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中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会

作者： Yang Cheng Feng Lu Bo Wang Jian Li Jin-Hee han Daisuke Ito Deok-Hoon Kong Lubin Jiang Jian Wu kwon-Soo ha Eizo Takashima Jetsumon Sattabongkot Won Sun Park Seok-Ho Hong Sanjay A.Desai Louis H.Miller Takafumi Tsuboi Eun-Taek han Department of Medical Environmental Biology and Tropical Medicine School of MedicineKangwon National University Department of Parasitology Wuxi Medical School Jiangnan University Laboratory of Malaria and Vector Research (LMVR) National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH) Division of Malaria Research Proteo-Science Center Ehime University Department of Molecular and Cellular Biochemistry School of Medicine Kangwon National University Key Laboratory of Molecular Virology & Immunology Unit of Human Parasite Molecular and Cell Biology Institut Pasteur of Shanghai Mahidol Vivax Research Unit Faculty of Tropical Medicine Mahidol University Department of Physiology School of Medicine Kangwon National University Department of Internal Medicine School of Medicine Kangwon National University

Plasmodium vivax, a major agent of malaria in both temperate and tropical climates, has a limited capacity for infecting humans lacking the Duffy(Fy) blood group antigen as this receptor is critical for erythrocyte invasion. Recent surveys in various endemic regions, however, have reported P. vivax infections in Duffy-negative individuals, suggesting that the parasite may utilize alternative receptor-ligand pairs to complete erythrocyte invasion. Here, we identified and characterized a novel parasite ligand, GPI-anchored micronemal antigen(Pv GAMA), that can bind human erythrocytes regardless of Duffy antigen status. Specific antibodies raised against PvG AMA localize the protein to the parasite microneme, consistent with a role in invasion. These antibodies also inhibited Pv GAMA binding to erythrocytes in a dose-dependent manner. Pv GAMA appears to play a role in a sialic acid-independent, chymotrypsin-sensitive invasion pathway. Thus, Pv GAMA may be an adhesion molecule for invasion of Duffy positive and negative human erythrocytes and is an important P. vivax vaccine candidate.

关键词： Plasmodium vivax GAMA erythrocyte binding Duffy negative sialic acid-independent vaccine candidate

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Chemical characterization of rainwater over Suwon region during farming and non-farming periods

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Journal of Agricultural Chemistry and Environment 2013年第1期2卷 1-7页

作者： Min-Kyeong Kim Jong-Sik Lee Goo-Bok Jung Byong-Gu Ko Soon-Ik kwon Min-Young Kim Kyu-Ho So Sun-Gang Yun Department of Agricultural Environment National Academy of Agricultural Science Rural Development Administration (RDA) Suwon Republic of Korea Dresearch Planning Division Rural Development Administration Suwon Republic of Korea

Recently, special attention has been givento acid rain and its problem to environment such as acid precipitation and air pollution in East *** the present study, rainwater samples werecollected from Apr to Oct (farming period) and from Nov to Mar (non-farming period) in 2009 ~ 2011. The samples were chemically characterized for the assessment of emission sources. Suwon region, a typical agricultural area in Gyeonggi province (South Korea) was chosen as a study site. The content of ionic species and theirtemporal variation were used forfactor analysis, which was used to presume the natural and anthropogenic sources depending upon the farming and non-farming periods. The cationsobserved during farming and non-farming periods were?> Na+> Ca2+> K+> H+> Mg2+and Na+> N?>Ca2+> H+= Mg2+> K+, respectively. The anions during farming and non-farming periods were?>?> Cl- and?>?> Cl-, respectively. While the amounts of sulfate, one of the major dissolved components of rainwater were 113.5 and 177.0 ueq.L-1, the ones of NSS-?(Non-Sea Salt sulfate) were 93.7 and 87.1% during farming and non-farming periods, respectively. The comparison of observed pH values (pHobs) with the theoretical pH values (pHthe) showed that the neutralization of rainwater considerably went along during farming and non-farming periods. The highest amountof rainfall throughout the year was310.5 mmin August and its corre sponding nitrogen loading was5.03 kg·ha-1. The major ion contents for crop growth, , Ca2+, K+, Mg2+, were 49.4, 5.5, 18.1,1.4 kg·ha-1from April to October. The major contributions to the existing chemical ions in rainwaters during farming and non-farming periods were from the natural sources (sea and soil) and the anthropogenic sources (human and animal waste, vehicular emission + fossil fuels combustion), respectively.

关键词： Acidity Discharge Nutrient Rainwater

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