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Chinese Business Review 2016年第10期15卷 479-484页

作者： sung wook choi Sahmyook University Seoul Korea

This study is conducted on the special provision of the Korean government to prevent youths＇ addiction to online games. Judging that the youths＇ addiction to online games is serious, the Korea government made a legal provision to control the phenomena of youths＇ online game addiction. At that time, there were lots of conflicting opinions in the course of implementation of the related governmental act. The purpose of this study is investigating what conflicting opinions there were in the course of the legislation and also the fundamental cause of the opinion confliction and the countermeasures thereby. Especially, it is noteworthy that two departments of the government had different legal approaches toward the issue. Thus, this study will present an affordable suggestion for other countries which have youths＇ online game addiction problems.

关键词： online game shutdown system game addiction Korea government legal regulation

Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration

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Neural Regeneration Research 2018年第10期13卷 1796-1803页

作者： Jongbae choi Jun Ho Kim Ji wook Jang Hyun Jung Kim sung Hoon choi sung Won Kwon R&D Center Genewel Co.Ltd. Department of Surgery CHA Bundang Medical CenterCHA University

The use of autologous nerve grafts remains the gold standard for treating nerve defects, but current nerve repair techniques are limited by donor tissue availability and morbidity associated with tissue loss. Recently, the use of conduits in nerve injury repair, made possible by tissue engineering, has shown therapeutic potential. We manufactured a biodegradable, collagen-based nerve conduit containing decellularized sciatic nerve matrix and compared this with a silicone conduit for peripheral nerve regeneration using a rat model. The collagen-based conduit contains nerve growth factor, brain-derived neurotrophic factor, and laminin, as demonstrated by enzyme-linked immunosorbent assay. Scanning electron microscopy images showed that the collagen-based conduit had an outer wall to prevent scar tissue infiltration and a porous inner structure to allow axonal growth. Rats that were implanted with the collagen-based conduit to bridge a sciatic nerve defect experienced significantly improved motor and sensory nerve functions and greatly enhanced nerve regeneration compared with rats in the sham control group and the silicone conduit group. Our results suggest that the biodegradable collagen-based nerve conduit is more effective for peripheral nerve regeneration than the silicone conduit.

关键词： nerve regeneration biodegradable decellularized collagen nerve conduit growth factor peripheral nerve injury regeneration silicone conduit rat model

Analytic design of information granulation-based fuzzy radial basis function neural networks with the aid of multiobjective particle swarm optimization

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International Journal of Intelligent Computing and Cybernetics 2012年第1期5卷 4-35页

作者： Byoung-Jun Park Jeoung-Nae choi wook-Dong Kim sung-Kwun Oh IT Convergence Technology Research Laboratory Electronics and Telecommunications Research Institute(ETRI)DaejeonSouth Korea Research Institute KDT Co.LtdBucheong-siSouth Korea Department of Electrical Engineering The University of SuwonHwaseong-siSouth Korea

Purpose–The purpose of this paper is to consider the concept of Fuzzy Radial Basis Function Neural Networks with Information Granulation(IG-FRBFNN)and their optimization realized by means of the Multiobjective Particle Swarm Optimization(MOPSO).Design/methodology/approach–In fuzzy modeling,complexity,interpretability(or simplicity)as well as accuracy of the obtained model are essential design *** the performance of the IG-RBFNN model is directly affected by some parameters,such as the fuzzification coefficient used in the FCM,the number of rules and the orders of the polynomials in the consequent parts of the rules,the authors carry out both structural as well as parametric optimization of the network.A multi-objective Particle Swarm Optimization using Crowding Distance(MOPSO-CD)as well as O/WLS learning-based optimization are exploited to carry out the structural and parametric optimization of the model,respectively,while the optimization is of multiobjective character as it is aimed at the simultaneous minimization of complexity and maximization of ***–The performance of the proposed model is illustrated with the aid of three *** proposed optimization method leads to an accurate and highly interpretable fuzzy ***/value–A MOPSO-CD as well as O/WLS learning-based optimization are exploited,respectively,to carry out the structural and parametric optimization of the *** a result,the proposed methodology is interesting for designing an accurate and highly interpretable fuzzy model.

关键词： Modelling Optimization techniques Neural nets Design calculations Fuzzy c-means clustering Multi-objective particle swarm optimization Information granulation-based fuzzy radial basis function neural network Ordinary least squaresmethod Weighted least square method

Assessment of the clear-sky bias issue using continuous PM10 data from two AERONET sites in Korea

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Journal of Environmental Sciences 2017年第3期29卷 151-160页

作者： Yongjoo choi Young sung Ghim Department of Environmental Science Hankuk University of Foreign StudiesYongin 449-791Korea

A bias in clear-sky conditions that will be involved in estimating particulate matter （PM） concentration from aerosol optical depth （AOD） was examined using PM10 from two Aerosol Robotic Network sites in Korea. The study periods were between 2004 and 2007 at Anmyon and between 2003 and 2011 at Gosan, when both PM10 and AOD were available. Mean PM10 when AOD was available （PMAOD） was higher than that from all PM10 data （PMall） by 5.1 and 9.9 μg/m3 at Anmyon and Gosan, which accounted for 11% and 26% of PMall, respectively. Because of a difference between mean PM10 under daytime clear-sky conditions （PMclear） and PMAoD, the variations in APM10, the difference of PMan from PMdear rather than from PMAoD, were investigated. Although monthly variations in APMlo at the two sites were different, they were positively correlated to those in AT, similarly defined as APM10 except for temperature, at both sites. APM10 at Anmyon decreased to a negative value in January due to an influence of the Siberian continental high-pressure system while APM10 at Gosan was high in winter due to an effect of photochemical production at higher temperatures than at Anmyon.

关键词： AERONETData recovery rateCloud amountWind speedPhotochemical productionSiberian high

Effect of gadolinium incorporation on optical characteristics of YNbO_4:Eu^(3+) phosphors for lamp applications

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Journal of Rare Earths 2012年第3期30卷 205-209页

作者： sung Hwan choi G. Anoop Dong wook Suh Kyung Pil Kim Hyun Ju Lee Jae Soo Yoo Display Materials Laboratory School of Chemical Engineering and Materials Science Chung-Ang University

Eu3＋-doped （Y,Gd）NbO4 phosphor was synthesized by solid-state reaction for possible application in cold cathode fluorescent lamps. A broad absorption band with peak maximum at 272 nm was observed which was due to the charge transfer between Eu3＋ ions and neighboring oxygen anions. A deep red emission at the peak wavelength of 612 nm was observed which could be attributed to the 5D0→7F2 transition in Eu3＋ ions. The highest luminance for Y1-x-yGdyNbO4：Eux3＋ under 254 nm excitation was achieved at Eu3＋ concentration of 18 mol.% （x=0.18） and Gd3＋ concentration of 8.2 mol.% （y=0.082）. The luminance of Y0.738Gd0.082NbO4：Eu3＋0.18 was higher than that of a typical commercial phosphor Y2O3：Eu3＋ and the CIE chromaticity coordinate was （0.6490, 0.3506）, which was deeper than that of Y2O3：Eu3＋. The particle size of the synthesized phosphors was controlled by the NaCl flux and particle size as high as 8 μm with uniform size distribution of particles was obtained.

关键词： YNbO4:Eu oxide phosphors rare earths

Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization

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World Journal of Gastroenterology 2006年第43期12卷 6992-6997页

作者： Do Young Kim Moon Seok choi Joon Hyoek Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo sung wook Shin sung wook Choo Young Soo Do Jong Chul Rhee Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea Depart- ment of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea

AIM: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). METHODS: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. RESULTS: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. CONCLUSION: The Milan criteria are still a useful selec- tion criteria showing favorable outcomes in HCC patientsreceiving TACE before LT.

关键词： Milan criteria Hepatocellular carcinoma Transarterial chemoembolization Liver transplantation

Zero-static-power nonvolatile logic-in-memory circuits for flexible electronics

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Nano Research 2017年第7期10卷 2459-2470页

作者： Byung ChulJang Sang Yoon Yang Hyejeong seong sung Kyu Kim Junhwan choi sung Gap Im sung-Yool choi School of Electrical Engineering Graphene/2D Materials Research Center Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Department of Chemical and Biomolecular Engineering Graphene/2D Materials Research Center Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Flexible logic circuits and memory with ultra-low static power consumption are in great demand for battery-powered flexible electronic systems. Here, we show that a flexible nonvolatile logic-in-memory circuit enabling normally-off computing can be implemented using a poly（1,3,5-trivinyl-l,3,5-trimethyl cyclotrisiloxane）（pV3D3）-based memristor array. Although memristive logic-in-memory circuits have been previously reported, the requirements of additional components and the large variation of memristors have limited demonstrations to simple gates within a few operation cycles on rigid substrates only. Using memristor-aided logic （MAGIC） architecture requiring only memristors and pV3D3-memristor with good uniformity on a flexible substrate, for the first time, we experimentally demonstrated our implementation of MAGIC-NOT and -NOR gates during multiple cycles and even under bent conditions. Other functions, such as OR, AND, NAND, and a half adder, are also realized by combinations of NOT and NOR gates within a crossbar array. This research advances the development of novel computing architecture with zero static power consumption for battery- powered flexible electronic systems.

关键词： memristor memristive logic circuit flexible nonvolatilelogic-in-memory circuit normally-off computing memristor-aided logic(MAGIC) architecture

Generation of tumor spheroids using a droplet-based microfluidic device for photothermal therapy

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Microsystems & Nanoengineering 2020年第1期6卷 796-805页

作者： Jong Min Lee Ji wook choi Christian D.Ahrberg Hyung Woo choi Jang Ho Ha Seok Gyu Mun sung Joon Mo Bong Geun Chung Department of Mechanical Engineering Sogang UniversitySeoulKorea Division of Chemical Industry Yeungnam University CollegeDaeguRepublic of Korea Research Center Sogang UniversitySeoulKorea Department of Biomedical Engineering Sogang UniversitySeoulKorea

Despite their simplicity,monolayer cell cultures are not able to accurately predict drug behavior in vivo due to their inability to accurately mimic cell-cell and cell-matrix *** contrast,cell spheroids are able to reproduce these interactions and thus would be a viable tool for testing drug ***,the generation of homogenous and reproducible cell spheroids on a large scale is a labor intensive and slow process compared to monolayer cell ***,we present a droplet-based microfluidic device for the automated,large-scale generation of homogenous cell spheroids in a uniform *** the microfluidic system,the size of the spheroids can be tuned to between 100 and 130μm with generation frequencies of 70 *** demonstrated the photothermal therapy(PTT)application of brain tumor spheroids generated by the microfluidic device using a reduced graphene oxide-branched polyethyleneimine-polyethylene glycol(rGO-BPEI-PEG)nanocomposite as the PTT ***,we generated uniformly sized neural stem cell(NSC)-derived neurospheres in the droplet-based microfluidic *** also confirmed that the neurites were regulated by ***,this droplet-based microfluidic device could be a powerful tool for photothermal therapy and drug screening applications.

关键词： fluid viable simplicity

Coronary sinus endocarditis in a hemodialysis patient:A case report and review of literature

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World Journal of Clinical Cases 2021年第17期9卷 4348-4356页

作者： Hui-Jeong Hwang sung-wook Kang Department of Cardiology Kyung Hee University Hospital at GangdongKyung Hee University College of MedicineSeoul 05278South Korea Department of Pulmonary Allergy and Critical Care MedicineKyung Hee University Hospital at GangdongSeoul 05278South Korea

BACKGROUND Infective endocarditis is more common in hemodialysis patients than in the general population and is sometimes difficult to *** coronary sinus(CS)vegetation is extremely rare and has a good prognosis,but complicated CS vegetation may have a poorer clinical *** report a case of CS vegetation accidentally found via echocardiography in a hemodialysis patient with undifferentiated *** CS vegetation may have been caused by endocardial denudation due to tricuspid regurgitant jet and subsequent *** SUMMARY A 91-year-old man with dyspnea and hypotension was transferred from a nursing *** was on regular hemodialysis and had a history of severe grade of tricuspid *** was no leukocytosis or fever upon *** and sequential blood cultures revealed absence of microorganism *** computed tomography showed lung consolidation and a large pleural effusion.A mobile band-like mass on the CS,suggestive of vegetation,was observed on *** diagnosed him with infective endocarditis involving the CS,pneumonia,and septic shock based on echocardiographic,radiographic,and clinical *** of broad-spectrum antibiotics,fluid resuscitation,inotropic support,and ventilator care were ***,the patient died from uncontrolled infection and septic *** CS vegetation can be fatal in hemodialysis patients with impaired immune systems,especially when it delays the diagnosis.

关键词： Coronary sinus Endocarditis Renal dialysis Echocardiography Diagnosis,differential Case report

Is endoscopic ultrasonography still the modality of choice in preoperative staging of gastric cancer?

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World Journal of Gastroenterology 2014年第38期20卷 13775-13782页

作者： sung wook Hwang Dong Ho Lee Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Department of Internal Medicine Seoul National University Bundang HospitalSeongnam

The treatment option for gastric cancer is usually based on preoperative staging by imaging modalities. Endoscopic ultrasonography (EUS) and computed tomography (CT) have been used as the diagnostic modality of choice in preoperative staging of gastric cancer. Magnetic resonance imaging (MRI) has been employed in several studies, and (18F) 2-Fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) has emerged as a new promising imaging modality. The purpose of this article is to provide summarized information on preoperative staging using EUS, multi-detector row CT (MDCT), MRI and PET for gastric cancer. In T staging, both EUS and MDCT show high accuracy. MRI seemed to have better performance, but the number of MRI studies is limited. FDG-PET is not able to properly evaluate the depth of invasion. In N staging, the diagnostic accuracy of EUS, MDCT and MRI is not sufficient. In preoperative M staging, MDCT and FDG-PET showed similar diagnostic accuracies. FDG-PET/CT fusion could be expected to show better performance in the future. Physicians should keep in mind that each diagnostic modality has advantages and limitations and choose an appropriate diagnostic strategy tailored for each patient.

关键词： Gastric cancer Endoscopic ultrasonography Computed tomography Magnetic resonance imaging Positron emission tomography