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Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling

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Cellular & Molecular Immunology 2022年第12期19卷 1373-1391页

作者： Hee Ja Kim Kyungwon Yang Kiyoon Kim Ye‐Ji Lee Sieun Lee sung yong ahn Young‐Ho ahn Jihee Lee Kang Department of Physiology College of MedicineEwha Womans UniversitySeoul07804Korea Inflammation-Cancer Microenvironment Research Center College of MedicineEwha Womans UniversitySeoul07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul07804Korea

The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and ***-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrine ***,we demonstrate that conditioned medium(CM)from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and *** exposure of CAFs to apoptotic 344SQ cells(ApoSQ)inhibited CAF migration and invasion and the expression of CAF activation *** secretion of Wnt‐induced signaling protein 1(WISP-1)by CAFs exposed to ApoSQ was required for these antimigratory and anti-invasive *** inhibition of Notch1 activation or siRNA-mediated Notch1 silencing prevented WISP-1 production by CAFs and reversed the antimigratory and anti-invasive *** expression of the Notch ligand delta-like protein 1 on the surface of ultraviolet-irradiated apoptotic lung cancer cells triggered Notch1-WISP-1 *** receptor brain-specific angiogenesis inhibitor 1(BAI1)-Rac1 signaling,which facilitated efferocytosis by CAFs,participated in crosstalk with Notch1 signaling for optimal production of *** addition,a single injection of ApoSQ enhanced WISP-1 production,suppressed the expression of CAF activation markers in isolated Thy1^(+)CAFs,and inhibited lung metastasis in syngeneic immunocompetent mice via Notch1 *** with CM from CAFs exposed to ApoSQ suppressed tumor growth and lung metastasis,whereas treatment with WISP-1-immunodepleted CM from CAFs exposed to ApoSQ reversed the antitumorigenic and antimetastatic ***,treatment with CM from CAFs exposed to apoptotic lung cancer cells could be therapeutically applied to suppress CAF activation,thereby preventing cancer progression and metastasis.

关键词： CAFs Apoptotic lung cancer cells Notch1 WiSP-1 Efferocytosis Migration Invasion Metastasis

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Incidence, prevalence and risk of stroke in patients with Takayasu arteritis: a nationwide population-based study in South Korea

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Stroke & Vascular Neurology 2022年第2期7卷 149-157页

作者： sung Soo ahn Minkyung Han yong-Beom Park Inkyung Jung Sang-Won Lee Department of Internal Medicine Yongin Severance HospitalYonsei University College of MedicineYonginSouth Korea Biostatistics Collaboration Unit Department of Biomedical Systems InformaticsYonsei University College of MedicineSeoulSouth Korea Division of Rheumatology Department of Internal MedicineYonsei University College of MedicineSeoulSouth Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulSouth Korea Division of Biostatistics Department of Biomedical Systems InformaticsYonsei University College of MedicineSeoulSouth Korea

Background Takayasu arteritis(TAK)is a disease associated with increased risk of cardiovascular *** aimed to evaluate the incidence,prevalence and risk of stroke in patients with *** Data from 1065 patients were obtained from a national database(2010–2018).The annual incidence and prevalence per 100000 persons were estimated using the registration population in the midst of every year,and the standardised incidence ratio(SIR)of stroke was compared with the general population based on the data from the 2006 national report for cardiovascular and cerebrovascular ***-adjusted incidence rate ratio(IRR)of stroke based on the time interval after diagnosis was also calculated.A time-dependent Cox regression was conducted to investigate predictive factors of *** The overall incidence rate of TAK ranged between 0.2 and 0.3/100000 person-years annually;the prevalence of TAK gradually increased,reaching 3.25/100000 person-years in ***-three(6.9%)patients experienced stroke during follow-up,and the risk of developing stroke was higher than the general population(overall SIR 7.39,95%CI 5.79 to 9.29;men:SIR 5.70,95%CI 2.84 to 10.20;women:SIR 7.06,95%CI 5.41 to 9.05).Most stroke events(90.9%)were cerebral infarction for men,whereas the proportion of cerebral infarction was lower(62.9%)in *** half of stroke events occurred within 6 months after diagnosis,and stroke was more common within 6 months of diagnosis compared with after 3 years in women(IRR 13.46,95%CI 6.86 to 26.40).In Cox regression analysis,age was the sole predictor of stroke(adjusted HR 1.02,95%CI 1.00 to 1.04,p=0.043).Conclusions The annual incidence of TAK was similar to the previous studies from Asia,and the risk of stroke increased in *** patterns of subtype and incidence of stroke were found according to sex,although age was the only predictor.

关键词： prevalence patients diagnosis

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RELOCATABLE MODULAR BUILDINGS FOR A SHORT-TERM INTERNATIONAL EVENT:THE PYEONG-CHANG WINTER OLYMPIC GAMES

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Journal of Green Building 2020年第3期15卷 3-35页

作者： Shin Hyun Kyu Lee Joo sung Jung Chan Woo ahn yong Han Ph.D.Student Architectural EngineeringHanyang Univ.ERICAAnsan15588Republic of Korea Research Professor Innovative Durable Building and Infrastructure Research CenterAnsan15588Republic of Korea Ph.D.&Group Leader POSCO Architectures&ConstructionsIncheon21998Republic of Korea Associate professor School of Architecture and Architectural EngineeringHanyang Univ.ERICAAnsan15588Republic of Korea

Modular methods based on the use of prefabricated structures are increasingly popular for construction projects as they contribute to sustainability by reducing waste and maintenance costs as well as improving time *** short-term international events,the use of relocatable modular buildings is a potential solution to the problem of“White Elephant”structures built specially for the events that serve no useful purpose once the event is *** paper focuses on a representative relocatable modular project created for the 2018 Winter Olympic Games in South Korea using a single case study approach to develop an in-depth understanding of the advantages and disadvantages of relocatable modular construction from a practitioner’s perspective and examine how this approach supports sustainability and the Olympic *** considerations are identified for each of the five main stages:1)planning,2)design and engineering,3)manufacturing,4)construction and 5)disassembly and *** findings show how the use of relocatable modular facilities can be a useful approach for international events.

关键词： Relocatable Building Modular Construction Prefabrication Sustainability International Event Case Study

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Settling and dewatering characteristics of granulated methane-oxidizing bacteria

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Journal of Environmental Sciences 2013年第2期25卷 280-286页

作者： Kwang Ho ahn Kwang Soo Kim sung Won Kang Chul yong Um Won Tae Lee Kwang Baik Ko Korea Institute of Construction Technology 283Goyangdae-RoIlsanseo-GuGoyang-SiGyeonggi-Do 411-712Korea School of Civil and Environmental Engineering Yonsei UniversitySinchondong 134SudaemunguSeoul 120-749Korea School of Civil and Environmental Engineering Kumoh National Institute of TechnologyDaehak-ro 61GumiGyeongbuk 730-701Korea

We evaluated the settling ability and dewaterability of granulated methane-oxidizing bacteria （GMOB） after granulation using a continuous-flow reactor. A comparative analysis on settling and dewatering characteristics due to changes in sludge retention time （SRT, 10, 15 and 20 days） during cultivation of GMOB was conducted. In assessing dewaterability, the specific resistance to filtration （SRF） of activated sludge and GMOB was found to be 8.21×1013-2.38×1014 and 4.88 × 1012-1.98×1013 m/kg, respectively. It was confirmed that as SRT decreased, SRF of GMOB increased. In the case of bound extracellular polymeric substance （EPS）, activated sludge registered 147.5 mg/g-VSS while GMOB exhibited 171-177.2 mg/g-VSS. In the case of extracellular polymeric substance soluble EPS in effluent, activated sludge measured 62 mg/L and GMOB had 17.4-21.4 mg/L. The particle size analysis showed that mean particle diameters of GMOB were 402, 369, and 350 μm, respectively, at SRTs of 20, 15 and 10 days. In addition, it was found that GMOB had a larger mean particle diameter and exhibited much better settleability and dewaterability than activated sludge did.

关键词： methane-oxidizing bacteria dewaterability specific resistance to filtration extracellular polymeric substances

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Effect of carbon on microstructure of CrAlC_xN_(1-x) coatings by hybrid coating system

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 78-82页

作者： sung-Kyu ahn Se-Hun KWON Kwang-Ho KIM National Core Research Center for Hybrid Materials Solution Pusan National University School of Materials Science and Engineering Pusan National University

A systematic investigation of the microstructure of CrA1CxN1-x coatings as a function of carbon contents was conducted. Quaternary CrA1CxN1-x coatings were deposited on Si wafers by a hybrid coating system combining an arc-ion plating technique and a DC reactive magnetron sputtering technique using Cr and AI targets in the Ar/N2/CH4 gaseous mixture. The effect of carbon content on microstructure of CrA1C^N~ x coatings was investigated with instrumental analyses of X-ray diffraction, X-ray photoelectron, and high-resolution transmission electron microscopy. The results show that the carbon content of CrA1CxN1-x coatings linearly increases with increasing CH4/（CH4/N2） gas flow rate ratio. The surface roughness of the CrA1CxN1-x coating layer decreases with the increase of carbon content.

关键词： CrA1C,N1-x, coating nanocomposite microstructure hybrid coating system

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Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats

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World Journal of Gastroenterology 2005年第47期11卷 7430-7435页

作者： Tae Young Oh Chang Yell Shin yong sung Sohn Dong Hwan Kim Byoung Ok ahn Eun Bang Lee Cho Hyun Park Dong-A Pharmaceutical Research Institute YonginKorea Department of General Surgery Catholic University of MedicineSeoulKorea

AIM: To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD ***: In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats. RESULTS: Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment. CONCLUSION: We suggest that DA-9601 is apromising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increasedmucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis.

关键词： DA-9601 Reflux gastritis Erosive gastritis Atrophic gastritis Sodium taurocholate

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Superior electrocatalytic negative electrode with tailored nitrogen functional group for vanadium redox flow battery

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Journal of Energy Chemistry 2023年第3期78卷 148-157,I0005页

作者： Min Gu Kang Wook ahn Joonhee Kang Shin Ae Song Kiyoung Kim Ju Young Woo yong-Cheol Jeong Bonwook Koo Dae Soo Jung sung Nam Lim Micro/Nano Scale Manufacturing Group Korea Institute of Industrial Technology143 HanggaulroSangrok-guAnsan-siGyeonggi-do 15588Republic of Korea Department of Energy Systems Engineering Soonchunhyang University22 Soonchunhyang-roShinchang-myeonAsan-siChungcheongnam-do 31538Republic of Korea Department of Nanoenergy Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Energy Storage Materials Center Energy&Environmental DivisionKorea Institute of Ceramic Engineering&Technology(KICET)101 Soho-roJinju-siGyeongsangnam-doRepublic of Korea

Development of electrodes with high electrocatalytic activity and stability is essential for solving problems that still restrict the extensive application of vanadium redox flow batteries(VRFBs).Here,we designed a novel negative electrode with superior electrocatalytic activity by tailoring nitrogen functional groups,such as newly formed nitro and pyridinic-N transformed to pyridonic-N,from the prenitrogen-doped *** was experimentally confirmed that an electrode with pyridonic-N and nitro fuctional groups(tailored nitrogen-doped graphite felt,TNGF) has superior electrocatalytic acivity with enhanced electron and mass *** functional theory calulations demonstrated the pyridonic-N and nitro functional groups promoted the adsorption,charge transfer,and bond formation with the vanadium species,which is consistent with expermental *** addition,the V2+/V3+redox reaction mechanism on pyridonic-N and nitro functional groups was estabilised based on density functional theory(DFT) *** TNGF was applied to a VRFB,it enabled enhanced-electrolyte utilization and energy efficiencies(EE) of 57.9% and 64.6%,respectively,at a current density of 250 mA cm^(-2).These results are 18.6% and 8.9% higher than those of VRFB with electrode containing graphitic-N and pyridinicN ***,TNGF-based VRFB still operated with an EE of 59% at a high current density of300 mA cm^(-2).The TNGF-based VRFB exhibited stable cycling performance without noticeable decay of EE over 450 charge-discharge cycles at a current density of 250 mA cm^(-2).The results of this study suggest that introducing pyridonic-N and nitro groups on the electrode is effective for improving the electrochemical performance of VRFBs.

关键词： Tailored nitrogen functional group Pyridonic-N Nitro Negative electrode Density functional theory Vanadium redoxﬂow batteries

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Feasibility of ABO-incompatible adult living donor liver transplantation for acute-on-chronic liver failure

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 662-664页

作者： Seok-Hwan Kim Gi-Won Song Shin Hwang Chul-Soo ahn Deok-Bog Moon Tae-yong Ha sung-Gyu Lee Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul 05505 Korea

To the Editor:In Korea,the annual number of deceased donors for or gan transplantation per million people is still less ***,approximately 40%of patients with acute liver failure or acute-on-chronic liver failure undergo living donor liver transplantation（LDLT）.;Although the use of ABO-incompatible（ABOi）living donors is an attrac tive option,ABOi LDLT has very restricted applications

关键词： ABO Feasibility of ABO-incompatible adult living donor liver transplantation for acute-on-chronic liver failure RIT

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Successful recanalization of chronic total occlusion of the superior mesenteric artery by transradial approach

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 627-630页

作者： Woo Taek KIM sung Gyun ahn Jun-Won LEE Joong Kyung sung Seung Hwan LEE Junghan YOON Division of Cardiology Wonju College of MedicineYonsei University

It is a challenge to confirm chronic mesenteric ischemia(CMI) as a cause of gastrointestinal(GI) symptoms such as postprandial epigastric bloating,anorexia,and debilitating weight *** intervention for CMI has been gaining popularity because of the high morbidity associated with surgical ***,in EVI for superior mesenteric artery(SMA) occlusion,the transfemoral approach is limited by difficulty in coaxial alignment of the guiding catheter,which leads to insufficient back-up ***,we report on a 58-year-old male patient with chronic total occlusion of the SMA,which was successfully revascularized by endovascular intervention via the left radial *** endovascular therapy may be another treatment option for the treatment of CMI.

关键词： Transluminal angioplasty Radial artery Superior mesenteric artery Chronic mesenteric ischemia

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Piezoelectric strain sensor with high sensitivity and high stretchability based on kirigami design cutting

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npj Flexible Electronics 2022年第1期6卷 529-536页

作者： Young-Gyun Kim Ji-Hyeon Song Seongheon Hong sung-Hoon ahn Department of Mechanical Engineering Seoul National UniversityGwanak-ro 1Gwanak-guSeoul 08826Republic of Korea MX Division Samsung ElectronicsSamsungro 129Suwon-siGyeonggi-do 16677Republic of Korea Department of Mechanical Engineering Dankook UniversityJukjeon-ro 152Suji-guYongin 16890Republic of Korea Institute of Advanced Machines and Design Seoul National UniversityGwanak-ro 1Gwanak-guSeoul 08826Republic of Korea

Wearable technology requires high-performance sensors with properties such as small size,flexibility,and wireless ***,sensitivity,and tunability are crucial sensor properties;stretchability and sensitivity ensure user comfort and accurate sensing performance,while tunability is essential for implementing sensors in diverse applications with different ranges of *** this study,we developed a high performance kirigami piezoelectric strain *** finite element analysis,the sensing performance was evaluated,and the kirigami patterns were *** electromechanical properties of sensors with four different kirigami patterns were analyzed.A sensor voltage measurement circuit was also designed,amplifying the output voltage 86.5 times by improving measurement accuracy.A piezoelectric kirigami sensor was constructed with a sensitivity of 9.86 V/cm^(2) and a stretchability of 320.8%,higher than those of previously reported kirigami piezoelectric strain ***,the fabricated sensor was successfully applied in a haptic glove for playing musical instruments.

关键词： stretch strain piezoelectric

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