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Journal of Life Sciences 2016年第4期10卷 203-214页

作者： sung-Chin chung Chemg-Jyh Yen Department of Creative Design National Yunlin University of Science and Technology Yunlin Taiwan Department of Educational Foundations and Leadership OM Dominion University Norfolk USA

Taiwan is located at the high-risk region of natural disasters with the frequently occurred earthquakes. The importance of the disaster prevention education on campus is made even more obvious by the fact that natural disasters often occur during the school days. Given the leading roles the school administrators and teachers playing in the disaster prevention education of their pupils, this study purposed to investigate how disaster prevention literacy was among them and how disaster prevention literacy differed across various background variables of them. Furthermore, the current study also examined if disaster prevention literacy changed by participation in the disaster prevention education program. The results suggested that, among three dimensions of disaster prevention literacy （i.e., knowledge, attitude, ＆ skills） the participants were highest on disaster prevention skills and lowest on disaster prevention knowledge. Additionally, three dimensions of disaster prevention literacy of the participants differed by school level, age, years of service, personal disaster experience, and school disaster-stricken status. The participation in the disaster prevention education program was also related to participants＇ disaster prevention literacy. The implications of the above findings were discussed and the recommendations were also made for future disaster prevention education programs and research.

关键词： Disaster prevention education on campus literacy knowledge attitude skills.

Endoscopic repair of delayed stomach perforation caused by penetrating trauma:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1228-1236页

作者： Jae Hyun Yoon chung Hwan Jun Jae Pil Han Ji-Woong Yeom Seung-Ku Kang Hyun Yi Kook sung KyuChoi Department of Gastroenterology and Hepatology Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea Department of Surgery Mokpo Hankook HospitalMokpo 58643South Korea Department of Cardiothoracic Surgery Mokpo Hankook HospitalMokpo 58643South Korea Department of Nursing Chonnam National University Hospitaland College of NursingGwangju 61469South Korea

BACKGROUND Primary endoscopic closure of a perforated gastric wall during endoscopic procedures is mostly effective and well-tolerated;however,there are very few studies on the efficacy of endoscopic management of delayed traumatic gastric ***,we report a novel case of a patient who was successfully treated for delayed traumatic stomach perforation using an alternative endoscopic *** SUMMARY A 39-year-old woman presented with multiple penetrating traumas in the back and left abdominal *** imaging studies revealed left diaphragmatic disruption and peri-splenic hemorrhage without gastric *** emergency primary repair of the disrupted diaphragm with omental reduction and suturing of the lacerated lung was performed;however,delayed free perforation of the gastric wall was noted on computed tomography after 3 *** an emergency abdominal surgery for the primary repair of the gastric wall,re-perforation was noted 15 d *** high risk associated with re-surgery prompted an endoscopic intervention using 2 endoloops and 11 endoscopic clips using a novel modified purse-string suture *** free perforated gastric wall was successfully repaired without additional surgery or *** patient was discharged after 46 d without any *** Endoscopic closure with endoloops and clips can be a useful therapeutic alternative to re-surgery for delayed traumatic gastric perforation.

关键词： Surgical endoscopy Trauma Stomach Re-perforation Endoloop Case report

Evaluation of non-ampullary duodenal polyps: Comparison of non-neoplastic and neoplastic lesions

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World Journal of Gastroenterology 2010年第43期16卷 5474-5480页

作者： sung Hoon Jung Woo Chul chung Eun Jung Kim Seol Hye Kim Chang Nyol Paik Bo In Lee Young Seok Cho Kang-Moon Lee Department of Internal Medicine College of Medicine The Catholic University of Korea

AIM: To evaluate duodenal polyps, divided into nonneoplastic and neoplastic lesions. In addition, the clinical characteristics of duodenal hyperplastic polyps are determined. METHODS: We analyzed medical records of 50 114 consecutive patients submitted to for first diagnostic esophago-gastroduodenoscopy between January 2004 and December 2009. We excluded lesions on the ampulla of Vater and submucosal tumors. We studied 510 cases that were diagnosed endoscopically with duodenal polyps and enrolled a total of 221 cases that had undergone tissue biopsy. We analyzed the differences between non-neoplastic and neoplastic lesions, and determined the clinical features of duodenal hyperplastic polyps. RESULTS: Non-neoplastic lesions were found in 196 patients and neoplastic lesions in 25 patients. On uni-variate analysis, there were significant differences in shape, location, and size. Polyps more than 10 mm in diameter or polyps in the second portion had independent risk factors for being neoplastic lesions, as identified by multivariate analysis. In 23 cases of hyperplastic polyps (79.3%), they were accompanied by gastroduodenal pathology, which was possibly associated with Helicobacter pylori . CONCLUSION: Polyps of more than 10 mm or polyps in the second portion of the duodenum should be evaluated by histological examination.

关键词： Duodenum Polyp Helicobacter pylori

Progress of Materials and Devices for Neuromorphic Vision Sensors

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Nano-Micro Letters 2022年第12期14卷 239-271页

作者： sung Woon Cho Chanho Jo Yong-Hoon Kim sung Kyu Park Department of Electrical and Electronics Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Advanced Components and Materials Engineering Sunchon National UniversitySunchŏnJeonnam 57922Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwon 16419Republic of Korea

The latest developments in bio-inspired neuromorphic vision sensors can be summarized in 3 keywords:smaller,faster,and smarter.(1)Smaller:Devices are becoming more compact by integrating previously separated components such as sensors,memory,and processing *** a prime example,the transition from traditional sensory vision computing to in-sensor vision computing has shown clear benefits,such as simpler circuitry,lower power consumption,and less data redundancy.(2)Swifter:Owing to the nature of physics,smaller and more integrated devices can detect,process,and react to input more *** addition,the methods for sensing and processing optical information using various materials(such as oxide semiconductors)are evolving.(3)Smarter:Owing to these two main research directions,we can expect advanced applications such as adaptive vision sensors,collision sensors,and nociceptive *** review mainly focuses on the recent progress,working mechanisms,image pre-processing techniques,and advanced features of two types of neuromorphic vision sensors based on near-sensor and in-sensor vision computing methodologies.

关键词： In-sensor computing Near-sensor computing Neuromorphic vision sensor Optoelectronic synaptic circuit Optoelectronic synapse

Generation of tumor spheroids using a droplet-based microfluidic device for photothermal therapy

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Microsystems & Nanoengineering 2020年第1期6卷 796-805页

作者： Jong Min Lee Ji Wook Choi Christian D.Ahrberg Hyung Woo Choi Jang Ho Ha Seok Gyu Mun sung Joon Mo Bong Geun chung Department of Mechanical Engineering Sogang UniversitySeoulKorea Division of Chemical Industry Yeungnam University CollegeDaeguRepublic of Korea Research Center Sogang UniversitySeoulKorea Department of Biomedical Engineering Sogang UniversitySeoulKorea

Despite their simplicity,monolayer cell cultures are not able to accurately predict drug behavior in vivo due to their inability to accurately mimic cell-cell and cell-matrix *** contrast,cell spheroids are able to reproduce these interactions and thus would be a viable tool for testing drug ***,the generation of homogenous and reproducible cell spheroids on a large scale is a labor intensive and slow process compared to monolayer cell ***,we present a droplet-based microfluidic device for the automated,large-scale generation of homogenous cell spheroids in a uniform *** the microfluidic system,the size of the spheroids can be tuned to between 100 and 130μm with generation frequencies of 70 *** demonstrated the photothermal therapy(PTT)application of brain tumor spheroids generated by the microfluidic device using a reduced graphene oxide-branched polyethyleneimine-polyethylene glycol(rGO-BPEI-PEG)nanocomposite as the PTT ***,we generated uniformly sized neural stem cell(NSC)-derived neurospheres in the droplet-based microfluidic *** also confirmed that the neurites were regulated by ***,this droplet-based microfluidic device could be a powerful tool for photothermal therapy and drug screening applications.

关键词： fluid viable simplicity

Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis

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Molecular Plant 2021年第11期14卷 1951-1960页

作者： Arabidopsis Sera Choi Maxim Prokchorchik Hyeonjung Lee Ravi Gupta Yoonyoung Lee Eui-Hwan chung Buhyeon Cho Min-sung Kim Sun Tae Kim Kee Hoon Sohn Department of Life Sciences Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Department of Plant Bioscience Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Department of Botany School of Chemical and Life SciencesJamia HamdardHamdard NagarNew Delhi 110062India Division of Biotechnology Korea UniversitySeoul 02841Republic of Korea The Institute of Crop Science and Resource Conservation(INRES) University of BonnNussallee 953115 BonnGermany

Plant pathogenic bacteria deliver effectors into plant cells to suppress immunity and promote pathogen survival;however, these effectors can be recognised by plant disease resistance (R) proteins to activate innate immunity. The bacterial acetyltransferase effectors HopZ5 and AvrBsT trigger immunity in Arabidopsis thaliana genotypes lacking SUPPRESSOR OF AVRBST-ELICITED RESISTANCE 1 (SOBER1). Using an Arabidopsis accession, Tscha-1, that naturally lacks functional SOBER1 but is unable to recognise HopZ5, we demonstrate that RESISTANCE TO P. SYRINGAE PV MACULICOLA 1 (RPM1) and RPM1-INTERACTING PROTEIN 4 (RIN4) are indispensable for HopZ5- or AvrBsT-triggered immunity. Remarkably, T166 of RIN4, the phosphorylation of which is induced by AvrB and AvrRpm1, was directly acetylated by HopZ5 and AvrBsT. Furthermore, we demonstrate that the acetylation of RIN4 T166 is required and sufficient for HopZ5- or AvrBsT-triggered RPM1-dependent defence activation. Finally, we show that SOBER1 interferes with HopZ5- or AvrBsT-triggered immunity by deacetylating RIN4 T166. We have thus elucidated detailed molecular mechanisms underlying the activation and suppression of plant innate immunity triggered by two bacterial acetyltransferases, HopZ5 and AvrBsT from different bacterial pathogens.

关键词： Acetyltransferase effectors Effector-triggered immunity Immunity suppressors NLR Plant deacetylase Plant immunity

Genome-wide SNP discovery and core marker sets for assessment of genetic variations in cultivated pumpkin(Cucurbita spp.)

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Horticulture Research 2020年第1期7卷 1139-1148页

作者： Nam Ngoc Nguyen Minkyung Kim Jin-Kee Jung Eun-Jo Shim Sang-Min chung Younghoon Park Gung Pyo Lee sung-Chur Sim Department of Bioresources Engineering Sejong UniversitySeoul 05006South Korea Seed Testing and Research Center Korea Seed&Variety ServiceGimcheon 39660South Korea Department of Life Sciences Dongguk UniversitySeoul 04620South Korea Department of Horticultural Bioscience Pusan National UniversityMiryang 50463South Korea Department of Plant Science and Technology Chung-Ang UniversityAnsung 17546South Korea Plant Engineering Research Institute Sejong UniversitySeoul 05006South Korea

Three pumpkin species Cucurbita maxima,***,and *** are commonly cultivated *** identify genome-wide SNPs in these cultivated pumpkin species,we collected 48 F1 cultivars consisting of 40 intraspecific hybrids(15 ***,18 ***,and 7 ***)and 8 interspecific hybrids(*** x ***).Genotyping by sequencing identified a total of 37,869 confident SNPs in this *** SNPs were filtered to generate a subset of 400 SNPs based on polymorphism and genome *** the 400 SNPs,288 were used to genotype an additional 188 accessions(94 F1 cultivars,50 breeding lines,and 44 landraces)with a SNP array-based *** polymorphisms were observed in 224 SNPs(78.0%)and were used to assess genetic variations between and within the four predefined populations in 223 cultivated pumpkin *** principal component analysis and UPGMA clustering found four major clusters representing three pumpkin species and interspecific *** genetic differentiation was supported by pairwise Fst and Nei’s genetic *** interspecific hybrids showed a higher level of genetic diversity relative to the other three *** the 224 SNPs,five subsets of 192,96,48,24,and 12 markers were evaluated for variety *** 192,96,and 48 marker sets identified 204(91.5%),190(85.2%),and 141(63.2%)of the 223 accessions,respectively,while other subsets showed<25%of variety identification *** SNP markers provide a molecular tool with many applications for genetics and breeding in cultivated pumpkin.

关键词： breeding cultivar Cucurbita

PSCA, Cox-2, and Ki-67 are independent, predictive markers of biochemical recurrence in clinically localized prostate cancer： a retrospective study

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Asian Journal of Andrology 2017年第4期19卷 458-462页

作者： sung Han Kim Weon Seo Park Bo Ram Park Jungnam Joo Jae Young Joung Ho Kyung Seo Jinsoo chung Kang Hyun Lee Department of Urology Center for Prostate Cancer Research Institute and Hospital of National Cancer Center Goyang Korea Department of Pathology Center for Prostate Cancer Research Institute and Hospital of National Cancer Center Goyang Korea Department of Statistics Biometric Research Branch Clinical Research Coordination Center Research Institute and Hospital of National Cancer Center Goyang Korea.

Prostate cancer is the second most common male cancer, with half of all patients going on to develop metastases. To better identify patients at high risk for prostate cancer progression and reduce prostate cancer-related mortality, improved prognostic factors are required. In this study, we used immunohistochemistry （IHC） to determine the prognostic values of multiple tissue biomarkers in hormone-na＇l＇ve prostatectomy specimens of prostate cancer. Using 510 prostatectomy specimens collected between 2002 and 2012, IHC analysis was performed for Cerb-2, Cyclin D1, VEGF, EGFR, Rb, PSCA, p53, Bcl-2, Cox-2, PMS2, and Ki-67 on formalin-fixed paraffin-embedded sections. The Cox proportional hazard model was used to determine the predictive risk factors for biochemical recurrence （BCR） of prostate cancer. During a median 44-month follow-up, 128 （25.1%） patients developed BCR. A multivariate regression analysis revealed that Ki-67 （hazard ratio [HR]. 1.60, P = 0.033）, PSCA （HR： 0.42, P 〈 0.001）, and Cox-2 （HR： 2.05, P = 0.003） were the only significant prognostic tissue markers of BCR. Resection margin status （HR： 1.67, P = 0.010）, pathologic pTO/l/2 stage （vs pT3/4; HR： 0.20, P = 0.002）, preoperative PSA levels （HR.. 1.03, P 〈 0.001）, biopsied （HR： 1.30, P = 0.022） and pathologic （HR： 1.42, P = 0.005） Gleason scores, and prostate size （HR： 0.97, P = 0.003） were significant clinicopathologic factors. The expression of Ki-67, PSCA, and Cox-2 biomarkers along with other clinicopathologic factors were prognostic factors for BCR in patients with clinically localized prostate cancer following radical prostatectomy.

关键词： biomarker immunohistochemistry prostatectomy recurrence tissue microarray

Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network

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Light(Science & Applications) 2022年第7期11卷 1595-1606页

作者： Geon Kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea sung Ryu Gunho Choi Hyun Jung chung Kyuseok Kim Doo Ryeon chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park Department of Physics Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea KAIST Institute for Health Science and Technology KAISTDaejeon 34141Republic of Korea Tomocube Inc. Daejeon 34109Republic of Korea Smart Healthcare&Device Research Center Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Emergency Medicine Bundang CHA HospitalSeongnam-siGyeonggi-Do 13496Korea Division of Infectious Diseases Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Laboratory Medicine Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Laboratory Medicine and Genetics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Applied Physics Stanford UniversityStanfordCA 94305USA Department of Physics Massachusetts Institute of TechnologyCambridgeMA 02139USA

The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial *** infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly *** studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to *** main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample ***,we propose a microscopy-based framework that identifies the pathogen from single to few *** framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural *** demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or *** performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical ***,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or *** believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections.

关键词： artificial neural exploit

Full-color monolithic hybrid quantum dot nanoring micro light-emitting diodes with improved efficiency using atomic layer deposition and nonradiative resonant energy transfer

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Photonics Research 2019年第4期7卷 416-422页

作者： sung-WEN HUANG CHEN CHIH-CHIANG SHEN TINGZHU WU ZHEN-YOU LIAO LEE-FENG CHEN JIA-ROU ZHOU CHUN-FU LEE CHIH-HAO LIN CHIEN-chung LIN CHIN-WEI SHER PO-Tsung LEE AN-JYE TZOU ZHONG CHEN HAO-chung KUO Institute of Electro-Optical Engineering Taiwan Chiao Tung University Department of Electronic Science Fujian Engineering Research Center for Solid-State Lighting Xiamen University Institute of Photonics System Taiwan Chiao Tung University HKUST Fok Ying Tung Research Institute Department of Electrical Engineering and Computer Sciences and TBSI University of California at Berkeley

Full-color displays based on micro light-emitting diodes(μLEDs) can be fabricated on monolithic epitaxial wafers. Nanoring(NR) structures were fabricated on a green LED epitaxial wafer; the color of NR-μLEDs was tuned from green to blue through strain relaxation. An Al_2O_3 layer was deposited on the sidewall of NR-μLEDs,which improved the photoluminescence intensity by 143.7%. Coupling with the exposed multiple quantum wells through nonradiative resonant energy transfer, red quantum dots were printed to NR-μLEDs for a full-color display. To further improve the color purity of the red light, a distributed Bragg reflector is developed to reuse the excitation light.

关键词： Full-color displays epitaxial wafers