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HSF1-mediated oxidative stress response to menadione in <i>Saccharomyces cerevisiae</i>KNU5377Y3 by using proteomic approach

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Advances in Bioscience and Biotechnology 2013年第1期4卷 44-54页

作者： Il-Sup Kim Hyun Kim Young-Saeng Kim Ingnyol Jin ho-sung yoon Advanced Bio-Resource Research Center Department of Biology Kyungpook National University Daegu Korea Department of Microbiology Kyungpook National University Daegu Korea

The hat shock transcription factor HSF1 inthe yeast Saccharomyces cerevisiae regulates a wide range of genes and functions in diverse cellular reactions. To investigate the physiological response of HSF1 inthe presence of menadione (MD) in S. cerevisiae KNU 5377Y3, wild-type (k3wt) and isogenic hsf1 mutant (k3h1) cells were introduced. HSF1 was induced when k3wt cells were exposed to the superoxide-generating agent MD and k3h1 cells were hypersensitive to MD. Under MD stress, k3h1 cells down-regulated the expression of metabolic enzymes (Hxk, Fba1, Pgk1, Eno2, and Adh1), antioxidant enzymes (Trx2 and porin), and molecular chaperones and their cofactors (Hsp104, Ssb1, Hsp60, Hsp42, Hsp26, Hsp12, Cpr1, and Sti1). In addition, k3h1 cells increased cellular hydroperoxide levels and protein carbonylation under MD stress as compared to k3wt cells. however, there was a moderate difference in the wild-type (b3wt) and mutant (b3h1) cells derived from S. cerevisiae S288Cunder the same conditions. Thus, these results show that HSF1 is an important component of the stress response system, acting as an activator of cell rescue genes in S. cerevisiae KNU5377Y3, and its expression protects the cells from MD-induced oxidative damage by maintaining redox homeostasis and proteostasis in the presence of MD.

关键词： Saccharomyces cerevisiae KNU5377Y3 HSF1 Gene Expression Menadione Redox

A macroscopic constitutive model of shape memory alloy considering cyclic effects

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Science China(Physics,Mechanics & Astronomy) 2013年第4期56卷 755-764页

作者： ZhoU Bo yoon sung-ho College of Pipeline and Civil Engineering China University of Petroleum School of Mechanical Engineering Kumoh National Institute of Technology

This paper presents a macroscopic constitutive model reproducing the hysteretic behaviors of the superelastic shape memory alloy (SMA) under cyclic loading. The progressive increase of residual strain with the increased cycle number in such materials is assumed to be a consequence of the progressive increase of residual stress-induced martensitic volume fraction upon the cyclic effects. The progressive decrease of phase transformation critical stresses with the increased cycle number in such materials is assumed to be a result from the progressive increase of phase transformation critical temperatures upon the cyclic effects. A cyclic evolution equation is supposed to describe the influences of cycle effects on the material properties of the SMA under cyclic loading. A phase transformation equation expressing the phase transformation behaviors of the SMA under cyclic loading is established based on the differential relationship between martensitic volume fraction and the free energy increment of phase transformation. A mechanical constitutive equation predicting the mechanical characteristics of the SMA under cyclic loading is developed on the basis of thermodynamics and continuum mechanics. The cyclic evolution equation, phase transformation equation, and mechanical constitutive equation together compose the presented macroscopic constitutive model considering cyclic effects. Results of the numerical simulations illustrate that it can well reproduce the superelastic hysteretic behaviors of the SMA under cyclic loading.

关键词： shape memory alloy cyclic effect cyclic evolution equation phase transformation equation mechanical constitutive equation

Analyzing the distinguishing factors that affect childhood obesity in South Korea

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Frontiers of Medicine 2018年第6期12卷 707-716页

作者： So Jung Yang Hun-sung Kim Kun-ho yoon Department of Medical Informatics College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Division of Endocrinology and Metabolism Department of lnternal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Understanding obesity in children is crucial because it can lead to adulthood obesity and result in fatal chronic diseases. Distinctive factors associated with obesity in adults have been described, but distinctive factors related to children remain unclear. We analyzed the correlation between the percentage of body mass index and lifestyle habits by conducting surveys on physical, nutritional, and psychological factors, and we used annual physical examination data to compare different traits among elementary school students (n = 197) and middle school students (n = 461). Our study revealed that the computing hours in elementary school students with overweight and obesity were significantly correlated with the percentage of body mass index (r = 0.29 on school days and r = 0.35 on days off, all P0.05) in the computing hours of middle school students with overweight and obesity. Childhood obesity can cause depression and reduce children’s quality of life because of their distorted body perception. In conclusion, physical factors directly affecting childhood obesity and psychological and environmental factors surrounding a child should be considered.

关键词： screen time quality of life eating habits childhood obesity percentage of body mass index

Enhanced refolding of lysozyme with imidazolium-based room temperature ionic liquids: Effect of hydrophobicity and sulfur residue

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Science China Chemistry 2012年第8期55卷 1657-1662页

作者： BAE Sang-Woo CHANG Woo-Jin KOO yoon-Mo HA sung ho Department of Biological Engineering Inha University Incheon 402-751 Republic of Korea Department of Mechanical Engineering School of Freshwater Sciences University of Wisconsin-Milwaukee Milwaukee WI 53201-0413 USA Department of Chemical Engineering and Nano-Bio Technology Hannam University Daejeon 305-811 Republic of Korea

The expression of recombinant proteins in microorganism frequently leads to the formation of insoluble aggregates, inclusion bodies （IBs）. Thus, the additional in vitro protein refolding process is required to convert inactive IBs into water-soluble active proteins. This study investigated the effect of sulfur residue and hydrophobicity of imidazolium-based room temperature ionic liquids （RTILs） on the refolding of lysozyme as a model protein in the batch dilution method which is the most commonly used refolding method. When lysozyme was refolded in the refolding buffer containing [BF4]-based RTILs with a systematic variety of alkyl chain on cations varying from two to eight, less hydrophobic imidazolium cations having shorter alkyl chains were effective to facilitate lysozyme refolding. Compared to the conventional refolding buffer, 2 times higher lysozyme re- folding yield was obtained in l-ethyl-3-methylimidazolium tetrafluoroborate （[EMIM][BF4]） containing refolding buffer. The refolding yield of lysozyme was even more increased by 2.5 times when 1-butyl-3-methylimidazolium methylsulfate （[BMIM][MS]） containing sulfur residue on anion was used. The sulfur residue in [BMIM][MS] is supposed to improve the refolding yield of lysozyme which has 4 intrarnolecular disulfide bonds. For dilution-based refolding of lysozyme, the opti- mum concentrations of RTILs in refolding buffer were found to be 1.0 M [EMIM][BF4] and 0.5 M [PMIM][MS], respectively. The optimum temperate for dilution-based refolding of lysozyme with RTILs was 4 ℃.

关键词： protein refolding room temperature ionic liquid dilution refolding lysozyme hydrophobicity sulfur

Internal modification in transparent hybrid germanium-silica plates using plasma formation induced by a femtosecond laser

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中国有色金属学会会刊：英文版 2012年第S3期22卷 808-812页

作者： Ji-Wook yoon Jung-Kyu PARK Kwang-ho KIM Myung-Chang KANG sung-Hak Cho Nano Machining Laboratory Korea Institute of Machinery and Materials Department of Nano-Mechatronics University of Science and Technology National Core Research Center for Hybrid Materials Solution Pusan National University

The fabrication of an internal diffraction grating with photoinduced refractive index modification in planar hybrid germanium-silica plates was demonstrated using low-density plasma formation excited by a high-intensity femtosecond (150 fs) Ti:sapphire laser (λp=790 nm).The refractive index modifications with diameters ranging from 400 nm to 3 μm were photoinduced after plasma formation occurred upon irradiation with peak intensities of more than 2×1013 W/*** graded refractive index profile was fabricated to be a symmetric around from the center of the point at which low-density plasma occurred.

关键词： diffraction grating refractive index modification plasma formation hybrid germanium-silica plate femtosecond laser

Linearization of T-S fuzzy systems and robust H_∞ control

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Journal of Central South University 2011年第1期18卷 140-145页

作者： yoon Tae-sung 王法广 PARK Seung-Kyu KWAK Gun-Pyong AHN ho-Kyun School of Mechatronics Changwon National University

Takagi-Sugeno(T-S) fuzzy model is difficult to be linearized because of membership functions ***,novel T-S fuzzy state transformation and T-S fuzzy feedback are proposed for the linearization of T-S fuzzy *** novel T-S fuzzy state transformation is the fuzzy combination of local linear transformation which transforms local linear models in the T-S fuzzy model into the local linear controllable canonical *** fuzzy combination of local linear controllable canonical model gives controllable canonical T-S fuzzy model and then nonlinear feedback is obtained *** the linearization of T-S fuzzy model,a robust H∞ controller with the robustness of sliding model control(SMC) is *** a result,controlled T-S fuzzy system shows the performance of H∞ control and the robustness of SMC.

关键词： T-S fuzzy control linearization H∞ control sliding mode control

Growth and Magnetic Properties of Sol-Gel Derived Co-Doped ZnO Thin Film

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Journal of Rare Earths 2006年第Z1期24卷 59-63页

作者： Young sung Kim Ki Chul Kim Won Pil Tae Dae ho yoon Tae Seok Park Su Jeong Suh Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea Cambridge-ETRI Joint R&D Centre Electronics and Telecommunications Research Institute Daejeon 305-350 Korea Ulsan Industry Promotion Techno Park Ulsan 683-804 Korea Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea Advanced Material Process of Information Technology Sungkyunkwan University Suwon 440-746 Korea

Zn1-xCoxO films were grown on glass by sol-gel spin coating process. A homogeneous and stable Zn1-xCoxO sol was prepared by dissolving zinc acetate dihydrate, cobalt acetate tetrahydrate and aluminium chloride hexahydrate as solutes in solution of isopropanol and monoethanolamine. The films were postheated and vacuum annealed, and investigated for c-axis preferred orientation and electromagnetic properties. Zn1-xCoxO films with different Co concentrations were oriented well along the c-axis, especially the Zn1-xCoxO film with 10% Co(atom fraction) was highly c-axis oriented. The transmittance spectra show that Zn1-xCoxO films occur d-d transition and sp-d exchange interaction between Co2+ ions. The electrical resistivity of the films at 10% Co had the lowest value because the crystallite size became largest and the crystallinity of the c-axis was improved. X-ray photoelectron spectroscopy and alternating gradient magnetometer analyses indicated that no Co metal cluster was formed, and the ferromagnetism at room temperature appeared. The characteristics of the electrical resistivity and room temperature ferromagnetism of sol-gel derived Zn1-xCoxO films suggest a potential application of dilute magnetic semiconductor devices.

关键词： sol-gel Zn1-xCoxO thin film dilute magnetic semiconductor (DMS)

Fabrication of practical deformable displays:advances and challenges

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Light(Science & Applications) 2023年第5期12卷 716-728页

作者： Dong Wook Kim Seong Won Kim Gyujeong Lee Jangyeol yoon Sangwoo Kim Jong-ho hong sung-Chan Jo Unyong Jeong Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-roNam-gu37673 PohangGyeongbukRepublic of Korea Physical Intelligence Department Max Planck Institute for Intelligent SystemsHisenbergstr.370569 StuttgartGermany Advanced Research Team Samsung Display Corporation1 Samsung-roYongin-siGyeonggi-doRepublic of Korea

Display form factors such as size and shape have been conventionally determined in consideration of usability and *** recent trends requiring wearability and convergence of various smart devices demand innovations in display form factors to realize deformability and large *** displays that are foldable,multi-foldable,slidable,or rollable have been commercialized or on the edge of product *** such two-dimensional(2D)expansion of displays,efforts have been made to develop three dimensional(3D)free-form displays that can be stretched and crumpled for use in realistic tactile sensation,artificial skin for robots,and on-skin or implantable *** review article analyzes the current state of the 2D and 3D deformable displays and discusses the technological challenges to be achieved for industrial commercialization.

关键词： artificial sensation dimensional

Epidemic obesity in children and adolescents:risk factors and prevention

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Frontiers of Medicine 2018年第6期12卷 658-666页

作者： Eun Young Lee Kun-ho yoon Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Korea Institute of Catholic Ubiquitous Health Care The Catholic University of KoreaSeoul 06591Korea

The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, with more than 100 million affected in 2015. Moreover, the epidemic of obesity in this population has been an important public health problem in developed and developing countries for the following reasons. Childhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseases, including type 2 diabetes, hypertension, and cardiovascular disease. Furthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death. Although an imbalance between caloric intake and physical activity is a principal cause of childhood and adolescent obesity, environmental factors are exclusively important for development of obesity among children and adolescents. In addition to genetic and biological factors, socioenvironmental factors, including family, school, community, and national policies, can play a crucial role. The complexity of risk factors for developing obesity among children and adolescents leads to difficulty in treatment for this population. Many interventional trials for childhood and adolescent obesity have been proven ineffective. Therefore, early identification and prevention is the key to control the global epidemic of obesity. Given that the proportion of overweight children and adolescents is far greater than that of obesity, an effective prevention strategy is to focus on overweight youth, who are at high risk for developing obesity. Multifaceted, comprehensive strategies involving behavioral, psychological, and environmental risk factors must also be developed to prevent obesity among children and adolescents.

关键词： obesity children adolescents epidemiology risk factor prevention