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A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo

Nano Research 2019年第12期12卷 3024-3030页

作者： Jin Sil Lee Youngmin Hwang Hyeryeon Oh sunghyun kim Jin-Hwa kim Jeung-Hoon Lee Yong Chui Shin Giyoong Tae Won II Choi Center for Convergence Bioceramic Materials Convergence R&D DivisionKorea Institute of Ceramic Engineering and Technology202Osongsaengmyeong l-rof Osong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology123 Cheomdan-gwagiroBuk-guGwangju 61005Republic of Korea SKINMED Co. Ltd.Daejeon 34028Republic of Korea Amicogen Inc.64 Dongburo 1259JinsungJinju 52621Republic of Korea

Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in *** n A(CsA),a fungal metabolite,has been reported to be a hair growth modulatory agent and is apotential drug for hair ***,the effect of topical application of CsA is limited by its poor water *** deliverysystems developed to enhance its solubility still showed poor skin *** overcome these limitations,in this study,we have developed a novel chitosan nanocapsule platform using Pluro nic F127 and chitosan without any chemical crosslinking or complicated preparati on steps for the enhanced water solubility and high tran sdermal penetration of *** chitosan nanocapsules(ChiNCs)optimized in terms of structural stability by using chitosan with various molecular weights ranging from 3 to 100 kDa enhanced the skin permeation of CsA through humancadaver skin in *** administration of the CsA loaded ChiNCs in creased the hair follicles by c.a.7 times higher than that of thecontrol group,and effectively induced hair growth in C57BL/6 mice in *** results suggest that ChiNCs could be used as a platform foreffective transdermal delivery of various hydrophobic drugs.

关键词： chitosan nanocapsule cyclosporin A transdermal delivery hair growth

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UBR弹性体复合材料的耐磨性能和滚动阻力研究

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轮胎工业 2010年第5期30卷 290-295页

作者： Gwanghoon Kwag Pillsung kim Shin Han Seunghwon Lee Hyungkyu Choi sunghyun kim 肖大玲 Kumho Petrochemical Co. Ltd.R &BD Center Konkuk University Department of Bioscience and Biotechnology 本刊编辑部

降低滚动阻力、提高抗湿滑性能和耐磨性能是研发高性能轮胎的主要手段.淀粉/白炭黑/溶聚丁苯橡胶(SSBR)复合材料被认为是当前最先进的轮胎制备技术.提高轮胎的耐磨性能,可提高燃油经济性和保护环境,轮胎、鞋底、输送带和胶管等橡胶产品... 详细信息

降低滚动阻力、提高抗湿滑性能和耐磨性能是研发高性能轮胎的主要手段.淀粉/白炭黑/溶聚丁苯橡胶(SSBR)复合材料被认为是当前最先进的轮胎制备技术.提高轮胎的耐磨性能,可提高燃油经济性和保护环境,轮胎、鞋底、输送带和胶管等橡胶产品的耐磨性能可用来预测其使用寿命.由于油价持续偏高,降低滚动阻力是节油的关键因素.

关键词：弹性体复合材料低滚动阻力耐磨性能 UBR 高性能轮胎溶聚丁苯橡胶抗湿滑性能燃油经济性

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东亚地区的国际资本流动:本国投资是否依赖区域或全球性储蓄?(英文)

东亚地区的国际资本流动:本国投资是否依赖区域或全球性储蓄?(英...

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北京论坛（2010）文明的和谐与共同繁荣——为了我们共同的家园：责任与行动

作者： Soyoung kim sunghyun H.kim Cyn Young Park Department of Economics.Seoul National University ADB. Suffolk University

Following capital account liberalization and financial market deregulation in the early 1990s, many East Asian economies experienced a surge in international capital *** addition,these East Asian economies have taken various steps to improve regional financial cooperation and integration since the 1997/98 Asian financial ***,freely mobile international capital flows can benefit countries by efficiently matching worldwide savings and investment *** paper investigates the extent to which the domestic investment of East Asian economies is financed by domestic and foreign savings,based on the framework extended from Feldstein and Horioka(1980).In particular,this paper focuses on the role of(East Asian) regional versus global saving in financing domestic investment in order to infer the relative importance of regional versus global capital markets in East *** results show that Japanese saving has played an important role in financing domestic investment of emerging East Asian economies,while savings from G6 economies(G7 excluding Japan) have not been a significant factor.

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Spatio-temporal variability in sea surface wind stress near and off the east coast of Korea

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Acta Oceanologica Sinica 2005年第1期24卷 107-114页

作者： NAM sunghyun kim Young Ho PARK Kyung-Ae kim Kuh Ocean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 KoreaOcean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 KoreaOcean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 KoreaOcean Laboratory/RIO School of Earth and Environmental Sciences Seoul National University Seoul 151-742 Korea

Sea surface wind stress variabilities near and off the east coast of Korea, are examined using 7 kinds of wind datasets from measurements at 2 coastal (land) stations and 2 ocean buoys,satellite scatterometer (QuikSCAT), and global reanalyzed products (ECMWF,NOGAPS,and NCEP/NCAR). Temporal variabilities are analyzed at 3 frequency bands; synoptic (2-20 d), intra-seasonal (20-90 d),and seasonal (>90 d).Synoptic and intra-seasonal variations are predominant near and off the Donghae City due to the passage of the mesoscale weather system. Seasonal variation is caused by southeastward wind stress during Asian winter monsoon. The sea surface wind stress from reanalyzed *** and KMA-B measurements off the coast show good agreement in the magnitude and direction,which are strongly aligned with the alongshore *** the land-based sites,wind stresses are much weaker by factors of 3-10 due to the mountainous landmass on the east parts of Korea *** first EOF modes(67%-70%) of wind stresses from reanalyzed and QuikSCAT data have similar structures of the strong southeastward wind stress in winter along the coast but show different curl structures at scales less than 200 km due to the orographic *** second EOF modes (23%-25%) show southwestward wind stress in every September along the east coast of the North Korea

关键词： sea surface wind stress spatio-temporal variability monsoon seasonal intra-seasonal synoptic band orographic effect

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Optimistic performance of carbon-free hydrazine fuel cells based on controlled electrode structure and water management

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Journal of Energy Chemistry 2020年第12期29卷 175-181页

作者： Hongsun Hwang Sujik Hong Do-Hyeong kim Moon-Sung Kang Jin-Soo Park sunghyun Uhm Jaeyoung Lee Electrochemical Reaction and Technology Laboratory(ERTL) School of Earth Sciences and Environmental EngineeringGwangju Institute of Science and Technology(GIST)Cwangju 61005Republic of Korea Ertl Center for Electrochemistry and Catalysis Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Department of Green Chemical Engineering Sangmyung UniversityCheonanChungnam 31066Republic of Korea Plant Engineering Center Institute for Advanced EngineeringYongin 17180Republic of Korea

In this study, we first attempted to discover the optimal configuration of membrane-electrode assemblies(MEAs) used to achieve a high performance of direct hydrazine fuel cells(DHFCs). We have investigated the effect of water management and the electrode thickness on the performance of DHFCs, depending on the hydrophobicity of the gas diffusion layers in the cathode and the catalyst loading in the anode with the carbon-supported Ni, synthesized by a polyol process. With the optimal water management and electrode thickness, the MEA constructed using the as-prepared Ni/C anode catalyst containing the metallic and low oxidative state and ultra-low Pt loading cathode reduced the ohmic resistance and mass transfer limitation in the current-voltage curves observed for the alkaline DHFC, achieving an impressive power performance over 500 mW cm^(–2).

关键词： Fuel cell Hydrazine Alkaline media Membrane-electrode assembly

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Suppressive effects of acetone extract from the stem bark of three Acacia species on nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophage cells

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 658-664页

作者： Kandhasamy Sowndhararajan Rameshkumar Santhanam sunghyun Hong Jin-Woo Jhoo Songmun kim Department of Biological Environment Kangwon National University Laboratory of Natural Products Institute of Bioscience Universiti Putra Malaysia Department of Animal Products and Food Science Kangwon National University

Objective: To compare the inhibitory effects of acetone extracts from the stem bark of three Acacia species(Acacia dealbata, Acacia ferruginea and Acacia leucophloea) on nitric oxide ***: The lipopolysaccharide(LPS)-stimulated RAW 264.7 macrophage cells were used to investigate the regulatory effect of acetone extracts of three Acacia stem barks on nitric oxide production and the expression of inducible nitric oxide synthase,cyclooxygenase-2 and tumor necrosis factor-a. Further, the phenolic profile of acetone extracts from the Acacia barks was determined by liquid chromatography-mass spectrometry/mass spectrometry ***: All the three extracts significantly decreased LPS-induced NO production as well as the expression of inducible nitric oxide synthase, cyclooxygenase-2 and tumor necrosis factor-a in a concentration dependent manner(25, 50 and 75 mg/m L). In the liquid chromatography-mass spectrometry/mass spectrometry analysis, acetone extract of Acacia ferruginea bark revealed the presence of 12 different phenolic components including quercetin, catechin, ellagic acid and rosmanol. However, Acacia dealbata and Acacia leucophloea barks each contained 6 different phenolic ***: The acetone extracts of three Acacia species effectively inhibited the NO production in LPS-stimulated RAW 264.7 cells and the presence of different phenolic components in the bark extracts might be responsible for reducing the NO level in cells.

关键词： Acacia Anti-inflammatory Nitric oxide Macrophage RAW 264.7 cell

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An experimental study on thermal characteristics of nanofluid with graphene and multi-wall carbon nanotubes

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Journal of Central South University 2015年第8期22卷 3202-3210页

作者： A.K.M Mahmudul Haque sunghyun Kwon Junhyo kim Jungpil Noh Sunchul Huh Hanshik Chung Hyomin Jeong Department of Ocean System Engineering Gyeongsang National University Department of Marine Environmental Engineering Gyeongsang National University Department of Marine Engineering Mokpo National Maritime University Department of Energy and Mechanical Engineering Gyeongsang National UniversityInstitute of Marine Industry

High-thermal conductivity enhancement of nanofluid is one of the promising topics of the nanoscience research field. This work reports the experimental study on the preparation of graphene(GN) and multi-walled carbon nanotubes(MWCNTs) based nanofluids with the assistance of sodium dodecyl benzene sulfonate(SDBS) and sodium dodecyl sulfate(SDS) surfactants, and their thermal behaviors. The present work suggests not a solution, but a solution approach and deduces a new conclusion by trying to resolve the agglomeration problem and improve the dispersibility of nanoparticles in the base fluid. The analysis results of FESEM, thermal conductivity, diffusivity, effusivity and heat transfer coefficient enhancement ratio of nanofluid with surfactants SDS and SDBS expose strong evidence of the dispersing effect of surfactant on the making of nanofluid.

关键词： graphene carbon nanotube surfactant dispersibility thermal conductivity

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How Do Phytochromes Transmit the Light Quality Information to the Circadian Clock in Arabidopsis？

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Molecular Plant 2014年第11期7卷 1701-1704页

作者： Miii Yeom Hyunmin kim Junhyun Lim Ah- Young Shin sunghyun Hong Jeong-II kim Hong Gil Nam Division of Molecular and Life Sciences PohangUniversity of Science and Technology Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Integrative Biosciences & Biotechnology in POSTECH Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Department of Molecular Biotechnology and Kumho Life Science Laboratory Chonnam National University Gwangju 500-757 Republic of Korea Center for Plant Aging Research Institute for Basic Science Daegu 711-873 Republic of Korea Department of New Biology DGIST Hyeongpoong-Myun Dalsung-gun Daegu 711-873 Republic of Korea

Dear Editor, Plants use light as an environmental signal to coor- dinate diverse physiological and developmental processes, thereby increasing their fitness. Light quality, quantity, and photoperiod change periodically under natural condi- tions of daily and seasonal cycles. Plants have developed a circadian clock to respond to these predictable, periodic environmental changes, providing plants with the ability to anticipate daily and seasonal environmental changes.

关键词： STABILITY PROTEIN COP1

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Structural basis of DNA binding by the NAC transcription factor ORE1,a master regulator of plant senescence

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Plant Communications 2023年第3期4卷 139-150页

作者： Inseop Chun Hyo Jung kim sunghyun Hong Yeon-Gil kim Min-Sung kim Department of Life Sciences Pohang University of Science and Technology(POSTECH)PohangGyeongbukRepublic of Korea Center for Plant Aging Research Institute for Basic ScienceDaeguRepublic of Korea Center for Genome Engineering Institute for Basic ScienceDaejeonRepublic of Korea Pohang Accelerator Laboratory Pohang University of Science and TechnologyPohangRepublic of Korea

Plants use sophisticated mechanisms of gene expression to control senescence in response to environmental stress or ***1(Arabidopsis thaliana NAC092)is a master regulator of senescence that belongs to the plant-specific NAC transcription factor protein ***1 has been reported to bind to multiple DNA targets to orchestrate leaf senescence,yet the mechanistic basis for recognition of the cognate gene sequence remains ***,we report the crystal structure of the ORE1-NAC domain alone and its DNA-binding *** structure of DNA-bound ORE1-NAC revealed the molecular basis for nucleobase recognition and phosphate backbone *** showthat local versatility in the DNA-binding site,in combination with domain flexibility of the ORE-NAC homodimer,is crucial for the maintenance of binding to intrinsically flexible *** results provide a platformfor understanding other plant-specific NAC protein-DNA interactions as well as insight into the structural basis of NAC regulators in plants of agronomic and scientific importance.

关键词： NAC transcription factor crystal structure DNA complex senescence regulator

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