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Etanercept-synthesizing adipose-derived stem cell secretome:A promising therapeutic option for inflammatory bowel disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 882-892页

作者： Say-June Kim ok-Hee Kim Ha-Eun hong Ji Hyeon Ju Do Sang Lee Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract,with tumor necrosis factor(TNF)-αplaying a key role in its ***,a decoy receptor for TNF,is used to treat inflammatory *** secretome derived from adipose-derived stem cells(ASCs)has anti-inflammatory effects,making it a promising therapeutic option for *** To investigate the anti-inflammatory effects of the secretome obtained from ASCs synthesizing etanercept on colon cells and in a dextran sulfate sodium(DSS)-induced IBD mouse *** ASCs were transfected with etanercept-encoding mini-circle plasmids to create etanercept-producing *** secretory material from these cells was then tested for anti-inflammatory effects both in vitro and in a DSS-induced IBD mouse *** This study revealed promising results indicating that the group treated with the secretome derived from etanercept-synthesizing ASCs[Etanercept-Secretome(Et-Sec)group]had significantly lower expression levels of inflammatory mediators,such as interleukin-6,Monocyte Chemoattractant Protein-1,and TNF-α,when compared to the control secretome(Ct-Sec).Moreover,the Et-Sec group exhibited a marked therapeutic effect in terms of preserving the architecture of intestinal tissue compared to the *** These results suggest that the secretome derived from ASCs that synthesize etanercept has potential as a therapeutic agent for the treatment of IBD,potentially enhancing treatment efficacy by merging the anti-inflam-matory qualities of the ASC secretome with etanercept's targeted approach to better address the multifaceted pathophysiology of IBD.

关键词： Adipose-derived stem cells Etanercept Inflammatory bowel disease Secretome Tumor necrosis factor-α

The secondary periodic element ■ and its applications

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Science China Mathematics 2025年第1期 207-222页

作者： Jianguo hong Xiangjun Wang Yu Zhang Science College Shijiazhuang University School of Mathematical Sciences Nankai University Center for Applied Mathematics Tianjin University

Let p≥7 be a *** prove that ■ survives to E∞in the Adams-Novikov spectral ***,using the Thom map Φ:■,we can see that h0h3also survives to E∞in the classical Adams spectral *** an application of these results,we ...

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Influences of tool plunge speed and tool plunge depth on friction spot joining of AA5454-O aluminum alloy plates with different thicknesses

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中国有色金属学会会刊：英文版 2012年第S3期22卷 629-633页

作者： sung-Ook YOON Myoung-Soo KANG Yong-Jai KWON sung-Tae hong Dong-Hwan PARK Kwang-Hak LEE Chang-Yong LIM Jong-Dock SEO School of Materials Science and Engineering University of Ulsan School of Mechanical Engineering University of Ulsan Institute of E-Vehicle Technology University of Ulsan Technical Research Laboratories Shin Young Co.Ltd.

AA5454-O aluminum alloy plates with the thicknesses of 1.4 and 1.0 mm were friction-spot-joined (FSJed).The plunge speed of the joining tool was changed in a range of 100 500 mm/min under a constant rotation speed of 500 r/*** plunge depth was ranged from 1.6 mm to 2.2 *** tool plunge speed did not make a remarkable effect on the surface appearance and macro-structure of the FSJed *** average hardness of the FSJed zone was greater than or equal to that of the base ***,there was no remarkable tendency in the average hardness change of the FSJed zone in spite of the variation in the tool plunge speed and tool plunge *** increase of the tool plunge depth resulted in the increase of the tensile shear ***,the change of the tool plunge speed did not lead to the remarkable variation in the tensile shear load of the FSJed *** was noteworthy that the FSJed plate exhibited the highest tensile shear load of about 4.0 kN.

关键词： friction spot joining AA5454-O aluminum alloy plunge speed plunge depth mechanical property

Microstructural Investigation of Alloy 617 Creep-ruptured at High Temperature in a Helium Environment

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Journal of Materials Science & Technology 2013年第12期29卷 1177-1183页

作者： Gyeong-Geun Lee Sujin Jung Jae-Young Park Woo-Gon Kim sung-Deok hong Yong-Wan Kim Nuclear Materials Division Korea Atomic Energy Research Institute

A very high temperature reactor （VHTR） is one of the next-generation nuclear reactors chosen by the Generation IV International Forum. A Ni-base superalloy, Alloy 617, is considered as a primary candidate material for an intermediate heat exchanger （IHX） and hot gas duct （HGD） of the VHTR because of the superior creep resistance at a high temperature above 850 ~C. In this study, the microstructures of the specimens creep- ruptured at high temperatures in a helium environment were investigated. The decrease in rupture time was more pronounced with increasing creep temperature. In the specimens crept at 950 ~C, the external Cr-oxide layer of the specimens increased in thickness with increasing creep rupture time, and delaminated after a long-time creep. The high creep stress induced a deep penetration of carbide depletion along the grain boundaries at the early stage of the creep test. The creep temperature enhanced the growth rate of the decarburized zone depth clearly, but the temperature effect on the growth of the external oxide and internal oxide was not well understood as the surface reaction and creep stress affected the microstructures complexly.

关键词： Alloy 617 Microstructure Creep Helium Oxide

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教学的文化实践属性及三个基本认识向度

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 137-143页

作者：程良宏王芸新疆师范大学教育科学学院新疆高等教育发展研究中心新疆乌鲁木齐830017

教学不仅是知识传递行为,而且是具有文化交往和文化生产属性的实践活动。文本认为,从教学目的、教学主体和教学内容入手探析教学在知识传递传承背后的文化实践特质,是理解教学具有文化交往和文化生产属性的三个基本认识向度。因此,要深... 详细信息

教学不仅是知识传递行为,而且是具有文化交往和文化生产属性的实践活动。文本认为,从教学目的、教学主体和教学内容入手探析教学在知识传递传承背后的文化实践特质,是理解教学具有文化交往和文化生产属性的三个基本认识向度。因此,要深入体认教学作为一种特殊的文化交往和生产实践形态,明晰以文化人、以文育人的导引和践行为目的指引,以教师与学生为文化交往和文化生产的实践主体,以教学过程中对教材与师生文化的理解再造为文化实践的基本内容。

关键词：教学实践教学的文化属性文化生产

Comparative study of tensile and high-cycle fatigue properties of extruded AZ91 and AZ91-0.3Ca-0.2Y alloys

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Journal of Materials Science & Technology 2021年第34期93卷 41-52页

作者： Ye Jin Kim Young Min Kim Seong-Gu hong Dae Woong Kim Chong Soo Lee sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Division of Industrial Metrology Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Energy Infra Material Measure Team Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Graduate Institute of Ferrous Technology Pohang University of Science and Technology.Pohang 37673Republic of Korea

Mg-Al-Zn-Ca-Y alloys with excellent ignition and corrosion resistances—termed SEN alloys(where the letters"S,""E,"and"N"stand for stainless,environmentally friendly,and non-flammable,respectively)—have been developed *** this study,the microstructure,tensile properties,and high-cycle fatigue properties of an extruded Mg-9.0Al-0.8Zn-0.1Mn-0.3Ca-0.2Y(SEN9)alloy are investigated and compared with those of a commercial Mg-9.0Al-0.8Zn-0.1Mn(AZ91)alloy extruded under the same *** the extruded SEN9 alloy and the extruded AZ91 alloy have a fully recrystallized structure comprising equiaxed grains,but the former has a smaller average grain size owing to the promoted dynamic recrystallization during *** extruded AZ91 alloy contains coarse Mg_(17)Al_(12) discontinuous precipitate(DP)bands parallel to the extrusion direction,which are formed during its cool down after *** contrast,the extruded SEN9 alloy contains relatively fine undissolved Al_(2)Ca,Al_(8)Mn_(4)Y,and Al_(2)Y second-phase particles,which are formed during the solidification stage of the casting *** tensile strength of the extruded SEN9 alloy,which has finer grains and more abundant particles,is slightly higher than that of the extruded AZ91 ***,the difference in their strengths is relatively small because the stronger solid-solution hardening and precipitation hardening effects in the extruded AZ91alloy offset the stronger grain-boundary hardening and dispersion hardening effects in the extruded SEN9alloy to some *** tensile elongation of the extruded AZ91 alloy is significantly lower than that of the extruded SEN9 alloy because the large cracks formed in the DP bands in the former cause its premature *** the extruded SEN9 alloy has higher tensile properties than the extruded AZ91alloy,the high-cycle fatigue life and fatigue strength of the former are shorter and lower,respectively,than those of the *** DP bands in the extruded

关键词： Mg-Al-Zn-Ca-Y alloy Extrusion Tensile properties High-cycle fatigue Crack source

Analysis of expanded criteria to select candidates for active surveillance of low-risk prostate cancer

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Asian Journal of Andrology 2015年第2期17卷 248-252,I0008,I0009页

作者： Jung Ki Jo Hart Sol Lee Young Ik Lee Sang Eun Lee sung Kyu hong Department of Urology Seoul National University Bundang Hospital Seongnam Korea.

We aimed to analyze the value of each criterion for clinically insignificant prostate cancer （PCa） in the selection of men for active surveillance （AS） of low-risk PCa. We identified 532 men who were treated with radical prostatectomy from 2006 to 2013 who met 4 or all 5 of the criteria for clinically insignificant PCa （clinical stage 〈 T1, prostate specific antigen [PSA] density 0.15, biopsy Gleason score 〈 6, number of positive biopsy cores 〈 2, and no core with 〉 50% involvement） and analyzed their pathologic and biochemical outcomes. Patients who met all 5 criteria for clinically insignificant PCa were designated as group A （n -- 172）, and those who met 4 of 5 criteria were designated as group B （n = 360）. The association of each criterion with adverse pathologic features was assessed via logistic regression analyses. Comparison of group A and B and also logistic regression analyses showed that PSA density 0.15 ng ml-1 and high （〉7） biopsy Gleason score were associated with adverse pathologic features. Higher （〉 Tlc） clinical stage was not associated with any adverse pathologic features. Although 〈 3 positive cores were not associated with any adverse pathology, 〉4 positive cores were associated with higher risk of extracapsular extension. Among potential candidates for AS, PSA density ~ 0.15 ng ml-~ and biopsy Gleason score ~ 6 pose significantly higher risks of harboring more aggressive disease. The eligibility criteria for AS may be expanded to include men with clinical stage T2 tumor and 3 positive cores.

关键词： prediction prostate prostatectomy prostatic neoplasms risk

Automatic salient object segmentation using saliency map and color segmentation

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Journal of Central South University 2013年第9期20卷 2407-2413页

作者： HAN sung-ho JUNG Gye-dong LEE Sangh-yuk hong Yeong-pyo LEE Sang-hun Department of Plasmabiodisplay Kwangwoon University Department of General Education Kwangwoon University Department of Electrical and Electronic Engineering Xi'an Jiaotong-Liverpool University Department of Hospital Management International University of Korea

A new method for automatic salient object segmentation is *** object segmentation is an important research area in the field of object recognition,image retrieval,image editing,scene reconstruction,and 2D/3D *** this work,salient object segmentation is performed using saliency map and color ***,color and intensity feature are extracted from mean shift segmentation(MSS)image,and saliency map is created using these *** average saliency per segment image is calculated using the color information from MSS image and generated saliency ***,second average saliency per segment image is calculated by applying same procedure for the first image to the thresholding,labeling,and hole-filling applied ***,labeling and hole-filling are applied to the mean image of the generated two images to get the final salient object *** effectiveness of proposed method is proved by showing 80%,89%and 80%of precision,recall and F-measure values from the generated salient object segmentation image and ground truth image.

关键词： salient object visual attention saliency map color segmentation

Neuroprotective effects of tamsulosin on intracerebral hemorrhage

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Neural Regeneration Research 2011年第32期6卷 2505-2510页

作者： hong-Jin Suh sung-Min So Young-Gil Na Il-Gyu Ko sung-Eun Kim Yun-Hee sung Mal-Soon Shin Chang-Ju Kim Young-Sam Cho Khae-Hawn Kim Department of Urology Incheon St. Mary's Hospital the Catholic University of Korea School of Medicine Department of Urology Chungnam National University School of Medicine Department of Physiology Kyung Hee University School of Medicine Department of Urology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Urology Gachon University Gil Hospital Gachon University of Medicine and Science

The alpha1 adrenoreceptor antagonist tamsulosin is primarily used to treat benign prostatic hypertrophy. In this study, we intragastrically administered rats with 0.01,0.1 and 1 mg/kg tamsulosin to investigate the effects of tamsulosin on memory function, and hippocampal cell apoptosis and proliferation following intracerebral hemorrhage. Step-down avoidance task results showed that tamsulosin treatment markedly alleviated intracerebral hemorrhage- induced short-term memory impairment. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling results showed that tamsulosin treatment markedly suppressed intracerebral hemorrhage-induced caspase-3 expression in the hippocampal CA1 region and cell proliferation in the hippocampal dentate gyrus. Tamsulosin treatment at a dose of 0.01 mg/kg exhibited the most potent inhibitory effects on cell apoptosis and proliferation. These findings suggest that tamsulosin treatment facilitates the recovery of rat memory function by inhibiting hippocampal cell apoptosis and proliferation followincl intracerebral hemorrhaQe.

关键词： tamsulosin, intracerebral hemorrhage short-term memory apoptosis cellproliferation hippocampus neural regeneration