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New insights into ATR inhibition in muscle invasive bladder cancer:The role of apolipoprotein B mRNA editing catalytic subunit 3B

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Oncology Research 2024年第6期32卷 1021-1030页

作者： HYUNHO KIM UIJU CHO SOOK HEE HONG HYUNG SOON PARK IN-HO KIM HO jung AN BYOUNG YONG SHIM JIN HYOUNG KANG Division of Medical Oncology Department of Internal MedicineSt.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Department of Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Division of Medical Oncology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulKorea

Background:Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC),an endogenous mutator,induces DNA damage and activates the ataxia telangiectasia and Rad3-related(ATR)-checkpoint kinase 1(Chk1)*** cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer(MIBC),it has a poor survival ***,this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B(APOBEC3B)expressing ***:Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with *** APOBEC3B expression in MIBC cell lines was assessed using real-time polymerase chain reaction and western blot *** blot analysis was performed to confirm differences in phosphorylated Chk1(pChk1)expression according to the APOBEC3B *** viability and apoptosis analyses were performed to examine the anti-tumor activity of ATR inhibitors combined with ***:There was a significant association between APOBEC3B and ATR expression in the tumor tissues obtained from patients with *** with higher APOBEC3B expression showed higher pChk1 expression than cells expressing low APOBEC3B *** treatment of ATR inhibitor and cisplatin inhibited cell growth in MIBC cells with a higher APOBEC3B *** to cisplatin single treatment,combination treatment induced more apoptotic cell death in the cells with higher APOBEC3B ***:Our study shows that APOBEC3B’s higher expression status can enhance the sensitivity of MIBC to cisplatin upon ATR *** result provides new insight into appropriate patient selection for the effective application of ATR inhibitors in MIBC.

关键词： Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC) Ataxia telangiectasia and Rad3-related(ATR) Bladder cancer DNA damage response DNA replication stress

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Clean-DM1, a Korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressionsin Pancreas and Liver Tissues

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Chinese Journal of Integrative Medicine 2024年第2期30卷 125-134页

作者： Piao Wang Yi Liu Seok Yong Kang Chenzi Lyu Xiang Han Tianjun Ho Kyung Jae Lee Xianglong Meng Yong-Ki Park Hyo Won jung Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Korea College of Pharmacy&Graduate School of Pharmaceutical Sciences Ewha Womans UniversitySeoul 03760Korea Korean Medicine R&D Center Dongguk UniversityGyeongju 38066Korea Shanxi Key Laboratory of Traditional Herbal Medicines Processing Shanxi University of Chinese MedicineJinzhong(030619)ShanxiProvinceChina

Objective:To investigate the effects of Clean-DM1(C-DM1),a polyherbal formulation of Radix Scrophulariae,Radix Astragali,Rhizoma Atractylodis,and Radix Salviae Miltiorrhizae,on high-fat diet(HFD)-induced diabetes ***:The information about active components of C-DM1 extract and molecular mechanism was obtained from network pharmacology *** compounds of C-DM1 extract by high performance liquid chromatography-mass spectrometry(HPLC-MS)analysis were conducted for quality *** in vivo study,mice were induced diabetes by HFD for 12 *** mice in the normal group(Nor)were maintained with a regular diet and treated with saline by *** HFD model mice were randomly divided into 3 groups,including a HFD diabetic model group,a C-DM1 extract-administered group(C-DM1,500 mg/kg),and metformin-administered groups(Met,500 mg/kg),8 mice in each *** intake,body weight(BW),and fasting blood glucose(FBG)levels were recorded weekly for 4 *** 4 weeks of treatment,alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood glucose,low-density lipoprotein cholesterol(LDL-C)were determined using an automated clinical chemistry analyzer,and homeostatic model for assessing insulin resistance(HOMA-IR)levels and oral glucose tolerance test(OGTT)were *** histopathological changes of liver and pancreatic tissues were observed by hematoxylin-eosin *** receptor substrate(IRS)/phosphatidylinositol 3 kinase(PI3K)/protein kinase B(AKT)and adenosine 5'-monophosphate-activated protein kinase(AMPK)expressions in liver and pancreas tissues were detected by Western blot ***:HPLC-MS identified dihydroisotanshinone,dihydroisotanshinone I,cryptotanshinone,harpagoside,and atractyloside A in C-DM1 *** administration of C-DM1 extract significantly decreased body weight,calorie intake,and the levels of blood glucose and insulin in the diabetic mice(P<0.05 or P<0.01).The C-DM1 extract administration improved the im

关键词： high-fat diet type 2 diabetes mellitus herbal formulation insulin receptor substrate/phosphatidylinositol 3 kinase/protein kinase B adenosine 5'-monophosphate-activated protein kinase network pharmacology high performance liquid chromatography-mass spectrometry analysis

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Stercoral perforation of the cecum:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1189-1194页

作者： Hung-Chun Yu Ta-Wei Pu jung-Cheng Kang Chao-Yang Chen Je-Ming Hu Ruei-Yu Su Department of Surgery Taichung Armed Forces General HospitalTaichung 411228Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 325Taiwan

BACKGROUND With less than 90 reported cases to date,stercoral perforation of the colon is a rare *** ulceration is thought to occur due to ischemic pressure necrosis of the bowel wall,which is caused by the presence of a stercoraceous *** underscore this urgent surgical situation concerning clinical presentation,surgical treatment,and results,we present the case of a 66-year-old man with a stercoral *** SUMMARY A 66-year-old man with a history of hypertension,hyperlipidemia,and gout presented at the emergency department with lower abdominal pain and a low-grade fever lasting for a few *** computed tomography indicated a suspected bezoar(approximately 7.6 cm)in the dilated cecum,accompanied by pericolic fat stranding,mild proximal dilatation of the ileum,pneumoperitoneum,and minimal ***,feculent peritonitis with isolated cecal perforation were ***,a right hemicolectomy with peritoneal lavage was performed.A histopathological examination supported the intraoperative *** In stercoral perforations,a diagnosis should be diligently pursued,especially in older adults,and prompt surgical intervention should be implemented.

关键词： Acute abdomen Colectomy Peritoneal lavage Pneumoperitoneum Bezoars Case report

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Mucinous neoplasm of the appendix:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 944-954页

作者： Hao-Cheng Chang jung-Cheng Kang Ta-Wei Pu Ruei-Yu Su Chao-Yang Chen Je-Ming Hu Department of Surgery Tri-Service General HospitalTaipei 114TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTaiwanChina Adventist HospitalTaipei 105TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105TaiwanChina Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105TaiwanChina Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 325TaiwanChina

BACKGROUND Appendiceal mucinous neoplasms(AMNs),although not classified as rare,are relatively uncommon tumors most often discovered incidentally during colorectal *** identification of AMNs is difficult due to non-specific sym-ptoms,overlapping tumor markers with other conditions,and the potential for *** underscores the urgent need for precision in diagnosis to pre-vent severe *** SUMMARY This case report describes the unexpected discovery and treatment of a low-grade AMN(LAMN)in a 74-year-old man undergoing laparoscopic hemicolectomy for transverse colon adenocarcinoma(AC).Preoperatively,non-specific gastroin-testinal symptoms and elevated tumor markers masked the presence of *** tumor,presumed to be an AMN peritoneal cyst intraoperatively,was con-firmed as LAMN through histopathological *** neoplasm exhibited mucin accumulation and a distinct immunohistochemical profile:Positive for Ho-meobox protein CDX-2,Cytokeratin 20,special AT-rich sequence-binding protein 2,and Mucin 2 but negative for cytokeratin 7 and Paired box gene *** profile aids in distinguishing appendiceal and ovarian mucinous *** recovery was uncomplicated,and the patient initiated adjuvant chemotherapy for the colon *** This case highlights the diagnostic complexity of AMNs,emphasizing the need for vigilant identification to avert potential complications,such as pseudomyxoma peritonei.

关键词： Adenocarcinoma Appendiceal neoplasms Low-grade appendiceal mucinous neoplasm Peritoneal neoplasms Pseudomyxoma peritonei Case report

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Utilizing Blockchain Technology to Improve WSN Security for Sensor Data Transmission

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Computers, Materials & Continua 2021年第8期68卷 1899-1918页

作者： sung-jung hsia. Wen-Tsai sung Department of Information Technology Takming University of Science and TechnologyTaipei City11451Taiwan Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung41170Taiwan

This paper proposes a method for improving the data security of wireless sensor networks based on blockchain *** technology is applied to data transfer to build a highly secure wireless sensor *** this network,the relay stations use microcontrollers and embedded devices,and the microcontrollers,such as Raspberry Pi and Arduino Yun,represents mobile *** proposed system uses microcontrollers to facilitate the connection of various sensor *** adopting blockchain encryption,the security of sensing data can be effectively improved.A blockchain is a concatenated transaction record that is protected by *** section contains the encrypted hash of the previous section,the corresponding timestamp,and transaction *** transaction data denote the sensing data of the wireless sensing *** proposed system uses a hash value representation calculated by the Merkel-tree algorithm,which makes the transfer data of the system difficult to be tamped ***,the proposed system can serve as a private cloud data *** this study,the system visualizes the data uploaded by sensors and create relevant charts based on big data *** the webpage server of the proposed system is built on an embedded operating system,it is easy to model and visualize the corresponding graphics using Python or JavaScript programming ***,this study creates an embedded system mobile database and web server,which can utilize JavaScript program language and *** runtime environment to apply blockchain technology to mobile *** proposed method is verified by the experiment using about 1600 data *** results show that the possibility of data being changed is very small,and the probability of data being changed is almost zero.

关键词： Blockchain embedded system big data analysis python javascript node.js

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RFID Positioning and Physiological Signals for Remote Medical Care

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Computer Systems Science & Engineering 2022年第4期41卷 289-304页

作者： Wen-Tsai sung sung-jung hsia. Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung411030Taiwan Department of Information Technology Takming University of Science and TechnologyTaipei City11451Taiwan

The safety of patients and the quality of medical care provided to them are vital for their *** study establishes a set of RFID(Radio Fre-quency Identiﬁcation)-based systems of patient care based on physiological sig-nals in the pursuit of a remote medical care *** RFID-based positioning system allows medical staff to continuously observe the patient's health and *** staff can thus respond to medical emergencies in time and appropriately care for the *** the COVID-19 pandemic broke out,the proposed system was used to provide timely information on the location and body temperature of patients who had been screened for the *** results of experiments and comparative analyses show that the proposed system is superior to competing systems in *** use of remote monitoring technology makes user interface easier to provide high-quality medical services to remote areas with sparse populations,and enables better care of the elderly and patients with mobility *** can be found from the experiments of this research that the accuracy of the position sensor and the ability of package delivery are the best among the other related *** presentation of the graphical interface is also the most cordial among human-computer interaction and the operation is simple and clear.

关键词： Remote medical care active RFID positioning physiological signal

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Improving Speech Enhancement Framework via Deep Learning

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Computers, Materials & Continua 2023年第5期75卷 3817-3832页

Speech plays an extremely important role in social *** individuals suffer from a“speech barrier,”which limits their communication with *** this study,an improved speech recognitionmethod is proposed that addresses the needs of speech-impaired and deaf individuals.A basic improved connectionist temporal classification convolutional neural network(CTC-CNN)architecture acoustic model was constructed by combining a speech database with a deep neural *** sensors were used to convert the collected voice signals into text or corresponding voice signals to improve *** method can be extended to modern artificial intelligence techniques,with multiple applications such as meeting minutes,medical reports,and verbatim records for cars,sales,*** experiments,a modified CTC-CNN was used to train an acoustic model,which showed better performance than the earlier common *** a CTC-CNN baseline acoustic model was constructed and optimized,which reduced the error rate to about 18%and improved the accuracy rate.

关键词： Artificial intelligence speech recognition speech to text CTC-CNN

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Home Monitoring of Pets Based on AIoT

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Computer Systems Science & Engineering 2022年第10期43卷 59-75页

作者： Wen-Tsai sung sung-jung hsia. Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung City411030Taiwan Department of Information Technology Takming University of Science and TechnologyTaipei City11451Taiwan

With technological and social development in recent decades,people have begun pursuing more comfortable lives that frequently feature household pets that are treated like members of the *** average,one out of every three households has a *** has also led to the creation and growth of many businesses in the pet industry.A few companies have developed a system that allows busy office workers to remotely care for pets at home based on the Internet of Things and an intelligent adjustment *** owners of two dogs,the authors of this study observed their pets’living habits and recorded environmental conditions that appear suitable for *** data were then used to develop an automatic control system to care for *** observational data on the pets’habits and environment were written in a program in Arduino by using the ESP8266 Wi-Fi *** module and booster module control is the switch and setting of various household *** to the loop setting of the program,the system does not need to manually switch or adjust the electrical settings of the ***,the pet's living environment is assessed by using various *** use of Arduino programs helps develop a system that can automatically adjust the environment to one that is most suitable for the pet's comfort.

关键词： Remote medical care active RFID positioning physiological signal

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Utilizing the Improved QPSO Algorithm to Build a WSN Monitoring System

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Computers, Materials & Continua 2022年第2期70卷 3529-3548页

This research uses the improved Quantum Particle Swarm Optimization(QPSO)algorithm to build an Internet of Things(IoT)life comfort monitoring system based on wireless sensing *** purpose is to improve the quality of intelligent *** functions of the system include automatic basketball court lighting system,monitoring of infants’sleeping posture and accidental falls of the elderly,human thermal comfort measurement and other related life comfort services,*** the hardware system of the IoT,this research is based on the latest version of ZigBee 3.0,which uses optical sensors,3-axis accelerometers,and temperature/humidity sensors in the IoT perception *** the network transmission layer,the central network architecture is used for *** the application layer,we have designed a graphical interface for real-time values and information that can be read at any time and place using mobile *** this study,authors use the improved QPSO algorithm in the calculation part,so that the target can be effectively positioned outside the numerous surveillance *** study uses various sensor data fusion technologies to make the IoT system becomes able to provide more extensive and even better services than ever *** short,this research work has proven to be an effective way to reduce power consumption,improve medical quality and provide higher comfort for intelligent lift level.

关键词： Quantum particle swarm optimization IoT wireless sensor network ZigBee

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Alkali Metal Ion Substituted Carboxymethyl Cellulose as Anode Polymeric Binders for Rapidly Chargeable Lithium-Ion Batteries

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Energy & Environmental Materials 2024年第1期7卷 77-82页

作者： Seoungwoo Byun Zhu Liu Dong Ok Shin Kyuman Kim Jaecheol Choi Youngjoon Roh Dahee Jin Seungwon jung Kyung-Geun Kim Young-Gi Lee Stefan Ringe Yong Min Lee Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Intelligent Sensors Research Section Electronics and Telecommunications Research Institute(ETRI)Daejeon 34129Korea Department of Advanced Device Technology University of Science and Technology(UST)Daejeon 34113Korea Intelligent Polymer Research Institute and ARC Centre of Excellence for Electromaterials Science University of WollongongWollongong NSW 2522Australia Department of Chemistry Korea UniversitySeoul 02841Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea

The increasing demand for short charging time on electric vehicles has motivated realization of fast chargeable lithium-ion batteries(LIBs).However,shortening the charging time of LIBs is limited by Li^(+)intercalation process consisting of liquid-phase diffusion,de-solvation,SEI crossing,and solid-phase ***,we propose a new strategy to accelerate the de-solvation step through a control of interaction between polymeric binder and solvent-Li^(+)*** this purpose,three alkali metal ions(Li^(+),Na^(+),and K^(+))substituted carboxymethyl cellulose(Li-,Na-,and K-CMC)are prepared to examine the effects of metal ions on their *** lowest activation energy of de-solvation and the highest chemical diffusion coefficient were observed for ***,Li-CMC cell with a capacity of 3 mAh cm^(-2)could be charged to>95%in 10 min,while a value above>85%was observed after 150 ***,the presented approach holds great promise for the realization of fast charging.

关键词： de-solvation digital twins fast charging graphite anodes polymeric binders

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