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Experience of primary intestinal lymphangiectasia in adults: Twelve case series from a tertiary referral hospital

World Journal of Clinical Cases 2024年第4期12卷 746-757页

作者： Ji Eun Na Ji Eun Kim Sujin Park Eun Ran Kim sung Noh hong Young-ho Kim Dong Kyung Chang Department of Internal Medicine Inje University Haeundae Paik HospitalBusan 48108South Korea Department of Medicine Samsung Medical CenterSeoul 06351South Korea Department of Pathology Samsung Medical CenterSeoul 06351South Korea

BACKGROUND While primary intestinal lymphangiectasia(PIL)is considered a rare condition,there have been several reported cases in ***,the absence of clear guidance from diagnosis to treatment and prognosis poses challenges for both physicians and *** To enhance understanding by investigating clinical presentation,diagnosis,treatment,complications,and prognoses in adult PIL *** We enrolled adult patients diagnosed with PIL between March 2016 and September *** primary outcome involved examining the diagnosis and treatment process of these *** secondary outcomes included identifying complications(infections,thromboembolism)and assessing prognoses(frequency of hospitalization and mortality)during the follow-up *** Among the 12 included patients,peripheral edema(100%)and diarrhea(75%)were the main presenting *** tests showed that all the pati-ents exhibited symptoms of hypoalbuminemia and ***,the predominant findings were edema of the small intestine(67%)and ascites(58%).The typical endoscopic finding with a snowflake appearance was observed in 75%of *** the 12 patients,two responded positive-ly to octreotide and sirolimus,and eight who could undergo maintenance therapy discontinued *** due to PIL led to infection in half of the patients,thromboembolism in three patients,and one *** PIL can be diagnosed in adults across various age groups,with different severity and treatment responses among patients,leading to diverse complications and ***,tailored treatments will be *** anticipate that our findings will contribute to the management of PIL,an etiology of protein-losing enteropathy.

关键词： Primary intestinal lymphangiectasia in adults Protein-losing enteropathy Diagnosis Treatment Prognosis

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Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells

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Chinese Journal of Natural Medicines 2015年第1期13卷 59-64页

作者： LI Juan FENG Juan LUO Cheng Herman ho-Yung sung JIANG Ren-Wang Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization Guangxi Institute of Botany Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of Pharmacy Jinan University State Key Laboratory of New Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Department of Chemistry The Hong Kong University of Science and Technology

Podophyllotoxone(1) was isolated from the roots of Dysosma versipellis. The structure was determined by spectroscopic analysis in combination with single-crystal X-ray analysis. The absolute configuration of compound 1 was assigned based on the Flack parameter. It showed significant inhibitory activities against human prostate cancer cells PC3 and DU145 with IC50 values being 14.7 and 20.6 μmol·L-1, respectively. It also arrested the cells at G2/M phase. Tubulin polymerization assay showed that it inhibited the tubulin polymerization in a dose-dependent manner, and molecular docking analysis revealed a different binding mode with tubulin as compared with those known tubulin inhibitors.

关键词： Podophyllotoxone Absolute configuration Prostate cancer Tubulin Molecular docking

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Clinical outcomes and predictive factors in oral corticosteroid-refractory active ulcerative colitis

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World Journal of Gastroenterology 2013年第2期19卷 265-273页

作者： Han ho Jeon Hyun Jung Lee Hui Won Jang Jin Young Yoon Yoon Suk Jung Soo Jung Park sung Pil hong Tae Il Kim Won ho Kim Jae Hee Cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Brain Korea 21 Project for Medical Science Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To evaluate the clinical outcomes and prognostic factors after intravenous corticosteroids following oral corticosteroid failure in active ulcerative colitis ***:Consecutive patients with moderate to severe ulcerative colitis who had been treated with a course of intravenous corticosteroids after oral corticosteroid therapy failure between January 1996 and July 2010 were recruited at Severance hospital,Seoul,South *** disease activity was measured by the Mayo score,which consists of stool frequency,rectal bleeding,mucosal appearance at flexible sigmoidoscopy,and Physician Global *** retrospectively evaluated clinical outcomes at two weeks,one month,three months,and one year after the initiation of intravenous corticosteroid *** weeks outcomes were classified as responders or *** month,three month and one year outcomes were classified into prolonged response,steroid dependency,and ***:Our study included a total of 67 eligible *** two weeks,56(83.6%) patients responded to intravenous *** one month,complete remission was documented in 18(32.1%) patients and partial remission in 26(46.4%).Eleven patients(19.7%) were refractory to the *** three months and one year,we found 37(67.3%) and 25(46.3%) patients in prolonged response,ten(18.2%) and 23(42.6%) patients in corticosteroid dependency,8(14.5%) and 6(11.1%) patients with no response,*** 9 patients were underwent elective proctocolectomy within 1 *** duration of oral corticosteroid therapy(> 14 d vs ≤ 14 d,P = 0.049) and lower hemoglobin level(≤ 11.0 mg/dL vs >11.0 mg/dL,P = 0.02) were found to be poor prognostic factors for response at two *** one year outcome,univariate analysis revealed that only a partial Mayo score(≥ 6 vs <6,P = 0.057) was found to be associated with a poor ***:The duration of oral corticosteroid therapy and lower hemoglobin level were strongly associ

关键词： Clinical outcome Prognosis Corticosteroid Ulcerative colitis

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C-type lectin receptors as potential targets for the treatment of gastrointestinal diseases related to fungal infection

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Gastroenterology Report 2019年第5期7卷 376-377,I0003页

作者： Hyun ho Choi Mong-hong Lee Guangdong Research Institute of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Many microorganisms reside in the gastrointestinal tract and the dysbiosis of microorganisms can affect our *** have a relatively low level of presence(about 0.1%of the totalmicroorganisms)compared with bacteria,which makes it easier to underestimate their potential threat to ***,fungal infections indeed participate in the onset and progression of many intestinal diseases,so they are crucially affecting our health[1,2].Recently,Li et *** that C-type lectin receptors(CLRs)on myeloid cells,including Dectin-1,Dectin-2,Dectin-3,and Mincle,play an important role in the immune function induced by fungal pathogens of the intestinal microbiota[3].

关键词： C型凝集素受体胃肠道疾病真菌感染

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Targeting host-microbe interaction in mucus layer:a potential treatment option for diseases

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Gastroenterology Report 2019年第1期7卷 1-2,I0001页

作者： Hyun ho Choi Mong-hong Lee Guangdong Research Institute of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongP.R.China

Human gut microbiota,containing at least 100 trillion bacteria,resides in the mucosal surface of the human *** individual is host to a distinct set of at least 160 species in the *** collective microbial genome encodes 500 times more genes than the human genome,and so it is tempting to consider human genes as noise in the storm of microbial signals[1].Recent data suggest that,while microbial signals modulate crucial functions of the healthy human body,there are also accumulating data suggesting that many human diseases have their origin in distorted gut microbiota composition[2].

关键词： intestine 疾病治疗黏液层

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Influence of Tropical Cyclone Landfalls on Spatiotemporal Variations in Typhoon Season Rainfall over South China

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Advances in Atmospheric Sciences 2010年第2期27卷 443-454页

作者： Min-Hee LEE Chang-hoi ho Joo-hong KIM Computational Science and Technology Seoul National University School of Earth and Environmental Sciences Seoul National University Met Office Hadley Centre

This study examined the impact of tropical cyclone (TC) landfalls on the spatiotemporal variations in the rainfall over South China for the period 1957–2005. The target region was selected to show the noteworthy contribution of TC landfalls to the total rainfall during the typhoon season (July–October). Two prevailing spatial variations in the rainfall were obtained from an EOF analysis. The first EOF mode displays singlesign variability over South China with an explained variance of 23.4%. The associated time series of this mode fluctuates on a decadal timescale and was found to be correlated with TC genesis in the South China Sea. The second EOF mode shows a seesaw pattern between Hainan Island/Guangdong Province and the remaining regions with an explained variance of 11.4%. This seesaw pattern results from an anti-correlation in seasonal TC landfalls between the two regions, which was found in previous studies. This is related to the strengthening (weakening) of the upper tropospheric jets and the corresponding development of a massive anticyclonic (cyclonic) circulation over East Asia. The EOF analysis was also conducted using just the data for rainfall caused by landfalling TCs. This revealed that the first EOF mode using just the TC-induced rainfall is nearly identical to the second mode from the total rainfall. The obvious seesaw pattern of the first mode when employing just the TC-induced rainfall in the EOF analysis implies that this pattern has larger temporal variability than the single-signed pattern (i.e., the first EOF mode using the total rainfall) in terms of TC landfalls. This study suggests that TC landfalls over South China and the accompanying rainfall significantly modulate the spatial variation of the typhoon season rainfall there.

关键词： rainfall tropical cyclone South China typhoon season

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Connection between inflammation and carcinogenesis in gastrointestinal tract: Focus on TGF-β signaling

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World Journal of Gastroenterology 2010年第17期16卷 2080-2093页

作者： Suntaek hong ho-Jae Lee Seong Jin Kim Ki-Baik Hahm Laboratory of Cancer Cell Biology Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Laboratory of Chemoprevention Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Laboratory of Cell Regulation and Carcinogenesis Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Laboratory of Translational Medicine Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Department of Gastroenterology Gachon Graduate School of MedicineIncheon 406-840South Korea

Inflammation is a primary defense process against various extracellular stimuli,such as viruses,pathogens,foods,and environmental *** cells respond to stimuli for short periods of time,it results in acute or physiological ***,if the stimulation is sustained for longer time or a pathological state occurs,it is known as chronic or pathological *** studies have shown that tumorigenesis in the gastrointestinal (GI) tract is closely associated with chronic inflammation,for which abnormal cellular alterations that accompany chronic inflammation such as oxidative stresses,gene mutations,epigenetic changes,and inflammatory cytokines,are shared with carcinogenic processes,which forms a critical cross-link between chronic inflammation and *** growth factor (TGF)-β is a multi-potent cytokine that plays an important role in regulation of cell growth,apoptosis and *** importantly,TGF-β is a strong anti-inflammatory cytokine that regulates the development of effector ***-β has a suppressive effect on carcinogenesis under normal conditions by inhibiting abnormal cell growth,but on the other hand,many GI cancers originate from uncontrolled cell growth and differentiation by genetic loss of TGF-β signaling molecules or perturbation of TGF-β *** a tumor has developed,TGF-β exerts a promoting effect on the tumor itself and stromal cells to enhance cell growth,alter the responsiveness of tumor cells to stimulate invasion and metastasis,and inhibited immune ***,novel development of therapeutic agents to inhibit TGF-β-induced progression of tumor and to retain its growth inhibitory activities,in addition to anti-inflammatory actions,could be useful in *** this review,we discuss the role of TGF-β in inflammation and carcinogenesis of the GI tract related to abnormal TGF-β signaling.

关键词： Inflammation Carcinogenesis Transforming growth factor-β Gastrointestinal tract

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Irinotecan therapy and molecular targets in colorectal cancer: A systemic review

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World Journal of Gastroenterology 2009年第29期15卷 3597-3602页

作者： Jessica Weekes Alfred King-Yin Lam Sabe Sebesan Yik-hong ho Discipline of Surgery (School of Medicine) and North Queensland Centre for Cancer Research (Australian Institute of Tropical Medicine) James Cook University Townsville Queensland 4811 Australia Discipline of Pathology Griffith Medical School Medicine and Oral Health Centre Gold Coast Campus Gold Coast Queensland 4222 Australia Medical Oncology Townsville Hospital Townsville Queensland 4811 Australia

Irinotecan is the second line chemotherapy for advanced stage colorectal cancer (CRC) after failure of first line chemotherapy with oxaliplatin and 5-fluorouracil. The aim of this review is to analyse the data on irinotecan as second line chemotherapy for advanced CRC and the potential roles of the molecular markers, p53 and vascular endothelial growth factor (VEGF) in the management of advanced CRC. Thus, the English literature from 1980 to 2008 concerning irinotecan, p53, VEGF and CRC was reviewed. On review, Phase and clinical trials showed thatirinotecan improves pain-free survival, quality of life, 1-year survival, progression-free survival and overall survival in advanced CRC. p53 and VEGF were expressed in CRC and had a predictive power of aggressive clinical behaviour in CRC. Irinotecan sensitizes p53 wild type, mutant and null cells to Fasmediated cell apoptosis in CRC cells. Wild type p53 cells were more sensitive to irinotecan than mutated p53. Irinotecan has an anti-VEGF effect inhibiting endothelial cell proliferation, increasing apoptosis and reducing microvascular density which is onlylimited by irinotecan toxicity levels. To conclude, irinotecan improves the patient's quality of life and the survival rates of patients with advanced CRC. p53 and VEGF status of the patients' tumour is likely to affect the responsiveness of CRC to irinotecan. It is recommended that studies of the expression of these molecular markers in relation to chemoresponsiveness ofirinotecan should be carried out for better management of patients with advanced CRC.

关键词： Colorectal cancer Irinotecan Molecular p53 Vascular endothelial growth factor

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CLGA Net:Cross Layer Gated Attention Network for Image Dehazing

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Computers, Materials & Continua 2023年第3期74卷 4667-4684页

作者： Shengchun Wang Baoxuan Huang Tsz ho Wong Jingui Huang hong Deng Hunan Normal University Changsha410006China Z-emotion Pty Ltd. Victoria3178Australia

In this paper,we propose an end-to-end cross-layer gated attention network(CLGA-Net)to directly restore fog-free *** with the previous dehazing network,the dehazing model presented in this paper uses the smooth cavity convolution and local residual module as the feature extractor,combined with the channel attention mechanism,to better extract the restored features.A large amount of experimental data proves that the defogging model proposed in this paper is superior to previous defogging technologies in terms of structure similarity index(SSIM),peak signal to noise ratio(PSNR)and subjective visual *** order to improve the efficiency of decoding and encoding,we also describe a fusion residualmodule and conduct ablation experiments,which prove that the fusion residual is suitable for the dehazing ***,we use fusion residual as a fixed module for encoding and *** addition,we found that the traditional defogging model based on the U-net network may cause some information losses in *** have achieved effective maintenance of low-level feature information through the cross-layer gating structure that better takes into account global and subtle *** also present the application of our CLGA-Net in challenging scenarios where the best results in both quantity and quality can be *** results indicate that the present cross-layer gating module can be widely used in the same type of network.

关键词： Deep learning dehazing image restoration end to end

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A study on effects of ceramic foam filter on flow aspect through water modeling experiment

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China Foundry 2017年第3期14卷 216-225页

作者： ho-Young Hwang Cheol-Hee Nam Young-Sim Choi Jun-ho hong Xun Sun Cyber Manufacturing Process Group Korea Institute of Industrial Technology Incheon 21999 South Korea Department of Robotics and Virtual Engineering Korea University of Science and Technology Daejeon 34113 South Korea Materials Science and Engineering Kyoto University Kyoto 606-8501 Japan Shenyang Research Institute of Foundry Shenyang 110022 China

Casting defects that are closely related to entrapped air bubbles and metallic oxides occur very frequently in the sand mold casting process. Many researchers have shown that these defects can be reduced by adopting an appropriate gating system design. however, it is difficult for field engineers to identify a specific gating system that is more appropriate for their products. In this study, we tried to draw a comparison between two gating system designs with and without a ceramic foam filter. The ceramic foam filter was added to the horizontal runner just after the down sprue to prevent air bubble generation and reduce turbulence without a change of gating system design. The water modeling experiment was conducted with four different amounts of the initial volumes of water in the reservoir to verify the effects of initial pouring velocity. The results of the experiment applying the filter showed remarkably changed flow characteristics. The use of the filter was found to convert the flow pattern of water in the desired direction. The ceramic foam filter performed well to reduce flow velocity and stabilize the water *** flow pattern without a filter can be improved significantly even with the the use of just a 10 PPI irregular filter. Although the study confirmed that use of the filter may change the flow characteristics, it needs to be noted that the use of the ceramic filter alone cannot solve all the problems caused by a poorly designed gating system.

关键词： ceramic foam filter sprue gating system design sand mold casting casting defect

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