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Extended lymph node dissection in robot-assisted radical prostatectomy： lymph node yield and distribution of metastases

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Asian Journal of Andrology 2014年第6期16卷 824-828页

作者： Kwang Hyun Kim Sey Kiat Lim Kyo Chul Koo Woong Kyu Han sung joon hong Koon Ho Rha Department of Urology Urological Science Institute Yonsei University College of Medicine Seoul Korea Department of Urology Ewha Womans University School ot Medicine Seoul Korea.

In this study, we reported our experience performing robotic extended lymph node dissection （eLND） in patients with prostate cancer. A total of 147 patients with intermediate and high-risk prostate cancer who underwent robotic eLND from May 2008 to December 2011 were included in this analysis. The dissection template extended to the ureter crossing the iliac vessels. We assessed lymph node yield, lymph node positivity, and perioperative outcomes. Lymph node positivity was also evaluated according to the number of lymph nodes （LNs） removed （〈22 vs 〉22）. The median number of LNs removed was 22 （11-51）, and 97 positive LNs were found in 24 patients （16.3%）. While the obturator fossa was the most common site for LN metastases （42.3%, 41/97）, the internal iliac area was the most common area for a single positive LN packet （20.8%, 5/24）. Eight patients （33.3%, 8/24） had positive LNs at the common iliac area. The incidence of positive LNs did not differ according to the number of LNs removed. Complications associated with eLND occurred in 21 patients （14.3%） and symptomatic lymphocele was found in five patients （3.4%）. In conclusion, robotic eLND can be performed with minimal morbidity. Furthermore, LN yield and the node positive rate achieved using this robotic technique are comparable to those of open series. In addition, the extent of dissection is more important than the absolute number of LNs removed in eLND, and the robotic technique is not a prohibitive factor for performing eLND.

关键词： lymph node excision prostatectomy prostatic neoplasm robotics

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Biochemical outcomes after robot-assisted radical prostatectomy in patients with follow-up more than 5-years

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Asian Journal of Andrology 2013年第3期15卷 404-408页

作者： Kwang Hyun Kim Sey Kiat Lim Tae-Young Shin Byung Ha Chung sung joon hong Koon Ho Rha Department of Urology Urological Science Institute Yonsei University College of Medicine Seoul Korea

In this study, we assessed biochemical outcomes after robot-assisted radical prostatectomy （RARP）. Between July 2005 and November 2007, one hundred and seventy-six consecutive patients treated by RARP without neoadjuvant treatment were included in this study. All procedures were performed by a single surgeon and the median follow-up period was 60 months （interquartile range （IQR）： 59-69）. The median prostate specific antigen was 7.50 ng ml-1 （IQR： 5.14-11.45） and 39.2% of the patients were classified as intermediate risk and 15.3% were classified as high risk; on final pathological examination, 35.2% of the patients had non-organ confined disease and 37.5% and 14.2% had Gleason scores of 7 and 8-10, respectively. The biochemical recurrence （BCR）-free survival rates at 3 and 5 years were 85.6% and 81.2%, respectively. The 5-year BCR-free survival rates stratified by pathologic Gleason scores were 93.1% in Gleason scores of 6 or less, 74.5% in a Gleason score of 7, and 58.1% in Gleason scores of 8 or greater, respectively （P〈0.001）. When stratified by pathologic stage, the BCR-free survival rates were 89.8% in pT2 patients, 66.2% in pT3a patients, and 39.3% in pT3b patients at 5 years following RARP, respectively （P〈0.001）. Preoperative prostate-specific antigen （PSA）, pathologic stage, postoperative Gleason score and surgical margin status were independently associated with BCR in multivariate analysis. In this study, we report biochemical outcomes after RARP with the longest follow-up periods to date in Asian men. We found that robotic surgery provided satisfactory biochemical outcomes, and that RARP is a safe and effective procedure in terms of oncologic outcomes.

关键词： prostatectomy prostatic neoplasm recurrence robotics

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-hong Kim Ruqayya Afridi Il-sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Thermoresponsive Al^(3+)-crosslinked poly(N-isopropylacrylamide)/alginate composite for green recovery of lithium from Li-spiked seawater

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Green Energy & Environment 2022年第2期7卷 334-344页

作者： sung Ho Park Sang joon Lee Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang790-784South Korea

With the rapid increase in the demand for lithium as an energy-critical element,the recovery of Li+ions from seawater is a worldwide challenging ***,we propose a new facile and fast selective recovery approach of Li+using an Al^(3+)-crosslinked poly(N-isopropylacrylamide)(PNIPAAm)/alginate(Alg)(PNP/Alg(Al)) *** in situ TEM images indicate that Alg-Al^(3+)coordination is reorganized via the rearrangement of PNIPAAm and Alg networks,as the temperature *** reorganization eventually leads to the formation of polycrystalline *** in situ FTIR results exhibit that PNP/Alg(Al) composite has peculiar phase transitions,which includes a retrogressive phase change from hydrophobic to *** synergetic effect of the strong repulsion force of Al^(3+) ions and the attractive force of negatively charged polymeric chains enables the efficient adsorption of Li+ions with a low affinity from Li-spiked seawater.7.3% of Li+ions are recovered from Li-spiked seawater although the concentration of Li-spiked seawater is very *** addition,Li+ions can be extracted from PNP/Alg(Al) composite with the use of a small thermal *** proposed thermoresponsive IPN gel provides a strong potential in practical applications for Li+recovery as an innovative energy-material strategy.

关键词： structure seawater lithium

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Effect of BainiticTreatment on Microstructure and Mechanical Properties of TRIP Cold-Rolled Steel Sheets

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Journal of Iron and Steel Research International 2011年第S1期18卷 1004-1007页

作者： Kim sung-joon Korea Institute of Machinery Science Changwon 641010Korea

The effects of bainitic treatment on microstructure and mechanical properties of 0.10C-1.5Mn-l.5Al TRIP-aided cold-rolled steels have been *** samples were heated by intercritical annealing at 820℃for 2 min and quenched in banitic temperature with different hoding time for 5 to 300s,two salt bath were used for the heat *** results show that the yield strength and elongation increase with the increasing of bainitic holding time,while the tensile strength *** volume fraction of retained austenite rise at the beginning of bainitic holding and then reduce,the carbon content of retained austenite increase during the bainitic *** tensile strengthen multiply elongation reaches the highest value at *** mechanical stability of retained austenite fits well with strain hardening during deformation.

关键词： TRIP bainitic treatment microstructure mechanical properties retained austenite

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Growth of BaTiO_3-Ag hybrid composite films at room temperature by aerosol deposition

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中国有色金属学会会刊：英文版 2012年第S3期22卷 735-739页

作者： Young joon YOON sung Hwan CHO Jihoon KIM Hyo Tae KIM hong Koo BAIK Jong-Hee KIM Nano-Convergence Intelligence Material Team Korea Institute of Ceramic Engineering and Technology Division of Advanced Materials Engineering Kongju National University Department of Materials Science and Engineering Yonsei University

Barium titanate (BaTiO3) and silver (Ag) composite film with high dielectric constant was grown at room temperature by an aerosol deposition *** dielectric constant increases by 0.5 times after adding Ag to the BaTiO3 matrix,compared with pure *** high dielectric constant can be attributed to the percolation effect of Ag inclusions in the BaTiO3 *** Ag was present in the form of discrete layer in the BaTiO3 *** dielectric properties of BaTiO3 Ag were discussed in detail taking into account the changes in microstructures.

关键词： composites percolation aerosol deposition BaTiO3 Ag

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Uncertainty analysis of flow rate measurement for multiphase flow using CFD

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Acta Mechanica Sinica 2015年第5期31卷 698-707页

作者： joon-Hyung Kim Uk-Hee Jung sung Kim joon-Yong Yoon Young-Seok Choi Department of Mechanical Design Engineering Hanyang University Thermal & Fluid System R&BD Group Korea Institute of Industrial Technology Energy System Engineering University of Science and Technology

The venturi meter has an advantage in its use,because it can measure flow without being much affected by the type of the measured fluid or flow ***,it has excellent versatility and is being widely applied in many *** flow of a liquid containing air is a representative example of a multiphase flow and exhibits complex flow *** particular,the greater the gas volume fraction（GVF）,the more inhomogeneous the flow *** a result,using a venturi meter to measure the rate of a flow that has a high GVF generates an *** this study,the cause of the error occurred in measuring the flow rate for the multiphase flow when using the venturi meter for analysis by *** ensure the reliability of this study,the accuracy of the multiphase flow models for numerical analysis was verified through comparison between the calculated results of numerical analysis and the experimental *** a result,the Grace model,which is a multiphase flow model established by an experiment with water and air,was confirmed to have the highest ***,the characteristics of the internal flow Held about the multiphase flow analysis result generated by applying the Grace model were analyzed to find the cause of the uncertainty occurring when measuring the flow rate of the multiphase flow using the venturi meter.A phase separation phenomenon occurred due to a density difference of water and air inside the venturi,and flow inhomogeneity happened according to the flow velocity difference of each *** was confirmed that this flow inhomogeneity increased as the GVF increased due to the uncertainty of the flow measurement.

关键词： Multiphase flow Measurement Numerical analysis Venturi meter Gas volume fraction(GVF) Uncertainty Multiphase flow model Grace model

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Efficacy of uncovered self-expandable metallic stent for colorectal obstruction by extracolonic malignancy

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 1005-1013页

作者： joon Seong Ahn sung Noh hong Dong Kyung Chang Young-Ho Kim Eun-Ran Kim Department of Internal Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea

BACKGROUND Self-expandable metallic stent(SEMS)is widely used for malignant colorectal ***,SEMS has been used for palliative option for colorectal obstruction caused by extracolonic malignancy(ECM).AIM To evaluate the efficacy of SEMS for colorectal obstruction caused by ECM,and to identify the factors associated with stent *** Seventy-two patients who were treated with uncovered SEMS insertion for malignant colorectal obstructions caused by colorectal metastasis or peritoneal seeding of ECM at Samsung Medical Center between April 2012 to March 2016 were *** analyzed technical and clinical outcomes of stent insertion,the factors associated with stent occlusion and long term outcomes after stent *** Technical success rate was determined as 90.3%with a clinical success rate of 87.7%.Stent occlusion developed in 28.1%,with a median duration of 51 ***,81.3%with stent occlusion could be treated with secondary stent *** failure was observed to be related to the male sex(P=0.020)and right colon obstruction(P=0.017).Stent length≤10 cm was found to be associated with stent occlusion(P=0.003).Median survival time after stent insertion was 4.7 mo and 40.4%were able to receive their oncological treatments after stent insertion without *** Uncovered SEMS is effective for the treatment of colorectal obstruction caused by ECM,considering life expectancy of patients with ECM.

关键词： Self-expandable metallic stent Colorectal stent Colorectal obstruction Extracolonic malignancy Retrospective study

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Pancreatic hardness: Correlation of surgeon's palpation, durometer measurement and preoperative magnetic resonance imaging features

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World Journal of Gastroenterology 2017年第11期23卷 2044-2051页

作者： Tae Ho hong joon-Il Choi Michael Yong Park sung Eun Rha Young joon Lee Young Kyoung You Moon Hyung Choi Department of Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Cancer Research Institute Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of Korea Department of Radiology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

AIM To evaluate the correlation between subjective assessments of pancreatic hardness based on the palpation, objective measurements using a durometer, and magnetic resonance imaging(MRI) findings for assessing pancreatic *** Eighty-three patients undergoing pancreatectomies were enrolled. An experienced surgeon subjectively evaluated the pancreatic hardness in the surgical field by palpation. The pancreatic hardness was also objectivelyevaluated using a durometer. Preoperative MRI findings were evaluated by a radiologist in terms of the apparent diffusion coefficient(ADC) values, the relative signal intensity decrease(RSID) of the pancreatic parenchyma, and the diameter of the pancreatic parenchyma and duct. Durometer measurement results, ADC values, RSID, pancreatic duct and parenchyma diameters, and the ratio of the diameters of the duct and parenchyma were compared between pancreases judged to be soft or hard pancreas on the palpation. A correlation analysis was also performed between the durometer and MRI *** The palpation assessment classified 44 patients as having a soft pancreas and 39 patients as having a hard pancreas. ADC values were significantly lower in the hard pancreas group. The ductal diameter and duct-to-pancreas ratio were significantly higher in the hard pancreas group. For durometer measurements, a correlation analysis showed a positive correlation with the ductal diameter and the duct-to-pancreas ratio and a negative correlation with ADC values. CONCLUSION Hard pancreases showed lower ADC values, a wider pancreatic duct diameter and a higher duct-to-pancreas ratio than soft pancreases. Additionally, the ADC values, diameter of the pancreatic duct and duct-to-pancreas ratio were closely correlated with the durometer results.

关键词： Pancreas Texture Hardness Magnetic resonance imaging Fistula

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Primary large cell neuroendocrine carcinoma in the common bile duct:First Asian case report

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World Journal of Gastroenterology 2014年第47期20卷 18048-18052页

作者： sung Bae Park Suk Bae Moon Young joon Ryu Jeana hong Yang Hee Kim Gi Bong Chae Seong Kweon hong Department of Surgery Kangwon National University HospitalKangwon National University School of MedicineChuncheon 200-947South Korea Department of Pathology Kangwon National University HospitalKangwon National University School of MedicineChuncheon 200-947South Korea Department of Pediatrics Kangwon National University HospitalKangwon National University School of MedicineChuncheon 200-947South Korea

Large cell neuroendocrine carcinoma (LCNEC) in the biliary system is a poorly differentiated, high-grade neuroendocrine tumor. These tumors exhibit aggressive behavior and an increased tendency for early nodal and distant metastases. Herein, we report an unusual case of a pure primary LCNEC of the common bile duct (CBD). A 75-year-old female presented with nausea and jaundice. The patient underwent a CBD excision with lymph node dissection. Upon histological and immunohistochemical examination, the tumor exhibited pure large cell-type neuroendocrine features. Metastases were noted in two of the eight lymph nodes. The patient was administered adjuvant chemotherapy. The patient’s cancer recurred 7 mo after surgery, and the patient died from liver failure 5 mo after recurrence. The prognosis of LCNEC of CBD remains poor despite curative resection and adjuvant chemotherapy. The role of additional therapies, such as multimodal treatment including radiation therapy, must be further studied to improve the prognoses of patients.

关键词： Neuro endocrine tumor Large cell neuroendocrine carcinoma Metastases Multimodal treatment Common bile duct

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