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Association between cytochrome CYP17A1, CYP3A4, and CYP3A43 polymorphisms and prostate cancer risk and aggressiveness in a Korean study population

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Asian Journal of Andrology 2015年第2期17卷 285-291,I0010页

作者： Jun Hyun Han Yong Seong Lee Hae Jong Kim shin Young Lee Soon chul Myung Department of Urology Hallym University Dongtan Sacred Heart Hospital Hwaseong-si 445-170 Korea Department of Urology Hallym University Kangnam Sacred Heart Hospital Seoul 150-950 Korea Advanced Urogenital Disease Research Center Chung-Ang University College of Medicine Seoul 156-756 Korea Research Institute for Translational System Biomics Chung-Ang University College of Medicine Seoul 156-756 Korea Department of Urology Seoul Medical Center Seoul 131-865 Korea Department of Urology Chung-Ang University Hospital Seou1156-756 Korea.

In this study, we evaluated genetic variants of the androgen metabolism genes CYP17A1, CYP3A4, and CYP3A43 to determine whether they play a role in the development of prostate cancer （PCa） in Korean men. The study population included 240 pathologically diagnosed cases of PCa and 223 age-matched controls. Among the 789 singie-nucleotide polymorphism （SNP） database variants detected, 129 were reported in two Asian groups （Han Chinese and Japanese） in the HapMap database. Only 21 polymorphisms of CYP17A1, CYP3A4, and CYP3A43 were selected based on linkage disequilibrium in Asians （d = 1）, locations （SNPs in exons were preferred）, and amino acid changes and were assessed. In addition, we performed haplotype analysis for the 21 SNPs in CYP17A1, CYP3A4, and CYP3A43 genes. To determine the association between genotype and haplotype distributions of patients and controls, logistic analyses were carried out, controlling for age. Twelve sequence variants and five major haplotypes were identified in CYP17A1. Five sequence variants and two major haplotypes were identified in CYP3A4. Four sequence variants and four major haplotypes were observed in CYP3A43. CYP17A1 haplotype-2 （Ht-2）（odds ratio [OR], 1.51; 95% confidence interval [Cl], 1.04-2,18） was associated with PCa susceptibility. CYP3A4 Ht-2 （OR. 1.87; 95% CI. 1.02-3.43） was associated with PCa metastatic potential according to tumor stage, rs17115149 （OR： 1.96; 95% Ch 1.04-3.68） and CYP17A1 Ht-4 （OR： 2.01; 95% Ch 1.07-4.11） showed a significant association with histologic aggressiveness according to Gleason score. Genetic variants of CYP17A1 and CYP3A4 may play a role in the development of PCa in Korean men.

关键词： androgens CYP17A1 CYP3A4 CYP3A43 genetics prostatic neoplasms

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Impact of tumor location on clinical outcomes of gastric endoscopic submucosal dissection

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World Journal of Gastroenterology 2014年第26期20卷 8631-8637页

作者： Ji Young Yoon Choong Nam Shim Sook Hee Chung Wan Park Hyunsoo Chung Hyuk Lee sung Kwan shin Sang Kil Lee Yong Chan Lee Jun chul Park Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine

AIM: To determine whether there is a correlation between the location of the lesion and endoscopic submucosal dissection (ESD) outcome.

关键词： Endoscopic submucosal dissection Gastric neoplasm Location Complication Outcomes

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汉语学习者定中式名名复合词韵律加工能力研究

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世界汉语教学 2024年第4期38卷 533-547页

作者：林嘉妮石基琳美国伊利诺伊大学香槟分校东亚语言文化系美国伊利诺伊大学香槟分校东亚语言文化系及语言学系

韵律句法学的研究显示,在汉语中韵律可以制约句法。述宾结构偏好1+2式(单音节+双音节),2+1式(双音节+单音节)通常受限制;名名复合词偏好2+1式,1+2式受限多。以往研究显示了母语者对于名名复合词1+2式的低接受度。本研究通过可接受度判... 详细信息

韵律句法学的研究显示,在汉语中韵律可以制约句法。述宾结构偏好1+2式(单音节+双音节),2+1式(双音节+单音节)通常受限制;名名复合词偏好2+1式,1+2式受限多。以往研究显示了母语者对于名名复合词1+2式的低接受度。本研究通过可接受度判断任务,探讨汉语二语者和传承语者对1+2式名名复合词的可接受度。研究发现:(1)母语者排斥1+2式韵律结构的名名复合词;(2)对二语者而言,1+2式和2+2式在接受度上无显著差异,表明他们没有完全掌握韵律规则;(3)传承语者偏好2+2式,但是对1+2式的排斥不如母语者强烈;(4)韵律与语义存在交互,只有在语义合理的情况下,母语者对2+2和1+2式韵律结构的接受度才有显著差异;当语义不合理时,这种差异不明显。

关键词：韵律名名复合词可接受度测试汉语二语习得传承语

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韩国松萎蔫病的研究及防控现状(英文)

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南京林业大学学报（自然科学版） 2010年第5期34卷 167-168页

作者： Sang-chul shin Il-sung Moon Hyerim Han 韩国森林研究院森林病虫害系

自从松萎蔫病于1988年首次报道以来,该病已经扩散到韩国大部分地区并引起未能预见的危害。从2000年该病危害急剧增加,到2006年危害面积已达7871hm2。2000—2008年伐除的病树已达1851225株,年经济损失达1000万美元。2006年后危害面积下降... 详细信息

自从松萎蔫病于1988年首次报道以来,该病已经扩散到韩国大部分地区并引起未能预见的危害。从2000年该病危害急剧增加,到2006年危害面积已达7871hm2。2000—2008年伐除的病树已达1851225株,年经济损失达1000万美元。2006年后危害面积下降,2008年下降到6015hm2。但至2008年该病已经扩散至韩国54个地区、县和11省。调查发现松材线虫可以被云杉花墨天牛(Monochamus saltuarius)所携带。防治的策略为:(1)连续地监测;(2)病株的早期检测;(3)伐除病株;(4)焚烧和熏蒸伐除的病木。对人文和旅游景点及成熟林可以采取注射法防治,也可采取飞防的方法防治天牛。韩国已经通过了法律,禁止病木的运输。在首次发现该病后连续3a未发生重复感染的地区,建立无病区和优选系统。

关键词：松萎蔫病防控现状韩国

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Experiments and computer simulation analysis of impact behaviors of micro-sized abrasive in waterjet cutting of thin multiple layered materials

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中国有色金属学会会刊：英文版 2012年第S3期22卷 864-869页

作者： Jung-Han LEE Kang-Su PARK Myung Chang KANG Bo Sik KANG Bo sung shin Engineering Research Center Pusan National University National Core Research Center Pusan National University Mechanical System Safety Research Division Korea Institute of Machinery and Materials

The abrasive waterjet (AWJ) is now widely used in the advanced cutting processes of polymers,metals,glass,ceramics and composite materials like thin multiple-layered material (TMM).Various research and development efforts have recently been made to understand the science of ***,the interaction mechanism between a workpiece and high-velocity abrasive particles still remains a complicated *** this work,the material removal mechanisms of AWJ such as micro penetration and micro dent were experimentally *** addition,a new computer simulation model considering high strain rate effect was proposed to understand the micro impact behavior of high-velocity micro-sized abrasives in AWJ cutting.

关键词： abrasive waterjet thin multiple layered materials micro-sized abrasive micro penetration micro dent

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Pancreatic arteriovenous malformation treated with transcatheter arterial embolization:Two case reports and review of literature

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世界临床病例杂志 2023年第28期11卷 6920-6930页

作者： Sang Hoon shin Chol Kyoon Cho sung Yeol Yu Department of Surgery Chonnam National University Hwasun HospitalHwasun 58128Jeollanam-doSouth Korea Department of Surgery Chonnam National University Medical SchoolChonnam National University Hwasun HospitalHwasun 58128Jeollanam-doSouth Korea Department of Surgery Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Various treatment methods are available for the treatment of pancreatic arteriovenous malformation(P-AVM);however,there are no established treatment options for asymptomatic *** SUMMARY A 47-year-old and a 50-year-old male patients sought treatment for P-AVM in the pancreas,which was incidentally detected during routine abdominal computed tomography and magnetic resonance imaging conducted as part of a health *** underwent transcatheter arterial embolization(TAE),and over the course of a 9-year follow-up period,the AVM did not worsen and was *** TAE can be considered as an alternative treatment option for P-AVM in selective cases where patients are asymptomatic or have a high surgical risk.

关键词： Pancreatic arteriovenous malformation Transcatheter arterial embolization Surgical treatment Asymptomatic Angiography Case report

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Hepatocellular carcinoma presenting as organized liver abscess:A case report

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World Journal of Clinical Cases 2023年第33期11卷 8078-8083页

作者： sung Hyeok Ryou Hyun Deok shin Suk Bae Kim Department of Internal Medicine Dankook University College of MedicineCheonan 31116ChungnamSouth Korea

BACKGROUND Hepatocellular carcinoma(HCC)is difficult to treat and has a high mortality rate,emphasizing the importance of early diagnosis and *** characteristic radiologic findings and underlying liver disease are present,a diagnosis can be made without a ***,when HCC is accompanied by a liver abscess,diagnosis might be delayed by atypical radiologic *** case report aims to assist in the diagnosis of HCC,which can manifest in various *** SUMMARY A 75-year-old male presented to the Emergency Department with worsening fever and mental *** was diagnosed with liver cirrhosis six months *** computed tomography(CT)raised our suspicion of an organized liver abscess.A follow-up CT scan after four weeks of antibiotic treatment showed a decrease in the liver lesion ***,high fever recurred,and C-reactive protein increased to 14 mg/*** of the liver lesion was performed,but no bacteria were *** culture revealed the presence of *** patient received an additional four weeks of antibiotics and antifungal agents before being *** 10 mo later,a CT scan showed an increase in the lesion size,and biopsy was *** biopsy revealed an organized abscess with focal carcinomatous changes,for which surgery was *** histopathological examination revealed HCC,clear-cell *** nontumor liver tissue showed cirrhosis and an organized *** Even if a liver abscess is suspected in a patient with cirrhosis,the possibility of HCC should be considered.

关键词： Liver abscess Hepatocellular carcinoma Infection Diagnosis Case report

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Realizing High Thermoelectric Performance in n-Type Se-Free Bi2Te3 Materials by Spontaneous Incorporation of FeTe2 Nanoinclusions

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Energy & Environmental Materials 2024年第4期7卷 344-354页

作者： Jamil Ur Rahman Woo Hyun Nam Yong-Jae Jung Jong Ho Won Jong-Min Oh Nguyen Van Du Gul Rahman Víctor M.García-Suárez Ran He Kornelius Nielsch Jung Young Cho Won-Seon Seo Jong Wook Roh Sang-il Kim Soonil Lee Kyu Hyoung Lee Hyun Sik Kim Weon Ho shin Leibniz Institute for Solid State and Materials Research Advanced Materials Convergence R&D Division Korea Institute of Ceramic Engineering & Technology Department of Electronic Materials Engineering Kwangwoon University Department of Energy Engineering Dankook University Faculty of Fundamental Science Phenikaa University Department of Physics Quaid-i-Azam University Departamento de Física Universidad de Oviedo Nanomaterials and Nanotechnology Research Center-CINN Department of Materials Science and Engineering Yonsei University School of Nano & Materials Science and Engineering Kyungpook National University Department of Materials Science and Engineering University of Seoul School of Materials Science and Engineering Changwon National University

Bi2Te3-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi2（Te,Se）3materials is still low due to the evaporation energy of Se (37.70 kJ mol-1) being much lower than that of Te (52.55 kJ mol-1).The evaporated Se from the material causes problems in interconnects of the module while degrading the efficiency.

关键词： Bi2Te3 energy harvesting FeTe2 nanoinclusion n-type materials thermoelectric

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Easy calibration method of vision system for in-situ measurement of strain of thin films

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中国有色金属学会会刊：英文版 2009年第B9期19卷 243-249页

作者： Jun-Hyub PARK Dong-Joong KANG Myung-Soo shin sung-Jo LIM Son-Cheol YU Kwang-Soo LEE Jong-Eun HA sung-Hoon CHOA Department of Mechatronics Engineering Tongmyong University School of Mechanical Engineering Pusan National University Department of Automotive Engineering Hoseo University Department of Automotive Engineering Seoul National University of Technology Department of Nano/IT Engineering Seoul N ational University of Technology

An easy calibration method was presented for in-situ measurement of displacement in the order of nanometer during micro-tensile test for thin films by using CCD camera as a sensing device. The calibration of the sensing camera in the system is a central element part to measure displacement in the order of nanometer using images taken with the camera. This was accomplished by modeling the optical projection through the camera lens and relative locations between the object and camera in 3D space. A set of known 3D points on a plane where the film is located on is projected to an image plane as input data. These points, known as a calibration points, are then used to estimate the projection parameters of the camera. In the measurement system of the micro-scale by CCD camera, the calibration data acquisition and one-to-one matching steps between the image and 3D planes need precise data extraction procedures and repetitive user's operation to calibrate the measuring devices. The lack of the robust image feature extraction and easy matching prevent the practical use of these methods. A data selection method was proposed to overcome these limitations and offer an easy and convenient calibration of a vision system that has the CCD camera and the 3D reference plane with calibration marks of circular type on the surface of the plane. The method minimizes the user's intervention such as the fine tuning of illumination system and provides an efficient calibration method of the vision system for in-situ axial displacement measurement of the micro-tensile materials.

关键词：标定方法视觉系统原位测试应变薄膜松

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Portal vein stenting as a significant risk factor for biliary stricture in adult living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 480-486页

作者： Min-Ho shin Deok-Bog Moon sung-Gyu Lee shin Hwang Ki-Hun Kim chul-Soo Ahn Tae-Yong Ha Gi-Won Song Dong-Hwan Jung Gil-Chun Park Young-In Yun Wan-Jun Kim Woo-Hyoung Kang Seok-Hwan Kim Gi-Young Ko Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 0lympic-ro 43 gilSongpa-guSeoul 05505Korea Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of Medicine88 0lympic-ro 43 gilSongpa-guSeoul 05505Korea

BACKGROUND: Although perioperative portal vein (PV) stent implantation is an effective treatment for steno-occlusive disease in adult living donor liver transplantation (LDLT) re-cipients, we experienced high incidence of biliary anastomotic strictures (BAS) after PV stenting. In this study, we sought to clarify the relation between BAS and PV stenting and to suggest the possible mechanism of BAS and measures to reduce its in-cidence. METHODS: We retrospectively analyzed 44 LDLT recipients who underwent PV stent implantation across the line of PV anastomosis regardless of the location of steno-occlusion (stent group) and their matched controls (non-stented LDLT recipients, n=131). RESULTS: The incidence of BAS was higher in patients in the stent group than that in the control group (43.2% vs 17.6%, P=0.001). Cumulative 6-month and 1-, 2- and 5-year BAS rates were 31.8%, 34.1%, 41.4% and 43.2%, respectively, in the stent group and 13.0%, 13.8%, 16.1% and 17.8%, respectively, in the control group (P=0.001). Multivariate analysis revealed that PV stenting was an independent risk factor for BAS. CONCLUSIONS: Although PV stent implantation is a reliable treatment modality for steno-occlusive PV in adult LDLT recipients, innovative methods to prevent the PV stent from crossing the line of PV anastomosis may be necessary to reduce the incidence of postoperative BAS.

关键词： portal vein stenting biliary stricture living donor liver transplantation

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