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World Journal of Gastroenterology 2014年第45期20卷 16913-16924页

作者： sung ill jang Gak Won Yun Dong Ki Lee Department of Internal Medicine Kangnam Sacred Heart Hospital Hallym University College of Medicine Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine

Endoscopic retrograde cholangiopancreatography (ERCP) is the essential first modality for common bile duct (CBD) stone therapy. The conventional endoscopic treatment for CBD stones is stone removal after endoscopic sphincterotomy (EST). Stone removal after papillary stretching using balloon dilation instead of the conventional method has been widely adopted. There are many reports regarding endoscopic papillary balloon dilation (EPBD) utilizing a small balloon (illar large balloon dilation (EPLBD), which is used to treat large CBD stones, was not widely adopted when first introduced due to concerns about perforation and severe pancreatitis from the use of a large balloon (12-20 mm). However, as experience with this procedure accumulates, the occurrence of PEP with EPLBD is confirmed to be much lower than with EPBD. This report reviews whether EPBD and EPLBD, two procedures that use balloon dilation but differ in terms of indications and concept, contribute to the occurrence of PEP.

关键词： Post-endoscopic retrograde cholangiopancreatography pancreatitis Endoscopic papillary balloon dilation Endoscopic papillary large balloon dilation Common bile duct stone

Ionizing terahertz waves with 260 MV/cm from scalable optical rectification

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Light(Science & Applications) 2024年第6期13卷 1075-1087页

作者： Hyeongmun Kim Chul Kang Dogeun jang Yulan Roh Sang Hwa Lee Joong Wook Lee Jae Hee sung Seong Ku Lee Ki-Yong Kim Advanced Photonics Research Institute GISTGwangju61005Korea Department of Physics and Optoelectronics Convergence Research Center Chonnam National UniversityGwangju61186Korea Pohang Accelerator Laboratory POSTECHPohang37673Korea Center for Relativistic Laser Science Institute for Basic ScienceGwangju61005Korea Institute for Research in Electronics and Applied Physics Department of PhysicsUniversity of MarylandCollege ParkMaryland20742USA

Terahertz(THz)waves,known as non-ionizing radiation owing to their low photon energies,can actually ionize atoms and molecules when a sufficiently large number of THz photons are concentrated in time and ***,we demonstrate the generation of ionizing,multicycle,15-THz waves emitted from large-area lithium niobate crystals via phase-matched optical rectification of 150-terawatt laser pulses.A complete characterization of the generated THz waves in energy,pulse duration,and focal spot size shows that the field strength can reach up to 260 megavolts per *** particular,a single-shot THz interferometer is employed to measure the THz pulse duration and spectrum with complementary numerical *** intense THz pulses are irradiated onto various solid targets to demonstrate THz-induced tunneling ionization and plasma *** study also discusses the potential of nonperturbative THz-driven ionization in gases,which will open up new opportunities,including nonlinear and relativistic THz physics in plasma.

关键词： optical interferometer matched

Harnessing SARS-CoV-2-specific CD8^(+)T cells to kill target tumor cells for cancer immunotherapy

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Cancer Communications 2024年第1期44卷 173-177页

作者： Keunok Jung Deok-Han Ko Jeong-Yun jang Young Rong Kim Jung Yeon Heo Yong-sung Kim Department of Allergy and Clinical Immunology Ajou University School of MedicineSuwonRepublic of Korea Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea Department of Infectious Diseases Ajou University School of MedicineSuwonRepublic of Korea

Dear Editor,During the coronavirus disease 2019(COVID-19)pan-demic era,many individuals were naturally infected with or vaccinated against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),resulting in the p... 详细信息

关键词： acute respiratory immunotherapy

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-sung jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

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Nano Research 2024年第10期17卷 9141-9151页

作者： Jeong Yu Lee Shonit Nair Sharma sung-Yu Hong Young-Guk Ko Yangsoo jang Minjae Do Michael Christopher Stark Qiwen Peng Benjamin Allen Mossburg Bo Chan Seo Yuhan Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 305-701Republic of Korea Department of Anesthesiology Perioperativeand Pain MedicineCenter for Accelerated Medical Innovation&Center for NanomedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Cardiovascular Product Evaluation Center Yonsei University College of MedicineSeoul 120-752Republic of Korea Division of Cardiology Department of Internal MedicineSeverance Cardiovascular HospitalYonsei University College of MedicineSeoul 120-752Republic of Korea

Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery *** advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention *** balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion ***,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a ***,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional *** the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH *** exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon *** with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the *** results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.

关键词： drug-eluting balloon layer-by-layer coating coronary artery disease paclitaxel

Paleozoic tectonic evolution of the proto-Korean Peninsula along the East Asian continental margin from detrital zircon U-Pb geochronology and Hf isotope geochemistry

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Geoscience Frontiers 2024年第1期15卷 97-117页

作者： Yirang jang sung Won Kim Vinod O.Samuel Sanghoon Kwon Seung-Ik Park M.Santosh Keewook Yi Department of Earth and Environmental Sciences Chonnam National UniversityGwangju 61186Republic of Korea Geology Division Korea Institute of Geoscience and Mineral ResourcesDaejeon 34132Republic of Korea Department of Earth System Sciences Yonsei UniversitySeoul 03722Republic of Korea Department of Geology Kyungpook National UniversityDaegu 41566Republic of Korea School of Earth Sciences and Resources China University of Geosciences BeijingBeijing 100083China Department of Earth Science University of AdelaideAdelaide SA 5005Australia Yonsei Frontiers Lab Yonsei UniversitySeoul 03722Republic of Korea Division of Earth and Environmental Sciences Korea Basic Science InstituteChungbuk 28119Republic of Korea

Detrital zircon geochronology and Hf isotope analysis can be used for inferring provenance characteristics,and to evaluate the tectonic evolution of sedimentary basins and their link with regional *** Paleozoic sequences of the Okcheon Belt consist of the Lower Paleozoic Joseon and the Upper Paleozoic Pyeongan supergroups with Middle Paleozoic hiatus locally on top of the Neoproterozoic bimodal volcanic rocks,reflecting an intracontinental rift setting between the two basements(*** and Yeongnam massifs)at southern part of the Korean *** detrital zircon U-Pb ages and Lu-Hf isotope results show that all these Paleozoic strata commonly have Paleoproterozoic and Paleozoic zircon ages with rare Meso-to Neoproterozoic *** individual zircon populations display following features,allowing estimation of their sedimentary provenances:(i)The Paleoproterozoic zircons(ca.1.85 Ga and 2.50 Ga)with similar ranges ofεHf(t)values are most common in the basement rocks of the Korean Peninsula,and were sourced from both the Gyeonggi and Yeongnam massifs.(ii)The Meso-to Neoproterozoic zircons,preserved only in the Middle to Late Cambrian clastic sedimentary rocks within the carbonate sequences probably reflect proximal provenance.(iii)The youngest Paleozoic zircons of each formation,almost coincident with their deposition ages,suggest presence of syndepositional magmatism,indicating proximal magmatic sources during their deposition.(iv)The Cambrian-Ordovician zircons,from the Lower Paleozoic sequences,but rare in the successive Upper Paleozoic sequences,suggest a provenance change after the hiatus between the two sedimentary successions.(v)The Permian zircons showing differentεHf(t)values indicate that detrital sources were varied at that *** integrated results in our study suggest provenance variability linked to diverse tectonic environments,reflecting prolonged subduction-related crustal evolution of the proto-Korean Peninsula during the Paleozo

关键词： Detrital zircon U-Pb and Hf isotopes Paleozoic metasedimentary rocks Okcheon Belt Taebaeksan zone Korean Peninsula

Dimensionality-driven metal to Mott insulator transition in two-dimensional 1T-TaSe2

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National Science Review 2024年第3期11卷 108-118页

作者： Ning Tian Zhe Huang Bo Gyu jang Shuaifei Guo Ya-Jun Yan Jingjing Gao Yijun Yu Jinwoong Hwang Cenyao Tang Meixiao Wang Xuan Luo Yu Ping Sun Zhongkai Liu Dong-Lai Feng Xianhui Chen sung-Kwan Mo Minjae Kim Young-Woo Son Dawei Shen Wei Ruan Yuanbo Zhang State Key Laboratory of Surface Physics New Cornerstone Science Laboratory and Department of PhysicsFudan University Shanghai Qi Zhi Institute Shanghai Research Center for Quantum Sciences Institute for Nanoelectronic Devices and Quantum Computing Fudan University Zhangjiang Fudan International Innovation Center Fudan University State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology(SIMIT)Chinese Academy of Sciences School of Physical Science and Technology ShanghaiTech University Korea Institute for Advanced Study School of Emerging Technology and Department of Physics University of Science and Technology of China Advanced Light Source Lawrence Berkeley National Laboratory ShanghaiTech Laboratory for Topological Physics Key Laboratory of Materials Physics Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of Sciences High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Collaborative Innovation Centre of Advanced Microstructures Nanjing University Department of Physics University of Science and Technology of China and Key Laboratory of Strongly Coupled Quantum Matter Physics Chinese Academy of Sciences National Synchrotron Radiation Laboratory University of Science and Technology of China

Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena. In the extreme two-dimensional limit, electron-electron interaction often dominates over other electronic energy scales, leading to strongly correlated effects such as quantum spin liquid and unconventional *** dominance is conventionally attributed to the lack of electron screening in the third dimension. Here, we discover an intriguing metal to Mott insulator transition in 1T-TaSe2that defies conventional wisdom. Specifically, we find that dimensionality crossover, instead of reduced screening, drives the transition in atomically thin 1T-TaSe2. A dispersive band crossing the Fermi level is found to be responsible for the bulk metallicity in the material. Reducing the dimensionality,however, effectively quenches the kinetic energy of these initially itinerant electrons, and drives the material into a Mott insulating *** dimensionality-driven metal to Mott insulator transition resolves the long-standing dichotomy between metallic bulk and insulating surface of 1T-TaSe2. Our work further reveals a new pathway for modulating two-dimensional materials that enables exploring strongly correlated systems across uncharted parameter space.

关键词： two-dimensional materials 1T-TaSe2 dimensionality crossover metal to Mott insulator transition

Real-Time Tunable Gas Sensing Platform Based on SnO_(2) Nanoparticles Activated by Blue Micro-Light-Emitting Diodes

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Nano-Micro Letters 2024年第12期16卷 103-119页

作者： Gi Baek Nam Jung-El Ryu Tae Hoon Eom Seung Ju Kim Jun Min Suh Seungmin Lee sungkyun Choi Cheon Woo Moon Seon Ju Park Soo Min Lee Byungsoo Kim sung Hyuk Park Jin Wook Yang Sangjin Min Sohyeon Park sung Hwan Cho Hyuk Jin Kim Sang Eon Jun Tae Hyung Lee Yeong Jae Kim Jae Young Kim Young Joon Hong Jong-In Shim Hyung-Gi Byun Yongjo Park Inkyu Park Sang-Wan Ryu Ho Won jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Research Laboratory of Electronics Department of Mechanical EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139USA Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Display Materials Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang University ERICAAnsan 15588Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok 25913Republic of Korea Advance Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Physics Chonnam National UniversityGwangju 500-757Republic of Korea

Micro-light-emitting diodes(μLEDs)have gained significant interest as an activation source for gas sensors owing to their advantages,including room temperature operation and low power ***,despite these benefits,challenges still exist such as a limited range of detectable gases and slow *** this study,we present a blueμLED-integrated light-activated gas sensor array based on SnO_(2)nanoparticles(NPs)that exhibit excellent sensitivity,tunable selectivity,and rapid detection with micro-watt level power *** optimal power forμLED is observed at the highest gas response,supported by finite-difference time-domain ***,we first report the visible light-activated selective detection of reducing gases using noble metal-decorated SnO_(2)*** noble metals induce catalytic interaction with reducing gases,clearly distinguishing NH3,H2,and ***-time gas monitoring based on a fully hardwareimplemented light-activated sensing array was demonstrated,opening up new avenues for advancements in light-activated electronic nose technologies.

关键词： Micro-LED Gas sensor array Low power consumption Metal decoration Real-time detection

Recovery mechanisms of somatosensory function in stroke patients: implications of brain imaging studies

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Neuroscience Bulletin 2013年第3期29卷 366-372页

作者： sung Ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Somatosensory dysfunction is associated with a high incidence of functional impairment and safety in patients with stroke. With developments in brain mapping techniques, many studies have addressed the recovery of various functions in such patients. However, relatively little is known about the mechanisms of recovery of somatosensory function. Based on the previous human studies, a review of 11 relevant studies on the mecha- nisms underlying the recovery of somatosensory function in stroke patients was conducted based on the fol- lowing topics：（1） recovery of an injured somatosensory pathway, （2） peri-lesional reorganization, （3） contribu- tion of the unaffected somatosensory cortex, （4） contribution of the secondary somatosensory cortex, and （5） mechanisms of recovery in patients with thalamic lesions. We believe that further studies in this field using combinations of diffusion tensor imaging, functional neuroimaging, and magnetoencephalography are needed. In addition, the clinical significance, critical period, and facilitatory strategies for each recovery mechanism should be clarified.

关键词： stroke somatosensory recovery brain mapping brain plasticity

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Perilesional reorganization of motor function in stroke patients

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Neural Regeneration Research 2010年第21期5卷 1668-1672页

作者： sung Ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Perilesional reorganization is an important recovery mechanism for stroke patients because it yields good motor outcomes. However, perilesional reorganization remains poorly understood. The scientific basis for stroke rehabilitation can be established when detailed mechanisms of recovery are clarified. In addition, studies at the subcortical level remain in the early stages. Therefore, the present study suggested that additional investigations should focus on perilesional reorganization at the subcortical level, identifying the critical period for this mechanism and determining treatment strategies and modalities to facilitate development. The present study reviews literature focused on perilesional reorganization in stroke patients with regard to demonstration, clinical characteristics, and rehabilitative aspects, as well as previous studies of perilesional reorganization at cortical and subcortical levels.

关键词： stroke motor recovery functional MRI diffusion tensor imaging brain plasticity reorganization

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