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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG PARK MINSUK KWON MINAE AN jung YONG HONG JOON OH PARK sung HEE LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

Utilizing Blockchain Technology to Improve WSN Security for Sensor Data Transmission

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Computers, Materials & Continua 2021年第8期68卷 1899-1918页

作者： sung-jung Hsiao Wen-Tsai sung Department of Information Technology Takming University of Science and TechnologyTaipei City11451Taiwan Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung41170Taiwan

This paper proposes a method for improving the data security of wireless sensor networks based on blockchain *** technology is applied to data transfer to build a highly secure wireless sensor *** this network,the relay stations use microcontrollers and embedded devices,and the microcontrollers,such as Raspberry Pi and Arduino Yun,represents mobile *** proposed system uses microcontrollers to facilitate the connection of various sensor *** adopting blockchain encryption,the security of sensing data can be effectively improved.A blockchain is a concatenated transaction record that is protected by *** section contains the encrypted hash of the previous section,the corresponding timestamp,and transaction *** transaction data denote the sensing data of the wireless sensing *** proposed system uses a hash value representation calculated by the Merkel-tree algorithm,which makes the transfer data of the system difficult to be tamped ***,the proposed system can serve as a private cloud data *** this study,the system visualizes the data uploaded by sensors and create relevant charts based on big data *** the webpage server of the proposed system is built on an embedded operating system,it is easy to model and visualize the corresponding graphics using Python or JavaScript programming ***,this study creates an embedded system mobile database and web server,which can utilize JavaScript program language and *** runtime environment to apply blockchain technology to mobile *** proposed method is verified by the experiment using about 1600 data *** results show that the possibility of data being changed is very small,and the probability of data being changed is almost zero.

关键词： Blockchain embedded system big data analysis python javascript node.js

Improving Speech Enhancement Framework via Deep Learning

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Computers, Materials & Continua 2023年第5期75卷 3817-3832页

Speech plays an extremely important role in social *** individuals suffer from a“speech barrier,”which limits their communication with *** this study,an improved speech recognitionmethod is proposed that addresses the needs of speech-impaired and deaf individuals.A basic improved connectionist temporal classification convolutional neural network(CTC-CNN)architecture acoustic model was constructed by combining a speech database with a deep neural *** sensors were used to convert the collected voice signals into text or corresponding voice signals to improve *** method can be extended to modern artificial intelligence techniques,with multiple applications such as meeting minutes,medical reports,and verbatim records for cars,sales,*** experiments,a modified CTC-CNN was used to train an acoustic model,which showed better performance than the earlier common *** a CTC-CNN baseline acoustic model was constructed and optimized,which reduced the error rate to about 18%and improved the accuracy rate.

关键词： Artificial intelligence speech recognition speech to text CTC-CNN

RFID Positioning and Physiological Signals for Remote Medical Care

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Computer Systems Science & Engineering 2022年第4期41卷 289-304页

作者： Wen-Tsai sung sung-jung Hsiao Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung411030Taiwan Department of Information Technology Takming University of Science and TechnologyTaipei City11451Taiwan

The safety of patients and the quality of medical care provided to them are vital for their *** study establishes a set of RFID(Radio Fre-quency Identiﬁcation)-based systems of patient care based on physiological sig-nals in the pursuit of a remote medical care *** RFID-based positioning system allows medical staff to continuously observe the patient's health and *** staff can thus respond to medical emergencies in time and appropriately care for the *** the COVID-19 pandemic broke out,the proposed system was used to provide timely information on the location and body temperature of patients who had been screened for the *** results of experiments and comparative analyses show that the proposed system is superior to competing systems in *** use of remote monitoring technology makes user interface easier to provide high-quality medical services to remote areas with sparse populations,and enables better care of the elderly and patients with mobility *** can be found from the experiments of this research that the accuracy of the position sensor and the ability of package delivery are the best among the other related *** presentation of the graphical interface is also the most cordial among human-computer interaction and the operation is simple and clear.

关键词： Remote medical care active RFID positioning physiological signal

Home Monitoring of Pets Based on AIoT

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Computer Systems Science & Engineering 2022年第10期43卷 59-75页

作者： Wen-Tsai sung sung-jung Hsiao Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung City411030Taiwan Department of Information Technology Takming University of Science and TechnologyTaipei City11451Taiwan

With technological and social development in recent decades,people have begun pursuing more comfortable lives that frequently feature household pets that are treated like members of the *** average,one out of every three households has a *** has also led to the creation and growth of many businesses in the pet industry.A few companies have developed a system that allows busy office workers to remotely care for pets at home based on the Internet of Things and an intelligent adjustment *** owners of two dogs,the authors of this study observed their pets’living habits and recorded environmental conditions that appear suitable for *** data were then used to develop an automatic control system to care for *** observational data on the pets’habits and environment were written in a program in Arduino by using the ESP8266 Wi-Fi *** module and booster module control is the switch and setting of various household *** to the loop setting of the program,the system does not need to manually switch or adjust the electrical settings of the ***,the pet's living environment is assessed by using various *** use of Arduino programs helps develop a system that can automatically adjust the environment to one that is most suitable for the pet's comfort.

关键词： Remote medical care active RFID positioning physiological signal

Utilizing the Improved QPSO Algorithm to Build a WSN Monitoring System

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Computers, Materials & Continua 2022年第2期70卷 3529-3548页

This research uses the improved Quantum Particle Swarm Optimization(QPSO)algorithm to build an Internet of Things(IoT)life comfort monitoring system based on wireless sensing *** purpose is to improve the quality of intelligent *** functions of the system include automatic basketball court lighting system,monitoring of infants’sleeping posture and accidental falls of the elderly,human thermal comfort measurement and other related life comfort services,*** the hardware system of the IoT,this research is based on the latest version of ZigBee 3.0,which uses optical sensors,3-axis accelerometers,and temperature/humidity sensors in the IoT perception *** the network transmission layer,the central network architecture is used for *** the application layer,we have designed a graphical interface for real-time values and information that can be read at any time and place using mobile *** this study,authors use the improved QPSO algorithm in the calculation part,so that the target can be effectively positioned outside the numerous surveillance *** study uses various sensor data fusion technologies to make the IoT system becomes able to provide more extensive and even better services than ever *** short,this research work has proven to be an effective way to reduce power consumption,improve medical quality and provide higher comfort for intelligent lift level.

关键词： Quantum particle swarm optimization IoT wireless sensor network ZigBee

A Sensor Network Web Platform Based on WoT Technology

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Computer Systems Science & Engineering 2021年第8期38卷 197-214页

作者： Shun-Yuan Wang Yun-jung Hsu sung-jung Hsiao Wen-Tsai sung Department of Electrical Engineering National Taipei University of TechnologyTaipei10608TaiwanChina Department of Information Technology Takming University of Science and TechnologyTaipei11451TaiwanChina Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung41170TaiwanChina

This study proposes a Web platform,the Web of Things(WoT),whose Internet of Things(IoT)architecture is used to develop the technology behind a new standard Web *** a remote sensor passes data to a microcontroller for processing,the protocol is often not *** study proposes a WoT platform that enables the use of a browser in a mobile device to control a remote hardware *** optimized code is written using an artificial intelligencebased algorithm in a *** data convergence technology is adopted to process the packets of different protocols and place them on the Web platform for access by other mobile *** platform has high efficiency and cross-platform advantages,with no limitation on the operating *** queueing telemetry transport(MQTT)technology is used to simplify the original HTTP *** that the mobile device is a subscriber,i.e.,the controller,and a microcontroller that connects the sensing device is the *** publishers and subscribers of MQTT need not know each other if they share a message *** intermediate agent role is much like a *** and subscribers do not need to interact,and publishers do not have to wait for subscriber confirmation to cause interactive permission be *** must publishers and subscribers be online at the same time,and they are free to choose when to get *** proposed WoT method is compared with the traditional IoT method regarding data *** results show that the proposed method can save time in processing large amounts of data,as the traditional IoT method wastes time,especially in data format transfer.

关键词： Embedded systems mobile Web servers big data analysis WoT IoT

Speech Recognition via CTC-CNN Model

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Computers, Materials & Continua 2023年第9期76卷 3833-3858页

作者： Wen-Tsai sung Hao-WeiKang sung-jung Hsiao Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung411030Taiwan Department of Information Technology Takming University of Science and TechnologyTaipei11451Taiwan

In the speech recognition system,the acoustic model is an important underlying model,and its accuracy directly affects the performance of the entire *** paper introduces the construction and training process of the acoustic model in detail and studies the Connectionist temporal classification(CTC)algorithm,which plays an important role in the end-to-end framework,established a convolutional neural network(CNN)combined with an acoustic model of Connectionist temporal classification to improve the accuracy of speech *** study uses a sound sensor,ReSpeakerMic Array v2.0.1,to convert the collected speech signals into text or corresponding speech signals to improve communication and reduce noise and hardware *** baseline acousticmodel in this study faces challenges such as long training time,high error rate,and a certain degree of *** model is trained through continuous design and improvement of the relevant parameters of the acousticmodel,and finally the performance is selected according to the evaluation ***,which reduces the error rate to about 18%,thus improving the accuracy ***,comparative verificationwas carried out from the selection of acoustic feature parameters,the selection of modeling units,and the speaker’s speech rate,which further verified the excellent performance of the CTCCNN_5+BN+Residual model *** terms of experiments,to train and verify the CTC-CNN baseline acoustic model,this study uses THCHS-30 and ST-CMDS speech data sets as training data sets,and after 54 epochs of training,the word error rate of the acoustic model training set is 31%,the word error rate of the test set is stable at about 43%.This experiment also considers the surrounding environmental *** the noise level of 80∼90 dB,the accuracy rate is 88.18%,which is the worst performance among all *** contrast,at 40–60 dB,the accuracy was as high as 97.33%due to less noise pollution.

关键词： Artificial intelligence speech recognition speech to text convolutional neural network automatic speech recognition

Intelligent Home Using Fuzzy Control Based on AIoT

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Computer Systems Science & Engineering 2023年第5期45卷 1063-1081页

作者： sung-jung Hsiao Wen-Tsai sung Department of Information Technology Takming University of Science and TechnologyTaipei City11451Taiwan China Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung411030Taiwan China

The Internet of Things has grown rapidly in recent years,and the technologies related to it have been widely used in various *** idea of this paper is to build a set of Internet of Things systems in a smart home wireless network environment,with the purpose of providing people with a more comfortable,convenient,and safe *** the sensing layer of the Internet of Things,we discuss the uses of common sensing technologies on the Internet and combine these with Arduino microprocessors to integrate temperature sensing modules,humidity sensing modules,gas sensing modules,and particulate matter 2.5(PM2.5)sensing *** the network layer,we discuss using the Wi-Fi wireless networking function composed of a home router and a wireless Wi-Fi chip Espressif system 8266(ESP8266)to transmit the collected home-sensing data to the ThingSpeak cloud ***,in the application layer part,the system uses a mobile device with fuzzy calculation optimization *** system is also connected remotely for home environment monitoring,so the home environment can be optimized anytime,anywhere.

关键词： Wireless sensor networks internet of things ESP8266 thingspeak fuzzy control