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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 10-11页

作者： sung-gyu lee Hepato-Biliary Surgery and Liver Transplantation Asan Medical CenterCollege of MedicineUlsan University

Salvage liver transplantation (LT) has been performed for recurred hepatocellular carcinoma(HCC) or for deterioration of liver function after resection of HCC. Controversies arise, howeverover the technical feasibilit... 详细信息

关键词： HCC Salvage living-donor liver transplantation to previously hepatectomized hepatocellular carcinoma patients

Sequential transcatheter arterial chemoembolization and portal vein embolization before right hemihepatectomy in patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 244-251页

作者： Gil Chun Park sung gyu lee Young In Yoon Kyu Bo sung Gi Young Ko Dong Il Gwon Dong Hwan Jung Yong Kyu Jung Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Background:Recent studies showed that sequential selective transcatheter arterial chemoembolization(TACE)and portal vein embolization(PVE)provided better future liver remnant(FLR)regeneration rate and disease-free survival following surgery compared with PVE *** present study aimed to clarify whether preoperative sequential TACE and PVE before right hemihepatectomy can reduce postoperative hepatocellular carcinoma(HCC)recurrence and improve long-term disease-free and overall ***:Recurrence and survival outcomes were retrospectively evaluated in 205 patients with HCC who underwent right hemihepatectomy by a single surgeon from November 1993 to November *** were divided into four groups according to the procedure performed before the surgery:sequential TACE and PVE(TACE-PVE),PVE-only,TACE-only,or na?ve control *** baseline patient and tumor characteristics,postoperative outcomes,recurrence-free survival and overall survival were ***:Baseline patient and tumor characteristics upon diagnosis were similar in all four groups,while sequential TACE and PVE were well *** TACE-PVE group had a higher mean increase in percentage FLR volume compared with that of the PVE-only group(17.46%±6.63%vs.12.14%±5.93%;P=0.001).The TACE-PVE group had significantly better overall and disease-free survival rates compared with the other groups(both P<0.001).Conclusions:Sequential TACE and PVE prior to surgery can be an effective therapeutic strategy for patients with HCC scheduled for major hepatic *** active application of preoperative sequential TACE and PVE for HCC would allow more patients with marginal FLR volume to become candidates for major hepatic resection by promoting compensatory FLR hypertrophy without the deterioration of basal hepatic functional reserve or tumor progression.

关键词： Sequential selective transcatheter Arterial chemoembolization Portal vein embolization Hepatocellular carcinoma Future liver remnant

A surgical technique using the gastroepiploic vein for portal inflow restoration in living donor liver transplantation in a patient with diffuse portomesenteric thrombosis

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国际肝胆胰疾病杂志:英文版 2023年第5期22卷 537-540页

作者： Sang-Hoon Kim Deok-Bog Moon Woo-Hyoung Kang Dong-Hwan Jung sung-gyu lee Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical Center and University of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea

Portal vein thrombosis(PVT)is no longer a definitive contraindication in liver transplants(LTs)[1].Complex vascular reconstructions such as cavoportal hemitransposition(CPHT)[2–5],renoportal anastomosis(RPA)[6,7],and use of sizable collaterals(pericholedochal varix[8,9],coronary vein,peripancreatic or perigastroesophageal varices[10],right superior colic vein[11],ileocolic vein[12],and left gastric vein[13]),or combined liverpancreas-small bowel transplant[14]are required for portal inflow in patients with total portosplenomesenteric thrombosis.

关键词： thrombosis anastomosis portal

Morbidity analysis of left hepatic trisectionectomy for hepatobiliary disease and live donor

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 362-369页

作者： Young-In Yoon sung-gyu lee Deok-Bog Moon Shin Hwang Ki-Hun Kim Hui-Ju Kim Ki-Hoon Choi Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine388-1 Poongnap-dongSongpa-guSeoul 138-736Korea Department of Surgery Gold Coast University HospitalSouthportQLD 4215Australia

Background:Despite remarkable advances in surgical techniques and perioperative management,left hepatic trisectionectomy(LHT)remains a challenging procedure with a somewhat high postoperative morbidity rate compared with less-extensive *** study aimed to analyze the short-and long-term outcomes of LHT and identify factors associated with the postoperative morbidity of this technically demanding surgical ***:The medical records of 53 patients who underwent LHT between June 2005 and October 2019 at a single institution were retrospectively *** independent prognostic factor of postoperative morbidity was analyzed using the logistic regression ***:Hepatocellular carcinoma was the most common indication for surgery(n=21),followed by hilar cholangiocarcinoma(n=14),intrahepatic cholangiocarcinoma(n=10),and other pathologies(including colorectal liver metastasis,hepatolithiasis,gallbladder cancer,living donor,hemangioma,and multilocular biliary cyst;n=8).The rates of postoperative morbidities of Clavien-Dindo grade 3 or higher and 90-day mortality were 39.6% and 1.9%,*** 1-,3-,and 5-year overall survival rates were 81.1%,61.4%,and 44.6%,*** analysis revealed that preoperative jaundice[hazard ratio(HR)=6.15,95%confidence interval(CI):1.57-24.17,P=0.009]and operative time>420 min(HR=4.66,95%CI:1.27–17.17,P=0.021)were independent predictors of postoperative ***:The in-hospital mortality of LHT surgery can be minimalized by a reliable preoperative evaluation of liver function and selection of the dominant anatomic features of right posterior sector,active and appropriate preoperative management for obstructive cholangitis and compensatory hypertrophy of the future remnant posterior sector,and the experience of the surgeon.

关键词： Left hepatic trisectionectomy Major hepatectomy Liver neoplasms Survival rate Morbidity

Salvage living donor liver transplantation for recurrent hepatocellular carcinoma after prior laparoscopic hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 473-476页

作者： Seok-Hwan Kim Ki-Hun Kim Tae-Yong Ha Dong-Hwan Jung Gil-Chun Park sung-gyu lee Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Surgery Chungnam National University HospitalChungnam National University School of MedicineDaejeonKorea

Salvage liver transplantation(LT)is frequently performed on patients who experience recurrent hepatocellular carcinoma(HCC)after primary hepatectomy for HCC[1,2].The main concern in these patients is the technical feasibility of salvage LT,especially as prior hepatectomy may result in heavy adhesions[3,4].Salvage living donor LT(LDLT)is a more demanding procedure than salvage deceased donor LT(DDLT)using an entire donor graft with a long vascular pedicle[5,6].Because less than optimal dissection of perihepatic adhesions could result in uncontrollable pinpoint bleedings at the dissection surface[1,5],many transplant surgeons avoid performing salvage *** invasive laparoscopic hepatectomy(LH)results in fewer intraperitoneal adhesions than the open method,reducing the difficulty of surgical dissection during future LT[7–10].To date,however,no study has compared salvage LDLT for recurrent HCC after LH to that after open hepatectomy(OH).

关键词： LDLT experience recurrent

Feasibility of ABO-incompatible adult living donor liver transplantation for acute-on-chronic liver failure

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 662-664页

作者： Seok-Hwan Kim Gi-Won Song Shin Hwang Chul-Soo Ahn Deok-Bog Moon Tae-Yong Ha sung-gyu lee Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul 05505 Korea

To the Editor:In Korea,the annual number of deceased donors for or gan transplantation per million people is still less ***,approximately 40%of patients with acute liver failure or acute-on-chronic liver failure undergo living donor liver transplantation（LDLT）.;Although the use of ABO-incompatible（ABOi）living donors is an attrac tive option,ABOi LDLT has very restricted applications

关键词： ABO Feasibility of ABO-incompatible adult living donor liver transplantation for acute-on-chronic liver failure RIT

Effect of characteristics and distribution of Mg_(17)Al_(12)precipitates on tensile and bending properties of high-Al-containing Mg alloys

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Journal of Magnesium and Alloys 2024年第2期12卷 779-793页

作者： Sumi Jo Gyo Myeong lee Jong Un lee Young Min Kim sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Magnesium Korea Institute of Materials ScienceChangwon 51508Republic of Korea

This study investigates the effect of characteristics and distribution of Mg_(17)Al_(12)precipitates on the uniaxial tensile and three-point bending properties of extruded Mg alloys containing high Al *** extruded Mg–9Al–1Zn–0.3Mn(AZ91)alloy contains lamellar-structured Mg_(17)Al_(12)discontinuous precipitates along the grain boundaries,which are formed via static precipitation during natural air *** extruded Mg–11Al–1Zn–0.3Mn(AZ111)alloy contains spherical Mg_(17)Al_(12)precipitates at the grain boundaries and inside the grains,which are formed via dynamic precipitation during *** to inhomogeneous distribution of precipitates,the AZ111 alloy consists of two different precipitate regions:precipitate-rich region with numerous precipitates and finer grains and precipitate-scarce region with a few precipitates and coarser *** AZ111 alloy exhibits a higher tensile strength than the AZ91 alloy because its smaller grain size and more abundant precipitates result in stronger grain-boundary hardening and precipitation hardening effects,***,the tensile elongation of the AZ111 alloy is lower than that of the AZ91 alloy because the weak cohesion between the dynamic precipitates and the matrix facilitates the crack initiation and *** bending,a macrocrack initiates on the outer surface of bending specimen in both *** AZ111 alloy exhibits higher bending yield strength and lower failure bending strain than the AZ91 *** bending specimens of the AZ91 alloy have similar bending formability,whereas those of the AZ111 alloy exhibit considerable differences in bending formability and crack propagation behavior,depending on the distribution and number density of precipitates in the *** bending specimens of the AZ111 alloy,it is found that the failure bending strain(ε_(f,bending))is inversely proportional to the area fraction of precipitates in the outer zone of bending specimen(A_(ppt)),with a relation

关键词： Mg–Al alloy Extrusion Bending Precipitation Microstructure

Enhanced prediction of anisotropic deformation behavior using machine learning with data augmentation

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Journal of Magnesium and Alloys 2024年第1期12卷 186-196页

作者： Sujeong Byun Jinyeong Yu Seho Cheon Seong Ho lee sung Hyuk Park Taekyung lee School of Mechanical Engineering Pusan National UniversityBusan 46241South Korea School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566South Korea

Mg alloys possess an inherent plastic anisotropy owing to the selective activation of deformation mechanisms depending on the loading *** characteristic results in a diverse range of flow curves that vary with a deformation *** study proposes a novel approach for accurately predicting an anisotropic deformation behavior of wrought Mg alloys using machine learning(ML)with data *** developed model combines four key strategies from data science:learning the entire flow curves,generative adversarial networks(GAN),algorithm-driven hyperparameter tuning,and gated recurrent unit(GRU)*** proposed model,namely GAN-aided GRU,was extensively evaluated for various predictive scenarios,such as interpolation,extrapolation,and a limited dataset *** model exhibited significant predictability and improved generalizability for estimating the anisotropic compressive behavior of ZK60 Mg alloys under 11 annealing conditions and for three loading *** GAN-aided GRU results were superior to those of previous ML models and constitutive *** superior performance was attributed to hyperparameter optimization,GAN-based data augmentation,and the inherent predictivity of the GRU for *** a first attempt to employ ML techniques other than artificial neural networks,this study proposes a novel perspective on predicting the anisotropic deformation behaviors of wrought Mg alloys.

关键词： Plastic anisotropy Compression Annealing Machine learning Data augmentation

Comparison of commercial silicon-based anode materials for the design of a high-energy lithium-ion battery

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Nano Research 2024年第6期17卷 5270-5277页

作者： Minhong Choi Eunhan lee Jaekyung sung Namhyung Kim Minseong Ko Division of Convergence Materials Engineering Pukyong National UniversityBusan 48547Republic of Korea Department of Materials Engineering and Convergence Technology Gyeongsang National University501 Jinju-daeroJinju 52828Republic of Korea Department of Materials System Engineering Pukyong National UniversityBusan 48547Republic of Korea

Silicon(Si)is considered a potential alternative anode for next-generation Li-ion batteries owing to its high theoretical capacity and ***,the commercial use of Si anodes is hindered by their large volume expansion(~300%).Numerous efforts have been made to address this *** these efforts,Si-graphite co-utilization has attracted attention as a reasonable alternative for high-energy anodes.A comparative study of representative commercial Si-based materials,such as Si nanoparticles,Si suboxides,and Si−Graphite composites(SiGC),was conducted to characterize their overall performance in high-energy lithium-ion battery(LIB)design by incorporating conventional ***-Si was found to exhibit poor electrochemical performance,with severe volume expansion during *** suboxide provided excellent cycling stability in a full-cell evaluation with stable volume variation after 50 cycles,but had a large irreversible capacity and remarkable volume expansion during the first *** displayed a good initial Coulombic efficiency and the lowest volume change in the first cycle owing to the uniformly distributed nano-Si layer on graphite;however,its long-term cycling stability was relatively *** complement each disadvantage of Si suboxide and SiGC,a new combination of these Si-based anodes was suggested and a reasonable improvement in overall battery performance was successfully achieved.

关键词： silicon-based anode high-energy comparison lithium ion battery blended electrode

Strengthening mechanisms analysis and tailoring of bimodal grain structures for enhanced strength in CoCrFeMnNi high-entropy alloys

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Rare Metals 2024年第8期43卷 3893-3903页

作者： Jaesoung lee Seulgi Kim Taehyun Kwon Young II Kim Suyeon Kim sung Ho Song Bin lee Dongju lee Department of Urban Energyand Environmental EngineeringChungbuk National UniversityCheongju 28644Republic of Korea Division of Advanced Materials Engineering Kongju National UniversityChungnam 330-717Republic of Korea Department of Advanced Materials Engineering for Information and Electronics Integrated-Education Institute for Frontier Science and Technology(BK21 Four)Kyung Hee UniversityYongin17104Republic of Korea

The CoCrFeMnNi high-entropy alloys(HEAs)with a(face-centered cubic) FCC structure has garnered considerable attention for its exceptional ductility and strain hardening ***,its yield strength is insufficient for structural *** this study,strengthening mechanisms in these HEAs were investigated to gain insight into the mechanical properties according to alloy powder ***,we present a novel approach to achieve both high strength and high ductility through the creation of a bimodal structure consisting of both coarse and fine grains via gas atomization and spark plasma sintering processes.A bimodally structured HEA prepared with a mass ratio of 2:8 between coarse particles(75-106 μm) and fine particles(≤25 μm)yielded optimal results,with a strength of 491.95 MPa and elongation of 19.64%.This strength value represents an~41% increase compared with the sample that displayed a fine single microstructure(347.08 MPa for yield strength).The strength enhancement was attributed to the prevention of plastic deformation initiation from the fine particles during *** innovative approach to the creation of HEAs with bimodal structures shows promise for various applications,such as structural components that require a combination of high strength and high ductility.

关键词： High-entropy alloys CrCoFeMoNi Bimodal Gas atomization Mechanical properties