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Green Energy & Environment 2022年第2期7卷 334-344页

作者： sung ho park Sang Joon Lee Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang790-784South Korea

With the rapid increase in the demand for lithium as an energy-critical element,the recovery of Li+ions from seawater is a worldwide challenging ***,we propose a new facile and fast selective recovery approach of Li+using an Al^(3+)-crosslinked poly(N-isopropylacrylamide)(PNIPAAm)/alginate(Alg)(PNP/Alg(Al)) *** in situ TEM images indicate that Alg-Al^(3+)coordination is reorganized via the rearrangement of PNIPAAm and Alg networks,as the temperature *** reorganization eventually leads to the formation of polycrystalline *** in situ FTIR results exhibit that PNP/Alg(Al) composite has peculiar phase transitions,which includes a retrogressive phase change from hydrophobic to *** synergetic effect of the strong repulsion force of Al^(3+) ions and the attractive force of negatively charged polymeric chains enables the efficient adsorption of Li+ions with a low affinity from Li-spiked seawater.7.3% of Li+ions are recovered from Li-spiked seawater although the concentration of Li-spiked seawater is very *** addition,Li+ions can be extracted from PNP/Alg(Al) composite with the use of a small thermal *** proposed thermoresponsive IPN gel provides a strong potential in practical applications for Li+recovery as an innovative energy-material strategy.

关键词： structure seawater lithium

Silent advanced large cell neuroendocrine carcinoma with synchronous adenocarcinoma of the colon:A case report

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2266-2272页

作者： Hyeon Seok Baek Sang Wook Kim Soo Teik Lee ho sung park Seung Young Seo Department of Internal Medicine Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju-si 56445Jeollabuk-doSouth Korea Department of Pathology Jeonbuk National University Medical SchoolJeonjusi 56445Jeollabuk-doSouth Korea

BACKGROUND Large cell neuroendocrine carcinoma(LCNEC)accounts for about 0.25%of colorectal cancer ***,synchronous LCNEC and adenocarcinoma coexistence in the colon is very *** are usually aggressive and have a poor ***,colorectal LCNEC patients complain of abdominal symptoms such as pain,diarrhea or hematochezia because it is often diagnosed as an advanced disease that accompanies metastatic *** SUMMARY We describe a case of relatively asymptomatic synchronous LCNEC and colon adenocarcinoma.A 62-year-old male patient visited our hospital due to anemia detected by a local health *** did not complain of melena,hematochezia or abdominal *** examination was unremarkable and his abdomen was soft,nontender and nondistended with no palpable *** tests revealed anemia with hemoglobin 5.1 g/*** revealed an ulcerofungating lesion in the ascending colon and about a 1.5 cm-sized large sessile polyp in the sigmoid *** biopsy of the ascending colon lesion revealed the ulcerofungating mass that was LCNEC and endoscopic mucosal resection at the sigmoid colon lesion showed a large polypoid lesion that was *** liver,lung,bone and lymph nodes metastasis was found on chest/abdominal computed tomography and positron emission *** patient was diagnosed with advanced colorectal LCNEC with liver,lung,bone and lymph node metastasis(stage IV)and synchronous colonic adenocarcinoma *** this case,no specific symptom except anemia was observed despite the multiple *** patient refused systemic chemotherapy and was discharged after *** We report a case of silent LCNEC of the colon despite the advanced state and synchronous adenocarcinoma.

关键词： Large cell neuroendocrine carcinoma Colon Synchronous Adenocarcinoma Case report

Neural Tract Degeneration Correlates with Functional Impairment in Patients with Anoxic Brain Injury:A Tract-based Spatial Statistics Study

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Neuroscience Bulletin 2020年第8期36卷 932-936页

作者： Ji-Yun park sung ho park Jeong-Hee Yang Han Do Lee Jiho Lee Ki-Hyun Byeon Seo Young park Dongseok Yang Department of Neurology University of Ulsan College of MedicineUlsan University HospitalUlsan 44033Korea Department of Neurosurgery Ulsan University HospitalUlsan 44033Korea Department of Plastic Surgery Biomedical Research InstituteSeoul National University HospitalSeoul 03080Korea Department of Physical Therapy College of UlsanUlsan 44022Korea Department of Occupational and Environmental Medicine University of Ulsan College of MedicineUlsan University HospitalUlsan 44033Korea Physical Medicine and Rehabilitation University of Ulsan College of MedicineUlsan University HospitalUlsan 44033Korea Department of Clinical Epidemiology and Biostatistics Asan Medical CenterSeoul 05505Korea

Dear Editor,Anoxic brain injury(ABI)is a devastating event caused by cardiac arrest,chemical exposure,or *** recent advances in medical diagnostic techniques and treatments,the survival rate after ABI is still very *** studies have reported that 52.6%-64.0%of people who received cardiopulmonary resuscitation after nontraumatic cardiac arrest die,and 9.0%-18.6%remain in a permanent vegetative state within 28 days of treatment[1,2].

关键词： Tract cardiac treatment

RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts

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Cellular & Molecular Immunology 2023年第1期20卷 94-109页

作者： Seyeon Bae Kibyeong Kim Keunsoo Kang Haemin Kim Minjoon Lee Brian Oh Kaichi Kaneko sungkook Ma Jae hoon Choi hojoong Kwak Eun Young Lee sung ho park Kyung-Hyun park-Min Arthritis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterHospital for Special SurgeryNew YorkNY10021USA Department of Medicine Weill Cornell Medical CollegeNew YorkNY10065USA Department of Biological Science Ulsan National Institute of Science&Technology(UNIST)Ulsan44919Republic of Korea Department of Life Science College of Natural SciencesResearch Institute for Natural SciencesHanyang UniversitySeoulKorea Department of Microbiology Dankook UniversityCheonan3116Republic of Korea Department of Molecular Biology and Genetics Cornell UniversityIthacaUSA Division of Rheumatology Department of Internal MedicineSeoul National University College of MedicineSeoulKorea BCMB Allied Program Weill Cornell Graduate School of Medical SciencesNew YorkNY10021USA

Monocyte/macrophage lineage cells are highly plastic and can differentiate into various cells under different environmental stimuli. Bone-resorbing osteoclasts are derived from the monocyte/macrophage lineage in response to receptor activator of NF-κB ligand (RANKL). however, the epigenetic signature contributing to the fate commitment of monocyte/macrophage lineage differentiation into human osteoclasts is largely unknown. In this study, we identified RANKL-responsive human osteoclast-specific superenhancers (SEs) and SE-associated enhancer RNAs (SE-eRNAs) by integrating data obtained from ChIP-seq, ATAC-seq, nuclear RNA-seq and PRO-seq analyses. RANKL induced the formation of 200 SEs, which are large clusters of enhancers, while suppressing 148 SEs in macrophages. RANKL-responsive SEs were strongly correlated with genes in the osteoclastogenic program and were selectively increased in human osteoclasts but marginally presented in osteoblasts, CD4+ T cells, and CD34+ cells. In addition to the major transcription factors identified in osteoclasts, we found that BATF binding motifs were highly enriched in RANKL-responsive SEs. The depletion of BATF1/3 inhibited RANKL-induced osteoclast differentiation. Furthermore, we found increased chromatin accessibility in SE regions, where RNA polymerase II was significantly recruited to induce the extragenic transcription of SE-eRNAs, in human osteoclasts. Knocking down SE-eRNAs in the vicinity of the NFATc1 gene diminished the expression of NFATc1, a major regulator of osteoclasts, and osteoclast differentiation. Inhibiting BET proteins suppressed the formation of some RANKL-responsive SEs and NFATc1-associated SEs, and the expression of SE-eRNA:NFATc1. Moreover, SE-eRNA:NFATc1 was highly expressed in the synovial macrophages of rheumatoid arthritis patients exhibiting high-osteoclastogenic potential. Our genome-wide analysis revealed RANKL-inducible SEs and SE-eRNAs as osteoclast-specific signatures, which may contribute to t

关键词： Osteoclasts super-enhancers enhancer RNAs Rheumatoid arthritis

Interesting Dynamic Contrast-Enhanced Magnetic Resonance Imaging Findings of Metaplastic Breast Carcinoma with Skeletal Muscle Metastasis

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Chinese Medical Journal 2018年第7期131卷 881-882页

作者： Sin Ae Choi Eun Jung Choi ho sung park Department of Radiology Research Institute of Clinical Medicine of Chonbuk National University Biomedical Research Institute of Chonbuk National University Hospital Chonbuk National University Medical School Jeonju 561-712 Korea Department of Pathology Research Institute of Clinical Medicine of Chonbuk National University Biomedical Research Institute of Chonbuk National University Hospital Chonbuk National University Medical School Jeonju 561-712 Korea

To the Editor： A 76-year-old woman presented with palpable masses in her right breast and right forearm. Physical examination revealed a 5-cm-sized mass in the lower outer quadrant of the right breast and a hard, fixed mass, measuring 4 cm in the right forearm. Mammography revealed a round, obscured, hyperdense mass without microcalcifications.

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Angiomyofibroblastoma of the vulva: A case report with literature review

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Case Reports in Clinical Medicine 2013年第3期2卷 221-224页

作者： Jung ho park Mi Kyung Shin Maria Lee sung Taek park sung-ho park hong-Bae Kim Department of Obstetrics & Gynecology Hallym University Kangdong Sacred Heart Hospital Seoul Korea Department of Obstetrics & Gynecology Hallym University Kangnam Sacred Heart Hospital Seoul Korea Department of Pathology Hallym University Kangnam Sacred Heart Hospital Seoul Korea Hallym University Collage of Medicine Chuncheon Korea

Angiomyofibroblastoma (AMF) is a rare kind of soft tissue tumor that occurs predominantly in the vulva. Due to their location, clinicians often confuse AMF with Bartholin’s cyst or perineal hernia. Radiological evaluation is performed to rule out perineal hernia and invasive neoplasm. Like other benign mesenchymal tumors of vulva, AMF shows indolent behavior and rarely recurs after complete surgical excision.

关键词： Angiomyofibroblastoma Vulvar Neoplasm

Ischemic colitis secondary to inferior mesenteric arteriovenous fistula and portal vein stenosis in a liver transplant recipient

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World Journal of Gastroenterology 2008年第26期14卷 4249-4252页

作者： In Hee Kim Dae Ghon Kim Hyo sung Kwak Hee Chul Yu Baik Hwan Cho ho sung park Division of Gastroenterology and Hepatology Department of Internal Medicine the Research Institute for Medical Sciences Chonbuk National University Medical School and Hospital Jeonju Jeonbuk 561-712 South Korea Division of Gastroenterology and Hepatology Department of Internal Medicine the Research Institute for Medical SciencesChonbuk National University Medical School and Hospital JeonjuJeonbuk 561-712 South Korea Department of Radiology Chonbuk National University Medical School and Hospital Jeonju Jeonbuk 561-712 South Korea Department of Surgery Chonbuk National University Medical School and Hospital Jeonju Jeonbuk 561-712 South Korea Department of Pathology Chonbuk National University Medical School and Hospital Jeonju Jeonbuk 561-712 South Korea

Arteriovenous fistula （AVF） involving the inferior mesenteric vessels is rare, and the affected patients usually present with abdominal pain, mass, or features of established portal hypertension. Colonic ischemia is a less common and more serious manifestation of AVE We report a case of ischemic colitis secondary to inferior mesentedc AVF in a patient who underwent a previous liver transplantation, subsequently developed portal vein stenosis, and then presented with acute lower gastrointestinal bleeding. He underwent percutaneous transhepatic placement of a portal vein stent and left colectomy.

关键词： Ischemic colitis Inferior mesenteric Arteriovenous fistula Portal vein stenosis

Co-operative roles of IL-4Rαand IL-13Rα1 in the progression of ovarian carcinomas and the survival of ovarian carcinoma patients

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Cancer Communications 2023年第7期43卷 850-854页

作者： Won Ku Choi Usama Khamis Hussein Asmaa Gamal Ahmed Junyue Zhang Kyoung Min Kim Ae Ri Ahn ho sung park See-Hyoung park Dong Hyu Cho Kyu Yun Jang Department of Obstetrics and Gynecology Jeonbuk National University Medical SchoolJeonjuRepublic of Korea Department of Pathology Jeonbuk National University Medical SchoolJeonjuRepublic of Korea Faculty of Science Beni-Suef UniversityBeni-SuefEgypt School of Biomedical Informatics The University of Texas Health Science Center at HoustonHoustonTexasUSA Faculty of Postgraduate Studies and Advanced Sciences Beni-Suef UniversityBeni-SuefEgypt Department of Orthopedic Surgery Jeonbuk National University Medical SchoolJeonjuRepublic of Korea Department of Bio and Chemical Engineering Hongik UniversitySejongRepublic of Korea Research Institute of Clinical Medicine of Jeonbuk National University JeonjuRepublic of Korea Biomedical Research Institute of Jeonbuk National University hospital JeonjuRepublic of Korea

Dear Editor,Recently,there has been a rise in interest in the roles of cytokines and cytokine receptors in malignant human *** receptors,especially typeⅡinterleukin-4 receptor(IL-4R),have recently been examined as novel therapeutic targets of human cancers[1-3].The typeⅡIL-4R complex is composed of IL-4Rαand interleukin-13 receptorα1(IL-13Rα1),and the expression of IL-4Rαand IL-13Rα1 was higher in cancer tissues compared with normal counterpart tissues[3,4].

关键词： operative patients cytokines

Design of Lorentz Force Type Integrated Motor-Bearing System Using Permanent Magnets and Concentrated Windings

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Design of Lorentz Force Type Integrated Motor-Bearing System...

Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists

第十一届IFTOMM世界大会

作者： sung-ho park Chong-Won Lee Yohji Okada Center for Noise and Vibration Control （NOVIC） Dept. of Mechanical Eng. KAIST Science TownDaejeon305-701Korea Center for Noise and Vibration Control （NOVIC） Dept. of Mechanical Eng. KAIST Science TownDaejeon305-701Korea Dept. of Mechanical Eng. Ibaraki University HitachiIbaraki-Pref.316-8511Japan

＜正＞The integrated motor-bearing system integrates both functions of active magnetic bearings and electric motor into a unit. In this paper, a generalized approach to generation of torque and radial force in integrated motor-bearing systems using Lorentz forces is presented. The constraints to arrangement of permanent magnets and distribution of concentrated coil windings are derived for the disk and cylindrical type configurations to be realized. It is found that the difference between the number of permanent magnets and the number of magnetic poles for motoring should be an integer multiple of the number of windings. The phase difference of position control current is determined by the rule that the number of poles for position control should be more or less by 2 than the number of the motoring poles. Typical feasible combinations of design parameters satisfying the constraints are also listed.

关键词： Bearingless motor Magnetic bearing Lorentz force AC Synchronous motor

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World Journal of Gastroenterology 2011年第21期17卷 2602-2610页

作者： Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun park Woo ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn park Yun Kyung Kang Sun hoo park Hye Seung Han Young Bae Kim ho sung park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists Department of Pathology Inha University Hospital Department of Pathology Yonsei University Wonju College of Medicine Wonju Christian Hospital Department of Pathology Sungkyunkwan University School of MedicineKangbuk Samsung Medical Center Department of Pathology Chungnam National University College of Medicine Department of Pathology Sungkyunkwan University School of MedicineSamsung Medical Center Department of Pathology Seoul National University College of Medicine Department of Pathology Soonchunhyang University Hospital Department of Pathology Kosin University College of Medicine Department of Pathology University of Ulsan College of MedicineAsan Medical Center Department of Pathology The Catholic University of KoreaSeoul St.Mary's Hospital Department of Pathology Seoul National University Boramae Hospital Department of Pathology Eulji General Hospital Department of Pathology Inje University Ilsan Paik Hospital Department of Pathology Kyunghee University College of Medicine Department of Pathology Pusan National University College of Medicine Department of Pathology Inje University Seoul Paik Hospital Department of Pathology Korea Cancer Center Hospital Department of Pathology Konkuk University Medical Center Department of Pathology Ajou University School of Medicine Department of Pathology Chonbuk National University Medical School Department of Pathology Korea University College of Medicine Department of Pathology Bundang Jesaeng Hospital Department of Pathology National Cancer Center The Korean Society of Pathologists 4FThe Korean Medical Association BuildingSeoul 140-721South Korea

The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of *** the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic *** pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western *** is geographically close to Korea,and academic exchanges are ***,Korean doctors are familiar with Western style medical *** a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in *** solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss

关键词： Intraepithelial neoplasia Stomach Dysplasia Adenoma Carcinoma Japanese Western Consensus Vienna