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Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia

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Asian Journal of Andrology 2010年第5期12卷 690-696页

作者： Koo Han Yoo Su Kang Kim Joo-Ho Chung sung-goo chang Department of Urology School of Medicine Kyung Hee University Seou1130-702 Korea Kohwang Medical Research Institute School of Medicine Kyung Hee University Seoul 130-702 Korea

The precise aetiology of benign prostatic hyperplasia （BPH） remains unclear; however, it is known that immunological inflammatory processes have a role in the pathogenesis of BPH initiation and progression. Nitric oxide synthase 2 （NOS2） inducible expression is closely correlated with prostatic disease, including prostate cancer and BPH. The aim of this study was to investigate the relationship between NOS2 polymorphisms and BPH. With a cohort of 205 controls and 229 BPH subjects, we genotyped three single nucleotide polymorphisms （SNPs） in the NOS2 gene, including rs2779248 （promoter, -278 T/C）, rs 10459953 （5＇-untranslated region） and rs2297518 （exon 16, missense, Ser608Leu）, using direct sequencing and restriction fragment length polymorphism. The genotypic and allelic frequencies between control and BPH subjects were compared, and the associations among the BPH subjects were analyzed. SNPStats, SNPAnalyzer and HelixTree programmes were used to analyze SNPs. There was no association on SNPs between control and BPH subjects. When BPH subjects were analyzed, there was no association on SNPs between the low and high prostate-specific antigen groups. However, one SNP （rs 10459953, odds ratio [OR] = 0.44, 95% confidence interval [CI] = 0.29-0.65, P 〈 0.0001, in codominant model; OR = 0.23, 95% CI = 0.12-0.46, P 〈 0.0001, in dominant model; and OR = 0.46, 95% CI = 0.24-0.86, P = 0.015, in recessive model） was associated with prostatic volume in BPH. We detected a strong association in genotype frequencies of NOS2 SNP （rs10459953） between subjects with small and large prostatic volume in BPH. The result suggests that NOS2 may be associated with prostatic volume in BPH.

关键词： benign prostatic hyperplasia nitric oxide synthase 2 single nucleotide polymorphism

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Bidirectional WDM Self-Healing Ring Network for Hub/Remote Nodes

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光学学报 2003年第S1期23卷 715-716页

作者： sung-Bum Park Seung goo Kang Sang Bae Lee chang-Hee Lee KAIST Dept. of Electrical Engineering and Computer Science 373-1 Kusong-dong Yusong-gu Daejeon 305-701 KoreaCurrent affiliation: Samsung Electronics Co. Ltd. Suwon KoreaXL Photonics Inc.Daejeon KoreaKIST Seoul KoreaKAIST Dept. of Electrical Engineering and Computer Science 373-1 Kusong-dong Yusong-gu Daejeon 305-701 Korea

We demonstrate a bidirectional WDM self-healing ring network for hub/remote nodes with one fiber. In this network, self-healing can be achieved within 8 ms. The transmission capacity can be doubled in the operating st... 详细信息

关键词： WDM on in Bidirectional WDM Self-Healing Ring Network for Hub/Remote Nodes for dBm

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Characteristics of gastric cancer recurrence five or more years after curative gastrectomy

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Chinese Journal of Cancer Research 2016年第5期28卷 503-510页

作者： chang-Hyun Shin Woo-Yong Lee Seung-Woo Hong Yeo-goo chang Department of Surgery Ilsan Paik HospitalInje University College of Medicine Department of Surgery Seoul Paik HospitalInje University College of Medicine

Objective： To investigate the characteristics of recurrences that occurred 5 or more years after curative resection for gastric ***： We analyzed recurrences among 1,299 patients with gastric cancer who underwent curative operations at the Department of Surgery, Inje University Seoul Paik Hospital between September 1998 and December 2002. Recurrences were classified as within 2 years （early）, 2-5 years （intermediate）, and more than 5 years （late） after gastrectomy. The clinicopathologic findings of the patients with late recurrence were compared with those of patients in the other two recurrence groups, with special reference to the patterns of recurrence. Both univariate and multivariate analyses were performed, incorporating factors such as operation type, T-stage, N-stage, stage, lymphatic invasion, neural invasion, histology, tumor size, and recurrence ***： At the time of last follow-up, recurrence occurred in 266 （20.5%） patients. Recurrence times were classified as 〈2 years （182 patients）, 2-5 years （61 patients）, or 〉5 years （23 patients）. The late recurrence rate was 8.6%. The occurrence of recurrence 〉5 years after gastrectomy was significantly correlated with age, operation type, T-stage, N-stage, stage, lymphatic invasion, neural invasion, histology, tumor size, location and recurrence site （P〈0.05）. The main recurrence patterns in the 23 patients with late recurrence were locoregional metastasis （10 patients, 43.5%）, peritoneal seeding （8 patients, 34.8%）, hematogenous metastasis （2 patients, 8.7%）, and multiple metastasis （3 patients, 13.0%）. A multivariate analysis showed that larger tumor size and younger age were independent prognostic factors for late recurrence. Additionally, locoregional and peritoneal recurrences were significantly more common than hematogenous recurrences. Conclusions： Although late recurrence was uncommon, younger age and larger tumor size were associated with high risk. Follow-up surveillance is recommended

关键词： Curative surgery gastric cancer gastrectomy late recurrence recurrence

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Middle cerebral artery occlusion methods in rat versus mouse model of transient focal cerebral ischemic stroke

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Neural Regeneration Research 2014年第7期9卷 757-758页

作者： Seunghoon Lee Minkyung Lee Yunkyung Hong Jinyoung Won Youngjeon Lee sung-goo Kang Kyu-Tae chang Yonggeun Hong Department of Rehabilitation Science Graduate School of Inje University Ubiquitous Healthcare & Anti-aging Research Center Inje University Cardiovascular & Metabolic Disease Center Inje University National Primate Research Center (NPRC) Korea Research Institute of Bioscience and Biotechnology (KRIBB) Ochang School of Biological Sciences College of Biomedical Science & Engineering Inje University Department of Physical Therapy Graduate School of Inje University

Experimental stroke research commonly employs focal cerebral ischemic rat models （Bederson et al., 1986a; Longa et al., 1989）. In human patients, ischemic stroke typically results from thrombotic or embolic occlusion of a major cerebral artery, usually the mid- dle cerebral artery （MCA）. Experimental focal cerebral ischemia models have been employed to mimic human stroke （Durukan and Tatlisumak, 2007）. Rodent models of focal cerebral ischemia that do not require craniotomy have been developed using intraluminal suture occlusion of the MCA （MCA occlusion, MCAO）（Rosamond et al., 2008）. Furthermore, mouse MCAO models have been wide- ly used and extended to genetic studies of cell death or recovery mechanisms （Liu and McCullough, 2011）. Genetically engineered mouse stroke models are particularly useful for evaluation of isch- emic pathophysiology and the design of new prophylactic, neuro- protective, and therapeutic agents and interventions （Armstead et al., 2010）. During the past two decades, MCAO surgical techniques have been developed that do not reveal surgical techniques for mouse MCAO model engineering. Therefore, we compared MCAO surgical methods in rats and mice.

关键词： MCAO CCA Middle cerebral artery occlusion methods in rat versus mouse model of transient focal cerebral ischemic stroke

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Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus

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World Journal of Gastroenterology 2016年第46期22卷 10131-10139页

作者： Kyung Sik Park Kwang Bum Cho Il Seon Hwang Jae Hyung Park Byung Ik Jang Kyeong Ok Kim sung Woo Jeon Eun Soo Kim chang Sik Park Joong goo Kwon Department of Internal Medicine Keimyung University School of Medicine Department of Pathology Keimyung University School of Medicine Department of Physiology Keimyung University School of Medicine Department of Internal Medicine Youngnam University College of Medicine Department of Internal Medicine Kyungpook National University School of Medicine Department of Advanced Materials Convergence Korea Institute of Ceramic Engineering and Technology Department of Internal Medicine Catholic University of Daegu School of Medicine

AIM To investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus(DM).METHODS Full-thickness gastric specimens were obtained from patients undergoing surgery for gastric cancer. H&E stain and Masson's Trichrome stain were performed to assess the degree of fibrosis. Immunohistochemical staining using various antibodies was also performed [antibodies against protein gene product 9.5(PGP9.5), neuronal nitric oxide synthase(n NOS), vasoactive intestinal peptide(VIP), neurokinin-1(NK1) receptor, c-Kit, and platelet-derived growth factor receptor-alpha,(PDGFRα)]. Immunofluorescent staining and evaluation with confocal microscopy were also *** Twenty-six controls and 35 diabetic patients(21 shortduration patients and 14 long-duration patients) were included. There were no significant differences in basic demographics between the two groups except in mean body mass index(BMI)(higher in the DM group). Proportions of moderate-to-severe intercellular fibrosis in the muscle layer were significantly higher in the DM group than in the control group(P changes in gastric motor activity in patients with DM.

关键词： Diabetes mellitus Interstitial cells of Cajal Fibroblast-like cell Gastroparesis Enteric nerve system

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Comparative study of rendezvous techniques in post-liver transplant biliary stricture

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World Journal of Gastroenterology 2012年第41期18卷 5957-5964页

作者： Jae Hyuck chang In Seok Lee Ho Jong Chun Jong Young Choi Seung Kyoo Yoon Dong goo Kim Young Kyoung You Myung-Gyu Choi Sok Won Han Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Department of Radiology College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Department of Surgery College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

AIM： To investigate the usefulness of a new rendezvous technique for placing stents using the Kumpe （KMP） catheter in angulated or twisted biliary strictures. METHODS： The rendezvous technique was performed in patients with a biliary stricture after living donor liver transplantation （LDLT） who required the exchange of percutaneous transhepatic biliary drainage catheters for inside stents. The rendezvous technique was performed using a guidewire in 19 patients （guidewire group） and using a KMP catheter in another 19 （KMP catheter group）. We compared the two groups retrospectively. RESULTS： The baseline characteristics did not differ between the groups. The success rate for placing insidestents was 100% in both groups. A KMP catheter was easier to manipulate than a guidewire. The mean pro- cedure time in the KMP catheter group （1012 s, range： 301-2006 s） was shorter than that in the guidewire group （2037 s, range： 251-6758 s, P = 0.022）. The cu- mulative probabilities corresponding to the procedure time of the two groups were significantly different （P = 0.008）. The factors related to procedure time were the rendezvous technique method, the number of inside stents, the operator, and balloon dilation of the stric- ture （P 〈 0.05）. In a multivariate analysis, the rendez- vous technique method was the only significant factor related to procedure time （P = 0.010）. The procedural complications observed included one case of mild acute pancreatitis and one case of acute cholangitis in the guidewire group, and two cases of mild acute pancre- atitis in the KMP catheter group. CONCLUSION： The rendezvous technique involving use of the KIVlp catheter was a fast and safe method for placing inside stents in patients with LDLT biliary stric- ture that represents a viable alternative to the guide- wire rendezvous technique,

关键词： Rendezvous Biliary stricture Liver trans-plantation Endoscopic retrograde cholangiography Percutaneous transhepatic biliary drainage

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Severe thrombocytopenia before liver transplantation is associated with delayed recovery of thrombocytopenia regardless of donor type

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World Journal of Gastroenterology 2008年第37期14卷 5723-5729页

作者： Jae Hyuck chang Jong Young Choi Hyun Young Woo Jung Hyun Kwon Chan Ran You Si Hyun Bae Seung Kew Yoon Myung-Gyu Choi In-Sik Chung Dong goo Kim Department of Internal Medicine College of Medicine the Catholic University of Korea505 Banpo-Dong Seocho-Gu Seoul 137-040 Korea Department of Surgery College of Medicine the Catholic University of Korea505 Banpo-Dong Seocho-Gu Seoul 137-040 Korea

AIM： To compare the recovery of thrombocytopenia and splenomegaly during long-term follow-up after liver transplantation in patients receiving a living donor transplant or a cadaveric donor transplant. METHODS： This was a retrospective cohort study of 216 consecutive liver transplant patients who survived for 〉 6 mo after transplantation; 169 received a liver transplant from a living donor and 47 from a cadaveric donor. The platelet counts or spleen volumes were examined before transplant, i, 6, and 12 mo after transplant, and then annually until 5 years after transplant. RESULTS： The mean follow-up period was 49 mo （range, 21-66）. Platelet counts increased continuously for 5 years after orthotopic liver transplant. The restoration of platelet counts after transplant was significantly slower in patients with severe pretransplant thrombocytopenia （〈 50000/μL） until 4 years after transplant （P = 0.005）. Donor type did not significantlyaffect the recovery of platelet count and spleen volume in either patient group. In multivariate analysis, pretransplant severe thrombocytopenia （〈 50000/μL） was an independent factor associated with sustained thrombocytopenia （P 〈 0.001, odds ratio 6.314; confidence interval, 2.828-14.095）. Thrombocytopenia reappeared after transplant in seven patients with portal flow disturbance near the anastomosis site. CONCLUSION： Our study suggests that severe thrombocytopenia before transplant is closely associated with delayed recovery of platelet count after transplant and donor type did not affect the recovery of thrombocytopenia. The reappearance of thrombocytopenia after transplant should be considered a possible indicator of flow disturbance in the portal vein.

关键词： Liver transplantation Thrombocytopenia Splenomegaly Hypersplenism

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A SIMPLE SELF-TUNING FUZZY PID CONTROLLER

A SIMPLE SELF-TUNING FUZZY PID CONTROLLER

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第11届国际模糊系统协会世界大会

作者： Hee-Sun Kim chang-goo Lee Department of Control and Instrumentation Engineering Chon-Buk UniversityJeon-juKOREA School of Electronic and Information Engineering Chon-Buk UniversityJeon-juKOREA

＜正＞ In this paper, we re-analyzed the structure of the fuzzy controller as that of the conventional PID controller, and proposed a neural network based self-tuning fuzzy PID controller of which output gains are adjusted automatically. The initial tuning parameters of the proposed controller are determined based on the tuning method of the conventional PID controller. Then, they are adjusted by using the proposed neural network learning algorithm. The experiment of its implementation on the magnetic levitation system, which is known to be heavily nonlinear, shows the proposed controller’s excellent performance.

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Exploring ideal operative time for best outcomes in gastric cancer surgery:A multi-institutional study based on KLASS-07 database

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Chinese Journal of Cancer Research 2023年第6期35卷 660-674页

作者： Shin-Hoo Park Ye-Rim Shin Hoon Hur chang Min Lee Jae Seok Min Seung Wan Ryu Hyun Dong Chae Oh Jeong chang-In Choi Kyo-Young Song Ho goon Kim Ye Seob Jee Kwang Hee Kim Jeong goo Kim Kyung Sook Yang Hua Huang sungsoo Park Division of Foregut Surgery Korea University College of MedicineSeoul 02841Republic of Korea Division of Foregut Surgery Korea University Anam HospitalSeoul 02841Republic of Korea Department of Surgery Ajou University School of MedicineSuwon 16499Republic of Korea Division of Foregut Surgery Korea University Ansan HospitalAnsan 15355Republic of Korea Department of Surgery Dongnam Institute of Radiological and Medical SciencesCancer CenterBusan 46033Republic of Korea Department of Surgery Keimyung University Dongsan Medical CenterDaegu 41931Republic of Korea Department of Surgery Catholic University of Daegu School of MedicineDaegu 42472Republic of Korea Department of Surgery Chonnam National University Medical SchoolHwasun 58128Republic of Korea Department of Surgery Pusan National University HospitalPusan 49241Republic of Korea Department of Surgery Catholic University of Seoul St Mary’s HospitalSeoul 06591Republic of Korea Department of Surgery Chonnam National University Medical SchoolGwangju 61469Republic of Korea Department of Surgery Dankook University College of MedicineCheonan 31116Republic of Korea Department of Surgery Busan Paik HospitalInje UniversityBusan 14905Republic of Korea Department of Surgery Daejeon St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaDaejeon 34943Republic of Korea Department of Biostatistics Korea University College of MedicineSeoul 02841Republic of Korea Department of Gastric Cancer and Soft Tissue Sarcoma Fudan University Shanghai Cancer CenterShanghai 200433China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200433China

Objective:While a rushed operation can omit essential procedures,prolonged operative time results in higher ***,the optimal operative time range remains *** study aimed to estimate the ideal operative time range and evaluate its applicability in laparoscopic cancer ***:A prospectively collected multicenter database of 397 patients who underwent laparoscopic distal gastrectomy were retrospectively *** ideal operative time range was statistically calculated by separately analyzing the operative time of uneventful ***,intraoperative and postoperative outcomes were compared among the shorter,ideal,and longer operative time ***:The statistically calculated ideal operative time was 135.4-165.4 *** longer operative time(LOT)group had a lower rate of uneventful,perfect surgery than the ideal or shorter operative time(IOT/SOT)group(2.8%vs.8.8%and 2.2%vs.13.4%,all P<0.05).Longer operative time increased bleeding,postoperative morbidities,and delayed diet and discharge(all P<0.05).Particularly,an uneventful,perfect surgery could not be achieved when the operative time exceeded 240 *** of ideal time range,SOT group achieved the highest percentage of uneventful surgery(13.4%),which was possible by surgeon's ability to retrieve a higher number of lymph nodes and perform≥150 gastrectomies ***:Operative time longer than the ideal time range(especially≥240 min)should be *** the essential operative procedure were faithfully conducted without compromising oncological safety,an operative time shorter than the ideal range leaded to a better *** to minimize operative time should be attempted with sufficient surgical experience.

关键词： Operative time laparoscopic surgery gastric cancer gastrectomy morbidity

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基于混合Contourlet变换和主成分变换的高光谱图像融合

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宇航学报 2009年第6期30卷 2360-2365,2425页

作者：常威威郭雷付朝阳刘坤西北工业大学自动化学院西安710072

针对高光谱图像波段多、存在噪声干扰等特点,提出了一种混合Contourlet和主成分分析(principal com-ponent analysis,简称PCA)变换的高光谱图像融合方法。首先将多个波段的高光谱图像进行Contourlet变换,得到系列多尺度、方向各异的子... 详细信息

针对高光谱图像波段多、存在噪声干扰等特点,提出了一种混合Contourlet和主成分分析(principal com-ponent analysis,简称PCA)变换的高光谱图像融合方法。首先将多个波段的高光谱图像进行Contourlet变换,得到系列多尺度、方向各异的子带系数,然后利用PCA变换对各子带系数分别进行自适应融合处理。实验结果表明该算法可以有效地进行高光谱图像融合,消除噪声干扰,获得比直接应用Contourlet变换和PCA变换更好的融合效果。

关键词：图像融合高光谱图像 Contourlet变换主成分分析

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