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Cytochrome P450 endoplasmic reticulumassociated degradation(ERAD): therapeutic and pathophysiological implications

Acta Pharmaceutica Sinica B 2020年第1期10卷 42-60页

作者： Doyoung Kwon sung-Mi kim Maria Almira Correia Department of Cellular and Molecular Pharmacology University of California San FranciscoSan FranciscoCA 94158-2517USA Pharmaceutical Chemistry University of California San FranciscoSan FranciscoCA 94158-2517USA Bioengineering and Therapeutic Sciences University of California San FranciscoSan FranciscoCA 94158-2517USA The Liver Center University of California San FranciscoSan FranciscoCA 94158-2517USA

The hepatic endoplasmic reticulum(ER)-anchored cytochromes P450(P450s)are mixedfunction oxidases engaged in the biotransformation of physiologically relevant endobiotics as well as of myriad xenobiotics of therapeutic and environmental relevance.P450 ER-content and hence function is regulated by their coordinated hemoprotein syntheses and proteolytic *** P450 proteolytic turnover occurs through a process known as ER-associated degradation(ERAD)that involves ubiquitindependent proteasomal degradation(UPD)and/or autophagic-lysosomal degradation(ALD).Herein,on the basis of available literature reports and our own recent findings of in vitro as well as in vivo experimental studies,we discuss the therapeutic and pathophysiological implications of altered P450 ERAD and its plausible clinical *** specifically(i)describe the P450 ERAD-machinery and how it may be repurposed for the generation of antigenic P450 peptides involved in P450 autoantibodypathogenesis in drug-induced acute hypersensitivity reactions and liver injury,or viral hepatitis;(ⅱ)discuss the relevance of accelerated or disrupted P450-ERAD to the pharmacological and/or toxicological effects of clinically relevant P450 drug substrates;and(ⅲ)detail the pathophysiological consequences of disrupted P450 ERAD,contributing to non-alcoholic fatty liver disease(NAFLD)/non-alcoholic steatohepatitis(NASH)under certain synergistic cellular conditions.

关键词： Cytochromes P450 Endoplasmic reticulumassociated degradation CHIP E3 ubiquitin ligase gp78/AMFR E3 ubiquitin ligase JNK1 AMPK1 Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis

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Intermediate space for housing design learned from tradition of Korean maru and Turkish sofa

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Frontiers of Architectural Research 2023年第2期12卷 277-290页

作者： JiaLu Gao In-sung kim College of Fine Arts Beihua UniversityJilin 132013China Yeungnam University Daehak-roGyeonbuk 38541Republic of Korea

The study examines traditional design approaches for intermediate spaces of residential buildings to support environmentally driven design strategies of current *** the evaluation of the potential of traditional design strategies,traditional houses of Korea and Turkey are explored by making a detailed comparison of maru and sofa according to theoretical considerations on intermediate *** examining the concept of the intermediate space and the general characteristics of Korean and Turkish traditional housing,10 cases from 17th to 19th centuries are selected and compared to clarify the features of maru and sofa as intermediate *** on the results,the arrangement of maru shows characteristics of contradiction between interior rooms and intermediate spaces in a monotonous structural repetition,while sofa presents an apparently hierarchical spatial *** has the placeness quality,while maru has the quality of plurality,actively mixing both inside and outside *** maru allows various free access with clear spatial continuity,sofa produces a sequential spatial experience with the pleasure of different architectural ***,the study suggests opened type and closed type of intermediate space as two possible strategies for modern houses based on the results of comparative *** environmental studies in architecture should consider intermediate spaces of various traditional houses due to the insights and possibilities these spatial elements may potentially provide to both architectural practice and theory,especially in a pandemic era.

关键词： Traditional Korean house Traditional Turkish house Maru Sofa Intermediate space

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Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： Jun-Kyul Song Min sung kim Seungwon Yoo Ja Hoon Koo Dae-Hyeong kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

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Counter-balancing effects of Si on C partitioning and stacking fault energy of austenite in 10Mn quenching and partitioning steel

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Journal of Materials Science & Technology 2022年第3期98卷 248-257页

作者： Dong Hwi kim Jee-Hyun Kang Hojun Gwon Joo Hyun Ryu sung-Joon kim Graduate Institute for Ferrous Technology Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Materials Science and Engineering Institute of Materials TechnologyYeungnam UniversityGyeongsan 38541Republic of Korea POSCO Technical Research Laboratories POSCOGwangyang 57807Republic of Korea

Silicon is an essential alloying element in quenching and partitioning(Q&P)steels,because it is known to suppress carbide precipitation during partitioning step and promote carbon partitioning to stabilize *** 2 wt%Si was added to 10Mn-2Al-0.2C steel,the size and fraction of the carbides formed during partitioning became smaller than in the Si-free ***,the suppression of carbide formation promoted C partitioning into austenite as ***,austenite stability was always lower with Si under the equivalent partitioning condition because Si effectively decreased the stacking fault energy of *** partitioning progressed,the both yield and tensile strengths of the Si-added steel exceeded that of the Si-free steel with the similar ductility *** was because Si was an effective solid solution strengthener,and the austenite in the Si-added steel exhibited the appropriate stability to gradually transform into martensite throughout the *** resulting strengthening effect compensated for the softening caused by martensite ***,strain hardening rate decreased continuously throughout deformation,which resulted in high tensile strength and ductility.

关键词： Steels Q&P steel Silicon Austenite stability Tensile deformation Stacking fault energy Medium Mn steel

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Association between preoperative high sensitive troponin I levels and cardiovascular events after hip fracture surgery in the elderly

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Journal of Geriatric Cardiology 2018年第3期15卷 215-221页

作者： Bum sung kim Tae-Hoon kim Jeong-Hwan Oh Chang Hee Kwon sung Hea kim Hyun-Joong kim Heung Kon Hwang Sang-Man Chung in-gu Seoul Republic of Korea Department of Orthopedic surgery Konkuk University Medical Center 120-1 Neungdong-ro Hwayang-dong Gwangjin-guSeoulRepublic of Korea

Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery （HFS）. We used high sensitive troponin I （hs-TnI） assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events （MACE） in elderly hip frac^u＇e patients. Method From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry. A total of 262 of these patients underwent HFS and hs-TnI assays. MACE was defined as postoperative all-cause deaths, heart failure （HF）, new-onset atrial fibrillation （AF）, myocardial infarction （MI） and cardiovascular re-hospitalization that occurred within 90 days postoperative. Results Of 262 HFS patients, MACE developed following HFS in 65 （24.8%）. Patients with MACE were older and had higher rates of renal insufficiency, coronary artery disease, prior HF, low left ventricular ejection fraction and use of beta blockers; higher levels of hs-Tnl and N-terminal pro-brain natriuretic peptide （NT-proBNP） and higher revised cardiac risk index. A preoperative hs-TnI≥ 6.5 ng/L was associated with high risk of postoperative HF, new-onset AF and MACE. In multivariable analysis, pre-operative independent predictors for MACE were age 〉 80 years [adjusted hazard ratio （HR）： 1.79, 95% confident interval （CI）： 1.03-3.13, P = 0.04], left ventricular ejection fraction （LVEF）〈 50% （adjusted HR： 3.17, 95% CI： 1.47-5.82, P 〈 0.01） and hs-TnI 〉 6.5 ng/L （adjusted HR： 3.75, 95% CI： 2.09~5.17, P 〈 0.01）. Conclusion In elderly patients with hip fracture who undergo HFS, a preoperative assessment of hs-TnI may help the risk refinement of cardiovascular complications.

关键词： Cardiovascular complication High sensitive troponin I Hip fracture surgery

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Oxidation behavior of high-strength FeCrAl alloys in a high-temperature supercritical carbon dioxide environment

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Progress in Natural Science:Materials International 2018年第6期28卷 731-739页

作者： Hongsheng Chen sung Hwan kim Chongsheng Long Chaewon kim Changheui Jang Department of Nuclear and Quantum Engineering Korea Advanced Institute of Science and Technology Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of China

The oxidation behavior of three high-strength FeCrAl alloys was investigated in supercritical carbon dioxide environment at 650 ℃. After exposure for 500 h, the weight gains of the FeCrAl alloys gradually decreased with increasing Al content. The oxide scales are primarily composed of α-Al;O;and spinel oxides. With increasing Al content, the amount of α-Al;O;increases and the C content decreased in the oxide scale and sub-scale ***, larger（Nb,Mo）C carbides formed in the sub-scale matrix and their number decreased with the increase of Al content.

关键词： High-strength FeCrAl alloy Supercritical carbon dioxide Oxidation α-Al2O3

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Simulation of Solid Particle Interactions Including Segregated Lamination by Using MPS Method

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Computer Modeling in Engineering & Sciences 2018年第7期116卷 11-29页

作者： Kyung sung kim Moo-Hyun kim Hakun Jang Hee Chen Cho Tongmyong University BusanRepublic of Korea Texas A&M University College StationTXU.S.A Mississippi State University MSU.S.A

A new MPS(Moving Particle Semi-implicit)method is developed to simulate the behaviors and interactions of multiple fine solid particles as a *** fluid particles are affected by viscosity,so solid particles are affected by *** solid particle dynamics for landslides,dumping,and gravity sorting *** can be difficult to simulate using conventional MPS methods,are modeled in this paper using the developed multi-solid-particle MPS method that benefits from drawing comparisons with the corresponding fluid particle *** present MPS results for dumping solid particles are verified against the corresponding DEM(Discrete Element Method)*** shape and angle of repose for solid particles are shown to be highly dependent on the friction coefficient between *** peculiar phenomenon of segregated lamination(gravity sorting)among grains of different densities has been successfully reproduced using the multi-solid-particle MPS *** quality is found to be dependent on the densities and frictional coefficients of the constituent *** behavior of heterogeneous mixtures of multiple solid and liquid particles are also compared and *** newly developed tool offers a window into the physical dynamics of sedimentology that the broader geoscience community might benefit from.

关键词： Fine solid particle MPS(Moving Particle Semi-implicit) friction force land sliding dumping segregated lamination heterogeneous multiple particles gravity sorting

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Permo-Triassic high-pressure metamorphism in the central western Korean Peninsula, and its link to Paleo-Tethyan Ocean closure: Key issues revisited

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Geoscience Frontiers 2018年第5期9卷 1325-1335页

作者： Hyeong Soo kim Sanghoon Kwon sung Won kim M.Santosh Department of Earth and Environmental Sciences Korea University Department of Earth System Sciences Yonsei University Geology Division Korea Institute of Geoscience and Mineral Resources School of Earth Sciences and Resources China University of Geosciences Centre for Tectonics Resources and Exploration Department of Earth Sciences University of Adelaide

Permo-Triassic high-pressure(HP) mafic granulites, together with the Bibong retrogressed eclogite,preserved along the central western Korean Peninsula provide important insights into the Late Permian to Triassic collisional orogeny in northeast Asia. The metamorphic pressureetemperatureetime(P-T-t)paths of these rocks, however, remain poorly constrained and even overestimated, owing to outdated geothermobarometers and inaccurate isopleth techniques. Here we evaluate the metamorphic Pe T conditions of Triassic HP mafic granulites including those in Baekdong, Sinri and Daepan and the Bibong Triassic retrogressed eclogite in the Hongseong area, and the Permo-Triassic Samgot mafic granulite in the Imjingang Belt of the central western Korean Peninsula through the application of modern phase equilibria techniques. The Baekdong and Samgot mafic granulites and the Bibong retrogressed eclogite yield a range of 12.0 -16.0 kbar and 800 -900℃, representing HP granulite facies conditions. The Sinri and Daepan granulites from the Hongseong area show relatively lower grade metamorphic conditions between HP granulite and normal granulite facies, and are characterized by sub-isothermal decompression during exhumation. The similarities in the metamorphic ages and the post-collisional igneous activity from the central western Korean Peninsula indicate that the Triassic ages represent the retrograde stage of the metamorphic Pe T paths. In contrast, the Late Permian metamorphic ages, which are older than protolith ages of the post-collisional igneous rocks, correspond to the possible prograde stage of metamorphism. The P-T-t paths presented in this paper, together with the metamorphic ages and post-orogenic igneous events reported from these areas suggest trace of the subduction, accretion and exhumation history, and indicate a tectonic linkage among the northeast Asian continents during the Paleo-Tethyan Ocean closure.

关键词： HP granulite Retrogressed eclogite Petrology and phase equilibria Metamorphic P-T-t paths Central western Korean Peninsula

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Do you have what it takes for challenging endoscopic submucosal dissection cases?

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World Journal of Gastroenterology 2011年第31期17卷 3580-3584页

作者： Kyoung-Oh kim sung Jung kim Tae Hyeon kim Jong-Jae Park Division of Gastroenterology and Hepatology Department of Internal MedicineHallym University Medical Center Division of Gastroenterology and Hepatology Department of Internal MedicineWonkwang University Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Guro Hospital Korea University College of Medicine

Endoscopic submucosal dissection(ESD) is a widely accepted treatment for early gastric cancer(EGC),especially in Korea and *** criteria for the therapeutic use of ESD for EGC have been expanded ***,attention should be drawn to the technical feasibility of the ESD treatment which depends on a lesion's location,size or fibrosis level,or operator's *** the case of a lesion with a high level of difficulty,a more experienced operator is ***,the treatment for a lesion with a high level of difficulty should be performed according to the degree of the operator's *** this paper,the authors describe the ESD procedure for lesions with a high level of difficulty.

关键词： Endoscopic submucosal dissection Anatomical location Technical feasibility

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Predictors and prognostic impact of post-operative atrial fibrillation in patients with hip fracture surgery

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World Journal of Clinical Cases 2022年第11期10卷 3379-3388页

作者： Seong Jun Bae Chang Hee Kwon Tae-Young kim Haseong Chang Bum sung kim sung Hea kim Hyun-Joong kim Department of Internal Medicine Konkuk University Medical CenterSeoul 05030South Korea Department of Orthopaedic Surgery Konkuk University Medical CenterSeoul 05030South Korea

BACKGROUND Atrial fibrillation(AF)is the most common arrhythmia developing in postoperative *** data are available regarding pre-operative risk factors and prognostic impact of post-operative AF(POAF)following hip fracture surgery(HFS)in Korean *** We aimed to investigate the incidence,predictors,and hospital prognosis of POAF in HFS *** This study included 245 patients without history of AF who underwent HFS between August 2014 and November *** was defined as new-onset AF that occurred during hospitalization after *** Twenty patients(8.2%)experienced POAF after *** developed on median post-operative day 2(interquartile range,1–3).Multivariable logistic regression analysis showed that age[odds ratio(OR),1.111;95%confidence interval(CI),1.022–1.209],chronic obstructive pulmonary disease(COPD)(OR,6.352;95%CI,1.561–25.841)and E/e’ratio(OR,1.174;95%CI,1.002–1.376)were significant predictors of *** with POAF had a significantly higher intensive care unit admission rate(55.0%vs 14.7%,P<0.001)and incidence of congestive heart failure(45.0%vs 10.7%,P<0.001).In multivariable logistic regression analysis,POAF was significantly associated with increased incidence of congestive heart failure(OR,4.856;95%CI,1.437–16.411)and intensive care unit admission(OR,6.615;95%CI,2.112–20.718).CONCLUSION POAF was frequently developed in elderly patients following ***,COPD and elevated E/e’ratio were found as significant predictors of POAF in HFS *** with POAF significantly experienced intensive care unit admission and incident congestive heart failure during hospitalization.

关键词： Atrial fibrillation Post-operative Predictor Prognosis Hip fracture surgery

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