Huang, Han-Xiong Bai, Hao-Fan Bai, Jiang-Bo Cao, Ping Chen, Qi-Ping Chen, Yong-Hao Duan, Wen-Hao Fan, An-Chuan Fan, Rui-Rui Feng, chang-Qing Gu, Min-Hao Han, chang-Cai Han, Zi-Jie He, Guo-Zhu He, Yong-Cheng Hong, Yang Hu, Yi-Wei Jiang, Zhi-Jie Kang, Ling Lan, chang-Lin Li, Bo Li, Feng Li, Qiang Li, Xiao Li, Yang Liu, Jie Liu, Rong Liu, Shu-Bin Liu, Yi-na Luan, Guang-Yuan ning, chang-Jun Qiu, Yi-Jia Ren, Wen-Kai Ren, Zhi-Zhou Song, Zhao-Hui Sun, Kang Tan, Zhi-Xin Tang, Jing-Yu Tang, Sheng-Da Wang, Li-Jiao Wang, Peng-Cheng Wang, Zhao-Hui Wen, Zhong-Wei Wu, Xiao-Guang Wu, Xuan Wu, Ze-Peng Xia, Cong Xie, Li-Kun Yi, Han Yu, Tao Yu, Yong-Ji Zhang, Guo-Hui Zhang, Hang-chang Zhang, Qi-Wei Zhang, Xian-Peng Zhang, Yu-Liang Zhang, Zhi-Yong Zhao, Mao-Yuan Zhou, Zhi-Hao Zhu, Ke-Jun Zou, Chong China Inst Atom Energy Key Lab Nucl Data Beijing 102413 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China Spallat neutron Source Sci Ctr Dongguan 523803 Peoples R China Chinese Acad Sci Inst High Energy Phys State Key Lab Particle Detect & Elect Beijing 100049 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Peking Univ Sch Phys State Key Lab Nucl Phys & Technol Beijing 100871 Peoples R China Fudan Univ Inst Modern Phys Shanghai 200433 Peoples R China Univ Sci & Technol China State Key Lab Particle Detect & Elect Hefei 230026 Peoples R China Univ Sci & Technol China Sch Nucl Sci & Technol Hefei 230026 Peoples R China Univ Sci & Technol China Dept Modern Phys Hefei 230026 Peoples R China China Acad Engn Phys Inst Nucl Phys & Chem Mianyang 621900 Peoples R China Univ Sci & Technol China USTC Archaeometry Lab Hefei 230026 Peoples R China northwest Inst nucl Technol Xian 710024 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China Univ Sci & Technol China Inst Adv Technol Hefei 230027 Peoples R China

The back-streaming white-neutron beamline (Back-n) of the China Spallation neutron Source is an essential neutron- research platform built for the study of nuclear data, neutron physics, and neutron applications. Many types of cross-sectional neutron-reaction measurements have been performed at Back-n since early 2018. These measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron beam. These gamma rays, commonly referred to as in-beam gamma rays, can induce a non-negligible experimental background in neutron-reaction measurements. Studying the characteristics of in-beam gamma rays is important for understanding the experimental background. However, measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons; thus, discriminating between neutron-induced signals and those from in-beam gamma rays is difficult. In this study, we propose the use of the black resonance filter method and a CeBr3 scintillation detector to measure the characteristics of the in-beam gamma rays of Back-n. Four types of black resonance filters, Ta-181, Co-59, Ag-nat, and Cd-nat, were used in this measurement. The time-of-flight (TOF) technique was used to select the detector signals remaining in the absorption region of the TOF spectra, which were mainly induced by in-beam gamma rays. The energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr3 scintillation detector and using Monte Carlo simulations. Based on the results of this study, the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated, which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n Black filter resonance technique In-beam gamma rays Back-n CeBr3 scintillator Black filter resonance technique C6D6 DETECTOR SYSTEM LInE

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Highly Weak-light Sensitive and Dual-band Switchable Photodetector Based on CuI/Si Unilateral Heterojunction

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无机材料学报 2024年第9期39卷 1063-1069页

作者： YAnG Jialin WAnG Liangjun RUAn Siyuan JIAnG Xiulin YAnG chang Key Laboratory of Polar Materials and Devices(MOE) Shanghai Center of Brain-inspired Intelligent Materials and DevicesDepartment of ElectronicsEast China Normal UniversityShanghai 200241China Institute of Intelligent Flexible Mechatronics Jiangsu UniversityZhenjiang 212013China Cell R&D Center JA Solar Holdings Co.LtdYangzhou 225000China

In recent years,copper iodide(CuI)is an emerging p-type wide bandgap semiconductor with high intrinsic Hall mobility,high optical absorption and large exciton binding ***,the spectral response and the photoelectric conversion efficiency are limited for CuI-based heterostructure devices,which is related to the difficulty in fabrication of high-quality CuI thin films on other *** this study,a p-CuI/n-Si photodiode has been fabricated through a facile solid-phase iodination *** the CuI thin film is polycrystalline with obvious structural defects,the CuI/Si diode shows a high weak-light sensitivity and a high rectification ratio of 7.6×10^(4),indicating a good defect *** is because of the unilateral heterojunction behavior of the formation of the p^(+)n *** this work,the mechanism of photocurrent of the p^(+)n diode has been studied *** monochromatic lasers with wavelengths of 400,505,635 and 780 nm have been selected for testing the *** zero-bias voltage,the device is a unilateral heterojunction,and only visible light can be absorbed at the Si *** the other hand,when a bias voltage of-3 V is applied,the photodiode is switched to a broader“UV-visible”band response ***,the detection wavelength range can be switched between the“Visible”and“UV-visible”bands by adjusting the bias ***,the obtained CuI/Si diode was very sensitive to weak light illumination.A very high detectivity of 10^(13)-1014 Jones can be achieved with a power density as low as 0.5μW/cm^(2),which is significantly higher than that of other Cu-based *** findings underscore the high application potential of CuI when integrated with the traditional Si industry.

关键词： er iodide heterojunction photodetector

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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing Wei chang Chen neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/n-methyl-Daspartate(AMPA/nMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

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MMCSC:一种跨模态的假新闻检测方法

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东北大学学报（自然科学版） 2024年第1期45卷 18-25页

作者：赵越郝琨赵敬信俊昌东北大学医学与生物信息工程学院辽宁沈阳110169 东北大学计算机科学与工程学院辽宁沈阳110169 辽宁省大数据管理与分析重点实验室辽宁沈阳110169

目前基于新闻内容的假新闻检测方法没有考虑到不同模态更高层的语义关联,缺少可以依据的信息对新闻进行判断,从而缺乏对有重要辨别特征的新闻的社交网络信息进行有效使用.针对这个问题,提出了基于新闻内容的假新闻检测方法,通过提取文... 详细信息

目前基于新闻内容的假新闻检测方法没有考虑到不同模态更高层的语义关联,缺少可以依据的信息对新闻进行判断,从而缺乏对有重要辨别特征的新闻的社交网络信息进行有效使用.针对这个问题,提出了基于新闻内容的假新闻检测方法,通过提取文本、图像和视频等多模态新闻的高层语义特征,分析不同模态高层语义信息,设计跨模态主题一致性和跨模态情感一致性计算方法.在此基础上,设计了一种跨模态内容语义一致性的假新闻检测模型MMCSC(multi-modal feature content semantic consistency).实验证明,相比于传统方法,所提出的MMCSC有较好的检测效果.

关键词：假新闻检测内容语义一致性跨模态主题一致性跨模态情感一致性

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Carbon dots-incorporated CuSeO_(3)rationally regulates activity and selectivity of the hydrogen species via light-converted electrons

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Chinese Chemical Letters 2024年第1期35卷 332-337页

作者： Yuqi Ren Hongxu Zhang Caihong Hao Qing chang ning Li Jinlong Yang Shengliang Hu Research Group of new Energy Materials and Devices North University of ChinaTaiyuan 030051China State Key Laboratory of new Ceramics and Fine Processing Tsinghua UniversityBeijing 100084China

The chemoselective hydrogenation of structurally diverse nitroaromatics is a challenging ***,catalyst activity tends to decrease when excellent selectivity is *** here present a novel photocatalyst combining amino-functionalized carbon dots(n-CDs)with copper selenite nanoparticles(n-CDs@CuSeO_(3))for simultaneously improving selectivity and *** visible light irradiation,the prepared n-CDs@CuSeO_(3)exhibits 100%catalytic selectivity for the formation of 4-aminostyrene at full conversion of 4-nitrostyrene in aqueous solvent within a few *** excellent photocatalytic performance is mainly attributed to the precise control of the hydrogen species released from the ammonia borane by means of light-converted electrons upon n-CDs@CuSeO_(3).Besides,the defect states at the interface of n-CDs and CuSeO_(3)enable holes to be trapped for promoting separation and transfer of photogenerated charges,allowing more hydrogen species to participate in catalytic reaction.

关键词： Heterostructure Carbon dots Photocatalysis Chemoselective hydrogenation Copper selenite

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Association of education with cholelithiasis and mediating effects of cardiometabolic factors:A Mendelian randomization study

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World Journal of Clinical Cases 2024年第20期12卷 4272-4288页

作者： chang-Lei Li Yu-Kun Liu Ying-Ying Lan Zu-Sen Wang Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Oncology Medicine The Affiliated Hospital of Qingdao UniversityQingdao 266002Shandong ProvinceChina

BACKGROUnD Education,cognition,and intelligence are associated with cholelithiasis occurrence,yet which one has a prominent effect on cholelithiasis and which cardiometabolic risk factors mediate the causal relationship remain *** To explore the causal associations between education,cognition,and intelligence and cholelithiasis,and the cardiometabolic risk factors that mediate the *** Applying genome-wide association study summary statistics of primarily European individuals,we utilized two-sample multivariable Mendelian randomization to estimate the independent effects of education,intelligence,and cognition on cholelithiasis and cholecystitis(FinnGen study,37041 and 11632 patients,respectively;n=486484 participants)and performed two-step Mendelian randomization to evaluate 21 potential mediators and their mediating effects on the relationships between each exposure and *** Inverse variance weighted Mendelian randomization results from the FinnGen consortium showed that genetically higher education,cognition,or intelligence were not independently associated with cholelithiasis and cholecystitis;when adjusted for cholelithiasis,higher education still presented an inverse effect on cholecystitis[odds ratio:0.292(95%CI:0.171-0.501)],which could not be induced by cognition or *** out of 21 cardiometabolic risk factors were perceived as mediators of the association between education and cholelithiasis,including body mass index(20.84%),body fat percentage(40.3%),waist circumference(44.4%),waist-to-hip ratio(32.9%),and time spent watching television(41.6%),while time spent watching television was also a mediator from cognition(20.4%)and intelligence to cholelithiasis(28.4%).All results were robust to sensitivity *** Education,cognition,and intelligence all play crucial roles in the development of cholelithiasis,and several cardiometabolic mediators have been identified for prevention of choleli

关键词： Cholelithiasis Mendelian randomization Mediation analysis Education attainment Cardiometabolic risk factors Cognition Intelligence

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Exposure Patterns of Multiple Pesticides and Urinary Alterations of Trimethylamine(TMA)and Trimethylamine n‑Oxide(TMAO)among Pregnant Women

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Environment & Health 2024年第3期2卷 126-139页

作者： Jiayun Ding Yiming Dai Zheng Wang Boya Zhang Sinan Xu Jianqiu Guo Xiaojuan Qi Dasheng Lu Xiuli chang Chunhua Wu Jiming Zhang Zhijun Zhou Key Laboratory of Public Health Safety of Ministry of Education Key Laboratory of Health Technology Assessment of National Health CommissionSchool of Public HealthFudan UniversityShanghai 200032China Shanghai Municipal Center for Disease Control and Prevention Shanghai 200336China

Environmental exposure to pesticides is widespread and commonly occurs in mixtures,and pregnant women are particularly *** n-oxide(TMAO),a dietary-derived catabolite linked to cardiometabolic disease,may be influenced by pesticide ***,limited knowledge exists regarding the associations,and studies have primarily been restricted to single *** address this gap,we examined the associations of pesticide exposure with urinary TMA,TMAO,and TMAO-to-TMA ratio among 1067 pregnant women residing in a rural *** class analysis(LCA)was applied to identify distinct patterns of pesticide exposure based on urinary metabolite *** linear regression(MLR)models and Bayesian kernel machine regression(BKMR)models were employed to estimate the effects of single pesticides,exposure patterns,and combined *** distinct pesticide exposure patterns were *** concentrations of pesticide metabolites were found to be associated with increased urinary TMAO levels(β:0.043 to 0.254,pn the MLR models for individual pesticides and exposure patterns,carbofuran phenol(CFP),pentachlorophenol(PCP),and 2-phenylphenol(OPP)exhibited positive associations with urinary TMA concentrations,while pyrethroid pesticide metabolites were correlated with the up-regulation of the TMAO-to-TMA *** positive associations of pesticide mixtures with TMA,TMAO,and TMAO-to-TMA ratio were observed in the BKMR model,primarily driven by PCP and *** findings provided a perspective to reveal that the mechanisms and contributions to TMAO alterations may vary among different pesticides in mixture exposure.

关键词： pesticide exposure trimethylamine trimethylamine n-oxide exposure patterns mixture exposure

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Reliability Analysis of a Switched Reluctance Starter/Generator

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Protection and Control of Modern Power Systems 2024年第1期9卷 112-121页

作者： Hao Chen Fan Yang Lijun Xu Qiwei Lu Xiqiang chang Xing Wang Lijiang Dong Yi Wen Jiang Chen Gang Miao Jianmin Hu Guanjun Wang Wei Li Xiaohua Bao School of Electrical Engineering China University of Mining and TechnologyXuzhou 221116China Xinjiang Institute of Engineering Urumqi 830000China International Joint Research Center of Central and Eastern European Countries on new Energy Electric Vehicle Technology and Equipment Xuzhou 221008China International Cooperation Joint Laboratory of new Energy Power Generation and Electric Vehicles of Jiangsu Province Colleges and Universities Xuzhou 221008China School of Information and Electrical Engineering China University of Mining and TechnologyXuzhouChina China University of Mining and Technology(Beijing) BeijingChina State Grid Xingjiang Electric Power Co. Ltd.UrumqiXinjiangChina China University of Mining and Technology XuzhouChina State Grid Xinjiang Company Limited Electric Power Research Institute UrumqiXinjiangChina Xinjiang Fukang Pumped Storage Power Company Limited UrumqiXinjiangChina State Grid Urumqi Electric Power Supply Company UrumqiXinjiangChina Wuxi Inspection and Testing Certification Research Institute WuxiJiangsuChina Anhui Wannan Electric Machine Co. Ltd.WannanAnhuiChina Hefei University of Technology in Electrical and Automation Engineering

In this paper,the combined k-out-of-n:G model and reliability block diagram model is used to analyze the reliability of a switched reluctance starter/generator ***,the different operational modes of a switched reluctance motor starter/generator are analyzed,and the fault states of the system are briefly *** the fault criteria of the system in different operational states are put ***,a relia-bility block diagram model is established to calculate the system-level reliability,and the k-out-of-n:G model is adopted to analyze the reliability of each part of the switched reluctance starter/generator *** verify effectiveness,the first-order Markov model is also used to analyze the reliability of each part of the switched reluc-tance starter/generator *** the compu-tational complexity and accuracy of the system,the k-out-of-n:G model is more suitable for system component level reliability ***,a 6/4 switched reluctance motor is used as the simulated and experimental platform *** final results verify the effectiveness of the reliability analysis model.

关键词： system switched generator

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基于第一性原理的β-C_(3)n_(2)笼中原子嵌入引起的超硬磁性新材料设计

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Science China Materials 2024年第6期67卷 2032-2038页

作者：孙丽萍付波涛常景 College of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610068China College of Physics and Electronic Engineering Center for Computational SciencesSichuan Normal UniversityChengdu 610068China

基于第一性原理计算,我们通过将客体原子嵌入β-C_(3)n_(2)笼状结构的内在空腔中,预测了机械超硬和可控磁性的共存.以氢掺杂(H@β-C_(3)n_(2))和氟掺杂(F@β-C_(3)n_(2))为例,我们的研究表明两种掺杂构型是稳定的,并发现它们分别属于反... 详细信息

基于第一性原理计算,我们通过将客体原子嵌入β-C_(3)n_(2)笼状结构的内在空腔中,预测了机械超硬和可控磁性的共存.以氢掺杂(H@β-C_(3)n_(2))和氟掺杂(F@β-C_(3)n_(2))为例,我们的研究表明两种掺杂构型是稳定的,并发现它们分别属于反铁磁半导体和铁磁半金属.这些有趣的磁相变源于它们在费米能级周围独特的能带结构,并可通过具有半填充占据的3D Hubbard模型和Stoner模型很好地解释.此外,H@β-C_(3)n_(2)和F@β-C_(3)n_(2)的高维氏硬度(49.0和48.2 GPa)表明它们具有笼状超硬材料特征.因此,氢和氟在β-C_(3)n_(2)笼中的掺杂分别产生了一种新型的超硬反铁磁半导体和超硬铁磁半金属,这些材料在极端条件下具有潜在的应用前景.我们的工作为设计具有优异机械性能和磁性的新型高性能多功能材料提供了一种有效的策略,这可能会为超硬材料未来在自旋电子学的应用提供理论依据.

关键词： first-principles calculations clathrateβ-C_(3)n_(2) super-hard materials ferromagnetic semi-metal

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