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Fibrinogen’s potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 203-204页

作者： Vishal Singh Arnab Choudhury Hyung Jin ahn Department of Pharmacology Physiology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkNJUSA Brain Health Institute Rutgers UniversityPiscatawayNJUSA

Alzheimer’s disease(AD)stands out as the primary manifestation of age-related dementia,portraying a chronic neurodegenerative disorder distinguished by the accumulation of fibrillar amyloid-β(Aβ)plaques and neurofibrillary tangles of hyperphosphorylated ***,from a clinical standpoint,AD presents itself as a complex condition with a spectrum of dysfunctions rather than a singular pathological *** often-overlooked aspect of the disease is the presence of extensive cerebrovascular abnormalities,given that the majority of AD patients experience altered cerebral blood flow,damaged vasculature,increased microinfarcts and *** models of AD further support this observation,showing cerebrovascular dysfunction such as impaired cerebral blood flow and altered cerebrovascular reactivity(Tataryn et al.,2021;Gareau et al.,2023).

关键词： cerebrovascular dysfunction Alzheimer

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam ahn Seongjoon So Chanwoo Park Jong-Seong Bae Taehyun Park Il Tae Kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Artificial layer Dielectric constant Zn metal anode Zinc aqueous battery

RELOCATABLE MODULAR BUILDINGS FOR A SHORT-TERM INTERNATIONAL EVENT:THE PYEONG-CHANG WINTER OLYMPIC GAMES

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Journal of Green Building 2020年第3期15卷 3-35页

作者： Shin Hyun kyu Lee Joo sung Jung Chan Woo ahn Yong Han Ph.D.Student Architectural EngineeringHanyang Univ.ERICAAnsan15588Republic of Korea Research Professor Innovative Durable Building and Infrastructure Research CenterAnsan15588Republic of Korea Ph.D.&Group Leader POSCO Architectures&ConstructionsIncheon21998Republic of Korea Associate professor School of Architecture and Architectural EngineeringHanyang Univ.ERICAAnsan15588Republic of Korea

Modular methods based on the use of prefabricated structures are increasingly popular for construction projects as they contribute to sustainability by reducing waste and maintenance costs as well as improving time *** short-term international events,the use of relocatable modular buildings is a potential solution to the problem of“White Elephant”structures built specially for the events that serve no useful purpose once the event is *** paper focuses on a representative relocatable modular project created for the 2018 Winter Olympic Games in South Korea using a single case study approach to develop an in-depth understanding of the advantages and disadvantages of relocatable modular construction from a practitioner’s perspective and examine how this approach supports sustainability and the Olympic *** considerations are identified for each of the five main stages:1)planning,2)design and engineering,3)manufacturing,4)construction and 5)disassembly and *** findings show how the use of relocatable modular facilities can be a useful approach for international events.

关键词： Relocatable Building Modular Construction Prefabrication Sustainability International Event Case Study

Linearization of T-S fuzzy systems and robust H_∞ control

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Journal of Central South University 2011年第1期18卷 140-145页

作者： YOON Tae-sung 王法广 PARK Seung-kyu KWAK Gun-Pyong ahn Ho-kyun School of Mechatronics Changwon National University

Takagi-Sugeno(T-S) fuzzy model is difficult to be linearized because of membership functions ***,novel T-S fuzzy state transformation and T-S fuzzy feedback are proposed for the linearization of T-S fuzzy *** novel T-S fuzzy state transformation is the fuzzy combination of local linear transformation which transforms local linear models in the T-S fuzzy model into the local linear controllable canonical *** fuzzy combination of local linear controllable canonical model gives controllable canonical T-S fuzzy model and then nonlinear feedback is obtained *** the linearization of T-S fuzzy model,a robust H∞ controller with the robustness of sliding model control(SMC) is *** a result,controlled T-S fuzzy system shows the performance of H∞ control and the robustness of SMC.

关键词： T-S fuzzy control linearization H∞ control sliding mode control

Invariant submanifolds for systems of vector fields of constant rank

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Science China Mathematics 2016年第7期59卷 1417-1426页

作者： ahn Heung Ju HAN Chong kyu School of Undergraduate Study Daegu Gyeongbuk Institute of Sceince and Technology Department of Mathematics College of Natural SciencesSeoul National University

Given a system of vector fields on a smooth manifold that spans a plane field of constant rank, we present a systematic method and an algorithm to find submanifolds that are invariant under the flows of the vector fields. We present examples of partition into invariant submanifolds, which further gives partition into orbits. We use the method of generalized Frobenius theorem by means of exterior differential systems.

关键词： control system vector fields reachability orbits invariant submanifolds

Uranium measurements using laser-induced breakdown spectroscopy in lithium chloride-potassium chloride salt of pyroprocessing

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Plasma Science and Technology 2020年第7期22卷 110-115页

作者： Seul-Ki HAN Se-Hwan PARK Seong-kyu ahn Korea Atomic Energy Research Institute Yuseong-guDaejeon 34057Republic of Korea

In pyroprocessing,uranium(U) is recovered from molten LiCl-KCl salt,and,for safeguard purposes,it is important to analyze the U and Plutonium(Pu) concentrations in a timely *** the present work,salt samples containing U were *** laser used in the present work was an Nd:YAG laser with a wavelength of 532 nm,a laser energy on the sample of11.5 mJ,and a pulse repetition rate of 10 *** plasma emission light was measured with an Echelle spectrometer.A total of 100 points on the sample surface were measured as the laser incident position was *** U and potassium(K) peaks in the spectrum were *** and multivariate analyzes were conducted to determine the accuracy and limit of detection(LOD) of the laser-induced breakdown spectroscopy.

关键词： LIBS uranium(U) safeguards LOD

Quantitative analysis of uranium in electrorecovery salt of pyroprocessing using laser-induced breakdown spectroscopy

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Plasma Science and Technology 2021年第5期23卷 96-103页

作者： Seul-Ki HAN Se-Hwan PARK Seong-kyu ahn Korea Atomic Energy Research Institute Yuseong-guDaejeon 34057Republic of Korea Korea Institute of Industrial Technology Yeonsu-guIncheon21999Republic of Korea

The amounts of nuclear materials in the Li Cl-KCl salt in pyroprocessing have to be analyzed to prevent the diversion of the nuclear *** alternative method to the chemical analysis has been pursued,and laser-induced breakdown spectroscopy(LIBS)is one *** the present work,an in situ and quantitative analysis method of electro-recovery(ER)salt was proposed and demonstrated by using LIBS combined with dipstick *** types of simulated salt samples were prepared:ER salt sample and salt obtained from the dipstick sampling,and pulsed neodymium-doped yttrium aluminum garnet(Nd:YAG)laser with a wavelength of 532 nm was focused on the salt to generate *** plasma emission was measured by using an Echelle spectrometer with a resolution of 0.01 nm in conjunction with an Intensified Charge-Coupled Detector *** U and other rare earth peaks in the spectra were *** best Limit of Detection and Root Mean Square Error of Calibration of U were 38 ppm and 0.0203 wt%,*** work shows that the U in the pyroprocessing ER salt can be monitored with LIBS.

关键词： LIBS uranium LOD RMSEC

Effect of post heat-treatment on the microstructure and high-temperature oxidation behavior of precipitation hardened IN738LC superalloy fabricated by selective laser melting

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Journal of Materials Science & Technology 2021年第17期76卷 95-103页

作者： kyu-Sik Kim Sangsun Yang Myeong-Se Kim Kee-ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon 22212Republic of Korea Korea Institute of Materials Science Changwon51508Republic of Korea Auratech Co. Ltd.Seongnam13449Republic of Korea

The present study investigated the effect of as-built and post heat-treated microstructures of IN738LC alloy fabricated via selective laser melting process on high temperature oxidation *** as-built microstructure showed fine cell and columnar structure due to high cooling *** element segregation was observed in inter-cell/inter-columnar *** post heat-treatment,the initially-observed cell structure disappeared,instead bimodal Ni_3(Al,Ti)particles *** temperature(1273 K and 1373 K)oxidation test results showed parabolic oxidation curves regardless of temperature and initial *** as-built IN738LC fabricated via the selective laser melting process displayed oxidation resistance similar to or slightly better than that of IN738LC fabricated via wrought or cast ***-treated SLM IN738LC,although had similar oxidation weight-gain values to those of the SLM asbuilt material at 1273K,showed relatively better oxidation resistance at 1373 *** Ni_3(Al,Ti)precipitate formed in the post heat treatment changed the local chemical composition,thereby led to changes in alumina former/chromia former location and fraction on the alloy *** was concluded that in heat-treated IN738LC increased alumina former fraction was found,and this resulted in excellent oxidation resistance and relatively low weight-gain.

关键词： IN738LC Selective laser melting High temperature oxidation Post heat-treatment Oxidation mechanism