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Incidence, prevalence and risk of stroke in patients with Takayasu arteritis: a nationwide population-based study in South Korea

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Stroke & Vascular Neurology 2022年第2期7卷 149-157页

作者： sung soo ahn Minkyung Han Yong-Beom Park Inkyung Jung Sang-Won Lee Department of Internal Medicine Yongin Severance HospitalYonsei University College of MedicineYonginSouth Korea Biostatistics Collaboration Unit Department of Biomedical Systems InformaticsYonsei University College of MedicineSeoulSouth Korea Division of Rheumatology Department of Internal MedicineYonsei University College of MedicineSeoulSouth Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulSouth Korea Division of Biostatistics Department of Biomedical Systems InformaticsYonsei University College of MedicineSeoulSouth Korea

Background Takayasu arteritis(TAK)is a disease associated with increased risk of cardiovascular *** aimed to evaluate the incidence,prevalence and risk of stroke in patients with *** Data from 1065 patients were obtained from a national database(2010–2018).The annual incidence and prevalence per 100000 persons were estimated using the registration population in the midst of every year,and the standardised incidence ratio(SIR)of stroke was compared with the general population based on the data from the 2006 national report for cardiovascular and cerebrovascular ***-adjusted incidence rate ratio(IRR)of stroke based on the time interval after diagnosis was also calculated.A time-dependent Cox regression was conducted to investigate predictive factors of *** The overall incidence rate of TAK ranged between 0.2 and 0.3/100000 person-years annually;the prevalence of TAK gradually increased,reaching 3.25/100000 person-years in ***-three(6.9%)patients experienced stroke during follow-up,and the risk of developing stroke was higher than the general population(overall SIR 7.39,95%CI 5.79 to 9.29;men:SIR 5.70,95%CI 2.84 to 10.20;women:SIR 7.06,95%CI 5.41 to 9.05).Most stroke events(90.9%)were cerebral infarction for men,whereas the proportion of cerebral infarction was lower(62.9%)in *** half of stroke events occurred within 6 months after diagnosis,and stroke was more common within 6 months of diagnosis compared with after 3 years in women(IRR 13.46,95%CI 6.86 to 26.40).In Cox regression analysis,age was the sole predictor of stroke(adjusted HR 1.02,95%CI 1.00 to 1.04,p=0.043).Conclusions The annual incidence of TAK was similar to the previous studies from Asia,and the risk of stroke increased in *** patterns of subtype and incidence of stroke were found according to sex,although age was the only predictor.

关键词： prevalence patients diagnosis

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Successful hemostasis of intractable rectal variceal bleeding using variceal embolization

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World Journal of Gastroenterology 2015年第8期21卷 2558-2562页

作者： sung soo ahn Eun Hye Kim Man Deuk Kim Won Jae Lee Seung Up Kim Department of Internal Medicine Yonsei University College of Medicine Department of Radiology Research Institute of Radiological Science Yonsei University College of Medicine Seoul Gookgwain School Institute of Gastroenterology Yonsei University College of Medicine Liver Cirrhosis Clinical Research Center

Portal hypertension causes portosystemic shunting along the gastrointestinal tract,resulting in *** varices and their bleeding is a rare complication,but it can be fatal without appropriate ***,because of its rarity,no established treatment strategy is yet *** the setting of intractable rectal variceal bleeding,a transjugular intravenous portosystemic shunt can be a treatment of choice to enable portal decompression and thus achieve ***,in the case of recurrent rectal variceal bleeding despite successful transjugular intravenous portosystemic shunt,alternative measures to control bleeding are ***,we report on a patient with liver cirrhosis who experienced recurrent rectal variceal bleeding even after successful transjugular intravenous portosystemic shunt and was successfully treated with variceal embolization.

关键词： Ectopic varices Rectal varices Transjugular intrav

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Association between follistatin-related protein 1 and the functional status of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

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Chinese Medical Journal 2021年第10期134卷 1168-1174页

作者： Taejun Yoon sung soo ahn Jung Yoon Pyo Jason Jungsik Song Yong-Beom Park Sang-Won Lee Department of Medical Science BK21 Plus ProjectYonsei UniversityCollege of MedicineSeoulRepublic of Korea Division of Rheumatology Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulRepublic of Korea

Background:Follistatin-like 1(FSTL1)plays both pro-inflammatory and anti-inflammatory roles in the inflammatory *** investigated whether serum FSTL1 could predict the current anti-neutrophil cytoplasmic antibody-associated vasculitis(AAV)-specific ***:We randomly selected 74 patients with AAV from a prospective and observational cohort of Korean patients with *** and laboratory data and AAV-specific indices were ***1 concentration was determined using the stored *** lowest tertile of the short-form 36-item health survey(SF-36)was defined as the current low *** cutoffs of serum FSTL1 for the current low SF-36 physical component summary(PCS)and SF-36 mental component summary(MCS)were extrapolated by the receiver operator characteristic ***:The median age was 62.5 years(55.4%were women).Serum FSTL1 was significantly correlated with SF-36 PCS(r=-0.374),SF-36 MCS(r=-0.377),and C-reactive protein(CRP)(r=0.307),but not with Birmingham vasculitis activity score(BVAS).In the multivariable linear regression analyses,BVAS,CRP,and serum FSTL1 were independently associated with the current SF-36 PCS(β=-0.255,β=-0.430,andβ=-0.266,respectively)and the current SF-36 MCS(β=-0.234,β=-0.229,andβ=-0.296,respectively).Patients with serum FSTL1≥779.8 pg/mL and those with serum FSTL1≥841.6 pg/mL exhibited a significantly higher risk of having the current low SF-36 PCS and SF-36 MCS than those without(relative risk 7.583 and 6.200,respectively).Conclusion:Serum FSTL1 could predict the current functional status in AAV patients.

关键词： Anti-neutrophil cytoplasmic antibody Follistatin-like 1 Functional status Vasculitis

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Integration of earth-abundant cocatalysts for high-performance photoelectrochemical energy conversion

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Journal of Energy Chemistry 2024年第1期88卷 336-355,I0008页

作者： Joonhee Ma Sang Hyun ahn soo Young Kim Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea School of Chemical Engineering and Materials Science Chung-Ang University84 Heukseok-roDongjak-guSeoul 06974Republic of Korea

Photoelectrochemical(PEC)energy conversion has emerged as a promising and efficient approach to sustainable energy harvesting and *** utilizing semiconductor photoelectrodes,PEC devices can harness solar energy and drive electrochemical reactions such as water splitting or carbon dioxide(CO_(2))reduction to generate clean fuels and value-added ***,PEC energy conversion faces several challenges such as high overpotential,sluggish reaction kinetics,charge carrier recombination,and stability issues,which limit its practical ***,significant research has been conducted to improve the overall conversion efficiency of PEC *** particularly promising approach is the use of cocatalysts,which involves introducing specific cocatalysts onto the photoelectrode surface to promote charge separation,improve reaction kinetics,and reduce the overpotential,thereby enhancing the overall performance of PEC energy *** review provides a comprehensive overview of the recent developments in the earth-abundant cocatalysts for PEC water splitting and CO_(2) *** main earth-abundant catalysts for the PEC water splitting include transition-metal dichalcogenide(TMD)-based materials,metal phosphides/carbides,and metal oxides/***,PEC-CO_(2)RR was divided into C_(1) and C_(2+)based on the final product since various products could be produced,focusing on diverse earth-abundant materials-based *** addition,we provide and highlight key advancements achieved in the very recent reports on novel PEC system design engineering with ***,the current problems associated with PEC systems are discussed along with a suggested direction to overcome these obstacles.

关键词： Solar energy Photo-electrochemical Water splitting CO_(2)reduction Cocatalysts

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Settling and dewatering characteristics of granulated methane-oxidizing bacteria

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Journal of Environmental Sciences 2013年第2期25卷 280-286页

作者： Kwang Ho ahn Kwang soo Kim sung Won Kang Chul Yong Um Won Tae Lee Kwang Baik Ko Korea Institute of Construction Technology 283Goyangdae-RoIlsanseo-GuGoyang-SiGyeonggi-Do 411-712Korea School of Civil and Environmental Engineering Yonsei UniversitySinchondong 134SudaemunguSeoul 120-749Korea School of Civil and Environmental Engineering Kumoh National Institute of TechnologyDaehak-ro 61GumiGyeongbuk 730-701Korea

We evaluated the settling ability and dewaterability of granulated methane-oxidizing bacteria （GMOB） after granulation using a continuous-flow reactor. A comparative analysis on settling and dewatering characteristics due to changes in sludge retention time （SRT, 10, 15 and 20 days） during cultivation of GMOB was conducted. In assessing dewaterability, the specific resistance to filtration （SRF） of activated sludge and GMOB was found to be 8.21×1013-2.38×1014 and 4.88 × 1012-1.98×1013 m/kg, respectively. It was confirmed that as SRT decreased, SRF of GMOB increased. In the case of bound extracellular polymeric substance （EPS）, activated sludge registered 147.5 mg/g-VSS while GMOB exhibited 171-177.2 mg/g-VSS. In the case of extracellular polymeric substance soluble EPS in effluent, activated sludge measured 62 mg/L and GMOB had 17.4-21.4 mg/L. The particle size analysis showed that mean particle diameters of GMOB were 402, 369, and 350 μm, respectively, at SRTs of 20, 15 and 10 days. In addition, it was found that GMOB had a larger mean particle diameter and exhibited much better settleability and dewaterability than activated sludge did.

关键词： methane-oxidizing bacteria dewaterability specific resistance to filtration extracellular polymeric substances

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Complete Convergence for Randomly Weighted Sums of Random Variables Satisfying Some Moment Inequalities

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Acta Mathematica Sinica,English Series 2021年第2期37卷 279-288页

作者： Ping Yan CHEN soo Hak sung Department of Mathematics Ji'nan UniversityGuangzhou 510630P.R.China Department of Applied Mathematics Pai Chai UniversityDaejeon 35345South Korea

For random variables and random weights satisfying Marcinkiewicz-Zygmund and Rosenthal type moment inequalities, we establish complete convergence results for randomly weighted sums of the random variables. Our results generalize those of(Thanh et al. SIAM J. Control Optim., 49,106–124(2011), Han and Xiang J. Ineq. Appl., 2016, 313(2016), Li et al. J. Ineq. Appl., 2017, 182(2017), and Wang et al. Statistics, 52, 503–518(2018).)

关键词： Randomly weighted sum complete convergence moment inequality

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Helicobacter pylori in gastric carcinogenesis

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 455-465页

作者： Hyo Jun ahn Dong soo Lee Division of Gastroenterology Department of Internal Medicine College of Medicine Daejeon St. Mary’s Hospital the Catholic University of Korea

Gastric cancer still is a major concern as the third most common cancer worldwide, despite declining rates of incidence in many Western countries. Helicobacter pylori(H. pylori) is the major cause of gastric carcinogenesis, and its infection insults gastric mucosa leading to theoccurrence of atrophic gastritis which progress to intestinal metaplasia, dysplasia, early gastric cancer, and advanced gastric cancer consequently. This review focuses on multiple factors including microbial virulence factors, host genetic factors, and environmental factors, which can heighten the chance of occurrence of gastric adenocarcinoma due to H. pylori infection. Bacterial virulence factors are key components in controlling the immune response associated with the induction of carcinogenesis, and cag A and vac A are the most well-known pathogenic factors. Host genetic polymorphisms contribute to regulating the inflammatory response to H. pylori and will become increasingly important with advancing techniques. Environmental factors such as high salt and smoking may also play a role in gastric carcinogenesis. It is important to understand the virulence factors, host genetic factors, and environmental factors interacting in the multistep process of gastric carcinogenesis. To conclude, prevention via H. pylori eradication and controlling environmental factors such as diet, smoking, and alcohol is an important strategy to avoid H. pylori-associated gastric carcinogenesis.

关键词： Helicobacter pylori Gastric cancer

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UBVVI Surface Photometry of the Spiral Galaxy NGC 300 in the Sculptor Group

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Chinese Journal of Astronomy and Astrophysics 2004年第4期4卷 299-310页

作者： Sang Chul Kim Hwankyung sung Hong soo Park Eon-Chang sung Korea Astronomy Observatory Taejon 305-348Republic of KoreaDepartment of Astronomy and Space ScienceSejong University98 Gunja-dongGwangjin-guSeoul 143-747Republic of KoreaAstronomy ProgramSEESSeoul National UniversitySeoul 151-742Republic of KoreaKorea Astronomy ObservatoryTaejon 305-348Republic of Korea

We present UBVI surface photometry over a 20.5' × 20.5' area of the late-type spiral galaxy NGC 300. We have derived isophotal maps, surface brightness profiles, ellipticity profiles, position angle profiles, and color profiles. By merging our I-band measurements with those of Boker et al. based on Hubble Space Telescope observations, we have obtained combined I-band surface brightness profiles for the region 0.02' < r < 500' and have decomposed the profiles into three components: a nucleus, a bulge, and an exponential disk.

关键词： galaxies: spiral - galaxies: photometry - galaxies: individual(NGC 300) - galaxies: nuclei

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Anatomical resection of hepatocellular carcinoma: A critical review of the procedure and its benefits on survival

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World Journal of Gastroenterology 2017年第7期23卷 1139-1146页

作者： Koo Jeong Kang Keun soo ahn Division of Hepatobiliary and Pancreatic Surgery Department of SurgerySchool of MedicineKeimyung University Dong-san Medical CenterDaegu 41931South Korea

Hepatocellular carcinoma(HCC) is the sixth most common type of cancer and the third most frequent cause of cancer-related death. Advances in preoperative assessment of HCC(e.g., imaging studies and liver function tests), surgical techniques, and postoperative care have improved the surgical outcomes and survival of patients who undergo hepatic resection for HCC. However, in the last 20 years, the long-term survival after hepatectomy has remained unsatisfactory owing to the high rates of local recurrence and multicentric occurrence. Anatomical liver resection(AR) was introduced in the 1980 s. Although several studies have revealed tangible benefits of AR for HCC, these benefits are still debated. Because most HCCs occur in patients with liver cirrhosis and poor hepatic function, there are many factors that affect survival, including the surgical method. Nevertheless, many studies have documented the perioperative and long-term benefits of AR in various conditions. In this article, we review the results of several recently published, well-designed comparative studies of AR, to investigate whether AR provides real benefits on survival outcomes. We also discuss the potential pitfalls associated with this approach.

关键词： Hepatocellular carcinoma Cirrhosis Curative Anatomical resection Prognosis

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CAD/CAM for scalable nanomanufacturing:A network-based system for hybrid 3D printing

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Microsystems & Nanoengineering 2017年第1期3卷 135-145页

作者： Hae-sung Yoon Hyun-Taek Lee Ki-Hwan Jang Chung-soo Kim Hyunseo Park Dae-Wook Kim Kunwoo Lee Sangkee Min sung-Hoon ahn BK21 Plus Transformative Training Program for Creative Mechanical and Aerospace Engineers Seoul National UniversitySeoul 08826Republic of Korea Department of Mechanical and Aerospace Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Mechanical Engineering University of Wisconsin-MadisonMadisonWI 53706USA Institute of Advanced Machines and Design Seoul National UniversitySeoul 08826Republic of Korea

Micro-and nano-structuring have been highlighted over several decades in both science and engineering *** addition to continuous efforts in fabrication techniques,investigations in scalable nanomanufacturing have been pursued to achieve reduced feature size,fewer constraints in terms of materials and dimensional complexity,as well as improved process *** this study,based on recent micro-/nanoscale fabrication processes,characteristics and key requirements for computer-aided design and manufacturing(CAD/CAM)systems for scalable nanomanufacturing were *** include a process knowledge database,standardized processing,active communication,adaptive interpolation,a consistent coordinate system,and management of peripheral *** scalable nanomanufacturing,it is important to consider the flexibility and expandability of each process,because hybrid and bridging processes represent effective ways to expand process *** an example,we describe a novel CAD/CAM system for hybrid three-dimensional(3D)printing at the *** novel hybrid process was developed by bridging aerodynamically focused nanoparticle printing,focused ion beam milling,micromachining,and spincoating *** system developed can print a full 3D structure using various inorganic materials,with a minimum process scale of 50 *** most obvious difference versus CAD/CAM at‘conventional’scales is that our system was developed based on a network to promote communication between users and process *** the network-based system,it is also possible to narrow the gap among different processes/*** anticipate that this approach can contribute to the development of CAD/CAM for scalable nanomanufacturing and a wide range of hybrid processes.

关键词： Computer-aided design and manufacturing(CAD/CAM) nanomanufacturing network-based 3D printing

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