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Organic X-Ray Image Sensors Using a Medium Bandgap Polymer Donor with Low Dark Current

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Energy & Environmental Materials 2024年第6期7卷 230-237页

作者： Jong-woon Ha Seung Hun Eom Bo Kyung Cha Seyeong Song Hyeong Ju Eun Jong H.Kim Jong Mok Park BongSoo Kim Byoungwook Park Seo-Jin Ko sung Cheol Yoon Changjin Lee In Hwan Jung Do-Hoon Hwang Department of Chemistry Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Korea Division of Advanced Energy Materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Korea Electro-Medical Device Research Center Korea Electrotechnology Research Institute(KERI)Ansan 15588Korea Graduate School of Carbon Neutrality School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Molecular Science and Technology Ajou UniversitySuwon 16449Korea Research Center for Advanced Specialty Chemicals Korea Research Institute of Chemical TechnologyUlsan 44412Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Organic and Nano Engineering Human-Tech Convergence ProgramHanyang University222 Wangsimni-roSeongdong-guSeoul 04763Korea

The development of portable X-ray detectors is necessary for diagnosing fractures in unconscious patients in emergency ***,this is quite challenging because of the heavy weight of the scintillator and silicon *** weight and thickness of X-ray detectors can be reduced by replacing the silicon layer with an organic *** study presents a novel bithienopyrroledione-based polymer donor that exhibits excellent photodetection properties even in a thick photoactive layer(~700 nm),owing to the symmetric backbone and highly soluble molecular structure of *** ability of bithienopyrroledione-based polymer donor to strongly suppress the dark current density(Jd~10−10 A cm^(−2))at a negative bias(−2.0 V)while maintaining high responsivity(R=0.29 A w−1)even at a thickness of 700 nm results in a maximum shot-noise-limited specific detectivity of D_(sh)^(*)=2.18×10^(13)Jones in the organic *** organic photodetectors are developed by slot-die coating for use in X-ray detectors,which exhibit D_(sh)^(*)=2.73×10^(12)Jones with clear rising(0.26 s)and falling(0.29 s)response times upon X-ray *** reliability is also proven by linear response of the X-ray detector,and the X-ray detection limit is 3 mA.

关键词： low dark current low detection limit organic photodetector printable X-ray

Uncoupling neurotrophic function from nociception of nerve growth factor: what can be learned from a rare human disease?

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Neural Regeneration Research 2019年第4期14卷 570-573页

作者： Kijung sung wanlin yang Chengbiao wu Department of Neurosciences University of California San Diego

Nerve growth factor(NGF) is a powerful trophic factor that provides essential support for the survival and differentiation of sympathetic and sensory neurons during development. However, NGF also activates nociceptors contributing significantly to inflammatory pain and neuropathic pain after tissue injury. As such anti-NGF based therapies represent a promising strategy for pain management. Because of dose-dependent serious side effects such as back pain, injection site hyperalgesia, clinical trials of using NGF to treat various disorders such as diabetic neuropathies, chemotherapy-induced and human immunodeficiency virus-associated peripheral neuropathies were all discontinued. Thus far, worldwide clinical applications of NGF in treating patients are very limited except in China. Hereditary sensory autonomic neuropathy type V(HSAN V) is an extremely rare disease. Genetic analyses have revealed that HSAN V is associated with autosomal recessive mutations in NGF. One of the mutations occurred at the 100^(th) position of mature NGF resulting in a change of residue from arginine to tryptophan(R100w). Although those HSAN V patients associated with the NGF^(R100w) mutation suffer from severe loss of deep pain, bone fractures and joint destruction, interestingly patients with the NGF^(R100w) mutation do not show apparent cognitive deficits, suggesting important trophic support function is preserved. we believe that NGF^(R100w) provides an ideal tool to uncouple the two important functions of NGF: trophic versus nociceptive. Studies from investigators including ourselves have indeed confirmed in animal testing that the NGF^(R100w) no longer induced pain. More importantly, the trophic function seemed to be largely preserved in NGF harboring the R100w mutation. On the mechanistic level, we found that the NGF^(R100w) mutation was capable of binding to and signaling through the tyrosine receptor kinase A receptor. But its ability to bind to and activate the 75 kDa neurotrophic

关键词： hereditary sensory and autonomic neuropathy V nerve growth factor NGFR100w mutation pain tyrosine receptor kinase A p75 neurotrophic factor receptor

A fast-running method for blast load prediction shielding by a protective barrier

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Defence Technology（防务技术） 2020年第2期16卷 308-315页

作者： S.-H.sung J.-w.Chong Agency for Defense Development Yuseong P.O.Box 35DaeJeon395-600South Korea

This study presents a simplified blast load prediction method on structures behind a protective *** proposed method is basically an empirical approach based on Kingery-Bulamsh(K-B)chart and finite element(FE)analysis *** this end,this study divides the structure into three regions by three critical *** loads at each critical point can be calculated based on K-B chart and an approximation according to FE analysis ***,peak reflected overpressure and impulse distributed on the structure can be approximately estimated by linearly connecting blast loads at each critical *** order to confirm a feasibility of the proposed method,a series of numerical simulations were carried *** simulation results were compared with FE analysis results which are presented in the open *** such comparisons,it was found that the proposed method is applicable to predict blast loads on structures behind a protective barrier.

关键词： Blast loads Protective barrier Shock wave Fast running model Kingery-Bulmash

Performance-based concept on seismic evaluation of existing bridges

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Earthquake Engineering and Engineering Vibration 2009年第1期8卷 127-135页

作者： Yu-Chi sung wen-I Liaoi w.Phillip Yen Department of Civil Engineering Taipei University of Technology Taipei 10608 Chinese Taipei Office of lnfrastructure R＆D Federal Highway Administration 6300 Georgetown Pike McLean VA 20121 USA

Conventional seismic evaluation of existing bridges explores the ability of a bridge to survive under significant earthquake excitations. This approach has several major drawbacks, such as only a single structural performance of near collapse is considered, and the simplified approach of adopting strength-based concept to indirectly estimate the nonlinear behavior of a structure lacks accuracy. As a result, performance-based concepts that include a wider variety of structural performance states of a given bridge excited by different levels of earthquake intensity is needed by the engineering community. This paper introduces an improved process for the seismic evaluation of existing bridges. The relationship between the overall structural performance and earthquakes with varying levels of peak ground acceleration （PGA） can successfully be linked. A universal perspective on the seismic evaluation of bridges over their entire life-cycle can be easily obtained to investigate multiple performance objectives. The accuracy of the proposed method, based on pushover analysis, is proven in a case study that compares the results from the proposed procedure with additional nonlinear time history analyses.

关键词： pushover analysis plastic hinge seismic capacity seismic demand performance-based concepts

High-performance self-powered color filter-free blue photodetector based on wide-bandgap halide perovskites

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Journal of Materials Science & Technology 2023年第21期152卷 100-108页

作者： Yeonghun Yun Hanbyeol Cho Jina Jung sung w.ong yang Devthade Vidyasagar Rajendra Kumar Gunasekaran Sangwook Lee School of Materials Science and Engineering Kyungpook National University(KNU)Daegu 41566South Korea KNU Advanced Material Research Institute Kyungpook National UniversityDaegu 41566South Korea Institute of Microstructure Technology&Light Technology Institute Karlsruhe Institute of TechnologyKarlsruhe 76131Federal Republic of Germany

Blue photodetectors(PDs)are attracting great attention for various *** blue PDs based on inorganic GaP or InGaN absorbers are limited by their expensive,complex,and high-temperature fabrication *** absorber-based blue PDs still have much lower photode-tecting properties than inorganic blue *** this study,a high-performance self-powered blue PD is developed using methylammonium lead halide(MAPbX_(3);X=I,Br,and Cl)perovskites based on the eco-nomic and facile solution process at low *** composition is obtained through halide-composition *** best-performing device exhibits an average external quantum efficiency and an average detectivity of 42.7%and 8.65×10^(11) Jones,respectively,within the blue *** peak responsivity of the proposed PD is 0.174 A w^(−1) at 455 nm,which is comparable to that of commercial gallium phosphide blue PD(0.180 A w^(−1) at 470 nm).Moreover,the proposed device exhibits excellent environmental stability under ambient air *** findings will act as a basis for next-generation image sensor technologies,such as vertically stacked red/green/blue PDs.

关键词： Perovskites Photodetectors Blue Composition engineering Self-powered wide bandgap

UV-assisted flash light welding process to fabricate silver nanowire/graphene on a PET substrate for transparent electrodes

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Nano Research 2018年第4期11卷 2190-2203页

作者： wan-Ho Chung sung-Hyeon Park sung-Jun Joo Hak-sung Kim Department of Mechanical Engineering Hanyang University 17 Haendang-Dong Seongdong-Gu Seoul 133-791 Republic of Korea Institute of Nano Science and Technology Hanyang University Seou1133-791 Republic of Korea

Graphene oxide and silver nanowires were bar coated onto polyethylene terephthalate （PET） substrates and then welded using an ultraviolet （UV）-assisted flash light irradiation process to achieve both high electrical conductivity and low haze. The irradiation process connected adjacent silver nanowires by welding, while simultaneously reducing the graphene oxide to graphene. This process was performed using a custom w-assisted flash light welding system at room temperature under ambient conditions and was extremely rapid, with processing time of several milliseconds. The effects of varying the weight fractions of the silver nanowires and graphene oxide and of varying the w-assisted flash light welding conditions （light energy and pulse duration） were investigated. The surface morphologies of the welded silver nanowire/graphene films were analyzed using scanning electron microscopy. Optical characterizations, including transmittance and haze measurements, were also conducted using a spectrophotometer. To test their resistance to oxidation, the welded silver nanowire/graphene films were subjected to high temperature in a furnace （100 ℃）, and their sheet resistances were measured every hour. The flash light welding process was found to yield silver nanowire/graphene films with high oxidation resistance, high conductivity （14.35 Ω·sq-1）, high transmittance （93.46%）, and low haze （0.9%）. This material showed uniform temperature distribution when applied as a resistive heating film.

关键词： silver nanowires graphene oxide transparent electrode flash light welding printed electronics

Initial Stability Study of Calcium Phosphate Coated Dental Implants

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Journal of wuhan University of Technology(Materials Science) 2005年第B12期20卷 246-248页

作者： Changkook YOU In-sung YEO Tae-kwan EOM M w AHN Sukyoung KIM School of Materials Sci. & Eng. Yeungnam University Gyeongbuk 712-749 Korea Department of Dentistry Special War Command Seoul 138-110 Korea R&D Center Osstem Co. Ltd. Yeonsan-Gu Busan 611-073 Korea Dept.of Orthopedic Surgery College of Medicine Yeungnam Univ. Daegu Korea

Thin film of biodegradable calcium phosphate coated on threaded commercially pure titanium （ cp- Ti ） dental implants has been investigated as one of alternatives to eliminate the problem of the long- term instability of plasma sprayed HA coated implants. In order to compare in-vivo bone-to-implant response behavior among as-machined, HA coated and CMP coated groups, each group was implanted into New Zealand white mature male rabbits for 2 and 6 weeks, and then in-vivo biological behavior was examined in terms of H＆E staining. Initial stability and removable torques of implants were compared among three groups. Measured removable torque of CMP coated specimen at 6 weeks after inplantation was significantly higher than that of non-coated group, but slightly lower than that of HA coated group, without any inflammatory response at the surrounding of the implants. The initial stability （ ISQ value ; implant stability quotient ） of CMP coated specimen at 2 weeks after implantation was slightly lower than that of HA coated group and significantly higher than that of non-coated group. However, after 6 weeks, ISQ value of CMP coated group was slightly higher than that of HA coated group and significantly higher than that of non-coated group.

关键词： calcium metaphosphate initial stability RFA ISQ value osseointegration

Late Mesozoic magmatism in the East Qinling Orogen, China and its tectonic implications

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Geoscience Frontiers 2019年第5期10卷 1803-1821页

作者： Fan yang Fei Xue M. Santosh Gongwen wang sung won Kim Zhiwei Shen wenjuan Jia Xuhuang Zhang School of Earth Sciences and Resources China University of Geosciences Beijing29 Xueyuan RoadBeijing 100083China Graduate School of Life and Environmental Sciences University of TsukubaIbaraki305-8572Japan Department of Earth Sciences School of Physical SciencesThe University of AdelaideSA 5005Australia State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityNorthern Taibai Str. 229Xi’an 710069China Geological Research Division Korea Institute of Geoscience and Mineral ResourcesDaejeon305-350Republic of Korea Xinjiang Zijin Zinc Industry Co. LtdKezhou 845450China Luanchuan Bureau of Geology and Resources Luoyang 417500China

The Qinling Orogen in Central China records the history of a complex geological evolution and tectonic transition from compression to extension during the Late Mesozoic,with concomitant voluminous granitoids *** this study,we present results from petrological,geochemical,zircon U-Pb-Lu-Hf isotopic studies on the Lengshui felsic dykes from Luanchuan region in the East Qinling *** also compile published geochronological,geochemical,and Hf isotopic data from Luanchuan region and present zircon Hf isotopic contour *** newly obtained age data yield two group of ages at w145 Ma and 140 Ma for two granite porphyries from the Lengshui felsic dykes,with the w145 Ma interpreted as response to the peak of magmatism in the region,and the w140 Ma as the timing of formation of the felsic *** corresponding Hf isotopic data of the granite porphyries display negative εHf(t) values of e16.67 to e4.61,and Hf crustal model ages (TDM^C) of 2255e1490 Ma,indicating magma sourced from the melting of Paleo- to Mesoproterozoic crustal *** compiled age data display two major magmatic pulses at 160e130 Ma and 111e108 Ma with magmatic quiescence in between,and the zircon Hf isotopic data display εHf(t) values ranging from e41.9 to 2.1 and TDM^C values of 3387e1033 Ma,suggesting mixed crustal and mantle-derived components in the magma source,and correspond to multiple tectonic events during the Late *** Luanchuan granitoids are identified as I-type granites and most of these are highly fractionated granites,involving magma mixing and mingling and crystal *** tectonic setting in the region transformed from the Late Jurassic syn-collision setting to Early Cretaceous within-plate setting,with Eew extension in the Early *** extension is correlated with the NeS trending post-collisional extension between the North China Craton and yangtze Craton as well as the Eew trending back-arc extension triggered by the westward Paleo-Pacific

关键词： Petrology Geochemistry Zircon U-Pb-Lu-Hf isotopes Zircon Hf isotopic mapping Luanchuan region East Qinling Orogen

Dendritic cell-mimicking scaffolds for ex vivo T cell expansion

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Bioactive Materials 2023年第3期21卷 241-252页

作者： Hye sung Kim Tzu-Chieh Ho Moshe J.willner Michael w.Becker Hae-won Kim Kam w.Leong Department of Biomedical Engineering Columbia UniversityNew YorkNYUSA Institute of Tissue Regeneration Engineering Dankook UniversityCheonanRepublic of Korea wilmot Cancer Institute University of Rochester Medical CenterRochesterNYUSA Department of Regenerative Dental Medicine College of DentistryDankook UniversityCheonanRepublic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonanRepublic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonanRepublic of Korea Department of Systems Biology Columbia University Irving Medical CenterNew YorkNY10032USA

we propose an ex vivo T cell expansion system that mimics natural antigen-presenting cells(APCs)for adoptive cell therapy(ACT).Microfiber scaffolds coated with dendritic cell(DC)membrane replicate physicochemical properties of dendritic cells specific for T cell activation such as rapid recognition by T cells,long duration of T cell tethering,and DC-specific co-stimulatory *** DC membrane-coated scaffold is first surface-immobilized with T cell stimulatory ligands,anti-CD3(αCD3)and anti-CD28(αCD28)antibodies,followed by adsorption of releasable interleukin-2(IL-2).The scaffolds present both surface and soluble cues to T cells ex vivo in the same way that these cues are presented by natural APCs in *** demonstrate that the DC-mimicking scaffold promotes greater polyclonal expansion of primary human T cells as compared toαCD3/αCD28-func-tionalized *** importantly,major histocompatibility complex molecules derived from the DC membrane of the scaffold allow antigen-specific T cell expansion with target cell-specific killing *** addition,most of the expanded T cells(~97%)can be harvested from the scaffold by density gradient ***,the DC-mimicking scaffold offers a scalable,modular,and customizable platform for rapid expansion of highly functional T cells for ACT.

关键词： Adoptive cell therapy Ex vivo T cell expansion Cytotoxic T cell Dendritic cell membrane Cell membrane coating Scaffold