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Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats

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Neural Regeneration Research 2011年第27期6卷 2085-2093页

作者： Sun-Hwa Lee Byung-soo Ahn Bong-soo Lim Seong-Kyu Kim Sam-Ki Kim Dae-Il Lee sung-Rae cho Deok-Gon Kim Jae-Bok Han Byung-Il min Department of East-West Medicine Graduate SchoolKyunghee University Department & Research Institute of Rehabilitation Medicine Yonsei University Department of Oriental Pediatrics Kyunghee Medical CenterKyunghee University Department of Physiology College of MedicineKyunghee University

We investigated the effects of ethanol extracted Scutellaria baicalensis（EESB） on spatial memory function and neurogenesis in the hippocampal dentate *** Sprague-Dawley rats were orally administered 50,100,or 200 mg/kg of EESB for 6 successive *** radial-arm maze test showed that 200 mg/kg of EESB improved the spatial memory of adult *** microscopy results showed that 100 mg/kg of EESB increased the number of bromodeoxyuridine（BrdU）-and neuron-specific nuclear protein-positive cells in the granular cell layer,and that 100 and 200 mg/kg of EESB increased the number of BrdU-/neuron-specific nuclear protein-positive cells in the sub-granular zone.200 mg/kg of EESB increased the number of BrdU-/glial fibrillary acid protein-positive cells in the subgranular *** findings indicate that EESB can effectively promote neurogenesis in the hippocampal dentate gyrus and improve spatial memory function.

关键词： Scutellaria baicalensis neurogenesis dentate gyrus hippocampus bromodeoxyuridine neuron-specific nuclear protein glial fibrillary acidic protein neural regeneration

Self-expandable metal stents for choledocholithiasis in Billroth II gastrectomy patients

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 546-552页

作者： min-Gui Han Eunae cho Chang-Hwan Park Chung-Hwan Jun Seon-Young Park Division of Gastroenterology Department of Internal MedicineChonnam National University Hospital42Jaebong-roDong-KuGwangju 61482Korea

Background: Efficient ampullary intervention is essential for endoscopic retrograde cholangiopancreatography(ERCP) in patients with a prior Billroth II gastrectomy. We retrospectively evaluated the safety and effectiveness of ampullary intervention using fully covered self-expandable metal stents(FCSEMSs) for the management of common bile duct(CBD) stones in a subset of patients with a history of Billroth II gastrectomy. Methods: This retrospective analysis involved patients with a prior Billroth II gastrectomy who underwent ampullary intervention with FCSEMSs for the management of CBD stones. The factors associated with FCSEMSs placement, treatment success, and procedural complications were analyzed. Results: A group of 15 patients(10 males; median age, 78 years) underwent biliary metal stent placement for high degree of CBD angulation(6), small or flat papilla with unclear margin(5), current use of double antiplatelet agents or an anticoagulant(2), unwanted instrumentation of the cystic duct(1), and insecure position of the scope(1). Ampullary intervention with FCSEMSs was successful in all patients. After dilating the ampulla of Vater and building a durable conduit with FCSEMSs immediately, CBD stones were removed successfully from all patients in a single session. A mild post-ERCP pancreatitis occurred in one patient, who recovered without complications. Conclusion: Ampullary intervention with FCSEMSs is safe and effective for the management of CBD stones in a subset of patients with a history of Billroth II gastrectomy.

关键词： Common bile duct stone Endoscopic retrograde cholangiopancreatography Stent placement Stone extraction

Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

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World Journal of Gastroenterology 2005年第14期11卷 2072-2079页

作者： Seung Oe Lim sung Gyoo Park Jun-Hi Yoo Young min Park Hie-Joon Kim Kee-Taek Jang Jae Won cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park School of Biological Sciences Seoul National University SeoulKorea Hepatology Center and Laboratory of Hepatocarcinogenesis Bundang Jesaeng General Hospital KyungkidoKorea School of Chemistry Seoul National University SeoulKorea Department of Pathology Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea General Surgery Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea Internal Medicine Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea

AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related ***: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically ***: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic ***: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis.

关键词： Heat shock protein Hepatocellular carcinoma Dysplastic nodule Hepatocarcinogenesis Immunohisto-chemistry Dot immunoblot analysis

Role of Jun amino-terminal kinase （JNK） in apoptosis of cavernosal tissue during acute phase after cavernosal nerve injury

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Asian Journal of Andrology 2018年第1期20卷 50-55页

作者： Won Hoon Song Hwancheol Son Soo Woong Kim Jae-Seung Paick min Chul cho Department of Urology Seoul National University College of Medicine Seou103080 Korea Department of Urology Seoul National University Boramae Medical Center Seeu107061 Korea

The present study aimed to identify which mitogen-activated protein kinase （p38 or Jun amino-terminal kinase [JNK]） was involved in cavernosal apoptosis during the acute phase after cavernosal nerve crush injury （CNCI） in rats to ameliorate apoptosis of cavernosal tissue, such as smooth muscle （SM）. A total of twenty 10-week-old male Sprague-Dawley rats were divided equally into two groups： sham surgery （S） and CNCI （I）. The I group approximated the clinical situation of men undergoing radical prostatectomy using two 60-second compressions of both CNs with a microsurgical vascular clamp. At 2-week postinjury, erectile response was assessed using electrostimulation. Penile tissues were harvested for immunohistochemistry analysis of alpha-SM actin （（x-SMA）, western blot analysis, and double immunofluorescence analysis of （x-SMA and phosphorylated p38 or JNK, as well as double immunofluorescent of TUNEL and phosphorylated p38 or JNK. At 2-week postinjury, the I group had a significantly lower intracavernous pressure （ICP）/mean arterial pressure （MAP） and a lower area under the curve （AUC）/MAP than the S group. The I group also exhibited decreased immunohistochemical staining of α-SMA, an increase in the number of SM cells positive for phosphorylated JNK, an increased number of apoptotic cells positive for phosphorylated JNK, and increased JNK phosphorylation compared with the S group. However, there was no significant difference in p38 phosphorylation expression or the number of SM cells positive for phosphorylated p38 between the two groups. In conclusion, our data suggest that JNK, not p38, is involved in cavernosal apoptosis during the acute phase after partial CN damage.

关键词： apoptosis erectile dysfunction Jun amino-terminal kinase mitogen-activated protein kinases p38 penis prostatectomy

Dietary sophorolipid accelerates growth by modulation of gut microbiota population and intestinal environments in broiler chickens

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Journal of Animal Science and Biotechnology 2022年第1期13卷 256-264页

作者： min-Jin Kwak min-Young Park Yong-Soon choi Junghwan cho Duleepa Pathiraja Jonggun Kim Hanbae Lee In-Geol choi Kwang-Youn Whang Department of Biotechnology Korea University145 Anam-roSeoul 02841Republic of Korea Pathway Intermediates Seoul 02841Republic of Korea

Background:Gut is a crucial organ for the host’s defense system due to its filtering action of the intestinal membrane from hazardous foreign *** strategy to strengthen the gut epithelial barrier function is to upregulate beneficial microflora populations and their ***(SPL),which is a glycolipid biosurfactant,could increase beneficial microflora and decrease pathogenic bacteria in the gastrointestinal ***,herein,we conducted an experiment with broiler chickens to investigate the fortifying effects of SPL on the host’s gut defense system by modulating the microbiota ***:A total of 5401-day-old chicks(Ross 308)were used,and they were immediately allotted into three treatment groups(6 replications with 30 chicks/pen)according to their initial body *** dietary treatments consisted of CON(basal diet),BAM(10 mg/kg bambermycin),and SPL(10 mg/kg SPL).During the experiment,birds freely accessed feed and water,and body weight and feed intake were measured at the end of each *** d 35,birds(one bird/pen)were sacrificed to collect jejunum and cecum ***:Dietary SPL and BAM supplementation significantly accelerated birds’growth and also significantly improved feed efficiency compared to *** microbial community was significantly separated by dietary SPL supplementation from that of CON,and dietary SPL supplementation significantly increased Lactobacillus *** Akkermansia ***,birds fed with dietary SPL also showed the highest concentration of cecal butyrate among all treatment *** morphological analysis showed that dietary SPL significantly increased villus height,ratio of villus height to crypt depth,goblet cell numbers,and the gene expression levels of claudin-1 and mucin ***,dietary SPL significantly decreased the mRNA expression level of pro-inflammatory cytokine,interleukin-6,and increased that of anti-inflammatory cytokine,interleukin-10,compared

关键词： Broilers Gut microbiota Gut morphology Local inflammation Mucus barrier Sophorolipids

Clinical characteristics of asymptomatic Terson syndrome in the patients with aneurysmal subarachnoid hemorrhage

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 292-300页

作者： Hae min Kang Jin Mo cho So Yeon Kim Jeong Hoon choi Department of Ophthalmology Catholic Kwandong UniversityInternational St.Mary’s HospitalIncheon 22711Republic of Korea Department of Neurosurgery Catholic Kwandong UniversityInternational St.Mary’s HospitalIncheon 22711Republic of Korea Department of Ophthalmology Choikang Eye ClinicSeoul 01110Republic of Korea

●AIM:To investigate clinical characteristics of asymptomatic Terson syndrome and its clinical impact in patients with aneurysmal subarachnoid hemorrhage(SAH).●METHODS:This retrospective,interventional study included 31 patients with aneurysmal SAH,and the medical records were *** addition to baseline characteristics of the study population such as age,sex,and underlying medical history,multi-modal imaging analysis,including fluorescein angiography(FA),spectral domain optical coherence tomography(SD-OCT),were also *** Coma Scale(GCS),Hunt-Hess(HH)grade,and Fisher scale at the time of admission,and functional outcome by using modified Rankin Scale(mRS)at 6 mo were compared.●RESULTS:Of the 31 patients,10 patients(32.3%)were diagnosed with Terson *** the patients with Terson syndrome did not report visual symptoms at the time of ophthalmologic *** showed microvascular changes of retinal capillaries and varying degrees of disc ***-OCT allowed intuitive anatomical localization of multi-layered retinal hemorrhages and assessment of ellipsoid zone *** patients with Terson syndrome showed significantly worse GCS(P=0.047)and HH grade(P=0.025)than those without,except Ficher scale(P=0.385).There was no significant difference in the mRS(P=0.250)at 6 *** baseline factors,the HH grade was the only significant factor associated with Terson syndrome(B=1.079,P=0.016).●CONCLUSION:In our study,32.3%of the patients have Terson syndrome without visual *** baseline HH grade is significantly correlated with Terson syndrome,and there is no significant difference in the functional outcome between the patients with and without Terson *** syndrome may develop without any visual symptoms as shown in our study,and ophthalmologic screening may be recommended to prevent further visual deterioration especially in the patients with poor HH grade at the time of aneurysmal SAH.

关键词： cerebral aneurysm subarachnoid hemorrhage Terson syndrome

User-independent optical path length compensation scheme with sub-nanosecond timing resolution for a 1×N quantum key distribution network system

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Photonics Research 2020年第3期8卷 296-302页

作者： BYUNG KWON PARK min KI WOO YONG-SU KIM YOUNG-WOOK cho sung MOON SANG-WOOK HAN Center for Quantum Information Korea Institute of Science and TechnologySeoul 02792South Korea Division of Nano and Information Technology Korea Institute of Science and Technology SchoolKorea University of Science and TechnologySeoul 02792South Korea

Quantum key distribution(QKD)networks constitute promising solutions for secure *** conventional point-to-point QKD,we developed 1×N QKD network systems with a sub-nanosecond resolution optical path length compensation *** a practical plug-and-play QKD architecture and compact timing control modules based on a field-programmable gate array,we achieved long-term stable operation of a 1×64 QKD network *** this architecture,64 users can simultaneously share secret keys with one server,without using complex software algorithms and expensive *** demonstrated the workings of a 1×4 QKD network system using the fiber network of a metropolitan area.

关键词： network resolution distribution

Room-temperature sputtered electrocatalyst WSe2 nanomaterials for hydrogen evolution reaction

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Journal of Energy Chemistry 2020年第8期29卷 107-111,I0004页

作者： Jae Hyeon Nam Myeong Je Jang Hye Yeon Jang Woojin Park Xiaolei Wang sung Mook choi Byungjin cho Department of Advanced Material Engineering Chungbuk National UniversityChungdae-ro 1Seowon-GuCheongjuChungbuk 28644Republic of Korea Surface Technology Department Korea Institute of Materials Science797 ChangwonDaeroSungsan-guChangwon 51508Republic of Korea Advanced Materials Engineering Korea University of Science and Technology(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea Department of Chemical and Materials Engineering University of Alberta9211116 Street NWEdmontonAlberta T6C 1H9Canada

The low-temperature physical vapor deposition process of atomically thin two-dimensional transition metal dichalcogenide(2D TMD) has been gaining attention owing to the cost-effective production of diverse electrochemical catalysts for hydrogen evolution reaction(HER) applications. We, herein, propose a simple route toward the cost-effective physical vapor deposition process of 2D WSe2 layered nanofilms as HER electrochemical catalysts using RF magnetron sputtering at room temperature(mined. The surface of the sputtered WSe2 films are partially oxidized, which may cause spherical-shaped particles. Regardless of the loading amount of WSe2, Tafel slopes of WSe2 electrodes in the HER test are narrowly distributed to be ~120–138 mV dec-1, which indicates the excellent reproducibility of intrinsic catalytic activity. By considering the trade-off between the loading amount and ECSA, the best HER performance is clearly observed in the 200 W-15 min sample with an overpotential of 220 mV at a current density of 10 mA cm-2. Such a simple sputtering method at low temperature can be easily expanded to other 2D TMD electrochemical catalysts, promising potentially practical electrocatalysts.

关键词： Two dimensional nanomaterials Sputtering WSe2 nanofilm Electrocatalyst Hydrogen evolution reaction

Toxicity and Carcinogenicity of Ozone in Combination with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and Dibutyl Phthalate in B6C3F1 Mice for 16 and 32 Weeks

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Biomedical and Environmental Sciences 2009年第3期22卷 216-222页

作者： min YOUNG KIM M YUNG cho Laboratory of Toxicology College of Veterinary MedicineSeoul National University Biological Engineering Department Massachusetts Institute of Technology

Objective To evaluate the toxic and carcinogenic potential of ozone alone or in combination with 4-（N-methyl-N-nitrosamino）-1-（3-pyridyl）-1-butanone （NNK） and/or dibutyl phthalate （DBP）. Methods Male and female B6C3F1 mice were exposed, through inhalation, intravenous administration and diet, to 0.5 ppm of ozone, 1.0 mg/kg of NNK and 5000 ppm of DBP, individually and in combination for 16 and 32 weeks. Results No treatment-related death was seen, but significant differences in body and organ weights between control and treated mice were observed during the study. No incidence of lung tumor incidence was recorded in mice exposed to either ozone alone or combined treatment. Oviductal carcinomas were observed in female mice exposed to ozone or DBP alone for 16 weeks and ozone in combination with NNK and DBP for 32 weeks. Conclusion Although ozone alone and in conjunction with NNK and/or DBP does not induce lung cancer under our experimental conditions, they induce oviductal carcinomas in B6C3F1 mice.

关键词： Ozone NNK DBP Combined treatment Toxicity Carcinogenicity