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Endoscopic papillary balloon dilation:Revival of the old technique

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World Journal of Gastroenterology 2013年第45期19卷 8258-8268页

作者： Seung Uk Jeong sung-Hoon moon Myung-Hwan Kim Department of Internal Medicine Jeju National University School of Medicine Jeju 690-767 South Korea Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang 431-070 South Korea Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea

Radiologists first described the removal of bile duct stones using balloon dilation in the early ***,there has been renewed interest in endoscopic balloon dilation with a small balloon to avoid the complications of endoscopic sphincterotomy(EST)in young patients undergoing laparoscopic ***,there is a disparity in using endoscopic balloon papillary dilation(EPBD)between the East and the West,depending on the origin of the *** the early 2000s,EST followed by endoscopic balloon dilation with a large balloon was introduced to treat large or difficult biliary *** balloon dilation with a large balloon has generally been recognized as an effective and safe method,unlike ***,fatal complications have occurred in patients with endoscopic papillary large balloon dilation(EPLBD).The safety of endoscopic balloon dilation is still a debatable ***,guidelines of indications and techniques have not been established in performing endoscopic balloon dilation with a small balloon or a large *** this article,we discuss the issue of conventional and large balloon endoscopic *** also suggest the indications and optimal techniques of EPBD and EPLBD.

关键词： Endoscopic papillary balloon dilation Endoscopic papillary large balloon dilation Common bile duct stone Endoscopic sphincterotomy Mechanical lithotripsy

Immunotherapy for pancreatic cancer

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World Journal of Clinical Cases 2021年第13期9卷 2969-2982页

作者： Jai Hoon Yoon Ye-Ji Jung sung-Hoon moon Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Hallym UniversityAnyang 14068South Korea Department of Internal Medicine University of Hallym College of MedicineHallym University Sacred Heart HospitalAnyang 14068South Korea

Pancreatic cancer, a highly lethal cancer, has the lowest 5-year survival rate forseveral reasons, including its tendency for the late diagnosis, a lack of serologicmarkers for screening, aggressive local invasion, its early metastaticdissemination, and its resistance to chemotherapy/radiotherapy. Pancreaticcancer evades immunologic elimination by a variety of mechanisms, includinginduction of an immunosuppressive microenvironment. Cancer-associatedfibroblasts interact with inhibitory immune cells, such as tumor-associatedmacrophages and regulatory T cells, to form an inflammatory shell-like desmoplasticstroma around tumor cells. Immunotherapy has the potential to mobilizethe immune system to eliminate cancer cells. Nevertheless, althoughimmunotherapy has shown brilliant results across a wide range of malignancies,only anti-programmed cell death 1 antibodies have been approved for use inpatients with pancreatic cancer who test positive for microsatellite instability ormismatch repair deficiency. Some patients treated with immunotherapy whoshow progression based on conventional response criteria may prove to have adurable response later. Continuation of immune-based treatment beyond diseaseprogression can be chosen if the patient is clinically stable. Immunotherapeuticapproaches for pancreatic cancer treatment deserve further exploration, given theplethora of combination trials with other immunotherapeutic agents, targetedtherapy, stroma-modulating agents, chemotherapy, and multi-way combinationtherapies.

关键词： Pancreatic adenocarcinoma Pancreatic cancer Immunotherapy Immune checkpoint inhibitor

Optimistic performance of carbon-free hydrazine fuel cells based on controlled electrode structure and water management

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Journal of Energy Chemistry 2020年第12期29卷 175-181页

作者： Hongsun Hwang Sujik Hong Do-Hyeong Kim moon-sung Kang Jin-Soo Park sunghyun Uhm Jaeyoung Lee Electrochemical Reaction and Technology Laboratory(ERTL) School of Earth Sciences and Environmental EngineeringGwangju Institute of Science and Technology(GIST)Cwangju 61005Republic of Korea Ertl Center for Electrochemistry and Catalysis Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Department of Green Chemical Engineering Sangmyung UniversityCheonanChungnam 31066Republic of Korea Plant Engineering Center Institute for Advanced EngineeringYongin 17180Republic of Korea

In this study, we first attempted to discover the optimal configuration of membrane-electrode assemblies(MEAs) used to achieve a high performance of direct hydrazine fuel cells(DHFCs). We have investigated the effect of water management and the electrode thickness on the performance of DHFCs, depending on the hydrophobicity of the gas diffusion layers in the cathode and the catalyst loading in the anode with the carbon-supported Ni, synthesized by a polyol process. With the optimal water management and electrode thickness, the MEA constructed using the as-prepared Ni/C anode catalyst containing the metallic and low oxidative state and ultra-low Pt loading cathode reduced the ohmic resistance and mass transfer limitation in the current-voltage curves observed for the alkaline DHFC, achieving an impressive power performance over 500 mW cm^(–2).

关键词： Fuel cell Hydrazine Alkaline media Membrane-electrode assembly

Teleconnections:Summer Monsoon over Korea and India

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Advances in Atmospheric Sciences 2002年第4期19卷 665-676页

作者： Baek-Jo Kim sung-Euii moon 陆日宇 R.H.Kripalani Meteorological Research Institute Korea Meteorological Administration Seoul 156-720 Korea Korea Meteorological Administration Seoul 156-720 Korea LASG Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100080 Indian Institute of Tropical Meteorology Pune 411008 India

This study investigates the relationship between the summer monsoon rainfall over Korea and India, by using correlation analysis and Singular Value Decomposition (SVD).Results reveal that summer monsoon rainfall over Korea is negatively (significant at the 99% level) cor-related with the rainfall over the northwest and central parts of India. In addition, coupled spatial modes be-tween the rainfall over Korea and India have been identified by the SVD analysis. The squared covariance fraction explained by the first mode is 70% and the correlation coefficient between the time coefficients of the two fields is significant at the 99% level, indicating that the coupled mode reflects a large part of the interaction between the summer monsoon rainfall over Korea and India. The first mode clearly demon-strates the existence of a significant negative correlation between the rainfall over the northwest and central parts of India and the rainfall over *** mechanisms of this correlation are investigated by analyzing the variation of upper-level at-mospheric circulation associated with the Tibetan high using NCEP/NCAR Reanalysis data.

关键词： summer monsoon rainfall tibetan high singular value decomposition (SVD)

Incidental frontoparietal parasagittal meningioma in a patient with acute bilateral optic neuritis

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 1064-1066页

作者： Su-Ho Lim sung-Hyuk moon Myung-Mi Kim Department of Ophthalmology Daegu Veterans Health Service Medical Center Department of Ophthalmology Yeungnam University College of Medicine Department of Ophthalmology Inje University Busan Paik Hospital

Dear Sir,Bilateral optic neuritis is not a rare condition in children following a viral syndrome[1].In contrast,simultaneous bilateral optic neuritis without known systemic disease has been considered a rare condition in adults[2].In addition,incidental extra-axial meningioma in a patient with bilateral optic neuritis has not been *** authors present a first case report on incidental parasagittal meningioma with bilateral optic neuritis.

关键词： Figure NMO

QKD system with fast active optical path length compensation

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 1-7页

作者： Byung Kwon Park Min Soo Lee Min Ki Woo Yong-Su Kim Sang-Wook Han sung moon Center for Quantum Information Korea Institute of Science and Technology Department of Nano-materials Science and Engineering Korea University of Science and Technology

We develop a quantum key distribution (QKD) system with fast active optical path length compensation. A rapid and reliable active optical path length compensation scheme is proposed and applied to a plug-and-play QKD system. The system monitors changes in key rates and controls it is own operation automatically. The system achieves its optimal performance within three seconds of operation, which includes a sifted key rate of 5.5 kbps and a quantum bit error rate of less than 2% after an abrupt temperature variation along the 25 km quantum channel. The system also operates well over a 24 h period while completing more than 60 active optical path length compensations.

关键词： quantum key distribution optical path length compensation plug and play field programmable gate array

Optimal Cyber Attack Strategy Using Reinforcement Learning Based onCommon Vulnerability Scoring System

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Computer Modeling in Engineering & Sciences 2024年第11期141卷 1551-1574页

作者： Bum-Sok Kim Hye-Won Suk Yong-Hoon Choi Dae-sung moon Min-Suk Kim Department of Electronic Information System Engineering Sangmyung UniversityCheonan31066Republic of Korea Department of Human Intelligence&Robot Engineering Sangmyung UniversityCheonan31066Republic of Korea Intelligent Convergence Research Laboratory Electronics and Telecommunications Research InstituteDaejeon34129Republic of Korea

Currently,cybersecurity threats such as data breaches and phishing have been on the rise due to the many differentattack strategies of cyber attackers,significantly increasing risks to individuals and *** technologies such as intrusion detection have been developed to respond to these cyber ***,advanced integrated cybersecurity that incorporates Artificial Intelligence has been the *** this paper,wepropose a response strategy using a reinforcement-learning-based cyber-attack-defense simulation tool to addresscontinuously evolving cyber ***,we have implemented an effective reinforcement-learning-basedcyber-attack scenario using Cyber Battle Simulation,which is a cyber-attack-defense *** scenarioinvolves important security components such as node value,cost,firewalls,and ***,we applieda new vulnerability assessment method based on the Common Vulnerability Scoring *** approach candesign an optimal attack strategy by considering the importance of attack goals,which helps in developing moreeffective response *** attack strategies are evaluated by comparing their performance using a variety ofReinforcement Learning *** experimental results show that RL models demonstrate improved learningperformance with the proposed attack strategy compared to the original *** particular,the success rateof the Advantage Actor-Critic-based attack strategy improved by 5.04 percentage points,reaching 10.17%,whichrepresents an impressive 98.24%increase over the original ***,the proposed method canenhance security and risk management capabilities in cyber environments,improving the efficiency of securitymanagement and significantly contributing to the development of security systems.

关键词： Reinforcement learning common vulnerability scoring system cyber attack cyber battle simulation

Endoscopic fibrin glue injection for closure of pancreatocutaneous fistula following transgastric endoscopic necrosectomy

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World Journal of Gastroenterology 2008年第39期14卷 6093-6095页

作者： Ji Woong Jang Do Hyun Park sung-Hoon moon Sang Soo Lee Dong Wan Seo sung Koo Lee Myung-Hwan Kim Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea

Transgastric endoscopic necrosectomy has been recently introduced as the effective and alternative management of infected pancreatic necrosis and pancreatic abscess. However,up to 40% of patients who undergo endoscopic necrosectomy may need an additional percutaneous approach for subsequent peripancreatic fluid collection or non-resolution of pancreatic necrosis. This percutaneous approach may lead to persistent pancreatocutaneous fistula,which remains a serious problem and usually requires prolonged hospitalization,or even open-abdominal surgery. We describe the first case of pancreatocutaneous fistula and concomitant abdominal wall defect following transgastric endoscopic necrosectomy and percutaneous drainage,which were endoscopically closed with fibrin glue injection via the necrotic cavity.

关键词： Fibrin glue Pancreatocutaneous fistula Infected pancreatic necrosis Pancreatic abscess Endoscopic necrosectomy

Highly Aligned Ternary Nanofiber Matrices Loaded with MXene Expedite Regeneration of Volumetric Muscle Loss

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Nano-Micro Letters 2024年第4期16卷 269-292页

作者： moon sung Kang Yeuni Yu Rowoon Park Hye Jin Heo Seok Hyun Lee Suck Won Hong Yun Hak Kim Dong‑Wook Han Department of Cogno‑Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Republic of Korea Medical Research Institute School of MedicinePusan National UniversityYangsan 50612Republic of Korea Department of Anatomy School of MedicinePusan National UniversityYangsan 50612Republic of Korea Engineering Research Center for Color‑Modulated Extra‑Sensory Perception Technology Pusan National UniversityBusan 46241Republic of Korea Department of Biomedical Informatics School of MedicinePusan National UniversityYangsan 50612Republic of Korea Periodontal Disease Signaling Network Research Center and Dental and Life Science Institute School of DentistryPusan National UniversityYangsan 50612Republic of Korea BIO‑IT Fusion Technology Research Institute Pusan National UniversityBusan 46241Republic of Korea Present Address:Osstem Implant Inc. Seoul 07789Republic of Korea

Current therapeutic approaches for volumetric muscle loss(VML)face challenges due to limited graft availability and insufficient *** overcome these limitations,tissue-engineered scaffolds have emerged as a promising *** this study,we developed aligned ternary nanofibrous matrices comprised of poly(lactide-co-ε-caprolactone)integrated with collagen and Ti_(3)C_(2)T_(x)MXene nanoparticles(NPs)(PCM matrices),and explored their myogenic potential for skeletal muscle tissue *** PCM matrices demonstrated favorable physicochemical properties,including structural uniformity,alignment,microporosity,and *** vitro assays revealed that the PCM matrices promoted cellular behaviors and myogenic differentiation of C2C12 ***,in vivo experiments demonstrated enhanced muscle remodeling and recovery in mice treated with PCM matrices following VML *** insights from next-generation sequencing revealed that MXene NPs facilitated protein and ion availability within PCM matrices,leading to elevated intracellular Ca^(2+)levels in myoblasts through the activation of inducible nitric oxide synthase(i NOS)and serum/glucocorticoid regulated kinase 1(SGK1),ultimately promoting myogenic differentiation via the m TOR-AKT ***,upregulated i NOS and increased NO–contributed to myoblast proliferation and fiber fusion,thereby facilitating overall myoblast *** findings underscore the potential of MXene NPs loaded within highly aligned matrices as therapeutic agents to promote skeletal muscle tissue recovery.

关键词： Ti_(3)C_(2)T_(x)MXene nanoparticle Ternary nanofibrous matrices Myogenesis Regeneration of volumetric muscle loss Next generation sequencing