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Temporal profiles of synaptic plasticity-related signals in adult mouse hippocampus with methotrexate treatment

Neural Regeneration Research 2012年第21期7卷 1651-1658页

作者： Miyoung Yang Juhwan kim sung-Ho kim Joong-Sun kim Taekyun Shin Changjong Moon Department of Veterinary Anatomy College of Veterinary Medicine and Animal Medical Institute Chonnam National University Department of Experimental Radiation Research Center Dongnam Institute of Radiological & Medical Sciences (DIRAMS) Department of Veterinary Anatomy College of Veterinary Medicine Jeju National University

Methotrexate, which is used to treat many malignancies and autoimmune diseases, affects brain functions including hippocampal-dependent memory function. However, the precise mechanisms underlying methotrexate-induced hippocampal dysfunction are poorly understood. To evaluate temporal changes in synaptic plasticity-related signals, the expression and activity of N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, extracellular signal-regulated kinase 1/2, cAMP responsive element-binding protein, glutamate receptor 1, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor were examined in the hippocampi of adult C57BL/6 mice after methotrexate （40 mg/kg） intraperitoneal injection. Western blot analysis showed biphasic changes in synaptic plasticity-related signals in adult hippocampi following methotrexate treatment. N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, and glutamate receptor 1 were acutely activated during the early phase （1 day post-injection）, while extracellular signal-regulated kinase 1/2 and cAMP responsive element-binding protein activation showed biphasic increases during the eady （1 day post-injection） and late phases （7-14 days post-injection）. Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression increased significantly during the late phase （7-14 days post-injection）. Therefore, methotrexate treatment affects synaptic plasticity-related signals in the adult mouse hippocampus, suggesting that changes in synaptic plasticity-related signals may be associated with neuronal survival and plasticity-related cellular remodeling.

关键词： hippocampus methotrexate neurotrophic factor synaptic plasticity-related signal neuralregeneration

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Neuroprotective effects of tamsulosin on intracerebral hemorrhage

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Neural Regeneration Research 2011年第32期6卷 2505-2510页

作者： Hong-Jin Suh sung-Min So Young-Gil Na Il-Gyu Ko sung-Eun kim Yun-Hee sung Mal-Soon Shin Chang-Ju kim Young-Sam Cho Khae-Hawn kim Department of Urology Incheon St. Mary's Hospital the Catholic University of Korea School of Medicine Department of Urology Chungnam National University School of Medicine Department of Physiology Kyung Hee University School of Medicine Department of Urology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Urology Gachon University Gil Hospital Gachon University of Medicine and Science

The alpha1 adrenoreceptor antagonist tamsulosin is primarily used to treat benign prostatic hypertrophy. In this study, we intragastrically administered rats with 0.01,0.1 and 1 mg/kg tamsulosin to investigate the effects of tamsulosin on memory function, and hippocampal cell apoptosis and proliferation following intracerebral hemorrhage. Step-down avoidance task results showed that tamsulosin treatment markedly alleviated intracerebral hemorrhage- induced short-term memory impairment. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling results showed that tamsulosin treatment markedly suppressed intracerebral hemorrhage-induced caspase-3 expression in the hippocampal CA1 region and cell proliferation in the hippocampal dentate gyrus. Tamsulosin treatment at a dose of 0.01 mg/kg exhibited the most potent inhibitory effects on cell apoptosis and proliferation. These findings suggest that tamsulosin treatment facilitates the recovery of rat memory function by inhibiting hippocampal cell apoptosis and proliferation followincl intracerebral hemorrhaQe.

关键词： tamsulosin, intracerebral hemorrhage short-term memory apoptosis cellproliferation hippocampus neural regeneration

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Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery

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Nano Research 2018年第2期11卷 1082-1098页

作者： Ka Young kim Hanyong Jin Jaehyeon Park sung Ho Jung Ji Ha Lee Hyesong Park sung Kuk kim Jeehyeon Bae Jong Hwa Jung Department of Chemistry and Research Institute of Natural Sciences Gyeongsang National University Jinju Republic of Korea School of Pharmacy Chung-Ang University Seoul Republic of Korea

Subcellular organelle-specific nanoparticles for simultaneous tumor targeting, imaging, and drug delivery are of enormous interest in cancer therapy. Herein, we report a selective mitochondria-targeting probe 1, which was synthesized by incorporating a triphenyl phosphine with a cyanostilbene and a long alkyl chain moiety. Probe 1 was found to display fluorescence via aggregation-induced emission （AIE）. The low molecular-weight cyanostilbene-based probe 1, with and without an anticancer drug, formed a narrow homogeneous nanorod with ca. 110 nm of length or nanopartides with ca. 20 nm diameter in aqueous media. The self-assembled cyanostilbene nanoparticles （N1） selectively accumulated in the mitochondria of cancer cells and emitted fluorescence. N1 was also able to deliver an anticancer drug, doxorubicin （DOX）, to the mitochondria with high efficiency. More importantl~ N1 exhibited highly selective cytotoxicity for cancer cells over normal cells. The great potential applications of this self-assembled nanoparticle to biological systems result from its ability to aggregate in the mitochondria. This aggregation led to a significant increase in the generation of intraceUular reactive oxygen species and to a decrease in the mitochondrial membrane potential in cancer cells. Furthermore, tumor tissue uptake experiments in mice proposed that the self-assembled N1 had the ability to internalize and deliver the anticancer drug into tumor tissues effectively. Moreover, both N1 and Nl-encapsulated doxorubicin （N1-DOX） effectively suppressed tumor growth in a xenograft model in vivo. Taken together, our findings indicate that applications of N1 as a mitochondrial targeting probe, drug delivery platform, and chemotherapeutic agent provide a unique strategy for potential image-guided therapy as well as a site-specific delivery system to cancer cells.

关键词： aggregation-inducedemission,chemotherap3 drug deliver3 mitochondria-targeting,fluorescence imaging

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Comparative effects of soy protein concentrate,enzyme‑treated soybean meal,and fermented soybean meal replacing animal protein supplements in feeds on growth performance and intestinal health of nursery pigs

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畜牧与生物技术杂志:英文版 2023年第5期14卷 2033-2047页

作者： Zixiao Deng Marcos Elias Duarte So Young kim Yunil Hwang sung Woo kim Department of Animal Science North Carolina State University116 Polk HallCampus Box 7621RaleighNC 27695USA CJ Cheiljedang Seoul 04560Korea

Background Soy protein supplements,with high crude protein and less antinutritional factors,are produced from soybean meal by different *** study evaluated the comparative effects of various soy protein supplements replacing animal protein supplements in feeds on the intestinal immune status,intestinal oxidative stress,mucosaassociated microbiota,and growth performance of nursery *** Sixty nursery pigs(6.6±0.5 kg BW)were allotted to five treatments in a randomized complete block design with initial BW and sex as *** were fed for 39 d in 3 phases(P1,P2,and P3).Treatments were:Control(CON),basal diet with fish meal 4%,2%,and 1%,poultry meal 10%,8%,and 4%,and blood plasma 4%,2%,and 1%for P1,P2,and P3,respectively;basal diet with soy protein concentrate(SPC),enzyme-treated soybean meal(ESB),fermented soybean meal with Lactobacillus(FSBL),and fermented soybean meal with Bacillus(FSBB),replacing 1/3,2/3,and 3/3 of animal protein supplements for P1,P2,and P3,*** were analyzed using the MIXED procedure in SAS *** The SPC did not affect the BW,ADG,and G:F,whereas it tended to reduce(P=0.094)the ADFI and tended to increase(P=0.091)crypt cell *** ESM did not affect BW,ADG,ADFI,and G:F,whereas tended to decrease(P=0.098)protein carbonyl in jejunal *** FSBL decreased(P<0.05)BW and ADG,increased(P<0.05)TNF-α,and Klebsiella and tended to increase MDA(P=0.065)and IgG(P=0.089)in jejunal *** FSBB tended to increase(P=0.073)TNF-α,increased(P<0.05)Clostridium and decreased(P<0.05)Achromobacter and alpha diversity of microbiota in jejunal *** Soy protein concentrate,enzyme-treated soybean meal,and fermented soybean meal with Bacillus could reduce the use of animal protein supplements up to 33%until 7 kg body weight,up to 67%from 7 to 11 kg body weight,and entirely from 11 kg body weight without affecting the intestinal health and the growth performance of nursery *** soybean meal with

关键词： Enzyme-treated soybean meal Fermented soybean meal Intestinal health Nursery pigs Soy protein concentrate

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Effectiveness of lorazepam-assisted interviews in an adolescent with dissociative amnesia A case report

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Neural Regeneration Research 2013年第2期8卷 186-190页

作者： Yuna Seo Mi-Hee Shin sung-Gon kim Ji-Hoon kim Department of Psychiatry Aram Hospital Department of Psychiatry Pusan National University School of Medicine Division of Child-Adolescent Psychiatry Department of Psychiatry Pusan National University School of Medicine

To facilitate gathering information during a psychiatric interview, some psychiatrists advocate augmenting the interview using drugs. Rather than barbiturates, benzodiazepines have been used for drug-assisted interviews. Dissociative amnesia is one of the indications for these interviews. Herein, we present the case of a 15-year-old female who was diagnosed as having dissociative amnesia because of conflicts with her friends. She was administered a Iorazepam-assisted interview to aid recovery of her memories. In this case, a small dose of Iorazepam was sufficient to recover her memories without any adverse effects.

关键词： neural regeneration clinical practice dissociative amnesia dissociative disorder dissociation drug-assisted interview amobarbital, Iorazepam benzodiazepine adolescent memory loss emotional distress distress grant-supported paper neuroregeneration

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Electrochemical characteristics of HVOF spray coated layer with WC-27NiCr and WC-10Co4Cr for Al bronze

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中国有色金属学会会刊：英文版 2012年第S3期22卷 753-759页

作者： Min-su HAN Seung-jun LEE Min-sung kim Seok-ki JANG Seong-jong kim Division of Marine Engineering Mokpo Maritime University

Among the environmentally friendly marine energies,tidal current power plants require low cost because they do not need to construct a large *** power is particularly reliable energy source because the power generation capacity is predictable regardless of weather or *** materials or stainless steel have been used as materials of blades for current power ***,their strength and welding performance generated many problems in field *** alloys with excellent cavitation resistance and corrosion resistance were applied as blade materials to improve the durability of copper *** were coated with WC-27NiCr and WC-10Co4Cr using the high velocity oxy-fuel (HVOF) *** metal spray coating technology has the advantage in terms of the selection of materials for cost effectiveness and environmental effects of corrosion because the properties of the coat layer can be controlled *** with WC-27NiCr and WC-10Co4Cr by HVOF,WC-27NiCr shows better corrosion resistance *** reason for this seems to be that corrosion resistance improves and a stable passive film forms due to the effects of Ni and Cr.

关键词： tidal power copper alloys HVOF coating corrosion resistance

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Precambrian metallogeny,tectonics and correlations-Preface

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Geoscience Frontiers 2018年第2期9卷 293-294页

作者： Qiong-Yan Yang sung-Won kim School of Earth Sciences and Resources China University of Geosciences BeijingBeijing 100083China Korea Institute of Geoscience and Mineral Resources Daejeon 305-350Republic of Korea

The Precambrian continental nuclei in various parts of the globe preserve the records of important magmatic, metamorphic and tectonic events associated with the secular evolution of the Earth. In this thematic section of “Geoscience Frontiers”, we assemble a set of four key papers that address these topics from four key terranes: Western Australia, North China, northwestern India and East Antarctica.

关键词： The Precambrian continental nuclei

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Clinicopathologic significance of expression of nuclear factor-kB RelA and its target gene products in gastric cancer patients

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World Journal of Gastroenterology 2012年第34期18卷 4744-4750页

作者： Hyuk-Chan Kwon sung-Hyun kim sung Yong Oh Suee Lee Ji Hyun Lee Jin Seok Jang Min Chan kim Ki Han kim Su-Jin kim Seong-Geun kim Hyo-Jin kim Department of Internal Medicine Dong-A University College of MedicineBusan 602-715South Korea Department of Surgery Dong-A University College of MedicineBusan 602-715South Korea Department of Pathology Dong-A University College of MedicineBusan 602-715South Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalBusan 602-715South Korea

AIM:To assess the prognostic significance of nuclear factor-kB (NF-kB) and its target genes in gastric cancer. METHODS:The tumor tissues of 115 patients with gastric cancer were immunohistochemically evaluated using monoclonal antibodies against NF-kB RelA. Preoperative serum levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) were assessed via enzyme-linked immuno-sorbent assay. C-reactive protein (CRP) and serum amyloid A (SAA) were measured via immunotrubidimetry. RESULTS:Positive rate of NF-kB RelA was 42.6%. NF-kB RelA expression in tumor tissues was also related to serum levels of IL-6 (P = 0.044) and CRP (P = 0.010). IL-6, SAA, CRP were related to depth of invasion, VEGF and SAA were correlated with lymph node metastasis. IL-6, VEGF, SAA and CRP were related to the stage. Univariate analysis demonstrated that immunostaining of NF-kB RelA, levels of IL-6, VEGF, SAA were significantly related with both disease free survival and over-all survival (OS). Multivariate analysis verified that NF-kB RelA [hazard ratio (HR): 3.40, P = 0.024] and SAA (HR: 3.39, P = 0.045) were independently associated with OS. CONCLUSION: Increased expression of NF-kB RelA and high levels of serum SAA were associated with poor OS in gastric cancer patients.

关键词： Nuclear factor-κB Vascular endothelial grow-th factor Interleukin-6 C-reactive protein Serum amy-loid A Stomach Carcinoma

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Proton pump inhibitors as a risk factor for recurrence of Clostridium-difficile-associated diarrhea

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World Journal of Gastroenterology 2010年第28期16卷 3573-3577页

作者： Ji Won kim Kook Lae Lee Ji Bong Jeong Byeong Gwan kim Sue Shin Joo sung kim Hyun Chae Jung In sung Song Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Boramae Hospital Seoul National University College of Medicine Seoul 156-707South Korea Department of Laboratory Medicine Seoul National University Boramae Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Hospital Seoul National University College of Medicine Seoul 110-744South Korea

AIM:To investigate the risk factors for Clostridiumdifficile-associated diarrhea(CDAD)recurrence,and its relationship with proton pump inhibitors(PPIs). METHODS:Retrospective data of 125 consecutive hospitalized patients diagnosed with CDAD between January 2006 and December 2007 were collected by medical chart *** data included patient characteristics at baseline,underlying medical disease, antibiotic history before receiving a diagnosis of CDAD, duration of hospital stay,severity of CDAD,concurrenttreatment with PPIs,laboratory parameters,response to CDAD therapy,and recurrence of disease within 90 d of successful *** clinical and laboratory parameters were compared in patients in whom CDAD did or did not recur. RESULTS:Of the 125 patients(mean age,67.6± 13.9 years)that developed CDAD,98(78.4%)did not experience recurrence(non-recurrent group)and 27 (21.6%)experienced one or more recurrences(recurrent group).Prior to the development of CDAD,96% of the 125 patients were prescribed antibiotics,and 56(44.8%)of the patients received *** older than 65 years(P=0.021),feeding via nasogastric tube(NGT)(P=0.045),low serum albumin level(P =0.025),and concurrent use of PPIs(P=0.014) were found to be risk factors for CDAD recurrence by univariate ***,sex,length of hospital stay,duration and type of antibiotics used,severity of disease,leukocyte count and C-reactive protein(CRP) were not associated with risk of CDAD *** multivariate analysis,the important risk factors were advanced age(>65 years,adjusted OR:1.32,95% CI:1.12-3.87,P=0.031),low serum albumin level(< 2.5 g/dL,adjusted OR:1.85,95%CI:1.35-4.91,P= 0.028),and concurrent use of PPIs(adjusted OR:3.48, 95%CI:1.64-7.69,P=0.016). CONCLUSION:Advanced age,serum albumin level< 2.5 g/dL,and concomitant use of PPIs were found to be significant risk factors for CDAD recurrence.

关键词： Clostridium difficile Diarrhea Recurrence Risk factors Proton pump inhibitors

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Analyzing the distinguishing factors that affect childhood obesity in South Korea

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Frontiers of Medicine 2018年第6期12卷 707-716页

作者： So Jung Yang Hun-sung kim Kun-Ho Yoon Department of Medical Informatics College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Division of Endocrinology and Metabolism Department of lnternal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Understanding obesity in children is crucial because it can lead to adulthood obesity and result in fatal chronic diseases. Distinctive factors associated with obesity in adults have been described, but distinctive factors related to children remain unclear. We analyzed the correlation between the percentage of body mass index and lifestyle habits by conducting surveys on physical, nutritional, and psychological factors, and we used annual physical examination data to compare different traits among elementary school students (n = 197) and middle school students (n = 461). Our study revealed that the computing hours in elementary school students with overweight and obesity were significantly correlated with the percentage of body mass index (r = 0.29 on school days and r = 0.35 on days off, all P0.05) in the computing hours of middle school students with overweight and obesity. Childhood obesity can cause depression and reduce children’s quality of life because of their distorted body perception. In conclusion, physical factors directly affecting childhood obesity and psychological and environmental factors surrounding a child should be considered.

关键词： screen time quality of life eating habits childhood obesity percentage of body mass index

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