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Effects of arginine supplementation on splenocyte cytokine mRNA expression in rats with gut-derived sepsis

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World Journal of Gastroenterology 2005年第45期11卷 7091-7096页

作者： Huey-Fang Shang Chun-Sen Hsu Chiu-Li yeh Man-Hui Pai sung-ling yeh Department of Microbiology and Immunology Taipei Medical University Taipei Taiwan China Department of Obstetrics and Gynecology TaipeiMedical University Municipal Wan Fang Hospital Taipei TaiwanChina Department of Anatomy Taipei Medical UniversityTaipei Taiwan China School of Nutrition and HealthSciences Taipei Medical University Taipei Taiwan China

AIM: To investigate the effects of arginine (Arg)-enriched diets before sepsis and/or Arg-containing total parenteral nutrition (TPN) after sepsis or both on cytokine mRNA expression levels in splenocytes of rats with gut-derived ***: Rats were assigned to four experimental groups. Groups 1 and 2 were fed with a semipurified diet, while groups 3 and 4 had part of the casein replaced by Arg which provided 2% of the total *** the rats were fed with these diets for 10 d, sepsis was induced by cecal ligation and puncture (CLP), at the same time an internal jugular vein was cannulated. All rats were maintained on TPN for 3 d. Groups 1 and 3were infused with conventional TPN, while groups 2 and 4 were supplemented with Arg which provided 2% of the total calories in the TPN solution. All rats were killed 3 d after CLP to examine their splenocyte subpopulation distribution and cytokine expression ***: Plasma interleukin (IL)-2, IL-4, tumor necrosis factor-α (TNF-α) and interferon (IFN-γ) were not detectable 3 d after CLP. There were no differences in the distributions of CD45Ra+, CD3+, CD4+, and CD8+cells in whole blood and splenocytes among the four groups. The splenocyte IL-2 mRNA expression in the Arg-supplemented groups was significantly higher than that in group 1. IL-4 mRNA expression in groups 3 and 4was significantly higher than that in groups 1 and 2. The mRNA expression of IL-10 and IFN-γ was significantly higher in group 4 than in the other three groups. There was no difference in TNF-α mRNA expression among the four ***: The influence of Arg on the whole blood and splenic lymphocyte subpopulation distribution is not obvious. However, Arg administration, especially before and after CLP, significantly enhances the mRNA expression levels of Th1 and Th2 cytokines in the spleen of rats with gut-derived sepsis.

关键词：精氨酸脾脏细胞细胞因子 mRNA 基因表达败血症

Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen Lin Wen-Feng Fang Jui-Ning yeh John Y Chiang Hsin-Ju Chiang Pei-Lin Shao Pei-Hsun sung Hon-Kan Yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(P<0.001).The protein levels of inflammation[interleukin(IL)-1β/tumor necrosis factor(TNF)-α/nuclear factor-κB/toll-like receptor(TLR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all P<0.001).Animals were euthanized by 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all P<0.0001),whereas arterial oxygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

The Optimization Design of the Nozzle Section for theWater Jet Propulsion System Applied in Jet Skis

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2277-2304页

作者： Cheng-yeh Li Jui-Hsiang Kao Department of Systems Engineering and Naval Architecture Taiwan Ocean UniversityKeelungTaiwanChina

The performance of a water jet propulsion system is related to the inlet duct,rotor,stator,and ***,the flow inlet design must fit the bottom line of the hull,and the design of the inlet duct is often limited by stern *** entire section,from the rotor to the nozzle through the stator,must be designed based on system integration in that the individual performance of these three components will influence each ***,the section from the rotor to the nozzle significantly impacts the performance of a water jet propulsion *** study focused on nozzle design and established referable analysis results to facilitate subsequent integrated studies on the design parameters regarding nozzle *** existing studies concentrate on discussions on rotor design and the tip leakage flow of rotors or have replaced the existing complex computational domain with a simple flow ***,research has yet to implement an integrated,optimal design of the section from the rotor to the *** the above,our program conducted preliminary research on this system integration design issue,discussed the optimal nozzle for this section in-depth,and proposed design suggestions based on the *** program used an existing model as the design *** study referred to the actual trial data as the design conditions for the proposed *** prior references’simple flow field form,this study added a jet ski geometry and free surface to the computational *** the linear hull shape was considered,the inflow in the inlet duct would be closer to the actual *** on the numerical calculation result,this study recommends that the optimal nozzle outlet area should be 37%of the inlet area and that the nozzle contour should be ***,for the pump head,static pressure had a more significant impact than dynamic pressure.

关键词： Water jet propulsion system rotor nozzle outlet area nozzle contour

Effects of glutamine-containing total parenteral nutrition on phagocytic activity and anabolic hormone response in rats undergoing gastrectomy

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World Journal of Gastroenterology 2005年第6期11卷 817-822页

作者： Chen-Hsien Lee Wan-Chun Chiu Soul-Chin Chen Chih-Hsiung Wu sung-ling yeh Institute of Nutrition and Health Sciences Department of Surgery

AIM: To investigate the effect of glutamine (Gln)-containing parenteral nutrition on phagocytic activity and to elucidate the possible roles of Gin in the secretion of anabolic hormones and nitrogen balance in rats undergoing a ***: Rats with an internal jugular catheter were divided into 2 experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN (control), and in the other group, 25%of the total amino acid nitrogen was replaced with *** receiving TPN for 3 d, one-third of the rats in each experimental group were sacrificed as the baseline *** remaining rats underwent a partial gastrectomy and were killed 1 and 3 d, respectively, after surgery. Plasma,peritoneal lavage fluid (PLF), and urine samples were collected for further ***: The Gin group had fewer nitrogen losses 1 and 2 d after surgery (d1, 16.6±242.5 vs -233.4±205.9 mg/d,d2, 31.8±238.8 vs-253.4±184.6 mg/d, P＜0.05). There were no differences in plasma growth hormone (GH) and insulin-like growth factor-1 levels between the 2 groups before or after surgery. The phagocytic activity of peritoneal macrophages was higher in the Gin group than in the control group 1 d after surgery (4 1185±931 vs 323±201,P＜0.05). There were no differences in the phagocytic activities of blood polymorphonuclear neutrophils between the 2 groups at the baseline or on the postoperative *** significant differences in interleukin-1β or interleukin-6concentrations in PLF were observed between the 2 ***, tumor necrosis factor-α level in PLF was significantly lower in the Gin group than in the control group on postoperative d ***: TPN supplemented with Gin can improve the nitrogen balance, and enhance macrophage phagocytic activity at the site of injury. However, Gin supplementation has no effect on phagocytic

关键词：谷氨酸盐肠道外营养学吞噬活性合成代谢激素分泌老鼠胃切除术消化系统

Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity

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World Journal of Gastroenterology 2005年第39期11卷 6197-6201页

作者： Ming-Tsan Lin sung-Pao Kung sung-ling yeh Koung-Yi Liaw Ming-Yang Wang Ming-Liang Kuo Po-Houng Lee Wei-Jao Chen Department of Surgery and Primary Care Medicine National Talwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan China Department of Surgery School of Medicine National Yang-Ming University Taipei Taiwan China Institute of Nutrition and Health Sciences Taipei Medical University Taipei Taiwan China Department of S-urgery National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan China Laboratory of Molecular and Cellular Toxicology Institute of Toxicology National Taiwan University College of Medicine Taipei Taiwan China

AIM: To evaluate whether the effect of Gln dipeptideenriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical ***: Forty-eight patients with major abdominal surgery were allocated to two groups to receive isonitrogenous (0.228 g nitrogen/kg per d) and isocaloric(30 kcal/kg per d) TPN for 6 d. Control group (Conv)using conventional TPN solution received 1.5 g amino adds/kg per day, whereas the test group received 0.972 g amino acids/kg per day and 0.417 g L-alanyl-L-glutamine(Ala-Gln)/kg per day. Blood samples were collected on d 1 and d 6 postoperatively for plasma interleukin (IL)-2,IL-6, IL-8, and interferon (IFN)-γ ***: Plasma IL-2 and IFN-γ were not ***-6 concentrations were significantly lower on the 6th postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE Ⅱ≤6, whereas no difference was noted in patients with APACHE Ⅱ＞6. There was no difference in IL-8 levels between the two *** difference in cumulative nitrogen balance was observed on d 2-5 after the operation between the two groups(Ala-Gln -3.2±1.6 g vs Conv -6.5±2.7 g). A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv ***: TPN supplemented with Gln dipeptide had no effect on plasma IL-8 levels after surgery. However,Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered.

关键词：谷氨酸盐肠内营养白细胞介素-6 手术治疗肠疾病

补充谷氨酰胺增强肠源性败血症大鼠肠粘膜免疫功能的研究

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补充谷氨酰胺增强肠源性败血症大鼠肠粘膜免疫功能的研究

A Multi-Objective Optimization for Locating Maintenance Stations and Operator Dispatching of Corrective Maintenance

作者： Yu-Ni Lai sung-ling yeh Ming-Tsan Lin 刘艳妮王劲

1前言败血症是临床上常见的大手术病人的术后并发症。败血症时,机体受到细菌毒素侵袭,可能会发生深部组织的破坏和代谢底物的改变。全肠外营养(total parenteral nutrition,TPN)的发展为那些不宜经胃肠道进食的患者提供了摄取足够的热...

1前言败血症是临床上常见的大手术病人的术后并发症。败血症时,机体受到细菌毒素侵袭,可能会发生深部组织的破坏和代谢底物的改变。全肠外营养(total parenteral nutrition,TPN)的发展为那些不宜经胃肠道进食的患者提供了摄取足够的热量和蛋白质的途径。然而,有证据显示TPN可导致肠萎缩和肠

关键词：

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Computers, Materials & Continua 2024年第6期79卷 3519-3547页

作者： Chao-Lung Yang Melkamu Mengistnew Teshome Yu-Zhen yeh Tamrat Yifter Meles Department of Industrial Management National Taiwan University of Science and TechnologyTaipie106Taiwan Department of Industrial Engineering University of Gondar Institute of TechnologyGondar196Ethiopia

In this study,we introduce a novel multi-objective optimization model tailored for modern manufacturing,aiming to mitigate the cost impacts of operational disruptions through optimized corrective *** to our approach is the strategic placement of maintenance stations and the efficient allocation of personnel,addressing a crucial gap in the integration of maintenance personnel dispatching and station *** model uniquely combines the spatial distribution of machinery with the expertise of operators to achieve a harmonious balance between maintenance efficiency and *** core of our methodology is the NSGA Ⅲ+Dispatch,an advanced adaptation of the Non-Dominated Sorting Genetic Algorithm Ⅲ(NSGA-Ⅲ),meticulously designed for the selection of maintenance stations and effective operator *** method integrates a comprehensive coding process,crossover operator,and mutation operator to efficiently manage multiple *** empirical testing,including a detailed analysis from a taiwan region electronic equipment manufacturer,validated the effectiveness of our approach across various scenarios of machine failure frequencies and operator *** findings reveal that the proposed model significantly outperforms current practices by reducing response times by up to 23%in low-frequency and 28.23%in high-frequency machine failure scenarios,leading to notable improvements in efficiency and cost ***,it demonstrates significant improvements in oper-ational efficiency,particularly in selective high-frequency failure contexts,while ensuring substantial manpower cost savings without compromising on operational *** research significantly advances maintenance strategies in production environments,providing the manufacturing industry with practical,optimized solutions for diverse machine malfunction ***,the methodologies and principles developed in this study have pote

关键词： Corrective maintenance multi-objective optimization non-dominated sorting genetic algorithmⅢ operator allocation maintenance station location

Impact of microplastics and nanoplastics on liver health:Current understanding and future research directions

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World Journal of Gastroenterology 2024年第9期30卷 1011-1017页

作者： Chun-Cheng Chiang Hsuan yeh Ruei-Feng Shiu Wei-Chun Chin Tzung-Hai Yen School of Medicine University of PittsburghPittsburghPA 15213United States Pittsburgh Liver Research Center University of PittsburghPittsburghPA 15213United States Division of Experimental Pathology Department of PathologyUniversity of PittsburghPittsburghPA 15213United States Division of Endocrinology Department of PediatricsUniversity of PittsburghPittsburghPA 15213United States Center of Excellence for The Oceans National Taiwan Ocean UniversityKeelung 20224Taiwan Institute of Marine Environment and Ecology National Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Materials Science and Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalTaoyuan 333TaiwanChina College of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina

With continuous population and economic growth in the 21st century,plastic pollution is a major global ***,the health concern of microplastics/nanoplastics(MPs/NPs)decomposed from plastic wastes has drawn public attention only in the recent *** article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ,which is one of the primary routes that MPs/NPs enter human *** interrelated mechanisms including oxidative stress,hepatocyte energy re-distribution,cell death and autophagy,as well as immune responses and inflammation,were also *** addition,the disturbance of microbiome and gut-liver axis,and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease,steatohepatitis,liver fibrosis,and cirrhosis were briefly ***,we discussed potential directions in regard to this trending topic,highlighted current challenges in research,and proposed possible solutions.

关键词： Microplastics Nanoplastics Liver Reactive oxidative species Cell death Autophagy Innate immunity Metabolic dysfunction-associated fatty liver disease Gut-liver axis

Severe dengue in the intensive care unit

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Journal of Intensive Medicine 2024年第1期4卷 16-33页

作者： Alexandre Mestre Tejo Debora Toshie Hamasaki Letícia Mattos Menezes yeh-Li Ho Intensive Care Unit Department of Intensive Medicine of the Cancer Institute of the State of São PauloHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão PauloBrazil Transfusion Medicine and Cell Therapy Department A.C.Camargo Cancer CenterSão PauloBrazil Intensive Care Unit of Infectious Disease Department Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão PauloBrazil

Dengue fever is considered the most prolific vector-borne disease in the world,with its transmission rate increasing more than eight times in the last two *** most cases present mild to moderate symptoms,5%of patients can develop severe *** the mechanisms are yet not fully comprehended,immune-mediated activation leading to excessive cytokine expression is suggested as a cause of the two main findings in critical patients:increased vascular permeability that may shock and thrombocytopenia,and coagulopathy that can induce *** risk factors of severe disease include previous infection by a different serotype,specific genotypes associated with more efficient replication,certain genetic polymorphisms,and comorbidities such as diabetes,obesity,and cardiovascular *** World Health Organization recommends careful monitoring and prompt hospitalization of patients with warning signs or propensity for severe disease to reduce *** review aims to update the diagnosis and management of patients with severe dengue in the intensive care unit.

关键词： Severe dengue Intensive care units Shock Pathogenesis Diagnosis Management