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Development of controlled release bi-layered tablets containing oxycodone hydrochloride

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 178-178页

作者： Kyung Hun Kim Kyung Soo Lee Il woo Jung Jin Seob Oh Seo Hyun Lim sung Hoon Lee woo Heon Song Jun Sang Park GLPharmTech Corporation #714JungangInduspia V137Sagimakgol-roJungwon-guSeongnamGyeonggidoRepublic of Korea Department of Pharmaceutical Engineering Cheongju University298Daeseong-roCheongwon-guCheongjuChungcheongbuk-doRepublic of Korea

Oxycodone hydrochloride is a semi-synthetic opioid agonist that provides very effective relief for moderate to severe pain in cancer and post-operative patients. Controlled release oxycodone formulations have been studied to enhance the therapeutic effect by providing constant release over the whole dosing interval and improve patient’s convenience by reducing the frequency of administration as well.

关键词： Oxycodone Control release Bi-layered tablet IVIVC

A Study on Water Repellent Effectiveness of Natural Oil-Applied Soil as a Building Material

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Open Journal of Civil Engineering 2015年第1期5卷 139-148页

作者： Jong-Kook Lee Jee-Eun Lee Seong-Cheol Park Hee-Dong cho Hye-woong Yoo Young-Sang Kim Seong-Ryong Ryu woo-Suk Kim Dong-Joon Ahn School of Architecture Kumoh National Institute of Technology Gumi Republic of Korea

This study was performed to investigate the water repellent effectiveness of natural oil-applied soil when it is used as a building material. Natural oil types such as olive oil, bean oil, perilla oil and linseed oil, which are being used for producing water repellent timber, are selected for the experiments. It is expected that perilla oil and in seed oil, which are drying oil types will have better water repellent effectiveness than the other types. For the evaluation of water repellence of natural oil-applied soil, a contact angle test was performed. A contact angle of water drop on various surface conditions were tested, and large differences were seen between the natural oil-applied soil and untreated soil. As a result, it is showed that all natural oil types have water repellent effectiveness. However, linseed oil, which is a drying oil type, shows an outstanding water repellent effectiveness value, while perila oil, which is also a drying oil type, shows the lowest value. Additionally, results show that there is no link between water repellent effectiveness and the number of applications of natural oil. Nevertheless, existing commercial water repellents show better performance than natural oil, and it is anticipated that the results of this study will provide essential information for further research to enhance the water repellent effectiveness of soil as a building material.

关键词： Natural Oil Water Repellent Soil as a Building Material Contact Angle Iodine Value

Clinical trial to evaluate the efficacy and safety of Tongxinluo in high risk group of cardiovascular diseases

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Clinical trial to evaluate the efficacy and safety of Tongxi...

第二届国际络病学大会

作者： Seong Uk Park woo Sang Jung Sang Kwan Moon Chang Nam Go Ki Ho cho Young Suk Kim Hyung Sup Bae Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University Department of Cardiovascular ＆ Neurologic Diseases Stroke Center College of Oriental Medicine Kyung Hee University

＜正＞Objective Arterial stiffness is an important, independent determinant of cardiovascular risk. Pulse wave velocity （PWV） has been used as a valuable index of arterial stiffness and as a surrogate marker for atherosclerosis. The Framingham risk score was developed using categorized risk factors to predict the 10 - year absolute risk of developing coronary heart disease （CHD）. This algorithm is established using recommended guidelines for blood pressure, total cholesterol, and high - density lipoprotein cholesterol in addition to age, smoking history and history of diabetes. Tongxinluo（TXL） has been shown to have anti - hyperlipidemic activity and anti - atherogenic effects. To determine its efficacy and safety, we examined whether TXL improves PWV, ABI, Framingham score, blood pressure, and lipid profile in high risk group of cardiovascular diseases. Methods 49 subjects with the high risk of cardiovascular diseases were recruited. Subjects were administered TXL with the dose of 1110mg three times a day for 8 weeks. baPWV, ABI, Framingham risk score, Blood pressure and serum lipid profile were assessed at baseline and after 4 and 8weeks. Results Total cholesterol, LDL cholesterol, triglyceride, total lipid and phospolipid significantly decreased after 4 weeks of medication. Total cholesterol, total lipid and phospolipid significantly decreased after 8 weeks of medication. There were no significant changes in Framingham risk scores, ABI, PWV and blood pressure. On safety assessment, there were no adverse effects, hepatic or renal toxicity. Conclusion We suggest that TXL is a safe and useful herbal medicine for hyperlipidemia and as for anti - atherognic effects, further research would be necessary.

关键词： Tongxinluo Atherosclerosis Hyperlipidemia Cardiovascular disease PWV Framingham risk score

MR成像在宫颈癌宫旁侵犯检测中的应用:对2012年——2016年文献的系统性回顾与荟萃分析

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国际医学放射学杂志 2018年第2期 243-244页

作者： S.woo C.H.Suh S.Y.Kim J.Y.cho S.H.Kim 孙成凤 Department of Radiology Seoul National University Hospital

摘要目的评估MRI在检测宫颈癌病人宫旁侵犯(PMI)中的诊断价值。方法检索了MEDLINE和EMBASE数据库中有关MR成像在宫颈癌PMI方面诊断性能的所有研

关键词： MR 特异度诊断性能宫颈癌

Risk factors for local recurrence after en bloc endoscopic submucosal dissection for early gastric cancer

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World Journal of Gastrointestinal Endoscopy 2016年第7期8卷 330-337页

作者： Ju Yup Lee Kwang Bum cho Eun Soo Kim Kyung Sik Park Yoo Jin Lee Yoon Suk Lee Byoung Kuk Jang woo Jin Chung Jae Seok Hwang Department of Internal Medicine Keimyung University School of Medicine

AIM: To investigate factors related to recurrence following en bloc resection using endoscopic submucosal dissection(ESD) in patients with early gastric cancer(EGC). METHODS: A total of 1121 patients(1215 lesions) who had undergone ESD for gastric neoplasia between April 2003 and May 2010 were retrospectively reviewed. Data from 401 patients(415 lesions) were analyzed, following the exclusion of those who underwent piecemeal resection, with deep resection margin invasion or lateral margin infiltration, and diagnosed with benign lesions. RESULTS: Local recurrence after en bloc ESD was found in 36 cases(8.7%). Unclear resection margins, long procedure times, and narrow safety margins were identified as risk factors for recurrence. Lesions located in the upper third of the stomach showed a higher rate of recurrence than those located in the lower third of the stomach(OR = 2.9, P = 0.03). The probability of no recurrence for up to 24 mo was 79.9% in those with a safety resection margin ≤ 1 mm and 89.5% in those with a margin > 1 mm(log-rank test, P = 0.03). CONCLUSION: Even in cases in which en bloc ESD is performed for EGC, local recurrence still occurs. To reduce local recurrences, more careful assessment will be needed prior to the implementation of ESD in casesin which the tumor is located in the upper third of the stomach. In addition, clear identification of tumor boundaries as well as the securing of sufficient safety resection margins will be important.

关键词： Early gastric cancer Endoscopic mucosal resection Recurrence En bloc resection Endoscopic submucosal dissection

Nardostachys jatamansi extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes

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World Journal of Gastroenterology 2010年第26期16卷 3249-3257页

作者： Mi-Young Song Ui-Jin Bae Bong-Hee Lee Kang-Beom Kwon Eun-A Seo sung-Joo Park Min-Sun Kim Ho-Joon Song Keun-Sang Kwon Jin-woo Park Do-Gon Ryu Byung-Hyun Park Department of Biochemistry Medical School and Diabetes Research Center Chonbuk National University Jeonju Jeonbuk 561-756 South Korea Department of Physiology School of Oriental Medicine Wonkwang University Iksan Jeonbuk 570-749 South Korea Department of Food and Nutrition School of Human Environmental Science Wonkwang University Iksan Jeonbuk 570-749 South Korea Department of Herbology School of Oriental Medicine Wonkwang University Iksan Jeonbuk 570-749 South Korea Department of Preventive Medicine Medical School Chonbuk National University Jeonju Jeonbuk 561-756 South Korea

AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were completely abolished when mice were pretreated with NJE. Inhibition of streptozotocin-induced hyperglycemia by NJE was mediated by suppression of nuclear factor (NF)-κB activation. In addition, NJE protected against cytokine-mediated cytotoxicity. Incubation of RINm5F cells and islets with NJE resulted in a signif icant reduction in cytokine-induced NF-κB activation and downstream events, inducible nitric oxide synthase expression and nitric oxide production. The protective effect of NJE was further demonstrated by the normal insulin secretion of cytokine-treated islets in response to glucose. CONCLUSION: NJE provided resistance to pancreatic β-cell damage from cytokine or streptozotocin treatment. The β-cell protective effect of NJE is mediated by suppressing NF-κB activation.

关键词： Nardostachys jatamansi Cytokines Streptozotocin Pancreatic β cells Nuclear factor κB Nitric oxide Diabetes mellitus

Synthesis and characterization of MH···HOR dihydrogen bonded ruthenium and osmium complexes（η~5-C_5H_4CH_2OH）MH（PPh_3）_2（M = Ru, Os）

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Science China Chemistry 2014年第8期57卷 1079-1089页

作者： BAI Wei TSE Sunny Kai San LEE Ka Ho sung Herman Ho-Yung WILLIAMS Ian Duncan LIN ZhenYang JIA GuoChen Department of Chemistry Institute for Advanced Study The Hong Kong University of Science and Technology

Treatment of RuCl2(PPh3)3 with 6-dimethylaminopentafulvene in THF in the presence of water produced(η5-C5H4cho) RuCl(PPh3)2, which was reduced by NaBH4 to give the Ru–H···HO dihydrogen bonded complex(η5-C5H4CH2OH) RuH(PPh3)2. The dihydrogen bonded complex(η5-C5H4CH2OH)RuH(PPh3)2 could also be synthesized by the reduction of complex(η5-C5H4cho)RuH(PPh3)2, which was obtained by the reaction of RuHCl(PPh3)3 with 6-dimethylaminopentafulvene in the presence of water. The analogous dihydrogen bonded osmium complex(η5-C5H4CH2OH)OsH(PPh3)2 was similarly prepared. Single crystal structures and DFT calculations support the presence of intra-molecular H···H interaction, with separations of around 1.9 to 2.0 .

关键词： ruthenium osmium hydride dihydrogen bonding H/D exchange

Xanthoma disseminatum with intracranial involvement

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Xanthoma disseminatum with intracranial involvement

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Tai Kyung Noh Hye Rim Moon chong Hyun Won sung Eun Chang Mi woo Lee Jee Ho choi Kee Chan Moon Department of Dermatology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

＜正＞Xanthoma disseminatum（XD） is a rare normolipidemic mucocutaneous xanthomatosis classified as a benign non-Langerhans cell *** is characterized by mucocutaneous xanthomas symmetrically distributed,typically inv...

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LAPAROSCOPIC SPHINCTER-SAVING PROCEDURE FOR LOW RECTAL CANCER

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LAPAROSCOPIC SPHINCTER-SAVING PROCEDURE FOR LOW RECTAL CANCE...

第六次全国大肠癌会议暨中日韩大肠癌会议

作者： Jun-Gi Kim Young-Jin Suh Ki-Won Suh Yong-sung Won Yun-Bok Lee woo-Bae Park Chung-Soo Chun Dept. of Surg. St. Vincent’s Hospital The Catholic University of KoreaSuwon Republic of Korea Dept. of Surg. St. Vincent’s Hospital The Catholic University of KoreaSuwon Republic of Korea Dept. of Surg. St. Vincent’s Hospital The Catholic University of KoreaSuwon Republic of Korea Dept. of Surg. St. Vincent’s Hospital The Catholic University of KoreaSuwon Republic of Korea Dept. of Surg. St. Vincent’s Hospital The Catholic University of KoreaSuwon Republic of Korea Dept. of Surg. St. Vincent’s Hospital The Catholic University of KoreaSuwon Republic of Korea Dept. of Surg. St. Vincent’s Hospital The Catholic University of KoreaSuwon Republic of Korea

＜正＞PURPOSE: High-dose preoperative radiotherapy has shown promising results in the treatment of low rectal cancer（LRC）. Laparoscopic procedure provides an enhanced view of the pelvic cavity that is not available by conventional method. We developed a sphincter-saving procedure combining the advantages of preoperative radiotherapy and laparoscopy for preserving anatomic and physiologic anal function. Our purpose is to show detailed information regarding procedure and early results. METHODS: From February 1996 to August 1997, eleven patients with LRC underwent the operation. Mean age was 56.1 years. Tumor located 4～8 cm from anal verge. All patients were treated with high-dose preoperative irradiation （4500～5040 cGy） over a period of 5 weeks. All were given our procedure four and a half to eight weeks after completion of radiation. Left colon and rectum were mobilized by laparoscopic oncologic dissection down to puborectalis muscle, after which specimen retrieval and coloanal anastomosis were performed transanally. We concluded with temporary transverse colostomy for fecal diversion. Careful follow-up of 4 to 21 months has so far been given. RESULTS: Every case was successful without any significant complication, and all revealed advantages of laparoscopy. There was one case of complete remission following radiation, and "five were stage Ⅰ, four stage Ⅱ, and one stage Ⅲ. Margin from the tumor was 1～5 cm distally, 19～32 cm proximally, 0.3～3.5 cm laterally. We had one local recurrence 11 months after operating. CONCLUSION: We have termed our procedure ’Laparoscopic Abdominal Transanal （LATA） Proctosigmoidectomy with coloanal anastomosis （LATA resection）’, and propose it as a functional and curative alternative for LRC while continuing to evaluate its efficacy.

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