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Neuronal injury and tumor necrosis factor-alpha immunoreactivity in the rat hippocampus in the early period of asphyxia-induced cardiac arrest under normothermia

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Neural Regeneration Research 2017年第12期12卷 2007-2013页

作者： Hyun-Jin Tae Il Jun Kang Tae-Kyeong Lee Jeong Hwi Cho Jae-Chul Lee Myoung Cheol Shin Yoon sung Kim Jun Hwi Cho Jong-Dai Kim Ji Hyeon ahn Joon Ha Park In-Shik Kim Hyang-Ah Lee Yang Hee Kim Moo-Ho Won Young Joo Lee Bio-Safety Research Institute College of Veterinary Medicine Chonbuk National University Iksan South Korea Department of Food Science and Nutrition Hallym University Chuncheon South Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon South Korea Department of Emergency Medicine School of Medicine Kangwon National University Chuncheon South Korea Department of Emergency Medicine Samcheok Medical Center Samcheok South Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon South Korea Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Chuncheon South Korea Department of Obstetrics and Gynecology School of Medicine Kangwon National University Chuncheon South Korea Department of Surgery School of Medicine Kangwon National University Chuncheon South Korea Department of Emergency Medicine Seoul Hospital College of Medicine Sooncheonhyang University Seoul South Korea

Low survival rate occurs in patients who initially experience a spontaneous return of circulation after cardiac arrest（CA）. In this study, we induced asphyxial CA in adult male Sprague-Daley rats, maintained their body temperature at 37 ± 0.5°C, and then observed the survival rate during the post-resuscitation phase. We examined neuronal damage in the hippocampus using cresyl violet（CV） and Fluore-Jade B（F-J B） staining, and pro-inflammatory response using ionized calcium-binding adapter molecule 1（Iba-1）, glial fibrillary acidic protein（GFAP）, and tumor necrosis factor-alpha（TNF-α） immunohistochemistry in the hippocampus after asphyxial CA in rats under normothermia. Our results show that the survival rate decreased gradually post-CA（about 63% at 6 hours, 37% at 1 day, and 8% at 2 days post-CA）. Rats were sacrificed at these points in time post-CA, and no neuronal damage was found in the hippocampus until 1 day post-CA. However, some neurons in the stratum pyramidale of the CA region in the hippocampus were dead 2 days post-CA. Iba-1 immunoreactive microglia in the CA1 region did not change until 1 day postCA, and they were activated（enlarged cell bodies with short and thicken processes） in all layers 2 days postCA. Meanwhile, GFAP-immunoreactive astrocytes did not change significantly until 2 days post-CA. TNF-α immunoreactivity decreased significantly in neurons of the stratum pyramidale in the CA1 region 6 hours post-CA, decreased gradually until 1 day post-CA, and increased significantly again 2 days post-CA. These findings suggest that low survival rate of normothermic rats in the early period of asphyxia-induced CA is related to increased TNF-α immunoreactivity, but not to neuronal damage in the hippocampal CA1 region.

关键词： nerve regeneration post-cardiac arrest syndrome normothermia neuronal damage gliosis tumor necrosis factor-alpha neural regeneration

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Fabrication of Nano-composite Parts Using Hybrid Rapid Prototyping System

Fabrication of Nano-composite Parts Using Hybrid Rapid Proto...

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亚洲精密工程、微纳技术国际会议

作者： Won-Shik Chu sung-Geun Kim Woo-Kyun Jung Hyung-Jung Kim sung-Hoon ahn Friedrich B.Prinz Seoul National University Seoul 151-742 Korea Seoul National University Seoul 151-742 Korea Seoul National University Seoul 151-742 Korea Seoul National University Seoul 151-742 Korea Seoul National University Seoul 151-742 Korea Stanford University CA 94305 USA

The rapid prototyping (RP) technology has been used for design verification, functionality test and fabrication of prototypes. In this paper, a hybrid rapid prototyping system, which can fabricate nano composites using various materials is introduced. This hybrid system adopts RP and machining process, so material deposition and removal can be performed on a single station. As an example, micro gears were fabricated using nano composite consisted of photo-curable polymer and Multi-wall Carbon Nano Tube (MWCNT). The micro gear samples fabricated by the hybrid RP technology showed higher precision than those made by casting or deposition process. As the second example stapes was fabricated using hydroxyapatite-acrylic composite.

关键词： Hybrid system, Micro machining, Nano composite, Rapid Prototyping, Precision

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Analysis on sports and recreation activity-related eye injuries presenting to the Emergency Department

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1499-1505页

作者： sungbae Moon Hyun Wook Ryoo Jae Yun ahn Jung Bae Park Kang Suk Seo Sang Do Shin Kyoung Jun Song Kang Hyun Lee In Sool Yoo Jin Seong Cho Hyun Ho Ryu Tae Oh Jeong Seok Ran Yeom Young Taek Kim sung Ok Hong Department of Emergency Medicine School of MedicineKyungpook National University Daegu 700-721 Korea Department of Emergency Medicine College of MedicineSeoul National University Seoul 110-799 Korea Department of Emergency Medicine Wonju College of Medicine Yonsei University Wonju Gangwon-do 220-701Korea Department of Emergency Medicine School of MedicineChungnam National University Daejeon 301-747 Korea Department of Emergency Medicine Gachon University Gil Medical Center Incheon 406-799 Korea Department of Emergency Medicine School of MedicineChonnam National University Gwangju 501-746 Korea Department of Emergency Medicine School of MedicineChonbuk National University Jeonju Jeollabuk-do 561-180Korea Department of Emergency Medicine School of MedicinePusan National University Busan 602-739 Korea Korean Centers for Disease Control & Prevention Cheongiu Chungcheongbuk-do 361-951 Korea

AIM：To investigate the incidence and general characteristics of sports-related eye injuries in patients visiting the Emergency Department. METHODS： A cross-sectional,multi-center,observational *** with an injured eye who visited the Emergency Department at one of nine hospitals in Korea were *** data were prospectively collected between March and September 2010 using a *** injuries that occurred during risky sports were examined by gender and ***,the rate of open globe injuries that occurred with and without protective eyewear was examined for each *** variables were compared using Student＇s t-test and categorical variables were compared using Chi-square ***： A total of 446 patients had sports-related eye ***（10-19 years old） and young adults（20-29 years old） had the most eye *** injuries accounted for 0.2% of Emergency Department *** was the most common cause of sports-related eye injuries,followed by soccer and *** gear was worn by 9.4% of all *** that were 30-39 years of age had the highest rate of protective gear use,followed by patients that were 40-49 years of *** proportion of sports-related eye injuries that were open-globe injuries was highest for soccer and ***： Although injuries were most common in patients below the age of 10 years,these patients had the lowest rate of protective eyewear *** in adults over 40 years of age most commonly occurred during hiking,but the rate of protective eyewear use was *** athletes should be educated on and provided with protective eyewear and policies protective gear use should be *** older adults,eye protection should be encouraged,especially during hiking.

关键词： athletic injuries eye injuries protective devices sports.

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复合材料层板的修补——Ⅱ:模型

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玻璃钢 1999年第4期 46-52页

作者： sung-Hoon ahn George S.Springer 美国斯坦福特大学航空航天系

为计算用斜接和均匀搭接方法修补的复合材料层板的破坏荷载而设计了模型。这些模型计及在层板和修补层片中每层的各向异性以及胶粘剂或层板和修补贴片间树脂隔层的非弹性特性。在这些模型基础上,编写了2个电子计算机编码用于计算破坏荷... 详细信息

为计算用斜接和均匀搭接方法修补的复合材料层板的破坏荷载而设计了模型。这些模型计及在层板和修补层片中每层的各向异性以及胶粘剂或层板和修补贴片间树脂隔层的非弹性特性。在这些模型基础上,编写了2个电子计算机编码用于计算破坏荷载值。第1个编码是为计算用均匀搭接方法修补的层板的破坏荷载,第2个供计算用斜接技术修补层板的破坏荷载。由这些模型(和相应的电算编码)计算的破坏荷载与试验数据作了比较,发现在模型和试验的结果之间有很好吻合。

关键词：复合材料层板斜接剪应变复合板角应变剪切性质方程式方程隔层结点(结构) 搭接叠接破坏荷载弹性力学性能预浸料塑性区塑性域修补材料手糊

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复合材料层板的修补——Ⅰ:试验结果

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玻璃钢 1999年第3期 44-52页

作者： sung-Hoon ahn George S.Springer 沈坤元美国斯坦福特大学航空航天系

用不同修补材料修补的各种基本层板的破坏荷载(根据无损层板的破坏荷载(见表2)标称的)对斜接修补示于图9～10,而对阶形搭接修补示于图11～12。在这些图中的结果是对干试件的和对浸水中14d增湿试件的。还得到曝露在100%湿空气180F下达到1... 详细信息

用不同修补材料修补的各种基本层板的破坏荷载(根据无损层板的破坏荷载(见表2)标称的)对斜接修补示于图9～10,而对阶形搭接修补示于图11～12。在这些图中的结果是对干试件的和对浸水中14d增湿试件的。还得到曝露在100%湿空气180F下达到1.1%含水量试件的资料。由水和湿空气增湿试件的破坏荷载显示相同的趋势。因此,由湿空气增湿试件的数据这里未给出,但在文献[29]中有。根据数据指出下列趋势: 对湿法手糊修补(斜接和阶形搭接),修补材料的类型未显著影响破坏荷载。当试件中干的并在70F下试验时,用预浸料修补(斜接和阶形搭接)的破坏荷载值高于

关键词：破坏荷载含水量增湿含水率加湿化工单元操作搭接长度固化温度层板门楣板板材手糊

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Anti-inflammatory effects of natural volatile organic compounds from Pinus koraiensis and Larix kaempferi in mouse model

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The Journal of Biomedical Research 2019年第5期33卷 343-350页

作者： Changhwan ahn Jae-Woo Kim Mi-Jin Park Seung Ryul Kim sung-Suk Lee Eui-Bae Jeung Laboratory of Veterinary Biochemistry and Molecular Biology Veterinary Medical Center and College of Veterinary MedicineChungbuk National UniversityCheongjuChungbuk 28644Republic of Korea Division of Wood Chemistry&Microbiology Department of Forest ProductsNational Institute of Forest ScienceSeoul 02455Republic of Korea Laboratory of Biochemistry School of MedicineChungbuk National UniversityCheongjuChungbuk 28644Republic of Korea.

Natural volatile organic compounds(VOCs) extracted from conifers such as P. koraiensis and L. kaempferi have long been studied for their anti-oxidant, anti-proliferative, and anti-inflammatory effects. To evaluate the anti-inflammatory effects of VOCs from P. koraiensis and L. kaempferi, lipopolysaccharide(LPS) was administered to generate a mouse model for inflammation by the nasal route to the lungs and intraperitoneally to the whole body. VOCs of P. koraiensis and L. kaempferi were exposed to the mice by standardized wood panels with closed system. Increased levels of serum IgE and PGE2 were observed after exposure to dexamethasone and VOCs. We further determined the expression levels of inflammatory cytokine mRNA in the LPS-induced inflammation model by the reverse transcription quantitative polymerase chain reaction. Furthermore, the levels of cyclooxygenase-2, tumor necrosis factor-α, interleukin-1β, and interleukin-13 were determined in peripheral blood mononuclear cells. Those inflammatory cytokines and the key enzyme for inflammation cyclooxygenase-2 expression in PBMCs were strongly reversed by dexamethasone and VOCs. Lung tissues after nasal LPS exposure showed increased cytokine mRNA expressions which were suppressed by treatment with dexamethasone and VOCs. Furthermore, the damage induced by LPS was attenuated by dexamethasone and VOCs. In conclusion, the results from the present study indicate that VOCs of P. koraiensis and L. kaempferi have a therapeutic potential in the treatment or prevention of local and systemic inflammation due to their immunosuppressive effects.

关键词： Pinus koraiensis Larix kaempferi inflammation cytokine lungs

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采用简化多晶硅TFT工艺的有源矩阵OLED显示器件

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现代显示 2003年第6期 20-23页

作者： yong In Park Tae Jun ahn sung Ki Kim Jae yong Park Juhn S.Yoo Chang Yeon Kim Chang Dong Kim 孙海涛 L.G.Philips LCD.533 Hogae-dongDongan-guAnyang-shiKyongki-do431-080Korea 北京维信诺科技有限公司

我们提出并开发了一种先进的6步光掩模工艺,可用于制备有源矩阵有机发光二极管(AMOLED)中p型沟道多晶硅薄膜晶体管(TFT)面板。通过去除电源线(Vdd)和触排(bank)光处理工艺,将8步掩模简化至6步。通过6步光掩模工艺制备的p型沟道TFT,场效... 详细信息

我们提出并开发了一种先进的6步光掩模工艺,可用于制备有源矩阵有机发光二极管(AMOLED)中p型沟道多晶硅薄膜晶体管(TFT)面板。通过去除电源线(Vdd)和触排(bank)光处理工艺,将8步掩模简化至6步。通过6步光掩模工艺制备的p型沟道TFT,场效应迁移率可达80cm2/Vsec,亚阈值(sub-threshold)电压波动降至0.3V/dec,阈值电压约为-2V。利用6步光掩模工艺成功地获得了采用电压驱动方式的7英寸WVGA(720×480)AMOLED面板。

关键词：光掩模 AMOLED 有源矩阵有机发光二极管多晶硅薄膜晶体管 TFT

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学生餐的盐含量以及小学、中学、高中对钠摄入的认知比较

学生餐的盐含量以及小学、中学、高中对钠摄入的认知比较

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作者： Sohyun ahn Seoyun Park Jin Nam Kim sung Nim Han Soo Bin Jeong Hye-Kyeong Kim 郭婧张帆 Department of Food Science and Nutrition The Catholic University of Korea Department of Food and Nutrition Seoul National University

过量的钠摄入可以导致高血压、脑卒中和胃癌,而过量的钠摄入又主要是由于烹饪时盐的过量使用。韩国的研究者最近做了一项调查,评估学生餐中盐的含量以及比较学生和食堂职工对钠摄入量认知的不同。该研究从韩国京畿道的24所学校(包括9所...

过量的钠摄入可以导致高血压、脑卒中和胃癌,而过量的钠摄入又主要是由于烹饪时盐的过量使用。韩国的研究者最近做了一项调查,评估学生餐中盐的含量以及比较学生和食堂职工对钠摄入量认知的不同。该研究从韩国京畿道的24所学校(包括9所小学、7所初中、8所高中)收集了382例食物,学生餐的盐含量根据每种食物的盐度和质量计算得来。小学、初中和高中每顿学生餐的盐含量分别为2.44g、3.96g和5.87g。仅学校的一顿午餐就已经提供了WHO推荐食盐每日摄入量的80%。从每餐饭的角度来说,面条、杂烩、调味酱和汤是食盐摄入的主要来源,并且调味酱、泡菜、煎炸食

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Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry

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Journal of Geriatric Cardiology 2020年第11期17卷 680-693页

作者： Myunhee Lee Dae-Won Kim Mahn-Won Park Kyusup Lee Kiyuk Chang Wook sung Chung Tae Hoon ahn Myung Ho Jeong Seung-Woon Rha Hyo-Soo Kim Hyeon Cheol Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung 无 KAMIR-NIH registry investigators Division of Cardiology Daejeon St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Division of Cardiology Seoul St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Gachon University Gil Medical CenterIncheonSouth Korea Chonnam National University Hospital GwangjuSouth Korea d Korea University Korea University Guro Hospital SeoulSouth Korea Seoul National University Hospital SeoulSouth Korea sungkyunkwan Universtiy Samsung Medical CenterSeoulSouth Korea Chungnam National University Hospital DaejeonSouth Korea Chungbuk National University Hospital CheongjuSouth Korea Kyungpook National University Hospital DaeguSouth Korea Keimyung University Dongsan Medical Center DaeguSouth Korea Yeungnam University Hospital DaeguSouth Korea Pusan National University Hospital BusanSouth Korea Wonkwang University Hospital IksanSouth Korea Chonbuk National University Hospital JeonjuSouth Korea Institute of Toxicology DaejeonSouth Korea 不详

Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention(PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction(AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH) between November 2011 and December 2015 were classified into male(n = 8021, 75.9%) and female(n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events(MACCE) in women with those in men after AMI by using propensity score(PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction(NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population(30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585;1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328;TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.

关键词： Acute myocardial infarction Asian population Gender difference Percutaneous coronary intervention

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Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2015年第14期21卷 4268-4274页

作者： Min-Young Lee Ki Sun Jung Hae Su Kim Ji Yun Lee sung Hee Lim Moonjin Kim Hyun Ae Jung sung Min Kim Jong Mu Sun Myung-Ju ahn Jeeyun Lee Se Hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung ahn Do Hyoung Lim Soon Il Lee Keon Woo Park Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine Division of Hematology-Oncology Department of Internal MedicineInje University Ilsan-Paik Hospital Division of Hematology-Oncology Department of Internal MedicineChung-Ang University Hospital Division of Hematology-Oncology Department of Internal MedicineSoonchunhyang University Hospital Division of Hematology-Oncology Department of Internal MedicineGachon University Gil Hospital Division of Hematology-Oncology Department of Internal MedicineDankook University College of Medicine

AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was ***-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and *** was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent *** primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely *** control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), ***: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC.

关键词： Clinical trial Phase Ⅱ Chemotherapy Carcinoma,Esop

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